F Kiefer

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Curr Pharm Des 16:2098-102. 2010
  2. doi request reprint [Neurobiology of behavioral addictions]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, J 5, 68159, Mannheim, Deutschland
    Nervenarzt 84:557-62. 2013
  3. doi request reprint New approaches to addiction treatment based on learning and memory
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Curr Top Behav Neurosci 13:671-84. 2013
  4. doi request reprint Association of leptin with food cue-induced activation in human reward pathways
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5 68159 Mannheim, Germany
    Arch Gen Psychiatry 69:529-37. 2012
  5. ncbi request reprint [Evidence-based treatment of alcoholism]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg, J5, 68159 Mannheim
    Nervenarzt 78:1321-9; quiz 1330-1. 2007
  6. doi request reprint Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
    F Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Pharmacogenomics J 11:368-74. 2011
  7. ncbi request reprint Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 13:124-9. 2008
  8. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 60:74-6. 2006
  9. doi request reprint [Neurobiology and genetics of addiction]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Universitat Heidelberg, J5, 68159, Mannheim, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:284-8. 2010
  10. ncbi request reprint Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 404:103-6. 2006

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Curr Pharm Des 16:2098-102. 2010
    ..To increase the efficacy of this drug, targeted treatment and individualized therapy approaches seem useful and necessary...
  2. doi request reprint [Neurobiology of behavioral addictions]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, J 5, 68159, Mannheim, Deutschland
    Nervenarzt 84:557-62. 2013
    ..The main focuses are on changes in neurocognitive processes, such as cue reactivity, reward and punishment processing and behavioral control...
  3. doi request reprint New approaches to addiction treatment based on learning and memory
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Curr Top Behav Neurosci 13:671-84. 2013
    ..These approaches suggest that the extinction of drug-related memories may represent a viable treatment strategy in the future treatment of addiction...
  4. doi request reprint Association of leptin with food cue-induced activation in human reward pathways
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5 68159 Mannheim, Germany
    Arch Gen Psychiatry 69:529-37. 2012
    ..Whereas the hypothalamic regulation of energy homeostasis by endocrine feedback signals has been widely investigated, its interplay with mesolimbic reward-associated pathways represents a rich field of future research...
  5. ncbi request reprint [Evidence-based treatment of alcoholism]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg, J5, 68159 Mannheim
    Nervenarzt 78:1321-9; quiz 1330-1. 2007
    ....
  6. doi request reprint Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
    F Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Pharmacogenomics J 11:368-74. 2011
    ..These results could help to identify those alcohol-dependent patients who may be at an increased risk of relapse and who may better respond to treatment with acamprosate...
  7. ncbi request reprint Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 13:124-9. 2008
    ..It is discussed whether especially these subjects should be targeted for pharmacological relapse prevention treatment with naltrexone...
  8. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 60:74-6. 2006
    ..We examined the relationship between efficacy of pharmacological anticraving treatment and HPA axis activity in the relapse prevention treatment of alcoholism...
  9. doi request reprint [Neurobiology and genetics of addiction]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Universitat Heidelberg, J5, 68159, Mannheim, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:284-8. 2010
    ..Genetic factors modulate the individual vulnerability. The challenge of future research will be to generate more efficient and individualized therapies based on the insights from neurobiology and genetics...
  10. ncbi request reprint Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 404:103-6. 2006
    ....
  11. doi request reprint [What can addiction research contribute towards the understanding of obesity?]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Universitat Heidelberg, J5, 68159, Mannheim, Deutschland
    Nervenarzt 80:1040-9. 2009
    ..The relevance of this topic for general psychiatry is reflected by the fact that including obesity in the psychiatric chapters of disease classification systems is currently being discussed...
  12. ncbi request reprint [Diagnostics and therapy of alcohol addiction]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Germany
    Fortschr Neurol Psychiatr 75:33-46. 2007
  13. doi request reprint Complete suppression of craving in alcohol-dependent individuals: is it possible?
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim 68159, Germany
    CNS Drugs 23:361-7. 2009
    ..Nevertheless, subgroups that carry specific characteristics associated with single receptor dysfunction might benefit from a targeted treatment. Further research is needed to enable clinicians to detect these subgroups...
  14. ncbi request reprint [Advances in the treatment of alcohol dependence: pharmacological relapse prevention]
    M N Smolka
    Klinik für Abhängiges Verhal ten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    MMW Fortschr Med 145:65-9. 2003
    ..The medical treatment, however, is not a replacement for a psychosocial treatment of the alcohol dependence, but should be accompanied by counselling and the attendance in self help groups...
  15. doi request reprint Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 205:389-97. 2009
    ..The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval...
  16. doi request reprint Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder--a case series
    Jochen Mutschler
    1Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:146-50. 2010
    ..We examined the safety and efficacy in relapse prevention of a series of alcoholics with borderline personality disorder (BPD)...
