Research Topics
Genomes and Genes
Species | Marcella RietschelSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Detail Information
Publications
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from EuropeM Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Mol Psychiatry 17:906-17. 2012..The area of interest is a critical interface between emotion regulation and cognition that is structurally and functionally abnormal in SCZ and bipolar disorder...- Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depressionMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
Biol Psychiatry 68:578-85. 2010..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression... 
The effects of a DTNBP1 gene variant on attention networks: an fMRI studyMarkus Thimm
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
Behav Brain Funct 6:54. 2010..Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers...- Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjectsAndreas Jansen
Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps University Marburg, Germany
BMC Psychiatry 9:60. 2009..In the present study, we therefore examined the relationship between G72 genotype status and a broad range of cognitive functions in 423 healthy individuals... - Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trialNader Perroud
MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
BMC Med 7:60. 2009..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment... - The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sampleVanessa Nieratschker
Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Schizophr Res 122:24-30. 2010..Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population... - Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-oldsBrigitte Schmid
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Int J Neuropsychopharmacol 13:703-14. 2010..These findings extend previous reports by demonstrating that the CRHR1 gene and stressful life events interact to predict both drinking initiation in adolescence and progression of heavy alcohol use in young adulthood... - Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adultsArlette F Buchmann
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
J Psychiatr Res 43:1205-12. 2009.... - A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestryJana Strohmaier
Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
Schizophr Res 118:98-105. 2010..In this HapMap-based study, we reappraised the association between Dysbindin and SCZ in a large sample of German ethnicity... - Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in DysbindinFrederike Schirmbeck
Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
J Autism Dev Disord 38:1977-81. 2008..Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA... - Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesisManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
J Child Psychol Psychiatry 53:351-9. 2012..Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene-environment interplay (genetic vulnerability vs. differential susceptibility)... - Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adultsManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Int J Neuropsychopharmacol 12:737-47. 2009..No evidence for GxE was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity... - Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804AChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Neuroimage 54:2514-23. 2011..Our findings confirm a key role for disturbed functional connectivity in the genetic risk architecture of schizophrenia and identify cognitive state-dependent and independent components with regard to WM function... - Genome-wide significant association between alcohol dependence and a variant in the ADH gene clusterJosef Frank
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
Addict Biol 17:171-80. 2012..The latter result may indicate that many more AD susceptibility genes still await identification... - An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responsesStephanie H Witt
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, J5, 68159 Mannheim, Germany
Psychoneuroendocrinology 36:1010-20. 2011.... - City living and urban upbringing affect neural social stress processing in humansFlorian Lederbogen
Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
Nature 474:498-501. 2011.... - Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphismManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Biol Psychiatry 66:102-9. 2009..The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults... - Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoterJens Treutlein
Department of Genetic Epidemiology, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
Schizophr Res 111:123-30. 2009.... - Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorderMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
Schizophr Res 110:33-9. 2009..It has been proposed as a predictor of clinical presentation and outcome, and may delineate a specific SZ phenotype for genetic and other biological studies. Research into PMA in BD has been scarce and inconclusive... - Neural mechanisms of a genome-wide supported psychosis variantChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Science 324:605. 2009.... - Association between a serotonin transporter length polymorphism and primary insomniaMichael Deuschle
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
Sleep 33:343-7. 2010..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia... - SCN1A affects brain structure and the neural activity of the aging brainSandra Meier
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
Biol Psychiatry 72:677-83. 2012..rs10930201 was further observed to be related to differences in neural activity during a working memory task... - Genome-wide association study of alcohol dependenceJens Treutlein
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
Arch Gen Psychiatry 66:773-84. 2009..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder... - A target sample of adolescents and reward processing: same neural and behavioral correlates engaged in common paradigms?Frauke Nees
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
Exp Brain Res 223:429-39. 2012.... - An integrated genome research network for studying the genetics of alcohol addictionRainer Spanagel
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
Addict Biol 15:369-79. 2010.... - Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPRJana Strohmaier
Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, Mannheim, Germany
World J Biol Psychiatry 12:528-38. 2011.... - Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusionsHeike Tost
Central Institute of Mental Health, 68159 Mannheim, Germany
J Affect Disord 120:54-61. 2010..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities... - G72 and its association with major depression and neuroticism in large population-based groups from GermanyMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Am J Psychiatry 165:753-62. 2008..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism... - Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factorsFrauke Nees
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Neuropsychopharmacology 37:986-95. 2012.... - Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agentsFrederike Schirmbeck
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Psychiatr Genet 22:245-52. 2012..The aim of this study was to replicate these findings in a European sample... - COMT val158met polymorphism and neural pain processingChristian Schmahl
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
PLoS ONE 7:e23658. 2012.... - Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brainJulia Linke
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany
Neuroimage 59:3288-96. 2012..In sum, our findings show that ANK3 rs10994336 or a variant in linkage-disequilibrium is functional in the human brain and also influences behavioral phenotypes related to bipolar disorder... - Genome-wide association studies of alcohol dependence and substance use disordersJens Treutlein
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
Curr Psychiatry Rep 13:147-55. 2011..This article focuses on GWAS of alcohol addiction and provides an overview of GWAS of other substance abuse disorders... 
Environment is importantMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
Curr Opin Psychiatry 21:323-4. 2008- The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-oldsBrigitte Schmid
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Addict Biol 14:489-99. 2009..Further studies are required to confirm these findings... - Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sampleAlexander Georgi
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
Psychiatr Genet 17:308-10. 2007..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia...