Andreas Meyer-Lindenberg

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Imaging genetics of schizophrenia
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Dialogues Clin Neurosci 12:449-56. 2010
  2. doi request reprint The future of fMRI and genetics research
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Neuroimage 62:1286-92. 2012
  3. doi request reprint Neural mechanisms of social risk for psychiatric disorders
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Nat Neurosci 15:663-8. 2012
  4. doi request reprint Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Nat Rev Neurosci 12:524-38. 2011
  5. doi request reprint False positives in imaging genetics
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Neuroimage 40:655-61. 2008
  6. doi request reprint From maps to mechanisms through neuroimaging of schizophrenia
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, J5, 68159 Mannheim, Germany
    Nature 468:194-202. 2010
  7. pmc More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams-Beuren syndrome
    Andreas Meyer-Lindenberg
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg
    EMBO Mol Med 1:6-9. 2009
  8. doi request reprint Neural connectivity as an intermediate phenotype: brain networks under genetic control
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Hum Brain Mapp 30:1938-46. 2009
  9. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
  10. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006

Collaborators

Detail Information

Publications96

  1. pmc Imaging genetics of schizophrenia
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Dialogues Clin Neurosci 12:449-56. 2010
    ..In future perspectives, approaches to characterize epistatic effects, the identification of new risk genes through forward-genetic approaches using imaging phenotypes, and the study of rare structural variants are considered...
  2. doi request reprint The future of fMRI and genetics research
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Neuroimage 62:1286-92. 2012
    ....
  3. doi request reprint Neural mechanisms of social risk for psychiatric disorders
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Nat Neurosci 15:663-8. 2012
    ....
  4. doi request reprint Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Nat Rev Neurosci 12:524-38. 2011
    ....
  5. doi request reprint False positives in imaging genetics
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Neuroimage 40:655-61. 2008
    ..In fact, our observations indicate that these statistical thresholds are conservative...
  6. doi request reprint From maps to mechanisms through neuroimaging of schizophrenia
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, J5, 68159 Mannheim, Germany
    Nature 468:194-202. 2010
    ..Characterizing the neural risk architecture of schizophrenia provides a translational research strategy for future treatments...
  7. pmc More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams-Beuren syndrome
    Andreas Meyer-Lindenberg
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg
    EMBO Mol Med 1:6-9. 2009
    ....
  8. doi request reprint Neural connectivity as an intermediate phenotype: brain networks under genetic control
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Hum Brain Mapp 30:1938-46. 2009
    ..These data provide convergent evidence for genetic control in humans over connectivity systems, whose characterization has promise for identifying neural systems mediating genetic risk for complex human behavior and psychiatric disease...
  9. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  10. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
    ....
  11. ncbi request reprint Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 63:475-83. 2008
    ..Currently available data on the heritability of these structural changes are inconsistent...
  12. ncbi request reprint Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 8:594-6. 2005
    ..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT...
  13. doi request reprint Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 54:2514-23. 2011
    ..Our findings confirm a key role for disturbed functional connectivity in the genetic risk architecture of schizophrenia and identify cognitive state-dependent and independent components with regard to WM function...
  14. pmc Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content
    Karen E Munoz
    Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Neuroimage 50:340-6. 2010
    ..These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS...
  15. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008
    ..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry...
  16. pmc Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia
    Daniel Paul Eisenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892 1365, USA
    Biol Psychiatry 67:287-90. 2010
    ..Task-independent effects of this polymorphism in schizophrenia have not yet been characterized...
  17. ncbi request reprint The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004
    ....
  18. ncbi request reprint Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia
    Oliver Grimm
    Central Institute of Mental Health Mannheim, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    JAMA Psychiatry 71:531-9. 2014
    ..Schizophrenia is highly heritable, raising the possibility that this phenotype is related to the genetic risk for the disorder...
  19. ncbi request reprint Allelic variation in RGS4 impacts functional and structural connectivity in the human brain
    Joshua W Buckholtz
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
    J Neurosci 27:1584-93. 2007
    ..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness...
  20. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  21. ncbi request reprint A validated network of effective amygdala connectivity
    Jason L Stein
    Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892 1257, USA
    Neuroimage 36:736-45. 2007
    ..This validated model can be used to study neurocognitive correlates as well as genotype or disease-related alterations of functional interactions in the limbic system...
  22. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
    ..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...
  23. doi request reprint Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant
    Susanne Erk
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, D 11017 Berlin, Germany
    J Neurosci 31:18180-4. 2011
    ....
  24. doi request reprint Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, 68159 Mannheim, Germany
    Schizophr Res 140:114-21. 2012
    ....
  25. ncbi request reprint Neural correlates of genetically abnormal social cognition in Williams syndrome
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Neurosci 8:991-3. 2005
    ..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior...
