Falk Kiefer

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Pharmacological relapse prevention of alcoholism: clinical predictors of outcome
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 11:83-91. 2005
  2. ncbi request reprint New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence
    Falk Kiefer
    University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
    Eur J Pharmacol 526:163-71. 2005
  3. ncbi request reprint Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    J Psychiatr Res 39:545-51. 2005
  4. doi request reprint Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Ann Nutr Metab 62:271-6. 2013
  5. doi request reprint Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence
    Christoph von der Goltz
    Dept of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Horm Behav 60:644-50. 2011
  6. doi request reprint Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Germany
    Addict Biol 17:807-16. 2012
  7. doi request reprint Association of leptin with food cue-induced activation in human reward pathways
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5 68159 Mannheim, Germany
    Arch Gen Psychiatry 69:529-37. 2012
  8. doi request reprint Psychological and hormonal features of smokers at risk to gain weight after smoking cessation--results of a multicenter study
    Anne Koopmann
    Dept of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Horm Behav 60:58-64. 2011
  9. doi request reprint Experience of social discrimination correlates with neurometabolism: a pilot study in heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, P O Box 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:197-203. 2013
  10. doi request reprint Diminished brain functional magnetic resonance imaging activation in patients on opiate maintenance despite normal spatial working memory task performance
    Patrick Bach
    Department Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Clin Neuropharmacol 35:153-60. 2012

Detail Information

Publications63

  1. ncbi request reprint Pharmacological relapse prevention of alcoholism: clinical predictors of outcome
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 11:83-91. 2005
    ..The efficacy of pharmacological relapse prevention in alcoholism with acamprosate and naltrexone has been supported by several controlled trials. It remains uncertain whether any differential indication for treatment exists...
  2. ncbi request reprint New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence
    Falk Kiefer
    University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
    Eur J Pharmacol 526:163-71. 2005
    ..New compounds are under investigation. This review discusses the neurobiological basis of alcohol addiction, pharmacological targets for relapse prevention treatment and pre-clinical and clinical results with the most promising drugs...
  3. ncbi request reprint Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    J Psychiatr Res 39:545-51. 2005
    ..Moreover, there are hints for an interaction between pharmacological anti-craving treatment, plasma concentration of leptin, and abstinence duration...
  4. doi request reprint Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Ann Nutr Metab 62:271-6. 2013
    ..The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution...
  5. doi request reprint Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence
    Christoph von der Goltz
    Dept of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Horm Behav 60:644-50. 2011
    ..Moreover, the effects on global distress indices as well as the earlier studied effects on reinstatement of drug seeking behaviors may point on an involvement of ORX in impaired brain stress systems...
  6. doi request reprint Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Germany
    Addict Biol 17:807-16. 2012
    ..However, this association could also be bidirectional with the attentional bias enhancing cue-induced neural activity...
  7. doi request reprint Association of leptin with food cue-induced activation in human reward pathways
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5 68159 Mannheim, Germany
    Arch Gen Psychiatry 69:529-37. 2012
    ..Whereas the hypothalamic regulation of energy homeostasis by endocrine feedback signals has been widely investigated, its interplay with mesolimbic reward-associated pathways represents a rich field of future research...
  8. doi request reprint Psychological and hormonal features of smokers at risk to gain weight after smoking cessation--results of a multicenter study
    Anne Koopmann
    Dept of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Horm Behav 60:58-64. 2011
    ..This interaction of behavioral and neuroendocrinological factors may constitute a high risk condition for gaining weight following smoking cessation...
  9. doi request reprint Experience of social discrimination correlates with neurometabolism: a pilot study in heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, P O Box 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:197-203. 2013
    ..Further research is needed to elucidate factors associated with chronic stigmatization...
  10. doi request reprint Diminished brain functional magnetic resonance imaging activation in patients on opiate maintenance despite normal spatial working memory task performance
    Patrick Bach
    Department Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Clin Neuropharmacol 35:153-60. 2012
    ..The objective of the study at hand was to investigate the effect of buprenorphine and methadone maintenance therapy on visuospatial working memory performance...
  11. doi request reprint Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder--a case series
    Jochen Mutschler
    1Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:146-50. 2010
    ..We examined the safety and efficacy in relapse prevention of a series of alcoholics with borderline personality disorder (BPD)...
  12. doi request reprint MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex
    Derik Hermann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Germany
    Addict Biol 17:659-67. 2012
    ..Increased Cho concentrations in fWM corroborate findings of WM abnormalities in opioid-dependent subjects...
  13. doi request reprint Attention shift towards smoking cues relates to severity of dependence, smoking behavior and breath carbon monoxide
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Eur Addict Res 17:217-24. 2011
    ..Future studies are warranted to further enhance our understanding of factors that affect attentional bias as appetitive responses towards smoking-related stimuli might be an important target for therapeutic interventions...
  14. doi request reprint Implications from addiction research towards the understanding and treatment of obesity
    Martin Grosshans
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 16:189-98. 2011
    ..In this review, recent findings on overlapping neurobiological and phenomenological pathways are summarized and the impact with regard to new treatment approaches for obesity is discussed...