  17. ncbi request reprint [Psychosocial treatment plus drug prophylaxis. Fewer recurrences after alcohol withdrawal]
    M N Smolka
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg, J5, D 68159 Mannheim
    MMW Fortschr Med 145:45. 2003
  18. doi request reprint [Pharmacology of disulfiram - an update]
    J Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Fortschr Neurol Psychiatr 76:225-31. 2008
    ..As an example we demonstrate a case, in which an acute neurological deficit was misjudged as a side effect of Disulfiram. Furthermore, the potential of Disulfiram as a promising treatment in addiction medicine will be discussed...
  19. doi request reprint Disulfiram, an option for the treatment of pathological gambling?
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany
    Alcohol Alcohol 45:214-6. 2010
    ..Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling...
  20. doi request reprint Impairment of inhibitory control in response to food-associated cues and attentional bias of obese participants and normal-weight controls
    S Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany
    Int J Obes (Lond) 36:1334-9. 2012
    ..In addition, we questioned whether an attentional bias towards food-associated cues can be observed in an early stage of information processing...
  21. doi request reprint [Learning and memory in the pathogenesis of addiction]
    C von der Goltz
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, J5, 68159, Mannheim, Deutschland
    Nervenarzt 79:1006-16. 2008
    ..The challenge of future research is to determine which drug-induced adaptations are relevant to the pathophysiology of addiction and to generate more efficient therapies for extinction of addiction-associated cognitions and behavior...
  22. doi request reprint Rivastigmine reduces tobacco craving in alcohol-dependent smokers
    A Diehl
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg, Square J 5, Mannheim 68159, Germany
    Pharmacopsychiatry 42:89-94. 2009
    ..Although alcohol-dependent smokers represent an important group for applying smoking interventions, a sufficient pharmacotherapy has not been established in this high-risk group so far...
  23. doi request reprint Avoidance of alcohol-related stimuli increases during the early stage of abstinence in alcohol-dependent patients
    Sabine Vollstädt-Klein
    Department of Addictive Behaviour and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Alcohol 44:458-63. 2009
    ..Furthermore, we investigated the influence of pre-treatment alcohol consumption and abstinence duration onto alcohol-related attentional bias...
  24. doi request reprint Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:13-6. 2010
    ..We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor...
  25. doi request reprint Attentional bias in alcohol-dependent patients: the role of chronicity and executive functioning
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:194-203. 2009
    ..Our results indicate that differences with regard to drinking-related variables as well as cognitive functioning seem to modulate attentional bias and need to be taken into account in models of drinking maintenance...
  26. doi request reprint Searching for responders to acamprosate and naltrexone in alcoholism treatment: rationale and design of the PREDICT study
    Karl Mann
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 33:674-83. 2009
    ..The "reward drinker/craver" is mainly associated with alterations in the dopaminergic and opioidergic system and responds to naltrexone...
  27. ncbi request reprint [A new pharmacological treatment option for alcohol dependence discovered in transnational study: neurokinin-1 receptor antagonist as a possible therapy for alcoholism?]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:283-5. 2008
    ..They could demonstrate that either the blockade of the receptor, or the lack of the receptors leds to a decreased alcohol intake as well as reduced alcohol tolerance and craving concomitantly accompanied by improved general well-beeing...
  28. ncbi request reprint [Recent results in relaps prevention of alcoholism with Disulfiram]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:243-51. 2008
    ..It acts as a psychological deterrence of a possible disulfiram-alcohol reaction. This paper describes the current clinical impact and possible future of disulfiram...
  29. doi request reprint D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 43:626-9. 2008
    ..The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour...
  30. doi request reprint Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, Square J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 35:570-7. 2010
    ..The aim of this study was to examine the possible association between orexin and leptin, and nicotine craving in smokers in a clinical case-control study under standardized conditions...
  31. doi request reprint Acamprosate: recent findings and future research directions
    Karl Mann
    The Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 32:1105-10. 2008
    ..Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy...
  32. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  33. doi request reprint Drugs for relapse prevention of alcoholism: ten years of progress
    Rainer Spanagel
    Department of Psychopharmacology and Department of Addictive Behaviour and Addiction Medicine at the Central Institute of Mental Health, Mannheim, Germany
    Trends Pharmacol Sci 29:109-15. 2008
    ..However, the heterogeneity in treatment response makes it necessary to characterize genetic and protein markers and endophenotypes for individualized pharmacotherapy...
  34. ncbi request reprint Pharmacological relapse prevention of alcoholism: clinical predictors of outcome
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 11:83-91. 2005
    ..The efficacy of pharmacological relapse prevention in alcoholism with acamprosate and naltrexone has been supported by several controlled trials. It remains uncertain whether any differential indication for treatment exists...
  35. ncbi request reprint Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    J Psychiatr Res 39:545-51. 2005
    ..Moreover, there are hints for an interaction between pharmacological anti-craving treatment, plasma concentration of leptin, and abstinence duration...
