Karl Mann

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. doi request reprint Individualised treatment in alcohol-dependent patients
    Karl Mann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Postbox 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S116-20. 2010
  2. pmc Effects of a manualized short-term treatment of internet and computer game addiction (STICA): study protocol for a randomized controlled trial
    Susanne Jäger
    Outpatient Clinic for Behavioural Addictions, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Trials 13:43. 2012
  3. doi request reprint [The concept of behavioral addiction and limits of the term addiction]
    K Mann
    Zentralinstitut fur Seelische Gesundheit, Klinik für Abhängiges Verhalten und Suchtmedizin, Mannheim, Germany
    Nervenarzt 84:548-56. 2013
  4. doi request reprint Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene
    Karl Mann
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 73:706-13. 2013
  5. ncbi request reprint The German Society for Addiction Research and Addiction Treatment
    Karl Mann
    University of Heidelberg, Central Institute of Mental Health, J 5, 68159 Mannheim, Germany
    Addiction 103:6-8. 2008
  6. ncbi request reprint The startle reflex in alcohol-dependent patients: changes after cognitive-behavioral therapy and predictive validity for drinking behavior. A pilot study
    Sabine Loeber
    Department of Addictive Behavior and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Psychother Psychosom 76:385-90. 2007
  7. ncbi request reprint Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter
    Gabriele Ende
    Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 37:1643-9. 2013
  8. doi request reprint A target sample of adolescents and reward processing: same neural and behavioral correlates engaged in common paradigms?
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Exp Brain Res 223:429-39. 2012
  9. doi request reprint Disulfiram, an option for the treatment of pathological gambling?
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany
    Alcohol Alcohol 45:214-6. 2010
  10. doi request reprint MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex
    Derik Hermann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Germany
    Addict Biol 17:659-67. 2012

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. doi request reprint Individualised treatment in alcohol-dependent patients
    Karl Mann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Postbox 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S116-20. 2010
    ..MR spectroscopy of brain glutamate levels may detect potential acamprosate responders. On such a basis, an individualised approach in the treatment of alcoholism ("personalised medicine") seems to hold promise...
  2. pmc Effects of a manualized short-term treatment of internet and computer game addiction (STICA): study protocol for a randomized controlled trial
    Susanne Jäger
    Outpatient Clinic for Behavioural Addictions, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Trials 13:43. 2012
    ..Despite a growing number of individuals seeking help, there are no specific treatments of established efficacy...
  3. doi request reprint [The concept of behavioral addiction and limits of the term addiction]
    K Mann
    Zentralinstitut fur Seelische Gesundheit, Klinik für Abhängiges Verhalten und Suchtmedizin, Mannheim, Germany
    Nervenarzt 84:548-56. 2013
    ..In specific cases the addiction model can also be applied for excessive sexual behavior, compulsive buying and obesity...
  4. doi request reprint Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene
    Karl Mann
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 73:706-13. 2013
    ..This study evaluated the efficacy of as-needed use of the opioid system modulator nalmefene in reducing alcohol consumption in patients with alcohol dependence...
  5. ncbi request reprint The German Society for Addiction Research and Addiction Treatment
    Karl Mann
    University of Heidelberg, Central Institute of Mental Health, J 5, 68159 Mannheim, Germany
    Addiction 103:6-8. 2008
  6. ncbi request reprint The startle reflex in alcohol-dependent patients: changes after cognitive-behavioral therapy and predictive validity for drinking behavior. A pilot study
    Sabine Loeber
    Department of Addictive Behavior and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Psychother Psychosom 76:385-90. 2007
    ..Further, we examined whether the affect-modulated startle reflex is a predictor of treatment success...
  7. ncbi request reprint Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter
    Gabriele Ende
    Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 37:1643-9. 2013
    ..This study investigated magnetic resonance spectroscopy (MRS)-detectable Glu levels in frontal WM of non-treatment-seeking heavy drinkers and its associations with AUD symptoms...
  8. doi request reprint A target sample of adolescents and reward processing: same neural and behavioral correlates engaged in common paradigms?
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Exp Brain Res 223:429-39. 2012
    ....
  9. doi request reprint Disulfiram, an option for the treatment of pathological gambling?
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany
    Alcohol Alcohol 45:214-6. 2010
    ..Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling...
