Christian Schmahl

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder
    Eric Vermetten
    University Medical Center, Utrecht, The Netherlands
    Psychopharmacol Bull 40:8-30. 2007
  2. doi request reprint Motives for nonsuicidal self-injury among women with borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 196:230-6. 2008
  3. ncbi request reprint [Importance of neurobiology for modular psychotherapy]
    C Schmahl
    Klinik für Psychosomatik und Psychotherapeutische Medizin, Zentralinstitut fur Seelische Gesundheit Mannheim, J 5, 68159, Mannheim, Deutschland
    Nervenarzt 84:1316-20. 2013
  4. pmc Gene expression profiles in relation to tension and dissociation in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 8:e70787. 2013
  5. ncbi request reprint Neural correlates of antinociception in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 63:659-67. 2006
  6. doi request reprint Pain sensitivity is reduced in borderline personality disorder, but not in posttraumatic stress disorder and bulimia nervosa
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:364-71. 2010
  7. pmc Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Psychiatry Neurosci 34:289-95. 2009
  8. doi request reprint Amygdala deactivation as a neural correlate of pain processing in patients with borderline personality disorder and co-occurrent posttraumatic stress disorder
    Anja Kraus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 65:819-22. 2009
  9. doi request reprint Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010
  10. pmc Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid posttraumatic stress disorder: a pilot study
    Petra Ludäscher
    Central Institute of Mental Health, Department of Psychosomatic Medicine and Psychotherapy, Mannheim, Germany
    J Psychiatry Neurosci 35:177-84. 2010

Detail Information

Publications49

  1. pmc Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder
    Eric Vermetten
    University Medical Center, Utrecht, The Netherlands
    Psychopharmacol Bull 40:8-30. 2007
    ..Primitive brain systems involved in fear responsivity and survival also mediate smell, including the olfactory cortex and amygdala. The purpose of this study was to measure neural correlates of olfaction in PTSD...
  2. doi request reprint Motives for nonsuicidal self-injury among women with borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 196:230-6. 2008
    ..NSSI was usually preceded by a large variety of negative feelings that were reported to clearly improve with NSSI. In conclusion, therapists should anticipate a multidimensional functional spectrum when exploring motives of NSSI...
  3. ncbi request reprint [Importance of neurobiology for modular psychotherapy]
    C Schmahl
    Klinik für Psychosomatik und Psychotherapeutische Medizin, Zentralinstitut fur Seelische Gesundheit Mannheim, J 5, 68159, Mannheim, Deutschland
    Nervenarzt 84:1316-20. 2013
    ..In addition, the use of neurobiological investigations within classical psychotherapy trials in the fields of borderline personality disorder and posttraumatic stress disorder will be depicted. ..
  4. pmc Gene expression profiles in relation to tension and dissociation in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 8:e70787. 2013
    ..Major limitations of the study are the the possibly heterogeneous cell proportions in whole blood and the heterogeneous medication. ..
  5. ncbi request reprint Neural correlates of antinociception in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 63:659-67. 2006
    ..We predicted that heat stimuli in patients with BPD would activate brain areas concerned with cognitive and emotional evaluation of pain...
  6. doi request reprint Pain sensitivity is reduced in borderline personality disorder, but not in posttraumatic stress disorder and bulimia nervosa
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:364-71. 2010
    ..To establish whether these findings are specific for BPD, we compared pain thresholds in patients with BPD, posttraumatic stress disorder (PTSD), bulimia nervosa, and healthy controls...
  7. pmc Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Psychiatry Neurosci 34:289-95. 2009
    ..Both groups exhibit volume reductions of the hippocampus and amygdala. Our aim was to investigate the influence of comorbid PTSD on hippocampus and amygdala volumes in patients with BPD...
  8. doi request reprint Amygdala deactivation as a neural correlate of pain processing in patients with borderline personality disorder and co-occurrent posttraumatic stress disorder
    Anja Kraus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 65:819-22. 2009
    ..This study aimed at clarifying whether central antinoceptive mechanisms discriminate BPD patients with and without co-occurrent PTSD...