  15. doi request reprint Searching for responders to acamprosate and naltrexone in alcoholism treatment: rationale and design of the PREDICT study
    Karl Mann
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 33:674-83. 2009
    ..The "reward drinker/craver" is mainly associated with alterations in the dopaminergic and opioidergic system and responds to naltrexone...
  16. doi request reprint The effect of pictorial warnings on cigarette packages on attentional bias of smokers
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Pharmacol Biochem Behav 98:292-8. 2011
    ....
  17. doi request reprint Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: a randomized trial
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 69:1060-6. 2011
    ..In this study, we assessed CET treatment effects on cue-induced responses using functional magnetic resonance imaging (fMRI)...
  18. doi request reprint Functional social support within a medical supervised outpatient treatment program
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Drug Alcohol Abuse 39:44-9. 2013
    ..This study examined functional social support (FSS) and its impact on treatment outcome in alcohol-dependent outpatients treated with supervised disulfiram...
  19. doi request reprint Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Nicotine Tob Res 15:1322-7. 2013
    ....
  20. doi request reprint Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 18:246-52. 2012
    ..The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking...
  21. doi request reprint The association of the appetitive peptide acetylated ghrelin with alcohol craving in early abstinent alcohol dependent individuals
    Anne Koopmann
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, J5 68159 Mannheim, Germany
    Psychoneuroendocrinology 37:980-6. 2012
    ....
  22. doi request reprint Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, Square J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 35:570-7. 2010
    ..The aim of this study was to examine the possible association between orexin and leptin, and nicotine craving in smokers in a clinical case-control study under standardized conditions...
  23. doi request reprint Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:13-6. 2010
    ..We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor...
  24. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 60:74-6. 2006
    ..We examined the relationship between efficacy of pharmacological anticraving treatment and HPA axis activity in the relapse prevention treatment of alcoholism...
  25. doi request reprint Factors affecting cognitive function of opiate-dependent patients
    Sabine Loeber
    Department of General Psychiatry, University of Heidelberg, Vossstrasse 2, 69115 Heidelberg, Germany
    Drug Alcohol Depend 120:81-7. 2012
    ....
  26. doi request reprint Disulfiram, an option for the treatment of pathological gambling?
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany
    Alcohol Alcohol 45:214-6. 2010
    ..Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling...
  27. ncbi request reprint Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 404:103-6. 2006
    ....
  28. ncbi request reprint Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 13:124-9. 2008
    ..It is discussed whether especially these subjects should be targeted for pharmacological relapse prevention treatment with naltrexone...
  29. doi request reprint Attentional bias in alcohol-dependent patients: the role of chronicity and executive functioning
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:194-203. 2009
    ..Our results indicate that differences with regard to drinking-related variables as well as cognitive functioning seem to modulate attentional bias and need to be taken into account in models of drinking maintenance...
  30. doi request reprint D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 43:626-9. 2008
    ..The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour...
  31. doi request reprint Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 205:389-97. 2009
    ..The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval...
  32. doi request reprint Pregabalin abuse among opiate addicted patients
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, J5 68159, Mannheim, Germany
    Eur J Clin Pharmacol 69:2021-5. 2013
    ..Thus, we hypothesized that pregabalin might be abused by patients who were undergoing an opiate replacement therapy and never had an indication for taking pregabalin on medical grounds...
  33. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  34. ncbi request reprint Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Curr Pharm Des 16:2098-102. 2010
    ..To increase the efficacy of this drug, targeted treatment and individualized therapy approaches seem useful and necessary...
  35. doi request reprint Consultation-liaison psychiatry in general hospitals: improvement in physicians' detection rates of alcohol use disorders
    Alexander Diehl
    Department of Addictive Behavior and Addiction Medicine, Division of Biostatistics, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
    Psychosomatics 50:599-604. 2009
    ..In the general hospital setting, alcohol-use disorders very commonly remain undetected...
  36. doi request reprint The vicious circle of perceived stigmatization, depressiveness, anxiety, and low quality of life in substituted heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Eur Addict Res 17:241-9. 2011
    ..Perceived stigmatization of drug addicts may interact with negative mood states and thus may contribute to the maintenance of addictive behavior...
  37. doi request reprint Results of a double-blind, placebo-controlled pharmacotherapy trial in alcoholism conducted in Germany and comparison with the US COMBINE study
    Karl Mann
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Addict Biol 18:937-46. 2013
    ..We suggest that identically designed RCTs conducted in different parts of the world may help improve the external validity of RCTs. This approach could be called 'comparative efficacy research'. ..
  38. doi request reprint Learning and memory in the aetiopathogenesis of addiction: future implications for therapy?
    Christoph von der Goltz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S183-7. 2009
    ....
  39. doi request reprint Drugs for relapse prevention of alcoholism: ten years of progress
    Rainer Spanagel
    Department of Psychopharmacology and Department of Addictive Behaviour and Addiction Medicine at the Central Institute of Mental Health, Mannheim, Germany
    Trends Pharmacol Sci 29:109-15. 2008
    ..However, the heterogeneity in treatment response makes it necessary to characterize genetic and protein markers and endophenotypes for individualized pharmacotherapy...