  26. ncbi request reprint The Early Recognition Inventory ERIraos detects at risk mental states of psychosis with high sensitivity
    Franziska Rausch
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Compr Psychiatry 54:1068-76. 2013
    ....
  27. ncbi request reprint Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13393-401. 2007
    ..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM...
  28. doi request reprint Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction
    Edda Bilek
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, 68159 Mannheim, Germany
    J Neurosci 33:7050-6. 2013
    ....
  29. pmc Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans
    Caroline F Zink
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 30:7017-22. 2010
    ....
  30. pmc Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome
    Andreas Meyer-Lindenberg
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, NIH, Department of Health and Human Services, Bethesda, MD 20892 1365, USA
    J Clin Invest 115:1888-95. 2005
    ..These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS...
  31. pmc Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:2200-8. 2008
    ..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis...
  32. ncbi request reprint Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits
    Heike Tost
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    Nat Neurosci 13:920-2. 2010
    ..Our findings suggest a role for D2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans...
  33. ncbi request reprint Neural basis of genetically determined visuospatial construction deficit in Williams syndrome
    Andreas Meyer-Lindenberg
    Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 4C101, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neuron 43:623-31. 2004
    ....
  34. pmc Neural mechanisms of genetic risk for impulsivity and violence in humans
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Proc Natl Acad Sci U S A 103:6269-74. 2006
    ....
  35. doi request reprint Differential effects of antipsychotic agents on obsessive-compulsive symptoms in schizophrenia: a longitudinal study
    Frederike Schirmbeck
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Psychopharmacol 27:349-57. 2013
    ..Further studies should address the pathogenetic mechanism, define patients at risk and facilitate early detection as well as therapeutic interventions...
  36. pmc Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    Hao Yang Tan
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:12536-41. 2007
    ..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia...
  37. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  38. ncbi request reprint Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
    Andreas Meyer-Lindenberg
    Unit on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, 10 4C101, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 5:267-71. 2002
    ....
  39. pmc A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:13936-41. 2010
    ..Our findings identify sex-dependent mechanisms impacting the structure and function of hypothalamic-limbic circuits that are of potential clinical and translational significance...
  40. pmc Stable cognitive deficits in schizophrenia patients with comorbid obsessive-compulsive symptoms: a 12-month longitudinal study
    Frederike Schirmbeck
    To whom correspondence should be addressed Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, PO Box 12 21 20, D 68072 Mannheim, Germany tel 0049 621 1703 2523, fax 0049 621 1703 1205, E mail
    Schizophr Bull 39:1261-71. 2013
    ..The association between comorbid OCSs in these patients and neuropsychological impairment remains unclear and somewhat contradictory. Longitudinal approaches investigating the stability of OCS-associated cognitive deficits are missing...
  41. doi request reprint Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agents
    Frederike Schirmbeck
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Psychiatr Genet 22:245-52. 2012
    ..The aim of this study was to replicate these findings in a European sample...
  42. pmc Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophrenia
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Neuropsychopharmacology 37:499-507. 2012
    ..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC...
  43. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    ..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia...
  44. pmc Hierarchical organization of human cortical networks in health and schizophrenia
    Danielle S Bassett
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:9239-48. 2008
    ....
  45. doi request reprint Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain
    Natalia Gass
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany Electronic address
    Eur Neuropsychopharmacol 23:1310-9. 2013
    ..These data may help in further characterizing the functional circuits modulated by antipsychotics that could be targeted by innovative drug treatments...
  46. pmc Know your place: neural processing of social hierarchy in humans
    Caroline F Zink
    Unit for Systems Neuroscience in Psychiatry, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 58:273-83. 2008
    ..Our results identify neural mechanisms that may mediate the enormous influence of social status on human behavior and health...
  47. pmc Activation of midbrain and ventral striatal regions implicates salience processing during a modified beads task
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 8:e58536. 2013
    ..To address this issue, we studied brain activity during a modified beads task which has been used to measure a "Jumping to Conclusions" (JTC) bias in schizophrenia patients...
  48. pmc The Williams syndrome chromosome 7q11.23 hemideletion confers hypersocial, anxious personality coupled with altered insula structure and function
    Mbemba Jabbi
    Section on Integrative Neuroimaging, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:E860-6. 2012
    ....
  49. ncbi request reprint D2 antidopaminergic modulation of frontal lobe function in healthy human subjects
    Heike Tost
    Department of Psychiatry and Psychotherapy, University of Heidelberg, Germany
    Biol Psychiatry 60:1196-205. 2006
    ..Two major neurophysiological models propose segregated functional circuits on the systems level as well as D(1) and D(2) receptor-dependent processing states on the cellular level (two-state model)...
