Marcella Rietschel

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
    Vanessa Nieratschker
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, Germany
    Front Behav Neurosci 4:23. 2010
  2. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  3. doi request reprint The genetics of alcohol dependence
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, University Medical Center Mannheim, University of Heidelberg, Germany
    Ann N Y Acad Sci 1282:39-70. 2013
  4. ncbi request reprint Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe
    M Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Mol Psychiatry 17:906-17. 2012
  5. ncbi request reprint Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Biol Psychiatry 68:578-85. 2010
  6. pmc The effects of a DTNBP1 gene variant on attention networks: an fMRI study
    Markus Thimm
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Behav Brain Funct 6:54. 2010
  7. pmc Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects
    Andreas Jansen
    Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps University Marburg, Germany
    BMC Psychiatry 9:60. 2009
  8. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
  9. ncbi request reprint The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample
    Vanessa Nieratschker
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Schizophr Res 122:24-30. 2010
  10. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010

Collaborators

Detail Information

Publications66

  1. pmc New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
    Vanessa Nieratschker
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, Germany
    Front Behav Neurosci 4:23. 2010
    ..The results of these studies may allow a more comprehensive re-evaluation of the dopamine hypothesis...
  2. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  3. doi request reprint The genetics of alcohol dependence
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, University Medical Center Mannheim, University of Heidelberg, Germany
    Ann N Y Acad Sci 1282:39-70. 2013
    ..To date, few genome-wide significant findings have been reported. However, through the polygenic approach, GWAS have both confirmed the existence of a multitude of novel risk genes and indicated interesting new candidates...
  4. ncbi request reprint Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe
    M Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Mol Psychiatry 17:906-17. 2012
    ..The area of interest is a critical interface between emotion regulation and cognition that is structurally and functionally abnormal in SCZ and bipolar disorder...
  5. ncbi request reprint Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Biol Psychiatry 68:578-85. 2010
    ..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression...
  6. pmc The effects of a DTNBP1 gene variant on attention networks: an fMRI study
    Markus Thimm
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Behav Brain Funct 6:54. 2010
    ..Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers...
  7. pmc Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects
    Andreas Jansen
    Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps University Marburg, Germany
    BMC Psychiatry 9:60. 2009
    ..In the present study, we therefore examined the relationship between G72 genotype status and a broad range of cognitive functions in 423 healthy individuals...
  8. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
    ..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
  9. ncbi request reprint The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample
    Vanessa Nieratschker
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Schizophr Res 122:24-30. 2010
    ..Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population...
  10. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010
    ..In this HapMap-based study, we reappraised the association between Dysbindin and SCZ in a large sample of German ethnicity...
  11. doi request reprint Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds
    Brigitte Schmid
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int J Neuropsychopharmacol 13:703-14. 2010
    ..These findings extend previous reports by demonstrating that the CRHR1 gene and stressful life events interact to predict both drinking initiation in adolescence and progression of heavy alcohol use in young adulthood...
  12. doi request reprint Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin
    Frederike Schirmbeck
    Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    J Autism Dev Disord 38:1977-81. 2008
    ..Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA...
  13. ncbi request reprint Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 66:102-9. 2009
    ..The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults...
  14. ncbi request reprint Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
    J Psychiatr Res 43:1205-12. 2009
    ....
  15. doi request reprint Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorder
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 110:33-9. 2009
    ..It has been proposed as a predictor of clinical presentation and outcome, and may delineate a specific SZ phenotype for genetic and other biological studies. Research into PMA in BD has been scarce and inconclusive...
  16. doi request reprint Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 54:2514-23. 2011
    ..Our findings confirm a key role for disturbed functional connectivity in the genetic risk architecture of schizophrenia and identify cognitive state-dependent and independent components with regard to WM function...
  17. doi request reprint Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Child Psychol Psychiatry 53:351-9. 2012
    ..Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene-environment interplay (genetic vulnerability vs. differential susceptibility)...
  18. doi request reprint Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Neuropsychopharmacol 16:549-56. 2013