  9. doi request reprint Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010
    ..Impulsivity is a key feature of BPD and can be related to anterior cingulate cortex function...
  10. pmc Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid posttraumatic stress disorder: a pilot study
    Petra Ludäscher
    Central Institute of Mental Health, Department of Psychosomatic Medicine and Psychotherapy, Mannheim, Germany
    J Psychiatry Neurosci 35:177-84. 2010
    ..Our aim was to investigate the psychologic, somatosensory (pain sensitivity) and neural correlates of dissociative states in patients with these disorders...
  11. doi request reprint Differentiation of pain ratings in combat-related posttraumatic stress disorder
    Anja Kraus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Pain 143:179-85. 2009
    ..Our results suggest an association of PTSD with reduced pain sensitivity, which could be related to PTSD-related (neuro-)psychological alterations or to a pre-existing risk factor for the disorder...
  12. pmc Emotional learning during dissociative states in borderline personality disorder
    Ulrich W Ebner-Priemer
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Germany
    J Psychiatry Neurosci 34:214-22. 2009
    ..The aim of our study was to determine whether high states of dissociative experience would specifically alter emotional learning, but not declarative knowledge...
  13. doi request reprint Impulsivity in relation to stress in patients with borderline personality disorder with and without co-occurring attention-deficit/hyperactivity disorder: an exploratory study
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 201:116-23. 2013
    ..We suggest that stress levels and co-occurring ADHD should receive attention in future studies on impulsivity in BPD...
  14. ncbi request reprint Emotions and memory in borderline personality disorder
    Dorina Winter
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Psychopathology 47:71-85. 2014
    ..This review discusses methodological challenges of studies on memory and emotions in BPD and makes suggestions for future research and clinical implications...
  15. ncbi request reprint Dissociation predicts poor response to Dialectial Behavioral Therapy in female patients with Borderline Personality Disorder
    Nikolaus Kleindienst
    Central Institute of Mental Health, Mannheim, Germany
    J Pers Disord 25:432-47. 2011
    ..The results suggest that dissociation in borderline-patients should be closely monitored and targeted during DBT. At this stage, research on treatment of dissociation (e.g., specific skills training) is warranted...
  16. doi request reprint Do improvements after inpatient dialectial behavioral therapy persist in the long term? A naturalistic follow-up in patients with borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 196:847-51. 2008
    ..The effects of inpatient dialectical behavior therapy seem to persist after patients returned to their usual lives...
  17. ncbi request reprint Alterations in default mode network connectivity during pain processing in borderline personality disorder
    Rosemarie C Kluetsch
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 69:993-1002. 2012
    ..Findings in healthy subjects indicate that painful stimulation leads to blood oxygenation level-dependent signal decreases and changes in the functional architecture of the DMN...
  18. ncbi request reprint Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings
    Christian Schmahl
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mannheim, Germany
    Pain 110:470-9. 2004
    ..These findings suggest that hypoalgesia in BPD may primarily be due to altered intracortical processing similar to certain meditative states...
  19. pmc COMT val158met polymorphism and neural pain processing
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    PLoS ONE 7:e23658. 2012
    ....
  20. doi request reprint Dialectical behaviour therapy for post-traumatic stress disorder after childhood sexual abuse in patients with and without borderline personality disorder: a randomised controlled trial
    Martin Bohus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany martin bohus zi mannheim de
    Psychother Psychosom 82:221-33. 2013
    ..The aim of the present study was to determine the efficacy of a newly developed modular treatment programme (DBT-PTSD) that combines principles of dialectical behaviour therapy (DBT) and trauma-focused interventions...
  21. doi request reprint Individual modulation of pain sensitivity under stress
    Tatyana Reinhardt
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Pain Med 14:676-85. 2013
    ..The aim of our study was to investigate the effect of stress on individual pain sensitivity in a relatively large female sample...
  22. pmc Voxel-based morphometry in women with borderline personality disorder with and without comorbid posttraumatic stress disorder
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 8:e65824. 2013
    ..We could replicate earlier findings of diminished limbic GMV in patients with BPD and additionally show that patients with co-morbid PTSD feature increased GMV in prefrontal regions associated with cognitive control...
  23. doi request reprint Evaluation of naltrexone for dissociative symptoms in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int Clin Psychopharmacol 27:61-8. 2012
    ..However, the effects were too small to reach statistical significance. Our data provide the first estimate of the pure pharmacological antidissociative efficacy of naltrexone from a rigorously designed trial...
  24. pmc Functional connectivity of pain-mediated affect regulation in Borderline Personality Disorder
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Heidelberg, Germany
    PLoS ONE 7:e33293. 2012
    ..This study provides new insights in pain processing in BPD, including enhanced coupling of limbic structures and basal ganglia...
  25. doi request reprint Salivary cortisol, heart rate, electrodermal activity and subjective stress responses to the Mannheim Multicomponent Stress Test (MMST)
    Tatyana Reinhardt
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Psychiatry Res 198:106-11. 2012
    ..As social-evaluative threat is not the main stress component of the MMST, this procedure represents a useful and complementary alternative to other established stress protocols...
  26. doi request reprint [Development of the "Mannheim Multicomponent Stress Test" (MMST)]
    Tatyana Kolotylova
    Zentralinstitut fur Seelische Gesundheit Mannheim, Klinik für Psychosomatik und Psychotherapeutische Medizin, Universitat Jena, Jena, Germany
    Psychother Psychosom Med Psychol 60:64-72. 2010
    ..We conclude that the Mannheim Multicomponent Stress Test (MMST) induces high levels of physiological and psychological stress and can serve as an economical method to investigate stress reactions in a laboratory setting...
  27. doi request reprint Metabolic alterations in the amygdala in borderline personality disorder: a proton magnetic resonance spectroscopy study
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, 68159 Mannheim, Germany
    Biol Psychiatry 67:399-405. 2010
    ..0 T in which we acquire data within only the small amygdala. The purpose of this study was to determine alterations of the metabolism in the amygdala in BPD patients...
  28. doi request reprint Voluntary exercise does not ameliorate context memory and hyperarousal in a mouse model for post-traumatic stress disorder (PTSD)
    Raffaele Cacciaglia
    Institute of Neuropsychology and Clinical Psychology, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 14:403-9. 2013
    ..However, studies that have tried to link physical exercise and contextual conditioning in an animal model of PTSD, revealed mixed findings...
  29. doi request reprint Affect regulation and pain in borderline personality disorder: a possible link to the understanding of self-injury
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 68:383-91. 2010
    ..Pain in BPD has further been observed to lead to a reduction in neural activity in the amygdala and anterior cingulate cortex, which may be attributed to patients' perception of relaxation...
  30. doi request reprint The latest neuroimaging findings in borderline personality disorder
    Jana Mauchnik
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 12:46-55. 2010
    ..Therefore, these findings convey a good impression of the current findings from neuroimaging research in this disorder and also of the necessary next steps with regard to content and methodology...
  31. ncbi request reprint Bispectral index monitoring during dissociative pseudo-seizure
    Alexander Sartorius
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    World J Biol Psychiatry 10:603-5. 2009
    ..This makes former assumptions plausible that hypnosis and severe forms of dissociation (or conversion) may share common aetiologies...
  32. ncbi request reprint Emotional modulation of pain: a clinical perspective
    Iris Klossika
    Department of Psychosomatic Medicine and Psychotherapy, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Pain 124:264-8. 2006
  33. ncbi request reprint Susceptibility to distraction by social cues in borderline personality disorder
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Psychopathology 47:148-57. 2014
    ..The aim of this study was to investigate the influence of task-irrelevant (neutral vs. negatively arousing) social cues on working memory performance in BPD patients compared to healthy controls (HC)...
  34. doi request reprint The latest neuroimaging findings in borderline personality disorder
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Curr Psychiatry Rep 16:438. 2014
    ..To clarify whether findings are specific to BPD, comparisons with other clinical groups are needed. ..
  35. ncbi request reprint New developments in the neurobiology of borderline personality disorder
    Martin Bohus
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 6:43-50. 2004
    ..Most of the neuropsychologic, physiologic, endocrinologic, and neuroimaging data support the theory that a dual brain pathology, affecting prefrontal and limbic circuits, may underlie this hyperarousal-dyscontrol syndrome...
  36. doi request reprint Sleep and dreaming in patients with borderline personality disorder: a polysomnographic study
    Michael Schredl
    Central Institute of Mental Health, Mannheim, Germany
    Psychiatry Res 200:430-6. 2012
    ....
  37. pmc Neuroimaging in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    J Psychiatr Res 40:419-27. 2006
    ..Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology...
  38. doi request reprint Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats
    Peggy Schneider
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Eur Neuropsychopharmacol 24:290-301. 2014
    ..The present animal model therefore represents a novel approach to assess the long-term consequences of peer-rejection during adolescence. ..
  39. ncbi request reprint Effectiveness of inpatient dialectical behavioral therapy for borderline personality disorder: a controlled trial
    Martin Bohus
    Department of Psychiatry and Psychotherapy with Polyclinic, Albert Ludwig University of Freiburg, Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Behav Res Ther 42:487-99. 2004
    ..Within a relatively short time frame, improvement was found across a broad range of psychopathological features. Stability of the recovery after one month following discharge, however, was not evaluated and requires further study...
  40. ncbi request reprint Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
    ..Measuring electric pain thresholds is a valid and reasonable method for larger studies...
  41. ncbi request reprint Increased delta power and discrepancies in objective and subjective sleep measurements in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Haupt strasse 5, 79104 Freiburg, Germany
    J Psychiatr Res 39:489-98. 2005
    ..Earlier findings in sleep EEG abnormalities in BPD may have been confounded by concomitant depressive symptoms...
  42. ncbi request reprint Altered pain processing in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 64:76-85. 2007
    ..Several brain areas related to pain processing are implicated in PTSD. To our knowledge, no functional imaging study has discussed whether patients with PTSD experience and process pain in a different way than control subjects...
  43. ncbi request reprint Neuroimaging of pain perception in Dutch veterans with and without posttraumatic stress disorder: preliminary results
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan, 100 3584, CX, Utrecht, The Netherlands
    Ann N Y Acad Sci 1071:401-4. 2006
    ..Fixed affects analysis demonstrated that stimuli subjectively perceived as more painful resulted in increased activation of the caudal ACC, whereas less painful stimuli resulted in increased activation of the rostral ACC in both groups...
  44. doi request reprint Attention-deficit hyperactivity disorder as a potentially aggravating factor in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Br J Psychiatry 192:118-23. 2008
    ..Clinical experience suggests that people with borderline personality disorder often meet criteria for attention-deficit hyperactivity disorder (ADHD). However, empirical data are sparse...
  45. ncbi request reprint Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 55:612-20. 2004
    ..Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpose of this study was to use the Stroop task as a probe of anterior cingulate function in PTSD...
  46. pmc Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Psychol Med 35:791-806. 2005
    ..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)...
  47. ncbi request reprint Borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Lancet 364:453-61. 2004
    ..Current strategies are focusing on the neurobiological underpinnings of the disorder and the development and dissemination of better and more cost-effective treatments to clinicians...
  48. ncbi request reprint Clonidine in acute aversive inner tension and self-injurious behavior in female patients with borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Clin Psychiatry 65:1414-9. 2004
    ....
  49. pmc Hippocampal and amygdalar volumes in dissociative identity disorder
    Eric Vermetten
    Department of Psychiatry, Rudolf Magnus Institute of Neurosciences, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Psychiatry 163:630-6. 2006
    ..The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma...