A Schmitt

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:91-100. 2004
  2. ncbi request reprint Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms
    Andrea Schmitt
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 80:305-13. 2005
  3. ncbi request reprint Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits
    Andrea Schmitt
    Central Institute of Mental Health, PO Box 12 21 20, D 68072 Mannheim, Germany
    Neurochem Res 28:235-41. 2003
  4. ncbi request reprint Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain
    Andrea Schmitt
    Central Institute of Mental Health, PO Box 122120, D 68072 Mannheim, Germany
    Neurosci Lett 347:81-4. 2003
  5. ncbi request reprint Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 36:292-6. 2003
  6. ncbi request reprint Altered NMDA receptor expression and behavior following postnatal hypoxia: potential relevance to schizophrenia
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 114:239-48. 2007
  7. ncbi request reprint Differential effects of long-term treatment with clozapine or haloperidol on GABA transporter expression
    M Zink
    Central Institute of Mental Health, Department of Psychiatry, Mannheim, Germany
    Pharmacopsychiatry 37:171-4. 2004
  8. ncbi request reprint Differential expression of glutamate transporters EAAT1 and EAAT2 in mice deficient for PACAP-type I receptor
    M Zink
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:1537-42. 2004
  9. pmc Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia
    J U Sommer
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S81-9. 2010
  10. ncbi request reprint Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods
    A Jatzko
    Central Institute of Mental Health, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Germany
    J Affect Disord 94:121-6. 2006

Detail Information

Publications27

  1. ncbi request reprint Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:91-100. 2004
    ..In contrast, chronic haloperidol treatment did increase total hippocampal volume suggesting that haloperidol alters neuroplastic processes or glial morphology rather than cell proliferation...
  2. ncbi request reprint Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms
    Andrea Schmitt
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 80:305-13. 2005
    ..Correlations point to the impact of S100B in neuroplasticity and ageing. Post-mortem studies should clarify the presence of altered S100B function in the brain and its relationship to neuroplastic or neurodegenerative processes...
  3. ncbi request reprint Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits
    Andrea Schmitt
    Central Institute of Mental Health, PO Box 12 21 20, D 68072 Mannheim, Germany
    Neurochem Res 28:235-41. 2003
    ..Because the effects seen in different brain areas clearly vary between haloperidol and clozapine, they may also be responsible for some of the differences in efficacy and side effects...
  4. ncbi request reprint Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain
    Andrea Schmitt
    Central Institute of Mental Health, PO Box 122120, D 68072 Mannheim, Germany
    Neurosci Lett 347:81-4. 2003
    ..We hypothesize that glutamate transporter downregulation by neuroleptics increases glutamatergic action at the postsynaptic neuron and thereby may be related to beneficial antipsychotic effects and side effects...
  5. ncbi request reprint Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 36:292-6. 2003
    ..As most patients had been treated with antipsychotics, medication effects cannot be excluded as a possible explanation for these results...
  6. ncbi request reprint Altered NMDA receptor expression and behavior following postnatal hypoxia: potential relevance to schizophrenia
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 114:239-48. 2007
    ..Compensatory upregulation of NR1 expression may occur due to NMDA receptor hypofunction. We discuss this animal model to further analyze effects of hypoxia as a factor of obstetric complications in the pathophysiology of schizophrenia...
  7. ncbi request reprint Differential effects of long-term treatment with clozapine or haloperidol on GABA transporter expression
    M Zink
    Central Institute of Mental Health, Department of Psychiatry, Mannheim, Germany
    Pharmacopsychiatry 37:171-4. 2004
    ..Whether this effect is due to the pathophysiology of schizophrenia or to antipsychotic treatment has not been investigated. We therefore established an animal trial of long-term antipsychotic treatment to address this question...
  8. ncbi request reprint Differential expression of glutamate transporters EAAT1 and EAAT2 in mice deficient for PACAP-type I receptor
    M Zink
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:1537-42. 2004
    ..Our data confirm the previously reported in-vitro-regulation of EAAT1 in the adult nervous system in vivo. EAAT2 expression, however, is unchanged in PAC1 knockout mice, most likely due to counterbalancing factors...
  9. pmc Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia
    J U Sommer
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S81-9. 2010
    ..Hence, hypoxia alters gene expression regionally specific, which is in agreement with reports on differentially expressed presynaptic genes in schizophrenia. Chronic clozapine treatment may contribute to normalize synaptic connectivity...
  10. ncbi request reprint Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods
    A Jatzko
    Central Institute of Mental Health, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Germany
    J Affect Disord 94:121-6. 2006
    ..To overcome these problems, the present study investigates volume changes in well-characterized chronic PTSD patients in comparison to controls using two different evaluation methods...
  11. ncbi request reprint Effects of antipsychotic treatment on membrane phospholipid metabolism in schizophrenia
    A Schmitt
    Central Institute of Mental Health, Mannheim, Federal Republic of Germany
    J Neural Transm 108:1081-91. 2001
    ....
  12. doi request reprint Circadian rhythms investigated on the cellular and molecular levels
    P J Gebicke-Haerter
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Pharmacopsychiatry 46:S22-9. 2013
    ..It is expected that disturbed rhythmic behaviour in mental disorders is reflected in altered oscillatory behaviour of gene expression...
  13. ncbi request reprint [Effective treatment of depressive disorder with psychotic symptoms by olanzapine combination therapy]
    A Schmitt
    Zentralinstitut fur Seelische Gesundheit, J5, Mannheim
    Dtsch Med Wochenschr 125:1526-9. 2000
    ..At psychiatric assessment he appeared to be depressed with reduced ability of affective changes and impaired formal reasoning. He exhibited delusions of guilt and reference. His sleep was impaired and appetite diminished...
  14. ncbi request reprint [Antipsychotics and phospholipid metabolism in schizophrenia]
    A Schmitt
    Zentralinstitut fur Seelische Gesundheit, Mannheim
    Fortschr Neurol Psychiatr 69:503-9. 2001
    ..Thus, specific mechanisms of the different antipsychotic therapies on phospholipid metabolism might serve to explain the divergent findings of (31)P-MRS in medicated patients...
  15. doi request reprint Does the degree of smoking effect the severity of tardive dyskinesia? A longitudinal clinical trial
    A Diehl
    Department of Addictive Behavior and Addiction Medicine, University of Heidelberg, Square J 5, 68159 Mannheim, Germany
    Eur Psychiatry 24:33-40. 2009
    ..Purpose of this study was to examine the correlation between the degree of smoking and the severity of TD with respect to differences caused by medication...
  16. ncbi request reprint Huntington's disease: phenomenological diversity of a neuropsychiatric condition that challenges traditional concepts in neurology and psychiatry
    Heike Tost
    Central Institute of Mental Health, University of Heidelberg, Germany
    Am J Psychiatry 161:28-34. 2004
  17. ncbi request reprint Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  18. ncbi request reprint Differential effects of long-term treatment with clozapine or haloperidol on GABAA receptor binding and GAD67 expression
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 66:151-7. 2004
    ..However, the reduced GAD67 expression seen in postmortem brains does not appear to reflect drug effects, since our animal model demonstrated increased gene expression...
  19. ncbi request reprint Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center study
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Schizophr Res 89:198-210. 2007
    ....
  20. ncbi request reprint D2 antidopaminergic modulation of frontal lobe function in healthy human subjects
    Heike Tost
    Department of Psychiatry and Psychotherapy, University of Heidelberg, Germany
    Biol Psychiatry 60:1196-205. 2006
    ..Two major neurophysiological models propose segregated functional circuits on the systems level as well as D(1) and D(2) receptor-dependent processing states on the cellular level (two-state model)...
  21. ncbi request reprint Disturbance in the neural circuitry underlying positive emotional processing in post-traumatic stress disorder (PTSD). An fMRI study
    Alexander Jatzko
    Central Institute of Mental Health ZI NMR Research, 122120, 68072, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 256:112-4. 2006
    ..This pilot study is the first to reveal alterations in the processing of positive emotions in PTSD possibly reflecting a neuronal correlate of the symptom of emotional numbness in PTSD...
  22. ncbi request reprint Pedophilia: neuropsychological evidence encouraging a brain network perspective
    Heike Tost
    Central Institute of Mental Health, NMR Research in Psychiatry, P O Box 122120, 68072 Mannheim, Germany
    Med Hypotheses 63:528-31. 2004
    ....
  23. ncbi request reprint Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Alcohol Clin Exp Res 28:1752-7. 2004
    ..To further characterize the influence of chronic ethanol exposure on the developing brain, we assessed the transcriptional and translational regulation of glutamate transporters in a less artificial in vitro system...
  24. ncbi request reprint Altered thalamic membrane phospholipids in schizophrenia: a postmortem study
    Andrea Schmitt
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 56:41-5. 2004
    ..This region might play an important role in the pathophysiology of schizophrenia and has not been studied thus far with respect to its membrane lipid composition...
  25. ncbi request reprint Helicobacter pylori vaccine development: facing the challenge
    Toni Aebischer
    Max Planck Institute for Infection Biology, Department of Molecular Biology, Schumannstrasse 21122, D 1011 7 Berlin, Germany
    Int J Med Microbiol 295:343-53. 2005
    ..Despite some important advances in recent years, important issues must be resolved before an H. pylori vaccine will become a reality...
  26. ncbi request reprint Protective drugs in acute large-dose exposure to organophosphates: a comparison of metoclopramide and tiapride with pralidoxime in rats
    Georg A Petroianu
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Anesth Analg 100:382-6. 2005
    ..Both tiapride and pralidoxime significantly decreased mortality in our model. The protection conferred by tiapride was significantly less than that conferred by pralidoxime at 30 min, but was not significantly different at 24 and 48 h...