  50. pmc Retinotopically defined primary visual cortex in Williams syndrome
    Rosanna K Olsen
    Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
    Brain 132:635-44. 2009
    ....
  51. doi request reprint City living and urban upbringing affect neural social stress processing in humans
    Florian Lederbogen
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
    Nature 474:498-501. 2011
    ....
  52. ncbi request reprint Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory
    Michael F Glabus
    Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
    Cereb Cortex 13:1352-61. 2003
    ..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM...
  53. ncbi request reprint Reduced activation in ventral striatum and ventral tegmental area during probabilistic decision-making in schizophrenia
    Franziska Rausch
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Schizophr Res 156:143-9. 2014
    ..Forthcoming studies with patients at risk for psychosis and drug-naive first episode patients are necessary to elucidate the development of these findings over time and the interplay with associated clinical symptoms. ..
  54. pmc Electroconvulsive therapy induces neurogenesis in frontal rat brain areas
    Dragos Inta
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 8:e69869. 2013
    ..We provide here the first evidence that ECT stimulates neurogenesis in areas outside the hippocampus. Our data may open research possibilities that focus on the plastic changes induced by ECT in frontal limbic circuitry. ..
  55. ncbi request reprint Neuroimaging evidence for a role of neural social stress processing in ethnic minority-associated environmental risk
    Ceren Akdeniz
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    JAMA Psychiatry 71:672-80. 2014
    ....
  56. ncbi request reprint Dysfunctional prefrontal regional specialization and compensation in schizophrenia
    Hao Yang Tan
    Unit on Functional MRI, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Dr, Rm 4C 216, MSC 1364, Bethesda, MD 20892 1364, USA
    Am J Psychiatry 163:1969-77. 2006
    ....
  57. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
    ....
  58. pmc Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?
    Herve Lemaitre
    Clinical Brain Disorder Branch, Gene Cognition and Psychosis program, NIH NIMH, Bethesda, MD 20892, USA
    Neurobiol Aging 33:617.e1-9. 2012
    ....
  59. pmc Impact of interacting functional variants in COMT on regional gray matter volume in human brain
    Robyn Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 45:44-51. 2009
    ....
  60. doi request reprint Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions
    Heike Tost
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Affect Disord 120:54-61. 2010
    ..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities...
  61. pmc Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:15117-22. 2007
    ....
  62. doi request reprint Test-retest reliability of evoked BOLD signals from a cognitive-emotive fMRI test battery
    Michael M Plichta
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany
    Neuroimage 60:1746-58. 2012
    ..The present study provides task-specific fMRI reliability performance measures that will inform the optimal use, powering and design of fMRI studies using comparable tasks...
  63. doi request reprint Neural mechanisms of a genome-wide supported psychosis variant
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Science 324:605. 2009
    ....
  64. ncbi request reprint Genetic contributions to human gyrification: sulcal morphometry in Williams syndrome
    J Shane Kippenhan
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 25:7840-6. 2005
    ....
  65. pmc Association between a serotonin transporter length polymorphism and primary insomnia
    Michael Deuschle
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Sleep 33:343-7. 2010
    ..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia...
  66. doi request reprint Test-retest reliability of fMRI-based graph theoretical properties during working memory, emotion processing, and resting state
    Hengyi Cao
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    Neuroimage 84:888-900. 2014
    ..Our findings can inform the choice of processing strategies, brain atlases and outcome properties for fMRI studies using active tasks, graph theory methods, and within-subject designs, in particular future pharmaco-fMRI studies. ..
  67. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
    ..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia...
  68. doi request reprint Test-retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measures
    Urs Braun
    Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Neuroimage 59:1404-12. 2012
    ..In conclusion, our study provides methodological recommendations which allow the computation of sufficiently robust markers of network organization using graph metrics derived from fMRI data at rest...
  69. ncbi request reprint Intermediate phenotypes and genetic mechanisms of psychiatric disorders
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Clinical Brain Disorders Branch, National Institute for Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 7:818-27. 2006
    ..Using imaging genetics as an example, we illustrate recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion...
  70. ncbi request reprint Clinical and positron emission tomography of Parkinson's disease caused by LRRK2
    Dena G Hernandez
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Porter Neuroscience Research Center, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Ann Neurol 57:453-6. 2005
    ....
  71. pmc Alterations in postnatal neurogenesis and dopamine dysregulation in schizophrenia: a hypothesis
    Dragos Inta
    Department for Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
    Schizophr Bull 37:674-80. 2011
    ....
  72. doi request reprint Evidence for a general face salience signal in human amygdala
    Andreia Santos
    Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 54:3111-6. 2011
    ..Given the critical involvement of the amygdala in several neuropsychiatric disorders, the current findings may contribute to further our understanding on dysfunctional neural circuits in these disorders...
