Research Topics
Genomes and GenesSpecies | Andreas Meyer-LindenbergSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Detail Information
Publications
Imaging genetics of schizophreniaAndreas Meyer-Lindenberg
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Dialogues Clin Neurosci 12:449-56. 2010..In future perspectives, approaches to characterize epistatic effects, the identification of new risk genes through forward-genetic approaches using imaging phenotypes, and the study of rare structural variants are considered...
The future of fMRI and genetics researchAndreas Meyer-Lindenberg
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Neuroimage 62:1286-92. 2012....- Neural mechanisms of social risk for psychiatric disordersAndreas Meyer-Lindenberg
Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Nat Neurosci 15:663-8. 2012.... - More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams-Beuren syndromeAndreas Meyer-Lindenberg
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg
EMBO Mol Med 1:6-9. 2009.... - Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicineAndreas Meyer-Lindenberg
Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
Nat Rev Neurosci 12:524-38. 2011.... - False positives in imaging geneticsAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
Neuroimage 40:655-61. 2008..In fact, our observations indicate that these statistical thresholds are conservative... - Neural connectivity as an intermediate phenotype: brain networks under genetic controlAndreas Meyer-Lindenberg
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Hum Brain Mapp 30:1938-46. 2009..These data provide convergent evidence for genetic control in humans over connectivity systems, whose characterization has promise for identifying neural systems mediating genetic risk for complex human behavior and psychiatric disease... - From maps to mechanisms through neuroimaging of schizophreniaAndreas Meyer-Lindenberg
Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, J5, 68159 Mannheim, Germany
Nature 468:194-202. 2010..Characterizing the neural risk architecture of schizophrenia provides a translational research strategy for future treatments... 
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depressionLukas Pezawas
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
Nat Neurosci 8:828-34. 2005....- Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulationEmily M Drabant
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1396-406. 2006.... - Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation studyAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 63:475-83. 2008..Currently available data on the heritability of these structural changes are inconsistent... - Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804AChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Neuroimage 54:2514-23. 2011..Our findings confirm a key role for disturbed functional connectivity in the genetic risk architecture of schizophrenia and identify cognitive state-dependent and independent components with regard to WM function... - Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotypeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
Nat Neurosci 8:594-6. 2005..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT... - Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic riskRoberta Rasetti
Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 166:216-25. 2009..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed... - Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophreniaDaniel Paul Eisenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892 1365, USA
Biol Psychiatry 67:287-90. 2010..Task-independent effects of this polymorphism in schizophrenia have not yet been characterized... - The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphologyLukas Pezawas
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 24:10099-102. 2004.... - Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblingsRobyn A Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
Biol Psychiatry 63:465-74. 2008..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry... - Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social contentKaren E Munoz
Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
Neuroimage 50:340-6. 2010..These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS... - Variation in DISC1 affects hippocampal structure and function and increases risk for schizophreniaJoseph H Callicott
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:8627-32. 2005.... - Allelic variation in RGS4 impacts functional and structural connectivity in the human brainJoshua W Buckholtz
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
J Neurosci 27:1584-93. 2007..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness... - Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variantSusanne Erk
Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, D 11017 Berlin, Germany
J Neurosci 31:18180-4. 2011.... - Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patientsChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, 68159 Mannheim, Germany
Schizophr Res 140:114-21. 2012.... - Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memoryHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:13393-401. 2007..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM... - Neural correlates of genetically abnormal social cognition in Williams syndromeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Neurosci 8:991-3. 2005..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior... - Know your place: neural processing of social hierarchy in humansCaroline F Zink
Unit for Systems Neuroscience in Psychiatry, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuron 58:273-83. 2008..Our results identify neural mechanisms that may mediate the enormous influence of social status on human behavior and health... - Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humansHao Yang Tan
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 118:2200-8. 2008..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis... - Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humansCaroline F Zink
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 30:7017-22. 2010.... - Neural basis of genetically determined visuospatial construction deficit in Williams syndromeAndreas Meyer-Lindenberg
Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 4C101, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neuron 43:623-31. 2004.... - Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuitsHeike Tost
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
Nat Neurosci 13:920-2. 2010..Our findings suggest a role for D2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans... - Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndromeAndreas Meyer-Lindenberg
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, NIH, Department of Health and Human Services, Bethesda, MD 20892 1365, USA
J Clin Invest 115:1888-95. 2005..These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS... - Neural mechanisms of genetic risk for impulsivity and violence in humansAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
Proc Natl Acad Sci U S A 103:6269-74. 2006.... - Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain functionHao Yang Tan
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:12536-41. 2007..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia... - Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophreniaAndreas Meyer-Lindenberg
Unit on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, 10 4C101, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
Nat Neurosci 5:267-71. 2002.... - Neurophysiological correlates of age-related changes in working memory capacityVenkata S Mattay
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neurosci Lett 392:32-7. 2006..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs... - A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and functionHeike Tost
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:13936-41. 2010..Our findings identify sex-dependent mechanisms impacting the structure and function of hypothalamic-limbic circuits that are of potential clinical and translational significance... - Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophreniaStefano Marenco
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
Neuropsychopharmacology 37:499-507. 2012..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC... - Hierarchical organization of human cortical networks in health and schizophreniaDanielle S Bassett
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 28:9239-48. 2008.... - Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
J Clin Invest 117:672-82. 2007..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia... - D2 antidopaminergic modulation of frontal lobe function in healthy human subjectsHeike Tost
Department of Psychiatry and Psychotherapy, University of Heidelberg, Germany
Biol Psychiatry 60:1196-205. 2006..Two major neurophysiological models propose segregated functional circuits on the systems level as well as D(1) and D(2) receptor-dependent processing states on the cellular level (two-state model)... - The Williams syndrome chromosome 7q11.23 hemideletion confers hypersocial, anxious personality coupled with altered insula structure and functionMbemba Jabbi
Section on Integrative Neuroimaging, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:E860-6. 2012.... - Dysfunctional prefrontal regional specialization and compensation in schizophreniaHao Yang Tan
Unit on Functional MRI, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Dr, Rm 4C 216, MSC 1364, Bethesda, MD 20892 1364, USA
Am J Psychiatry 163:1969-77. 2006.... - City living and urban upbringing affect neural social stress processing in humansFlorian Lederbogen
Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
Nature 474:498-501. 2011.... - Retinotopically defined primary visual cortex in Williams syndromeRosanna K Olsen
Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
Brain 132:635-44. 2009.... - Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memoryMichael F Glabus
Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
Cereb Cortex 13:1352-61. 2003..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM... - Age-related alterations in simple declarative memory and the effect of negative stimulus valenceVishnu P Murty
National Institutes of Health, Bethesda, MD, USA
J Cogn Neurosci 21:1920-33. 2009.... - Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?Herve Lemaitre
Clinical Brain Disorder Branch, Gene Cognition and Psychosis program, NIH NIMH, Bethesda, MD 20892, USA
Neurobiol Aging 33:617.e1-9. 2012.... - Impact of interacting functional variants in COMT on regional gray matter volume in human brainRobyn Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroimage 45:44-51. 2009.... - Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusionsHeike Tost
Central Institute of Mental Health, 68159 Mannheim, Germany
J Affect Disord 120:54-61. 2010..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities... - Test-retest reliability of evoked BOLD signals from a cognitive-emotive fMRI test batteryMichael M Plichta
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany
Neuroimage 60:1746-58. 2012..The present study provides task-specific fMRI reliability performance measures that will inform the optimal use, powering and design of fMRI studies using comparable tasks... - Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritabilityAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Arch Gen Psychiatry 66:467-77. 2009..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia... - Neural mechanisms of a genome-wide supported psychosis variantChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Science 324:605. 2009.... - Genetic contributions to human gyrification: sulcal morphometry in Williams syndromeJ Shane Kippenhan
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 25:7840-6. 2005.... - Association between a serotonin transporter length polymorphism and primary insomniaMichael Deuschle
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
Sleep 33:343-7. 2010..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia... - Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agentsFrederike Schirmbeck
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Psychiatr Genet 22:245-52. 2012..The aim of this study was to replicate these findings in a European sample... - Test-retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measuresUrs Braun
Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Neuroimage 59:1404-12. 2012..In conclusion, our study provides methodological recommendations which allow the computation of sufficiently robust markers of network organization using graph metrics derived from fMRI data at rest... - Alterations in postnatal neurogenesis and dopamine dysregulation in schizophrenia: a hypothesisDragos Inta
Department for Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
Schizophr Bull 37:674-80. 2011.... - Evidence for a general face salience signal in human amygdalaAndreia Santos
Central Institute of Mental Health, Mannheim, Germany
Neuroimage 54:3111-6. 2011..Given the critical involvement of the amygdala in several neuropsychiatric disorders, the current findings may contribute to further our understanding on dysfunctional neural circuits in these disorders... - Intermediate phenotypes and genetic mechanisms of psychiatric disordersAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Clinical Brain Disorders Branch, National Institute for Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 7:818-27. 2006..Using imaging genetics as an example, we illustrate recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion... - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndromeStefano Marenco