  10. doi request reprint MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex
    Derik Hermann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Germany
    Addict Biol 17:659-67. 2012
    ..Increased Cho concentrations in fWM corroborate findings of WM abnormalities in opioid-dependent subjects...
  11. doi request reprint Experience of social discrimination correlates with neurometabolism: a pilot study in heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, P O Box 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:197-203. 2013
    ..Further research is needed to elucidate factors associated with chronic stigmatization...
  12. doi request reprint Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Addiction 105:1741-9. 2010
    ..In this study we address this hypothesis in the context of alcohol dependence...
  13. doi request reprint Diminished brain functional magnetic resonance imaging activation in patients on opiate maintenance despite normal spatial working memory task performance
    Patrick Bach
    Department Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Clin Neuropharmacol 35:153-60. 2012
    ..The objective of the study at hand was to investigate the effect of buprenorphine and methadone maintenance therapy on visuospatial working memory performance...
  14. ncbi request reprint [Recent results in relaps prevention of alcoholism with Disulfiram]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:243-51. 2008
    ..It acts as a psychological deterrence of a possible disulfiram-alcohol reaction. This paper describes the current clinical impact and possible future of disulfiram...
  15. doi request reprint Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats
    Derik Hermann
    Department of Addiction Medicine, Central Institute for Mental Health, Mannheim, Germany
    Biol Psychiatry 71:1015-21. 2012
    ..Our understanding of this pathophysiological mechanism originates largely from animal studies, but human data are needed for translation into successful medication development...
  16. doi request reprint Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Germany
    Addict Biol 17:807-16. 2012
    ..However, this association could also be bidirectional with the attentional bias enhancing cue-induced neural activity...
  17. doi request reprint Searching for responders to acamprosate and naltrexone in alcoholism treatment: rationale and design of the PREDICT study
    Karl Mann
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 33:674-83. 2009
    ..The "reward drinker/craver" is mainly associated with alterations in the dopaminergic and opioidergic system and responds to naltrexone...
  18. doi request reprint Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, Square J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 35:570-7. 2010
    ..The aim of this study was to examine the possible association between orexin and leptin, and nicotine craving in smokers in a clinical case-control study under standardized conditions...
  19. doi request reprint Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder--a case series
    Jochen Mutschler
    1Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:146-50. 2010
    ..We examined the safety and efficacy in relapse prevention of a series of alcoholics with borderline personality disorder (BPD)...
  20. doi request reprint Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: a randomized trial
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 69:1060-6. 2011
    ..In this study, we assessed CET treatment effects on cue-induced responses using functional magnetic resonance imaging (fMRI)...
  21. ncbi request reprint Impaired decision making in opiate addiction correlates with anxiety and self-directedness but not substance use parameters
    Tagrid Leménager
    Department of Addictive Behavior and Addiction Medicine, the Central Institute of Mental Health, Mannheim, Germany
    J Addict Med 5:203-13. 2011
    ..This study examined the potential influences of personality traits, affective symptoms, and pharmacological variables on decision making, as measured by the Iowa Gambling Task (IGT) in a sample of opioid-dependent patients...
  22. doi request reprint Effects of alcoholism and continued abstinence on brain volumes in both genders
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 35:1678-85. 2011
    ....
  23. ncbi request reprint Reduced fMRI activation of an occipital area in recently detoxified alcohol-dependent patients in a visual and acoustic stimulation paradigm
    Derik Hermann
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 12:117-21. 2007
    ..Attention deficits or a persisting neuronal alteration in the first weeks of alcohol abstinence may have contributed to this result...
  24. ncbi request reprint Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
    ..Cannabinoids present neurotoxic and neuroprotective properties in in vitro studies, inconsistent alterations in human neuroimaging studies, neuropsychological deficits, and an increased risk for psychotic episodes...
  25. doi request reprint Consultation-liaison psychiatry in general hospitals: improvement in physicians' detection rates of alcohol use disorders
    Alexander Diehl
    Department of Addictive Behavior and Addiction Medicine, Division of Biostatistics, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
    Psychosomatics 50:599-604. 2009
    ..In the general hospital setting, alcohol-use disorders very commonly remain undetected...
  26. ncbi request reprint Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  27. doi request reprint Severity of dependence modulates smokers' neuronal cue reactivity and cigarette craving elicited by tobacco advertisement
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 16:166-75. 2011
    ..Tobacco advertisement seems to likewise appeal to smokers and non-smokers, clarifying the potential danger especially for young non-smokers...
  28. doi request reprint Effects of repeated withdrawal from alcohol on recovery of cognitive impairment under abstinence and rate of relapse
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Alcohol 45:541-7. 2010
    ..The aim of the present study was to investigate whether repeated withdrawal from alcohol affects recovery of cognitive function and is related to relapse...
  29. ncbi request reprint Blockade of cue-induced brain activation of abstinent alcoholics by a single administration of amisulpride as measured with fMRI
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 30:1349-54. 2006
    ..We tested the effects of the atypical dopamine D(2/3) blocker amisulpride on cue-induced brain activation in a functional magnetic resonance imaging (fMRI) paradigm...
  30. ncbi request reprint Impairment of cognitive abilities and decision making after chronic use of alcohol: the impact of multiple detoxifications
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, 68159 Mannheim, Germany
    Alcohol Alcohol 44:372-81. 2009
    ..In the present study, the effect of previous detoxifications on prefrontal function and decision making was examined in alcohol-dependent patients. Further, we examined whether the length of abstinence affects cognitive function...
  31. doi request reprint Reward and relief craving tendencies in patients with alcohol use disorders: results from the PREDICT study
    Angelika Glöckner-Rist
    GESIS Leibniz Institute for the Social Sciences, Department of Survey Design and Methodology, Mannheim, Germany
    Addict Behav 38:1532-40. 2013
    ..In personalized treatment, patients of such different subgroups might respond differently to various psychotherapeutic and pharmacological interventions aimed at relapse prevention...
  32. doi request reprint Factors affecting cognitive function of opiate-dependent patients
    Sabine Loeber
    Department of General Psychiatry, University of Heidelberg, Vossstrasse 2, 69115 Heidelberg, Germany
    Drug Alcohol Depend 120:81-7. 2012
    ....
  33. ncbi request reprint Increased activation of the ACC during a spatial working memory task in alcohol-dependence versus heavy social drinking
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 34:771-6. 2010
    ..To transfer these results into adults, we used the same task in adults...
  34. pmc Dextromethorphan withdrawal and dependence syndrome
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg
    Dtsch Arztebl Int 107:537-40. 2010
    ..Dextromethorphan is avidly taken, mainly by young people, as a psychoactive drug. The currently available data yield incomplete information about the extent of the problem and its significance for addiction medicine in Germany...
  35. doi request reprint Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Drug Alcohol Depend 114:242-5. 2011
    ..Chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (THC) and cannabidiol (CBD)...
  36. pmc Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:986-95. 2012
    ....
  37. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  38. doi request reprint Decision making of heavy cannabis users on the Iowa Gambling Task: stronger association with THC of hair analysis than with personality traits of the Tridimensional Personality Questionnaire
    Derik Hermann
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Eur Addict Res 15:94-8. 2009
    ..It is unclear whether impairment in decision making, measured by the Iowa Gambling Task (IGT), in addiction is substance-induced or the consequence of personality structure...
  39. doi request reprint Attentional bias in alcohol-dependent patients: the role of chronicity and executive functioning
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:194-203. 2009
    ..Our results indicate that differences with regard to drinking-related variables as well as cognitive functioning seem to modulate attentional bias and need to be taken into account in models of drinking maintenance...
  40. pmc Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism
    Jelka Tzschoppe
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 39:875-84. 2014
    ..This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders. ..
  41. ncbi request reprint The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing
    Angela Heinrich
    Department of Cognitive and Clinical Neuroscience Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Bipolar Disord 15:440-5. 2013
    ....
  42. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
    ..The latter result may indicate that many more AD susceptibility genes still await identification...
  43. doi request reprint Neuropsychological functioning of opiate-dependent patients: a nonrandomized comparison of patients preferring either buprenorphine or methadone maintenance treatment
    Sabine Loeber
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Am J Drug Alcohol Abuse 34:584-93. 2008
    ..In the present study, we investigated whether buprenorphine as a partial mu-opioid receptor agonist is associated with less cognitive impairment than methadone...
  44. doi request reprint Avoidance of alcohol-related stimuli increases during the early stage of abstinence in alcohol-dependent patients
    Sabine Vollstädt-Klein
    Department of Addictive Behaviour and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Alcohol 44:458-63. 2009
    ..Furthermore, we investigated the influence of pre-treatment alcohol consumption and abstinence duration onto alcohol-related attentional bias...