  73. pmc Human neuroimaging of oxytocin and vasopressin in social cognition
    Caroline F Zink
    Genes, Cognition, and Psychosis Program, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Horm Behav 61:400-9. 2012
    ..This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
  74. pmc A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    Stephen J Huffaker
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Med 15:509-18. 2009
    ..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target...
  75. pmc Enuresis as a premorbid developmental marker of schizophrenia
    Thomas M Hyde
    Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
    Brain 131:2489-98. 2008
    ..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors...
  76. ncbi request reprint Abnormal amygdala activation profile in pedophilia
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 258:271-7. 2008
    ..More extensive research in this field would be of benefit for both the victims and the offenders...
  77. pmc A genetic model for understanding higher order visual processing: functional interactions of the ventral visual stream in Williams syndrome
    Deepak Sarpal
    Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Cereb Cortex 18:2402-9. 2008
    ....
  78. ncbi request reprint Imaging genetics for neuropsychiatric disorders
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892, USA
    Child Adolesc Psychiatr Clin N Am 16:581-97. 2007
    ..These data provide convergent evidence for neural circuitry mediating emotional regulation and social cognition under genetic control in humans...
  79. doi request reprint Impact of prosocial neuropeptides on human brain function
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Mannheim, Germany
    Prog Brain Res 170:463-70. 2008
    ....
  80. doi request reprint Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Biol Psychiatry 68:578-85. 2010
    ..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression...
  81. pmc Cognitive fitness of cost-efficient brain functional networks
    Danielle S Bassett
    Genes Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:11747-52. 2009
    ..More generally, they echo the saying that "less is more": The information processing performance of a network can be enhanced by a sparse or low-cost configuration with disproportionately high efficiency...
  82. pmc Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypes
    Heike Tost
    Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Neurosci Biobehav Rev 34:689-700. 2010
    ..This paper discusses the pathophysiological concepts, molecular mechanisms and neuroimaging evidence that link psychosis to disturbances in dopamine neurotransmission...
  83. doi request reprint Polypharmacy in schizophrenia
    Mathias Zink
    Central Institute of Mental Health, Mannheim, Germany
    Curr Opin Psychiatry 23:103-11. 2010
    ..We review the empirical basis supporting these attempts and their relevance for clinical practice...
  84. ncbi request reprint Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Rev Neurosci 7:380-93. 2006
    ....
  85. doi request reprint MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia
    Nuran Tunc-Skarka
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 48:525-31. 2009
    ..Furthermore, they elucidate why reports of a reduced N-acetylaspartate concentration in schizophrenia were not always corroborated...
  86. doi request reprint Psychology. Trust me on this
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, University of Heidelberg, 68159 Mannheim, Germany
    Science 321:778-80. 2008
  87. doi request reprint Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review
    Dragos Inta
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Neurosci Biobehav Rev 34:285-94. 2010
    ..They may provide insight into the pathophysiology of schizophrenia and prove useful in the development of new therapeutics...
  88. ncbi request reprint Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimaging
    Brooke K Gerton
    Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1365, USA
    Neuropsychologia 42:1781-7. 2004
    ....
  89. pmc Age-related changes in midbrain dopaminergic regulation of the human reward system
    Jean Claude Dreher
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:15106-11. 2008
    ....
  90. pmc Transitions between dynamical states of differing stability in the human brain
    Andreas Meyer-Lindenberg
    Clinical Brain Disorders Branch, National Institute of Mental Health, and Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:10948-53. 2002
    ....
  91. ncbi request reprint Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006
    ..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine...
  92. ncbi request reprint Executive function and cognitive subprocesses in first-episode, drug-naive schizophrenia: an analysis of N-back performance
    Stephan Krieger
    Department of Psychiatry, Justus Liebig University Medical School, Giessen, Germany
    Am J Psychiatry 162:1206-8. 2005
    ..This study investigated changes in the cognitive architecture of N-back performance in schizophrenia...
  93. ncbi request reprint Oxytocin modulates neural circuitry for social cognition and fear in humans
    Peter Kirsch
    Cognitive Neuroscience Group, Center for Psychiatry and Psychotherapy, Justus Liebig University, D 35385 Giessen, Germany
    J Neurosci 25:11489-93. 2005
    ....
  94. doi request reprint MAOA and the neurogenetic architecture of human aggression
    Joshua W Buckholtz
    Vanderbilt Brain Institute and Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
    Trends Neurosci 31:120-9. 2008
    ..Our construct provides a neurobiologically consistent model for gene-environment interactions in impulsive aggression...
  95. pmc The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
    Mitsuyuki Matsumoto
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 105:6133-8. 2008
    ..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy...