Marcella Rietschel

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  2. doi request reprint The genetics of alcohol dependence
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, University Medical Center Mannheim, University of Heidelberg, Germany
    Ann N Y Acad Sci 1282:39-70. 2013
  3. doi request reprint Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe
    M Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Mol Psychiatry 17:906-17. 2012
  4. doi request reprint Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Biol Psychiatry 68:578-85. 2010
  5. pmc The effects of a DTNBP1 gene variant on attention networks: an fMRI study
    Markus Thimm
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Behav Brain Funct 6:54. 2010
  6. pmc Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects
    Andreas Jansen
    Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps University Marburg, Germany
    BMC Psychiatry 9:60. 2009
  7. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
  8. doi request reprint The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample
    Vanessa Nieratschker
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Schizophr Res 122:24-30. 2010
  9. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010
  10. doi request reprint Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds
    Brigitte Schmid
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int J Neuropsychopharmacol 13:703-14. 2010

Collaborators

Detail Information

Publications45

  1. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  2. doi request reprint The genetics of alcohol dependence
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, University Medical Center Mannheim, University of Heidelberg, Germany
    Ann N Y Acad Sci 1282:39-70. 2013
    ..To date, few genome-wide significant findings have been reported. However, through the polygenic approach, GWAS have both confirmed the existence of a multitude of novel risk genes and indicated interesting new candidates...
  3. doi request reprint Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe
    M Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Mol Psychiatry 17:906-17. 2012
    ..The area of interest is a critical interface between emotion regulation and cognition that is structurally and functionally abnormal in SCZ and bipolar disorder...
  4. doi request reprint Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Biol Psychiatry 68:578-85. 2010
    ..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression...
  5. pmc The effects of a DTNBP1 gene variant on attention networks: an fMRI study
    Markus Thimm
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Behav Brain Funct 6:54. 2010
    ..Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers...
  6. pmc Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects
    Andreas Jansen
    Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps University Marburg, Germany
    BMC Psychiatry 9:60. 2009
    ..In the present study, we therefore examined the relationship between G72 genotype status and a broad range of cognitive functions in 423 healthy individuals...
  7. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
    ..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
  8. doi request reprint The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample
    Vanessa Nieratschker
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Schizophr Res 122:24-30. 2010
    ..Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population...
  9. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010
    ..In this HapMap-based study, we reappraised the association between Dysbindin and SCZ in a large sample of German ethnicity...
  10. doi request reprint Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds
    Brigitte Schmid
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int J Neuropsychopharmacol 13:703-14. 2010
    ..These findings extend previous reports by demonstrating that the CRHR1 gene and stressful life events interact to predict both drinking initiation in adolescence and progression of heavy alcohol use in young adulthood...
  11. doi request reprint Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
    J Psychiatr Res 43:1205-12. 2009
    ....
  12. doi request reprint Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin
    Frederike Schirmbeck
    Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    J Autism Dev Disord 38:1977-81. 2008
    ..Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA...
  13. doi request reprint Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Child Psychol Psychiatry 53:351-9. 2012
    ..Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene-environment interplay (genetic vulnerability vs. differential susceptibility)...
  14. doi request reprint Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int J Neuropsychopharmacol 12:737-47. 2009
    ..No evidence for GxE was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity...
  15. doi request reprint Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 54:2514-23. 2011
    ..Our findings confirm a key role for disturbed functional connectivity in the genetic risk architecture of schizophrenia and identify cognitive state-dependent and independent components with regard to WM function...
  16. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
    ..The latter result may indicate that many more AD susceptibility genes still await identification...
  17. doi request reprint A target sample of adolescents and reward processing: same neural and behavioral correlates engaged in common paradigms?
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Exp Brain Res 223:429-39. 2012
    ....
  18. doi request reprint Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 66:102-9. 2009
    ..The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults...
  19. doi request reprint An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses
    Stephanie H Witt
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 36:1010-20. 2011
    ....