  45. ncbi request reprint Alcoholism in women: is it different in onset and outcome compared to men?
    Alexander Diehl
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 257:344-51. 2007
    ..29+/-11.26 days) and men (284.72+/-12.16 days). At the end of the 12 months both groups had an abstinence rate of approximately 50% and a drop-out rate of 33%...
  46. doi request reprint Results of a double-blind, placebo-controlled pharmacotherapy trial in alcoholism conducted in Germany and comparison with the US COMBINE study
    Karl Mann
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Addict Biol 18:937-46. 2013
    ..We suggest that identically designed RCTs conducted in different parts of the world may help improve the external validity of RCTs. This approach could be called 'comparative efficacy research'. ..
  47. doi request reprint Cost-effective primary care-based strategies to improve smoking cessation: more value for money
    Hans Joachim Salize
    Central Institute of Mental Health, Mannheim, Germany
    Arch Intern Med 169:230-5; discussion 235-6. 2009
    ..Evidence from cost-effective smoking cessation programs is scarce. This study determined the cost-effectiveness of 3 smoking cessation strategies as provided by general practitioners (GPs) in Germany...
  48. ncbi request reprint Cue exposure in the treatment of alcohol dependence: effects on drinking outcome, craving and self-efficacy
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Br J Clin Psychol 45:515-29. 2006
    ..We hypothesized that cue exposure treatment is associated with a stronger decline of craving, a stronger increase in self-efficacy and has beneficial effects on drinking behaviour after discharge...
  49. doi request reprint Acamprosate: recent findings and future research directions
    Karl Mann
    The Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 32:1105-10. 2008
    ..Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy...
  50. ncbi request reprint The vicious circle of perceived stigmatization, depressiveness, anxiety, and low quality of life in substituted heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Eur Addict Res 17:241-9. 2011
    ..Perceived stigmatization of drug addicts may interact with negative mood states and thus may contribute to the maintenance of addictive behavior...
  51. ncbi request reprint Alcohol consumption significantly influences the MR signal of frontal choline-containing compounds
    Gabriele Ende
    Department of Neuroimaging and Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, PO Box 12 21 20, D 68072 Mannheim, Germany
    Neuroimage 32:740-6. 2006
    ....
  52. ncbi request reprint Long-term behavior in treated alcoholism: Evidence for beneficial carry-over effects of abstinence from smoking on alcohol use and vice versa
    Thomas Hintz
    Department for Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Addict Behav 32:3093-100. 2007
    ..We conclude that it is warranted and recommendable to explore the willingness of alcohol-dependent patients to quit smoking and to offer them treatment options addressing this point...
  53. ncbi request reprint A pilot study of oxcarbazepine versus acamprosate in alcohol-dependent patients
    Bernhard Croissant
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 30:630-5. 2006
    ..Furthermore, OXC has revealed a mood-stabilizing effect in bipolar affective disorders. We have compared OXC with ACP in relapse prevention in recently withdrawn alcohol-dependent patients...
  54. doi request reprint From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits
    Angela Heinrich
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, 68159, Germany Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Eur J Neurosci 38:2941-5. 2013
    ..Our findings support the hypothesis that the schizophrenia-related risk variant of rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral as well as an imaging genetics level. ..
  55. ncbi request reprint Self-concept deficits in massively multiplayer online role-playing games addiction
    Tagrid Leménager
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Eur Addict Res 19:227-34. 2013
    ..The aim of this study was to examine differences in self-concept and degree of avatar identification in World of Warcraft addicted, non-addicted and naive (nonexperienced) participants...
  56. doi request reprint Rapid partial regeneration of brain volume during the first 14 days of abstinence from alcohol
    Julia van Eijk
    Department of Neuroimaging, Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 37:67-74. 2013
    ..The aim of this study was to investigate whether volumetric amelioration takes place already within the first 2 weeks of abstinence...
  57. ncbi request reprint [Expenditures for members of a health insurance company suffering from alcoholism - a payer's view]
    Klaus Stamm
    Zentralinstitut fur Seelische Gesundheit, Mannheim
    Psychiatr Prax 34:194-9. 2007
    ..In this study, expenditures of a health insurance company for alcoholics are calculated and analysed...
  58. ncbi request reprint Co-occurring disorders: policy and practice in Germany
    Thomas Hintz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Addict 15:261-7. 2006
    ..In general, treatment conditions for COD patients are improving, but further efforts are necessary. Guidelines and treatment strategies for COD patients have been recently published in Germany...