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:15117-22. 2007.... - Clinical and positron emission tomography of Parkinson's disease caused by LRRK2Dena G Hernandez
Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Porter Neuroscience Research Center, 9000 Rockville Pike, Bethesda, MD 20892, USA
Ann Neurol 57:453-6. 2005.... - Activation of midbrain and ventral striatal regions implicates salience processing during a modified beads taskChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
PLoS ONE 8:e58536. 2013..To address this issue, we studied brain activity during a modified beads task which has been used to measure a "Jumping to Conclusions" (JTC) bias in schizophrenia patients... - Human neuroimaging of oxytocin and vasopressin in social cognitionCaroline F Zink
Genes, Cognition, and Psychosis Program, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
Horm Behav 61:400-9. 2012..This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior... - Enuresis as a premorbid developmental marker of schizophreniaThomas M Hyde
Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
Brain 131:2489-98. 2008..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors... - Abnormal amygdala activation profile in pedophiliaAlexander Sartorius
Central Institute of Mental Health, J5, 68159, Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 258:271-7. 2008..More extensive research in this field would be of benefit for both the victims and the offenders... - A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophreniaStephen J Huffaker
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Nat Med 15:509-18. 2009..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target... - A genetic model for understanding higher order visual processing: functional interactions of the ventral visual stream in Williams syndromeDeepak Sarpal
Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
Cereb Cortex 18:2402-9. 2008.... - Imaging genetics for neuropsychiatric disordersAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892, USA
Child Adolesc Psychiatr Clin N Am 16:581-97. 2007..These data provide convergent evidence for neural circuitry mediating emotional regulation and social cognition under genetic control in humans... - Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depressionMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
Biol Psychiatry 68:578-85. 2010..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression... - Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypesHeike Tost
Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
Neurosci Biobehav Rev 34:689-700. 2010..This paper discusses the pathophysiological concepts, molecular mechanisms and neuroimaging evidence that link psychosis to disturbances in dopamine neurotransmission... - Cognitive fitness of cost-efficient brain functional networksDanielle S Bassett
Genes Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:11747-52. 2009..More generally, they echo the saying that "less is more": The information processing performance of a network can be enhanced by a sparse or low-cost configuration with disproportionately high efficiency... - Impact of prosocial neuropeptides on human brain functionAndreas Meyer-Lindenberg
Central Institute of Mental Health, Mannheim, Germany
Prog Brain Res 170:463-70. 2008.... - Polypharmacy in schizophreniaMathias Zink
Central Institute of Mental Health, Mannheim, Germany
Curr Opin Psychiatry 23:103-11. 2010..We review the empirical basis supporting these attempts and their relevance for clinical practice... - Psychology. Trust me on thisAndreas Meyer-Lindenberg
Central Institute of Mental Health, J5, University of Heidelberg, 68159 Mannheim, Germany
Science 321:778-80. 2008 - Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviourAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, Maryland 20892-1365, USA
Nat Rev Neurosci 7:380-93. 2006.... - Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive reviewDragos Inta
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Neurosci Biobehav Rev 34:285-94. 2010..They may provide insight into the pathophysiology of schizophrenia and prove useful in the development of new therapeutics... - MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophreniaNuran Tunc-Skarka
Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
Neuroimage 48:525-31. 2009..Furthermore, they elucidate why reports of a reduced N-acetylaspartate concentration in schizophrenia were not always corroborated... - A validated network of effective amygdala connectivityJason L Stein
Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892 1257, USA
Neuroimage 36:736-45. 2007..This validated model can be used to study neurocognitive correlates as well as genotype or disease-related alterations of functional interactions in the limbic system... - Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimagingBrooke K Gerton
Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892-1365, USA
Neuropsychologia 42:1781-7. 2004.... - Transitions between dynamical states of differing stability in the human brainAndreas Meyer-Lindenberg
Clinical Brain Disorders Branch, National Institute of Mental Health, and Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:10948-53. 2002.... - Age-related changes in midbrain dopaminergic regulation of the human reward systemJean Claude Dreher
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:15106-11. 2008.... - Executive function and cognitive subprocesses in first-episode, drug-naive schizophrenia: an analysis of N-back performanceStephan Krieger
Department of Psychiatry, Justus-Liebig-University Medical School, Giessen, Germany
Am J Psychiatry 162:1206-8. 2005.... - Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotypeAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Biol Psychiatry 60:1250-8. 2006..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine... - MAOA and the neurogenetic architecture of human aggressionJoshua W Buckholtz
Vanderbilt Brain Institute and Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
Trends Neurosci 31:120-9. 2008..Our construct provides a neurobiologically consistent model for gene-environment interactions in impulsive aggression... - The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophreniaMitsuyuki Matsumoto
Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
Proc Natl Acad Sci U S A 105:6133-8. 2008..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy... - Oxytocin modulates neural circuitry for social cognition and fear in humansPeter Kirsch
Cognitive Neuroscience Group, Center for Psychiatry and Psychotherapy, Justus-Liebig University, D-35385 Giessen, Germany
J Neurosci 25:11489-93. 2005....