    ....
  19. ncbi request reprint No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sample
    Frederike Schirmbeck
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:127. 2007
  20. ncbi request reprint Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample
    Alexander Georgi
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Psychiatr Genet 17:308-10. 2007
    ..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia...
  21. doi request reprint BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    Eur Neuropsychopharmacol 23:902-9. 2013
    ....
  22. doi request reprint Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int J Neuropsychopharmacol 12:737-47. 2009
    ..No evidence for GxE was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity...
  23. ncbi request reprint Induction and quantification of prefrontal cortical network plasticity using 5 Hz rTMS and fMRI
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Hum Brain Mapp 35:140-51. 2014
    ..In further studies this approach could be used to study pharmacological, genetic and disease-related alterations...
  24. ncbi request reprint Neuroimaging evidence for a role of neural social stress processing in ethnic minority-associated environmental risk
    Ceren Akdeniz
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    JAMA Psychiatry 71:672-80. 2014
    ..Pathoepidemiological models propose a role for chronic social stress and perceived discrimination for mental health risk in ethnic minorities, but the neurobiology is unexplored...
  25. ncbi request reprint Subtype differences in adults with attention-deficit/hyperactivity disorder (ADHD) with regard to ADHD-symptoms, psychiatric comorbidity and psychosocial adjustment
    Esther Sobanski
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J 5, 68159 Mannheim, Germany
    Eur Psychiatry 23:142-9. 2008
    ..To date, nearly all research of subtype differences in ADHD has been performed in children and only two studies, with conflicting results, have covered this subject in adults with ADHD...
  26. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
    ..The latter result may indicate that many more AD susceptibility genes still await identification...
  27. ncbi request reprint Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia
    Oliver Grimm
    Central Institute of Mental Health Mannheim, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    JAMA Psychiatry 71:531-9. 2014
    ..Schizophrenia is highly heritable, raising the possibility that this phenotype is related to the genetic risk for the disorder...
  28. ncbi request reprint G72 and its association with major depression and neuroticism in large population-based groups from Germany
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Psychiatry 165:753-62. 2008
    ..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism...
  29. doi request reprint Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Eur Neuropsychopharmacol 23:358-67. 2013
    ....
  30. doi request reprint A target sample of adolescents and reward processing: same neural and behavioral correlates engaged in common paradigms?
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Exp Brain Res 223:429-39. 2012
    ....
  31. doi request reprint An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses
    Stephanie H Witt
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 36:1010-20. 2011
    ....
  32. ncbi request reprint A systems medicine research approach for studying alcohol addiction
    Rainer Spanagel
    Insitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Addict Biol 18:883-96. 2013
    ....
  33. doi request reprint Longer telomere length in patients with schizophrenia
    Vanessa Nieratschker
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159 Mannheim, Germany
    Schizophr Res 149:116-20. 2013
    ....
  34. doi request reprint City living and urban upbringing affect neural social stress processing in humans
    Florian Lederbogen
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
    Nature 474:498-501. 2011
    ....
  35. ncbi request reprint No association between the serine racemase gene (SRR) and schizophrenia in a German case-control sample
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:125. 2007
  36. pmc Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  37. doi request reprint From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits
    Angela Heinrich
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, 68159, Germany Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Eur J Neurosci 38:2941-5. 2013
    ..Our findings support the hypothesis that the schizophrenia-related risk variant of rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral as well as an imaging genetics level. ..
  38. pmc Association between a serotonin transporter length polymorphism and primary insomnia
    Michael Deuschle
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Sleep 33:343-7. 2010
    ..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia...
  39. doi request reprint Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction
    Edda Bilek
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, 68159 Mannheim, Germany
    J Neurosci 33:7050-6. 2013
    ....
  40. doi request reprint Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter
    Jens Treutlein
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Schizophr Res 111:123-30. 2009
    ....
  41. pmc Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism
    Jelka Tzschoppe
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 39:875-84. 2014
    ..This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders. ..
  42. ncbi request reprint Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agents
    Frederike Schirmbeck
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Psychiatr Genet 22:245-52. 2012
    ..The aim of this study was to replicate these findings in a European sample...
  43. ncbi request reprint Premorbid adjustment in schizophrenia--an important aspect of phenotype definition
    Christine Schmael
    Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D 68159 Mannheim, Germany
    Schizophr Res 92:50-62. 2007
    ..Studies of schizophrenia patients systematically assessed for PMA have used small patient samples and have rarely used controls...
  44. doi request reprint Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions
    Heike Tost
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Affect Disord 120:54-61. 2010
    ..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities...
  45. doi request reprint The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds
    Brigitte Schmid
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 14:489-99. 2009
    ..Further studies are required to confirm these findings...
  46. ncbi request reprint Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 64:585-90. 2007
    ..Recent evidence suggests that gene x environment interactions could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with attention-deficit/hyperactivity disorder (ADHD)...
  47. doi request reprint Neural mechanisms of a genome-wide supported psychosis variant
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Science 324:605. 2009
    ....
  48. ncbi request reprint The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing
    Angela Heinrich
    Department of Cognitive and Clinical Neuroscience Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Bipolar Disord 15:440-5. 2013
    ....
  49. ncbi request reprint A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala
    Fabian Streit
    Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Stress 17:352-61. 2014
    ..This study provides first evidence for the assumption that a NPSR1 variant modulates brain activation under stress, interacting with the environmental risk factor urban upbringing...
  50. doi request reprint A risk variant for alcoholism in the NMDA receptor affects amygdala activity during fear conditioning in humans
    Raffaele Cacciaglia
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Biol Psychol 94:74-81. 2013
    ..Carriers of the risk variant additionally exhibit dampened insula activation, a finding that further strengthens our data, given the importance of this brain region in fear conditioning. ..
  51. doi request reprint SCN1A affects brain structure and the neural activity of the aging brain
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
    Biol Psychiatry 72:677-83. 2012
    ..rs10930201 was further observed to be related to differences in neural activity during a working memory task...
  52. ncbi request reprint Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159 Mannheim, Germany
    Eur Neuropsychopharmacol 24:837-45. 2014
    ....
  53. doi request reprint Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age
    Vanessa Nieratschker
    Departments of Genetic Epidemiology in Psychiatry Addictive Behavior and Addiction Medicine Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Germany, Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Germany Institute of Neuroscience and Medicine, Research Centre Julich, Germany Department of Genomics, Life and Brain Center Institute of Human Genetics University of Bonn, Germany and German Center for Neurodegenerative Disorders DZNE, Germany
    Addict Biol 19:305-11. 2014
    ....
  54. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  55. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  56. pmc Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR
    Jana Strohmaier
    Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, Mannheim, Germany
    World J Biol Psychiatry 12:528-38. 2011
    ....
  57. ncbi request reprint What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, 15, 68159 Mannheim, Germany
    Arch Gen Psychiatry 63:1368-76. 2006
    ..Familial features of bipolar disorder should help define more homogeneous subtypes, but there are few data indicating which clinical features of bipolar disorder are the most familial...
  58. pmc Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:986-95. 2012
    ....
  59. pmc COMT val158met polymorphism and neural pain processing
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    PLoS ONE 7:e23658. 2012
    ....
  60. ncbi request reprint No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample
    Alexander Georgi
    Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 16:183-4. 2006
    ..This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population...
  61. doi request reprint Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain
    Julia Linke
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 59:3288-96. 2012
    ..In sum, our findings show that ANK3 rs10994336 or a variant in linkage-disequilibrium is functional in the human brain and also influences behavioral phenotypes related to bipolar disorder...
  62. ncbi request reprint No association between a common haplotype of the 6 and 10-repeat alleles in intron 8 and the 3'UTR of the DAT1 gene and adult attention deficit hyperactivity disorder
    Daniel Brüggemann
    Department of Genetic Epidemology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:121. 2007
  63. doi request reprint Environment is important
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
    Curr Opin Psychiatry 21:323-4. 2008
  64. doi request reprint Genome-wide association studies of alcohol dependence and substance use disorders
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 13:147-55. 2011
    ..This article focuses on GWAS of alcohol addiction and provides an overview of GWAS of other substance abuse disorders...
  65. ncbi request reprint Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Am J Med Genet B Neuropsychiatr Genet 131:1-5. 2004
    ..49, 95% CI: 0.3-0.82; genotype-wise: 15,5% vs. 29,0%, P = 0.005, OR = 0.45, 95% CI: 0.26-0.77). We suggest that this deletion may influence translational efficiency, thereby possibly affecting the development of bipolar affective disease...