  59. doi request reprint Modifications of the Obsessive Compulsive Drinking Scale (OCDS-G) for use in longitudinal studies
    Helmut Nakovics
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Addict Behav 33:1276-81. 2008
    ..The short version of the OCDS seems to be sufficient. If different effects on cognitive and behavioral levels are expected, the 12-item version without the quantity items should be applied...
  60. ncbi request reprint Monitoring the effects of chronic alcohol consumption and abstinence on brain metabolism: a longitudinal proton magnetic resonance spectroscopy study
    Gabriele Ende
    Nuclear Magnetic Resonance Research in Psychiatry and Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 58:974-80. 2005
    ..This study focused on metabolic brain alterations in recently detoxified alcohol-dependent patients (S1) and their possible reversibility after 3 (S2) and 6 months (S3) of abstinence...
  61. ncbi request reprint Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery
    Michael N Smolka
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Psychopharmacology (Berl) 184:577-88. 2006
    ..Cue-induced brain activation is associated with self-reported craving but further correlates are widely unknown...
  62. ncbi request reprint Low efficacy of non-opioid drugs in opioid withdrawal symptoms
    Derik Hermann
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 10:165-9. 2005
    ..Only benzodiazepines and tricyclic antidepressants were reported to have a moderate positive effect on opioid withdrawal...
  63. doi request reprint Treating alcoholism reduces financial burden on care-givers and increases quality-adjusted life years
    Hans Joachim Salize
    Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    Addiction 108:62-70. 2013
    ..The study assessed the alcoholism-related financial burden borne by informal care-givers and relatives of German alcoholic patients...
  64. ncbi request reprint Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients
    Andreas Heinz
    Central Institute of Mental Health, Mannheim, Germany
    Am J Psychiatry 162:1515-20. 2005
    ..In this study, positron emission tomography (PET) was used to compare dopamine synthesis capacity in the striatum in alcoholic patients and healthy comparison subjects...
  65. doi request reprint Drinking against unpleasant emotions: possible outcome of early onset of alcohol use?
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 34:1052-7. 2010
    ..The purpose of this study was to examine whether this effect may be the consequence of a higher susceptibility to develop "drinking to cope" motives among early initiators...
  66. ncbi request reprint Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Curr Pharm Des 16:2098-102. 2010
    ..To increase the efficacy of this drug, targeted treatment and individualized therapy approaches seem useful and necessary...
  67. ncbi request reprint Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    Michael N Smolka
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Neurosci 25:836-42. 2005
    ....
  68. ncbi request reprint Brain networks subserving fixed versus performance-adjusted delay stop trials in a stop signal task
    Mira Fauth-Bühler
    Department of Addictive Behavior and Addiction Medicine, Medical Faculty Mannheim Heidelberg University, Central Institute of Mental Health, Mannheim, Germany
    Behav Brain Res 235:89-97. 2012
    ..Fixed delay stop signal tasks may be more appropriate in studies assessing the neural basis of individual differences in performance, such as studies of personality traits or genetic associations...
  69. ncbi request reprint The long-term course of alcoholism, 5, 10 and 16 years after treatment
    Karl Mann
    Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany
    Addiction 100:797-805. 2005
    ..To discover the long-term stability of drinking behaviour following an in-patient treatment episode...
  70. ncbi request reprint New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence
    Falk Kiefer
    University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
    Eur J Pharmacol 526:163-71. 2005
    ..New compounds are under investigation. This review discusses the neurobiological basis of alcohol addiction, pharmacological targets for relapse prevention treatment and pre-clinical and clinical results with the most promising drugs...
  71. doi request reprint Alcohol and the human brain: a systematic review of different neuroimaging methods
    Mira Bühler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 35:1771-93. 2011
    ..A systematic review summarizing these contributions has not previously been conducted, and this is the goal of the current paper...
  72. ncbi request reprint Reward craving and withdrawal relief craving: assessment of different motivational pathways to alcohol intake
    Andreas Heinz
    Department of Addictive Behaviour and Addiction Medicine, Humboldt University, Berlin, Germany
    Alcohol Alcohol 38:35-9. 2003
    ....
  73. doi request reprint Reduced affective symptoms during tobacco dependence treatment with varenicline
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Addiction 104:859-61. 2009
    ....
  74. ncbi request reprint Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  75. ncbi request reprint Does psychiatric comorbidity in alcohol-dependent patients affect treatment outcome?
    Karl Mann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 254:172-81. 2004
    ..Male comorbid (40.9%) and non-comorbid (35.3%) patients showed no significant differences regarding relapse rates...
  76. ncbi request reprint The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis
    Karl Mann
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 28:51-63. 2004
    ..An assessment of the efficacy of treatment with acamprosate was, therefore, undertaken using meta-analytical techniques...
  77. ncbi request reprint Candidate genes for alcohol dependence: animal studies
    Gunter Schumann
    Molecular Genetics Laboratory, Department of Psychiatry, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Alcohol Clin Exp Res 27:880-8. 2003
  78. ncbi request reprint Dysregulation of the hypothalamic-pituitary-thyroid axis in alcoholism
    Derik Hermann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Addiction 97:1369-81. 2002
    ..We discuss further additional effects of alcohol on thyroid-hormone metabolizing deiodinases and on monoaminergic systems, which may interact directly with mood states among abstinent alcoholics...
  79. ncbi request reprint Pharmacotherapy of alcohol dependence: a review of the clinical data
    Karl Mann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    CNS Drugs 18:485-504. 2004
    ..Pharmacotherapy should be used in association with appropriate psychosocial support and specific treatment provided for any underlying psychiatric comorbidities...
  80. ncbi request reprint Brain activation elicited by affectively positive stimuli is associated with a lower risk of relapse in detoxified alcoholic subjects
    Andreas Heinz
    Department of Psychiatry, Charite University Medical Center Berlin, CCM, Berlin, Germany
    Alcohol Clin Exp Res 31:1138-47. 2007
    ..We assessed whether brain activation elicited by (1) alcohol associated, (2) affectively positive, and (3) negative versus neutral stimuli is associated with the subsequent risk of relapse...
  81. ncbi request reprint HPA-axis activity in alcoholism: examples for a gene-environment interaction
    Toni Kim Clarke
    Section of Addiction Biology, Institute of Psychiatry, King s College, London, UK
    Addict Biol 13:1-14. 2008
    ....
  82. ncbi request reprint Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study
    Markus Gastpar
    Department of Psychiatry of the University of Essen, Germany
    J Clin Psychopharmacol 22:592-8. 2002
    ..Nevertheless, the question arises whether self-reports of drinking are more reliable than gamma-GT as a measure of recent alcohol consumption...
  83. ncbi request reprint [The qualified-detoxification-of-alcoholics procedure--in light of the development of guidelines for the treatment of substance-related disorders]
    Lutz G Schmidt
    Psychiatrische Klinik und Poliklinik der Johannes Gutenberg Universität Mainz
    Z Arztl Fortbild Qualitatssich 96:295-300. 2002
    ....
  84. ncbi request reprint Therapy and supportive care of alcoholics: guidelines for practitioners
    Andreas Heinz
    Department of Psychiatry of the Charité, Humboldt University Berlin, Schumannstrasse 20 21, Berlin 10117, Germany
    Best Pract Res Clin Gastroenterol 17:695-708. 2003
    ..If adequate treatment is available, relapse rates were as low as 50% in those follow-up studies that examined treatment periods of up to 2 years, so that there is no justification for therapeutic nihilism...
  85. ncbi request reprint Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
    Biol Psychiatry 61:1011-4. 2007
    ..However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers...
  86. ncbi request reprint Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: a positron emission tomography study using carbon 11-labeled carfentanil
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Arch Gen Psychiatry 62:57-64. 2005
    ..Blockade of mu-opiate receptors with naltrexone reduces the relapse risk among some but not all alcoholic individuals...
  87. doi request reprint Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior
    Gunter Schumann
    Interdisciplinary Research Group Addiction, MRC SGDP Center, Institute of Psychiatry at King s College, POB 080, London SE5 8AF, England
    Arch Gen Psychiatry 65:826-38. 2008
    ..Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models...
  88. doi request reprint Amygdala volume associated with alcohol abuse relapse and craving
    Jana Wrase
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Am J Psychiatry 165:1179-84. 2008
    ..This study sought an association in alcohol-dependent subjects between volumes of reward-related brain regions, alcohol craving, and the risk of relapse...
  89. ncbi request reprint Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving
    Andreas Heinz
    Department of Psychiatry, Charite, Campus Mitte, Berlin, Germany
    Am J Psychiatry 161:1783-9. 2004
    ..Prolonged D(2) receptor dysfunction in the ventral striatum may interfere with a dopamine-dependent error detection signal and bias the brain reward system toward excessive attribution of incentive salience to alcohol-associated stimuli...
  90. ncbi request reprint Pharmacotherapy and behavioral intervention for alcohol dependence
    Falk Kiefer
    JAMA 296:1727-8; author reply 1728-9. 2006
  91. ncbi request reprint Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics
    Sabine M Grüsser
    Department of Medical Psychology, Campus Charite Mitte, Charite University Medicine Berlin, Berlin, Germany
    Psychopharmacology (Berl) 175:296-302. 2004
    ..Animal experiments have provided evidence that the striatum and medial prefrontal cortex play a predominant role in the acquisition and maintenance of drug-seeking behavior...
  92. ncbi request reprint Investigating the structure of craving using structural equation modeling in analysis of the obsessive-compulsive drinking scale: a multinational study
    Wencke A J M de Wildt
    Jellinek Addiction Treatment Centre, Amsterdam, The Netherlands
    Alcohol Clin Exp Res 29:509-16. 2005
    ..The Obsessive-Compulsive Drinking Scale (OCDS) seems to measure certain aspects of craving, but its theoretical basis remains unclear. The aim of this study was to investigate the structure of alcohol craving, using OCDS data...
  93. ncbi request reprint Deposition of cannabinoids in hair after long-term use of cannabis
    Gisela Skopp
    Institute of Legal Medicine and Traffic Medicine, Ruprecht Karls University, Voss Str 2, 69115 Heidelberg, Germany
    Forensic Sci Int 170:46-50. 2007
    ..023 or 0.014). A significant relationship between THC and the amount of cannabis used could not be established. As a conclusion, the sum of major cannabinoids in hair of regular users may provide a better measure of drug use than THC...
  94. ncbi request reprint [Prevention of alcoholism: what are effective strategies?]
    Sabine Loeber
    Lehrstuhl für Suchtforschung der Universität Heidelberg, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Psychiatr Prax 33:108-16. 2006
    ..This review provides information about the current state of knowledge concerning alcohol prevention...
  95. ncbi request reprint The efficacy of the dopamine D2/D3 antagonist tiapride in maintaining abstinence: a randomized, double-blind, placebo-controlled trial in 299 alcohol-dependent patients
    Stefan Bender
    Department of Psychiatry and Psychotherapy, Rhine State Hospital, University Hospital Essen, Germany
    Int J Neuropsychopharmacol 10:653-60. 2007
    ..Regarding the high success rate in the placebo group the influence of psychosocial treatment in studies investigating drug effects on the course of alcohol dependence has to be considered...
  96. ncbi request reprint The effect of computerized tailored brief advice on at-risk drinking in subcritically injured trauma patients
    Tim Neumann
    Department of Anaesthesiology and Intensive Care Medicine, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Germany
    J Trauma 61:805-14. 2006
    ..We hypothesized that computer technology can screen and provide an intervention that reduces at-risk drinking (British Medical Association criteria) in injured ED patients...
  97. ncbi request reprint Challenges to medications development in treating alcohol dependence: an international perspective
    John M Littleton
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Cooper and University Drives, Lexington 40546 0236, USA
    Alcohol Alcohol 39:271-5. 2004
    ..The investment risk to industry should be appraised not only in terms of the rather poor results of previous marketing efforts but with a view to the opportunity to penetrate a potentially enormous and largely untapped market...
  98. ncbi request reprint Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Nat Neurosci 8:20-1. 2005
    ..s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression...
  99. ncbi request reprint Gender differences in the performance of a computerized version of the alcohol use disorders identification test in subcritically injured patients who are admitted to the emergency department
    Tim Neumann
    Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine, Campus Mitte, Schumannstrasse 20 21, 10117 Berlin, Germany
    Alcohol Clin Exp Res 28:1693-701. 2004
    ..An additional purpose of the study was to determine whether computerized screening for alcohol problems is feasible in this setting...
  100. ncbi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  101. pmc Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents
    Sylvane Desrivieres
    Section of Addiction Biology, Interdisciplinary Research Group Addiction and NIHR Biomedical Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    PLoS ONE 3:e1769. 2008
    ....