  36. ncbi request reprint New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence
    Falk Kiefer
    University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
    Eur J Pharmacol 526:163-71. 2005
    ..New compounds are under investigation. This review discusses the neurobiological basis of alcohol addiction, pharmacological targets for relapse prevention treatment and pre-clinical and clinical results with the most promising drugs...
  37. doi request reprint The effect of pictorial warnings on cigarette packages on attentional bias of smokers
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Pharmacol Biochem Behav 98:292-8. 2011
    ....
  38. doi request reprint [Treatment outcome after inpatient alcohol withdrawal: impact of motivational interventions: a comparative study]
    S Loeber
    Klinik für Abhängiges Verhalten und Suchtmedizin, Lehrstuhl für Suchtforschung, Zentralinstitut fur Seelische Gesundheit, J5, 68159, Mannheim, Deutschland
    Nervenarzt 80:1085-92. 2009
    ....
  39. ncbi request reprint [Illegal purchase of psychotropic drugs from the internet]
    J Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Quadrat J 5, 68159 Mannheim
    Nervenarzt 78:818-20. 2007
    ....
  40. ncbi request reprint Extended-release intramuscular naltrexone: a viewpoint by Falk Kiefer
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Drugs 66:1752-3. 2006
  41. doi request reprint Consultation-liaison psychiatry in general hospitals: improvement in physicians' detection rates of alcohol use disorders
    Alexander Diehl
    Department of Addictive Behavior and Addiction Medicine, Division of Biostatistics, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
    Psychosomatics 50:599-604. 2009
    ..In the general hospital setting, alcohol-use disorders very commonly remain undetected...
  42. doi request reprint [Methylphenidate. Therapy option for adults with ADHD and comorbid substance use disorder?]
    G Paslakis
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, J5, 68159, Mannheim
    Nervenarzt 81:277-88. 2010
    ....
  43. doi request reprint Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  44. doi request reprint Learning and memory in the aetiopathogenesis of addiction: future implications for therapy?
    Christoph von der Goltz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S183-7. 2009
    ....
  45. ncbi request reprint Combined therapy: what does acamprosate and naltrexone combination tell us?
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Alcohol Alcohol 39:542-7. 2004
    ..It remains to be answered whether data justify the combination of both drugs in clinical practice...
  46. pmc Suppression of the HPA axis stress-response: implications for relapse
    Byron Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Alcohol Clin Exp Res 29:1351-5. 2005
    ..Alterations in HPA axis responsivity may therefore have a negative impact upon clinical outcome in alcohol-dependent subjects, and disinhibition of the axis with medication may have therapeutic potential...
  47. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
    ..Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according to preliminary findings...
  48. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
    ....
  49. ncbi request reprint Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Arch Gen Psychiatry 60:92-9. 2003
    ..Since it remains uncertain whether both substances are equally efficient and whether a combination of both drugs potentiates the efficacy, we conducted the first published controlled study comparing and combining both compounds...
  50. ncbi request reprint Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship
    Falk Kiefer
    Psychopharmacology (Berl) 164:239-40. 2002
  51. ncbi request reprint Is withdrawal-induced anxiety in alcoholism based on beta-endorphin deficiency?
    Falk Kiefer
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
    Psychopharmacology (Berl) 162:433-7. 2002
    ..During alcohol withdrawal, a decreased secretion of beta E with a delayed normalization has been reported, but up to now only few data became available regarding the interaction of plasma beta E and psychopathological parameters...
  52. ncbi request reprint Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Biol Psychiatry 60:784-7. 2006
    ..Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD)...
  53. ncbi request reprint HPA-axis activity in alcoholism: examples for a gene-environment interaction
    Toni Kim Clarke
    Section of Addiction Biology, Institute of Psychiatry, King s College, London, UK
    Addict Biol 13:1-14. 2008
    ....
  54. ncbi request reprint Characterization of the facial expression of emotions in schizophrenia patients: preliminary findings with a new electromyography method
    Karsten Wolf
    Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
    Can J Psychiatry 51:335-41. 2006
    ..We investigated facial expression of emotions (FEE) in schizophrenia patients, using an improved and highly selective facial electromyography (EMG) method, and we examined the correlation between FEE and psychopathology...
  55. ncbi request reprint Measuring alcohol consumption in man--it is time for a change
    Falk Kiefer
    Addiction 101:1215-6; author reply 1216-7. 2006
  56. ncbi request reprint Adjunctive use of reboxetine in schizophrenia
    Thomas J Raedler
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martini str 52, 20246 Hamburg, Germany
    Eur Psychiatry 19:366-9. 2004
    ..We sought to study the efficacy and tolerability of the adjunctive use of reboxetine in a cohort of schizophrenic patients with prominent depressive or negative symptoms...
  57. ncbi request reprint Pharmacotherapy and behavioral intervention for alcohol dependence
    Falk Kiefer
    JAMA 296:1727-8; author reply 1728-9. 2006
  58. ncbi request reprint Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
    Biol Psychiatry 53:345-51. 2003
    ....
  59. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...