  20. doi request reprint City living and urban upbringing affect neural social stress processing in humans
    Florian Lederbogen
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
    Nature 474:498-501. 2011
    ....
  21. doi request reprint Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction
    Edda Bilek
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, 68159 Mannheim, Germany
    J Neurosci 33:7050-6. 2013
    ....
  22. doi request reprint Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Neuropsychopharmacol 16:549-56. 2013
    ....
  23. doi request reprint Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorder
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 110:33-9. 2009
    ..It has been proposed as a predictor of clinical presentation and outcome, and may delineate a specific SZ phenotype for genetic and other biological studies. Research into PMA in BD has been scarce and inconclusive...
  24. doi request reprint Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter
    Jens Treutlein
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Schizophr Res 111:123-30. 2009
    ....
  25. doi request reprint BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: A prospective study
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    Eur Neuropsychopharmacol 23:902-9. 2013
    ....
  26. doi request reprint Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: Findings from a longitudinal study
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany Department of Psychology, University of Potsdam, Germany Electronic address
    Eur Neuropsychopharmacol 23:358-67. 2013
    ....
  27. pmc Association between a serotonin transporter length polymorphism and primary insomnia
    Michael Deuschle
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Sleep 33:343-7. 2010
    ..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia...
  28. doi request reprint Neural mechanisms of a genome-wide supported psychosis variant
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Science 324:605. 2009
    ....
  29. doi request reprint Longer telomere length in patients with schizophrenia
    Vanessa Nieratschker
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159 Mannheim, Germany Department of Psychiatry and Psychotherapy, University of Tuebingen, Calwerstrasse 14, 72076 Tuebingen, Germany Electronic address
    Schizophr Res 149:116-20. 2013
    ....
  30. doi request reprint Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agents
    Frederike Schirmbeck
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Psychiatr Genet 22:245-52. 2012
    ..The aim of this study was to replicate these findings in a European sample...
  31. doi request reprint SCN1A affects brain structure and the neural activity of the aging brain
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
    Biol Psychiatry 72:677-83. 2012
    ..rs10930201 was further observed to be related to differences in neural activity during a working memory task...
  32. doi request reprint Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  33. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  34. pmc Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR
    Jana Strohmaier
    Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, Mannheim, Germany
    World J Biol Psychiatry 12:528-38. 2011
    ....
  35. doi request reprint G72 and its association with major depression and neuroticism in large population-based groups from Germany
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Psychiatry 165:753-62. 2008
    ..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism...
  36. doi request reprint Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions
    Heike Tost
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Affect Disord 120:54-61. 2010
    ..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities...
  37. pmc Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:986-95. 2012
    ....
  38. pmc COMT val158met polymorphism and neural pain processing
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    PLoS ONE 7:e23658. 2012
    ....
  39. doi request reprint A risk variant for alcoholism in the NMDA receptor affects amygdala activity during fear conditioning in humans
    Raffaele Cacciaglia
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Biol Psychol 94:74-81. 2013
    ..Carriers of the risk variant additionally exhibit dampened insula activation, a finding that further strengthens our data, given the importance of this brain region in fear conditioning. ..
  40. doi request reprint Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain
    Julia Linke
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 59:3288-96. 2012
    ..In sum, our findings show that ANK3 rs10994336 or a variant in linkage-disequilibrium is functional in the human brain and also influences behavioral phenotypes related to bipolar disorder...
  41. doi request reprint Genome-wide association studies of alcohol dependence and substance use disorders
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 13:147-55. 2011
    ..This article focuses on GWAS of alcohol addiction and provides an overview of GWAS of other substance abuse disorders...
  42. pmc New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
    Vanessa Nieratschker
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, Germany
    Front Behav Neurosci 4:23. 2010
    ..The results of these studies may allow a more comprehensive re-evaluation of the dopamine hypothesis...
  43. doi request reprint The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds
    Brigitte Schmid
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 14:489-99. 2009
    ..Further studies are required to confirm these findings...
  44. ncbi request reprint Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample
    Alexander Georgi
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Psychiatr Genet 17:308-10. 2007
    ..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia...
  45. doi request reprint Environment is important
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
    Curr Opin Psychiatry 21:323-4. 2008