Alexander Sartorius

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint ECT anesthesia: the lighter the better?
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 39:201-4. 2006
  2. ncbi request reprint Deep brain stimulation of the lateral habenula in treatment resistant major depression
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Med Hypotheses 69:1305-8. 2007
  3. ncbi request reprint Bispectral index monitoring during dissociative pseudo-seizure
    Alexander Sartorius
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    World J Biol Psychiatry 10:603-5. 2009
  4. ncbi request reprint Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 7:246-50. 2006
  5. ncbi request reprint Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Neuroreport 18:1469-73. 2007
  6. doi request reprint Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain
    Alexander Sartorius
    Central Institute of Mental Health, J5, Mannheim, Germany
    J Neurosci Methods 172:215-9. 2008
  7. doi request reprint Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 42:270-6. 2009
  8. doi request reprint Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
  9. doi request reprint Rethinking restimulation: a case report
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Heidelberg University, Germany
    J ECT 28:248-9. 2012
  10. ncbi request reprint Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Neuroreport 14:2199-201. 2003

Detail Information

Publications46

  1. ncbi request reprint ECT anesthesia: the lighter the better?
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 39:201-4. 2006
    ..Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated...
  2. ncbi request reprint Deep brain stimulation of the lateral habenula in treatment resistant major depression
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Med Hypotheses 69:1305-8. 2007
    ..Possible criteria for patient selection, ethical issues and locus of DBS are carefully discussed...
  3. ncbi request reprint Bispectral index monitoring during dissociative pseudo-seizure
    Alexander Sartorius
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    World J Biol Psychiatry 10:603-5. 2009
    ..This makes former assumptions plausible that hypnosis and severe forms of dissociation (or conversion) may share common aetiologies...
  4. ncbi request reprint Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 7:246-50. 2006
    ..Our data show a significant inverse correlation (p = 0.018) between PLA2 protein levels and MRS Cho/NAA levels suggesting a possible downregulation of PLA2 in compensation for an upregulation of other phospholipases...
  5. ncbi request reprint Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Neuroreport 18:1469-73. 2007
    ..Our results corroborate previous findings of an amino-acid influence on the pathomechanisms of mood disorders...
  6. doi request reprint Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain
    Alexander Sartorius
    Central Institute of Mental Health, J5, Mannheim, Germany
    J Neurosci Methods 172:215-9. 2008
    ..An influence of tCr on the brain's energy regulating system seems plausible...
  7. doi request reprint Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 42:270-6. 2009
    ..An increasing number of studies uses serum BDNF levels as a potential indicator for central nervous system alterations...
  8. doi request reprint Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
    ..4 T animal system seems a promising tool to study underlying mechanisms since it allows for an accurate quantification of metabolites with distinction of glutamate, GABA and glutamine, as well as separation of taurine from choline...
  9. doi request reprint Rethinking restimulation: a case report
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Heidelberg University, Germany
    J ECT 28:248-9. 2012
    ..In this patient, the refractory period turned out to be longer than 1 minute, and ST was lower in all 5 instances of restimulation. This ST decrease could be clinically useful in one-session restimulations...
  10. ncbi request reprint Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Neuroreport 14:2199-201. 2003
    ..A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed...
  11. ncbi request reprint Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression
    Gabriele Ende
    Division Neuroimaging, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 257:36-9. 2007
    ..Abnormal levels of choline-containing compounds most likely reflect altered membrane phospholipid metabolism. A reduced level in the hippocampus and an increased level in the putamen suggest regionally opponent membrane abnormalities...
  12. ncbi request reprint Choline rise in the rat hippocampus induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 53:620-3. 2003
    ..We hypothesized a hippocampal choline increase in the rat brain under electroconvulsive shock (ECS) treatment...
  13. ncbi request reprint Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
    ..Cannabinoids present neurotoxic and neuroprotective properties in in vitro studies, inconsistent alterations in human neuroimaging studies, neuropsychological deficits, and an increased risk for psychotic episodes...
  14. ncbi request reprint Genetic fate mapping of type-1 stem cell-dependent increase in newborn hippocampal neurons after electroconvulsive seizures
    Tillmann Weber
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, 68159, Germany
    Hippocampus 23:1321-30. 2013
    ..The ability of high- and low-frequency ECS to induce normally quiescent type-1 cells to proliferate and generate new neurons sets it apart from other antidepressant treatments and may underlie the superior clinical efficacy of ECT...
  15. doi request reprint Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Drug Alcohol Depend 114:242-5. 2011
    ..Chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (THC) and cannabidiol (CBD)...
  16. doi request reprint Creatine transporter expression after antidepressant therapy in rats bred for learned helplessness
    Patrick Lugenbiel
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:329-33. 2010
    ..In WT animals there was no treatment effect. In summary, our data presented here suggest an association between depressive behavior and cellular energy metabolism in defined brain areas...
  17. ncbi request reprint Neuron specific enolase and serum remain unaffected by ultra high frequency left prefrontal transcranial magnetic stimulation in patients with depression: a preliminary study
    Heiko Ullrich
    Department of Psychiatry and Psychotherapy, Kreisklinikum Siegen GmbH, Siegen, Germany
    J Neural Transm 120:1733-6. 2013
    ..Neither in the ultra high frequency group, nor in the sham group a difference between baseline and end could be found. No evidence for a significant rise in brain damage markers in rTMS was found in this preliminary study. ..
  18. doi request reprint Functionally altered neurocircuits in a rat model of treatment-resistant depression show prominent role of the habenula
    Natalia Gass
    Research Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Eur Neuropsychopharmacol 24:381-90. 2014
    ..Our findings also define neurocircuits that can be studied for TRD treatment in patients, and could be employed for translational research in rodent models. ..
  19. ncbi request reprint Burst suppression: a more valid marker of postictal central inhibition?
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    J ECT 29:25-8. 2013
    ....
  20. doi request reprint Electroconvulsive therapy in a patient after radiation treatment of a brain metastasis: a case report
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    J ECT 28:250-1. 2012
    ....
  21. ncbi request reprint Ultra-high-frequency left prefrontal transcranial magnetic stimulation as augmentation in severely ill patients with depression: a naturalistic sham-controlled, double-blind, randomized trial
    Heiko Ullrich
    Department of Psychiatry and Psychotherapy, Kreisklinikum Siegen GmbH, Siegen, Germany
    Neuropsychobiology 66:141-8. 2012
    ..We evaluated the treatment response to an ultra-high-frequency (UHF; 30 Hz) approach, which was used to maximize the rTMS efficacy in severely ill patients...
  22. doi request reprint Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats
    Derik Hermann
    Department of Addiction Medicine, Central Institute for Mental Health, Mannheim, Germany
    Biol Psychiatry 71:1015-21. 2012
    ..Our understanding of this pathophysiological mechanism originates largely from animal studies, but human data are needed for translation into successful medication development...
  23. doi request reprint In vivo voxel based morphometry: detection of increased hippocampal volume and decreased glutamate levels in exercising mice
    Sarah Biedermann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim, Germany
    Neuroimage 61:1206-12. 2012
    ..An inverse correlation of hippocampal gray matter volume and glutamate concentration indicates a possible implication of the glutamatergic system for hippocampal volume...
  24. doi request reprint Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula
    Carolin Hoyer
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Neuropsychobiology 65:147-52. 2012
    ..However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated...
  25. doi request reprint Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 261:575-82. 2011
    ....
  26. doi request reprint Influence of anesthetic drugs and concurrent psychiatric medication on seizure adequacy during electroconvulsive therapy
    Bogata D Bundy
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychiatry 71:775-7. 2010
    ..We hypothesized a negative influence of anesthetics and benzodiazepines but a positive effect of antidepressants and antipsychotics concurrently applied during ECT on seizure adequacy...
  27. ncbi request reprint Abnormal amygdala activation profile in pedophilia
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 258:271-7. 2008
    ..More extensive research in this field would be of benefit for both the victims and the offenders...
  28. doi request reprint One ring to rule them all?--Temporospatial specificity of deep brain stimulation for treatment-resistant depression
    Carolin Hoyer
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, 68159 Mannheim, Germany Electronic address
    Med Hypotheses 81:611-8. 2013
    ....
  29. doi request reprint Exercise boosts hippocampal volume by preventing early age-related gray matter loss
    Johannes Fuss
    RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim ZI, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Hippocampus 24:131-4. 2014
    ..Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology...
  30. pmc Electroconvulsive therapy induces neurogenesis in frontal rat brain areas
    Dragos Inta
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 8:e69869. 2013
    ..We provide here the first evidence that ECT stimulates neurogenesis in areas outside the hippocampus. Our data may open research possibilities that focus on the plastic changes induced by ECT in frontal limbic circuitry. ..
  31. doi request reprint Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge
    Peggy Schneider
    Central Institute of Mental Health, Institute of Psychopharmacology, 68159 Mannheim, Germany
    Brain Behav Immun 26:277-83. 2012
    ..The FACS analysis showed a significant increase in CD25(+) microglia in the hippocampus compared to controls. The results support the role of microglia as a mediator in the immune-CNS communication and the effects of peripheral IL-2...
  32. ncbi request reprint Diffusion weighted MRI in the early phase after electroconvulsive therapy
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Neurol Res 29:256-9. 2007
    ..These findings are in line with previous negative studies using conventional MRI. Higher resolution DWI and serial imaging may be necessary to visualize possible minimal signal changes after ECT...
  33. ncbi request reprint Remission of polydipsia as antipsychotic effect of clozapine
    M Zink
    Central Institute of Mental Health, Clinic of Psychiatry and Psychotherapy, P O Box 122120, Mannheim 68072, Germany
    Eur Psychiatry 19:320-1. 2004
  34. ncbi request reprint Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients
    D F Braus
    Central Institute of Mental Health ZI, NMR Research, Mannheim, Germany
    Schizophr Res 39:19-29. 1999
    ..There is, however, strong evidence that neuroleptics themselves influence fMRI activation patterns and that there are major differences between typical neuroleptics and atypical antipsychotics...
  35. doi request reprint Impact of the anesthetic agents ketamine, etomidate, thiopental, and propofol on seizure parameters and seizure quality in electroconvulsive therapy: a retrospective study
    Carolin Hoyer
    Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim Heidelberg, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 264:255-61. 2014
    ..Based on the data of this retrospective study, the use of ketamine or etomidate as anesthetic in ECT might be advantageous due to the induction of high-quality seizures...
  36. pmc Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat
    Natalia Gass
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 39:895-906. 2014
    ..These findings may help to clarify the brain systems underlying different dose-dependent behavioral profiles of ketamine in the rat...
  37. doi request reprint Preliminary evaluation of clinical outcome and safety of ketamine as an anesthetic for electroconvulsive therapy in schizophrenia
    Laura Kranaster
    Laura Kranaster, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Germany
    World J Biol Psychiatry 15:242-50. 2014
    ..However, due to the potential to provoke dissociative symptoms, ketamine anaesthesia is rather hesitantly used in schizophrenia patients for fear of causing disease exacerbation...
  38. doi request reprint Efficacy and cognitive side effects of electroconvulsive therapy (ECT) in depressed elderly inpatients with coexisting mild cognitive impairment or dementia
    Lucrezia Hausner
    Department of Geriatric Psychiatry, Central Institute of Mental Health, Sq J5, D 68159 Mannheim, Germany
    J Clin Psychiatry 72:91-7. 2011
    ..To study cognitive performance in depressed geriatric inpatients with or without preexisting cognitive impairment who received a first course of electroconvulsive therapy (ECT)...
  39. ncbi request reprint Lithium and ECT--concurrent use still demands attention: three case reports
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    World J Biol Psychiatry 6:121-4. 2005
    ..Clinical consequences are discussed and disturbances of the blood brain barrier system as a speculative cause are hypothesized taking previous studies, animal studies and an additional reported clinical case into account...
  40. ncbi request reprint Management of severe postictal agitation after electroconvulsive therapy with bispectrum electroencephalogram index monitoring: a case report
    Laura Kranaster
    From the Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg and Department of Anaesthesiology and Critical Care Medicine, Medical Centre Mannheim, Mannheim, Germany
    J ECT 28:e9-e10. 2012
    ..1%. Bispectral index (BIS) monitoring made prediction and prevention of PIA possible to some degree. Postictal agitation might occur in vulnerable patients when initial depth of anesthesia is too light...
  41. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  42. ncbi request reprint Electroconvulsive therapy in a patient receiving rivastigmine
    Mathias Zink
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    J ECT 18:162-4. 2002
    ..The hypothesis that this drug may indeed protect against unfavorable side effects of ECT should be further tested in clinical trials...
  43. ncbi request reprint Implications of fMRI and genetics for the law and the routine practice of forensic psychiatry
    Harald Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, Mannheim, Germany
    Neurocase 14:7-14. 2008
    ..Rather, optimal integration of neurobiological findings requires cooperation among many disciplines such as medicine, criminology, sociology, psychology, politics and neuroscience...
  44. ncbi request reprint [Treating depressive disorders with continuation electroconvulsive therapy]
    A Sartorius
    Zentralinstitut fur Seelische Gesundheit, J5, Mannheim
    Nervenarzt 76:1363-9. 2005
    ..Today, cECT is underindicated as a result of assumed problems, fears, and stigmas. We would therefore recommend broader use of this proven treatment tool for keeping major depression in remission...
  45. ncbi request reprint Imaging new neurons in vivo: a pioneering tool to study the cellular biology of depression?
    Benedikt Römer
    Central Institute of Mental Health Mannheim, University of Heidelberg, Germany
    Bioessays 30:806-10. 2008
    ..This makes it possible to study the role of neural progenitor cells in a wide variety of human brain disorders...
  46. ncbi request reprint [Continuation ECT]
    Alexander Sartorius
    Zentralinstitut fur Seelische Gesundheit, Mannheim
    Psychiatr Prax 32:408-11. 2005
    ..We would therefore recommend a broader use of this proven treatment tool for keeping major depressions in remission...