  40. ncbi request reprint [A new pharmacological treatment option for alcohol dependence discovered in transnational study: neurokinin-1 receptor antagonist as a possible therapy for alcoholism?]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:283-5. 2008
    ..They could demonstrate that either the blockade of the receptor, or the lack of the receptors leds to a decreased alcohol intake as well as reduced alcohol tolerance and craving concomitantly accompanied by improved general well-beeing...
  41. ncbi request reprint [Recent results in relaps prevention of alcoholism with Disulfiram]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:243-51. 2008
    ..It acts as a psychological deterrence of a possible disulfiram-alcohol reaction. This paper describes the current clinical impact and possible future of disulfiram...
  42. ncbi request reprint Extended-release intramuscular naltrexone: a viewpoint by Falk Kiefer
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Drugs 66:1752-3. 2006
  43. doi request reprint A systems medicine research approach for studying alcohol addiction
    Rainer Spanagel
    Insitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Addict Biol 18:883-96. 2013
    ....
  44. doi request reprint New approaches to addiction treatment based on learning and memory
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Curr Top Behav Neurosci 13:671-84. 2013
    ..These approaches suggest that the extinction of drug-related memories may represent a viable treatment strategy in the future treatment of addiction...
  45. doi request reprint Avoidance of alcohol-related stimuli increases during the early stage of abstinence in alcohol-dependent patients
    Sabine Vollstädt-Klein
    Department of Addictive Behaviour and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Alcohol 44:458-63. 2009
    ..Furthermore, we investigated the influence of pre-treatment alcohol consumption and abstinence duration onto alcohol-related attentional bias...
  46. doi request reprint Complete suppression of craving in alcohol-dependent individuals: is it possible?
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim 68159, Germany
    CNS Drugs 23:361-7. 2009
    ..Nevertheless, subgroups that carry specific characteristics associated with single receptor dysfunction might benefit from a targeted treatment. Further research is needed to enable clinicians to detect these subgroups...
  47. doi request reprint Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  48. doi request reprint Acamprosate: recent findings and future research directions
    Karl Mann
    The Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 32:1105-10. 2008
    ..Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy...
  49. ncbi request reprint Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship
    Falk Kiefer
    Psychopharmacology (Berl) 164:239-40. 2002
  50. ncbi request reprint Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Arch Gen Psychiatry 60:92-9. 2003
    ..Since it remains uncertain whether both substances are equally efficient and whether a combination of both drugs potentiates the efficacy, we conducted the first published controlled study comparing and combining both compounds...
  51. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
    ....
  52. ncbi request reprint Combined therapy: what does acamprosate and naltrexone combination tell us?
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Alcohol Alcohol 39:542-7. 2004
    ..It remains to be answered whether data justify the combination of both drugs in clinical practice...
  53. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
    ..Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according to preliminary findings...
  54. pmc Suppression of the HPA axis stress-response: implications for relapse
    Byron Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Alcohol Clin Exp Res 29:1351-5. 2005
    ..b>Falk Kiefer discussed the relationship between basal HPA axis responsivity and clinical outcome following treatment with ..
  55. ncbi request reprint Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Biol Psychiatry 60:784-7. 2006
    ..Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD)...
  56. ncbi request reprint HPA-axis activity in alcoholism: examples for a gene-environment interaction
    Toni Kim Clarke
    Section of Addiction Biology, Institute of Psychiatry, King s College, London, UK
    Addict Biol 13:1-14. 2008
    ....
  57. ncbi request reprint Is withdrawal-induced anxiety in alcoholism based on beta-endorphin deficiency?
    Falk Kiefer
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
    Psychopharmacology (Berl) 162:433-7. 2002
    ..During alcohol withdrawal, a decreased secretion of beta E with a delayed normalization has been reported, but up to now only few data became available regarding the interaction of plasma beta E and psychopathological parameters...
  58. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  59. ncbi request reprint Characterization of the facial expression of emotions in schizophrenia patients: preliminary findings with a new electromyography method
    Karsten Wolf
    Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
    Can J Psychiatry 51:335-41. 2006
    ..We investigated facial expression of emotions (FEE) in schizophrenia patients, using an improved and highly selective facial electromyography (EMG) method, and we examined the correlation between FEE and psychopathology...
  60. ncbi request reprint Adjunctive use of reboxetine in schizophrenia
    Thomas J Raedler
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martini str 52, 20246 Hamburg, Germany
    Eur Psychiatry 19:366-9. 2004
    ..We sought to study the efficacy and tolerability of the adjunctive use of reboxetine in a cohort of schizophrenic patients with prominent depressive or negative symptoms...
  61. ncbi request reprint Measuring alcohol consumption in man--it is time for a change
    Falk Kiefer
    Addiction 101:1215-6; author reply 1216-7. 2006
  62. ncbi request reprint Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
    Biol Psychiatry 53:345-51. 2003
    ....
  63. ncbi request reprint Pharmacotherapy and behavioral intervention for alcohol dependence
    Falk Kiefer
    JAMA 296:1727-8; author reply 1728-9. 2006