F A Henn

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Structural neuroimaging in schizophrenia. An integrative view of neuromorphology
    F A Henn
    NMR Research, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 249:48-56. 1999
  2. ncbi request reprint Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia
    G Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 41:389-95. 2000
  3. ncbi request reprint Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients
    D F Braus
    Central Institute of Mental Health ZI, NMR Research, Mannheim, Germany
    Schizophr Res 39:19-29. 1999
  4. doi request reprint Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression
    M Zink
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Neuropharmacology 58:465-73. 2010
  5. ncbi request reprint Differential effects of long-term treatment with clozapine or haloperidol on GABA transporter expression
    M Zink
    Central Institute of Mental Health, Department of Psychiatry, Mannheim, Germany
    Pharmacopsychiatry 37:171-4. 2004
  6. ncbi request reprint Lower concentration of thalamic n-acetylaspartate in patients with schizophrenia: a replication study
    G Ende
    Central Institute of Mental Health, 68159 Mannheim, Germany
    Am J Psychiatry 158:1314-6. 2001
  7. ncbi request reprint Altered NMDA receptor expression and behavior following postnatal hypoxia: potential relevance to schizophrenia
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 114:239-48. 2007
  8. ncbi request reprint Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:91-100. 2004
  9. ncbi request reprint Favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics: an MRSI study
    D F Braus
    NMR Research, Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 34:251-3. 2001
  10. ncbi request reprint Hippocampal 1H-MRSI in ecstasy users
    T Obergriesser
    NMR Research, Central Institute of Mental Health P O Box l22120 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 251:114-6. 2001

Detail Information

Publications35

  1. ncbi request reprint Structural neuroimaging in schizophrenia. An integrative view of neuromorphology
    F A Henn
    NMR Research, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 249:48-56. 1999
    ....
  2. ncbi request reprint Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia
    G Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 41:389-95. 2000
    ..Further studies will be needed to corroborate a possible favorable effect of atypical antipsychotics on the NAA signal...
  3. ncbi request reprint Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients
    D F Braus
    Central Institute of Mental Health ZI, NMR Research, Mannheim, Germany
    Schizophr Res 39:19-29. 1999
    ..There is, however, strong evidence that neuroleptics themselves influence fMRI activation patterns and that there are major differences between typical neuroleptics and atypical antipsychotics...
  4. doi request reprint Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression
    M Zink
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Neuropharmacology 58:465-73. 2010
    ..Therefore, gene expression of glutamate transporters that strictly control synaptic glutamate concentrations have to be assessed in animal models of stress and depression...
  5. ncbi request reprint Differential effects of long-term treatment with clozapine or haloperidol on GABA transporter expression
    M Zink
    Central Institute of Mental Health, Department of Psychiatry, Mannheim, Germany
    Pharmacopsychiatry 37:171-4. 2004
    ..Whether this effect is due to the pathophysiology of schizophrenia or to antipsychotic treatment has not been investigated. We therefore established an animal trial of long-term antipsychotic treatment to address this question...
  6. ncbi request reprint Lower concentration of thalamic n-acetylaspartate in patients with schizophrenia: a replication study
    G Ende
    Central Institute of Mental Health, 68159 Mannheim, Germany
    Am J Psychiatry 158:1314-6. 2001
    ..Using proton magnetic resonance spectroscopic imaging, the authors measured thalamic N-acetylaspartate (NAA) concentrations in patients with schizophrenia...
  7. ncbi request reprint Altered NMDA receptor expression and behavior following postnatal hypoxia: potential relevance to schizophrenia
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 114:239-48. 2007
    ..Compensatory upregulation of NR1 expression may occur due to NMDA receptor hypofunction. We discuss this animal model to further analyze effects of hypoxia as a factor of obstetric complications in the pathophysiology of schizophrenia...
  8. ncbi request reprint Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:91-100. 2004
    ..In contrast, chronic haloperidol treatment did increase total hippocampal volume suggesting that haloperidol alters neuroplastic processes or glial morphology rather than cell proliferation...
  9. ncbi request reprint Favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics: an MRSI study
    D F Braus
    NMR Research, Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 34:251-3. 2001
    ..These results suggest a favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics...
  10. ncbi request reprint Hippocampal 1H-MRSI in ecstasy users
    T Obergriesser
    NMR Research, Central Institute of Mental Health P O Box l22120 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 251:114-6. 2001
    ..In an exploratory study we compared the hippocampal 1H-MRSI (magnetic resonance spectroscopic imaging) spectra of five MDMA users with those of controls with no history of substance abuse. Although 1H..
  11. ncbi request reprint Differential expression of glutamate transporters EAAT1 and EAAT2 in mice deficient for PACAP-type I receptor
    M Zink
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:1537-42. 2004
    ..Our data confirm the previously reported in-vitro-regulation of EAAT1 in the adult nervous system in vivo. EAAT2 expression, however, is unchanged in PAC1 knockout mice, most likely due to counterbalancing factors...
  12. ncbi request reprint Learned helplessness in the rat: improvements in validity and reliability
    B Vollmayr
    Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Brain Res Brain Res Protoc 8:1-7. 2001
    ..Bull. 21 (1985) 443; Neurosci. Res. 38 (200) 193]. This allows us to use animals which are not helpless after inescapable shock as a stressed control, but sensitivity, specificity and variability of test results have to be reassessed...
  13. ncbi request reprint Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus
    J Thome
    Laboratory of Biochemistry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 50:809-12. 2001
    ..These changes may be relevant to such clinical disorders as psychoses, depression, and posttraumatic stress disorder that are sensitive to stress and involve changes in neural and synaptic plasticity...
  14. ncbi request reprint Signal enhancement through heteronuclear polarisation transfer in in-vivo 31P MR spectroscopy of the human brain
    W Weber-Fahr
    NMR Research in Psychiatry, Central Institute of Mental Health, P O Box 122120, 68072 Mannheim, Germany
    MAGMA 16:68-76. 2003
    ..With optimised echo times, in-vivo (31)P signal enhancement of the same order was obtained in studies of the human brain...
  15. ncbi request reprint Brain-derived-neurotrophic-factor (BDNF) stress response in rats bred for learned helplessness
    B Vollmayr
    Central Institute of Mental Health, J5, D-68159 Mannheim, Germany
    Mol Psychiatry 6:471-4, 358. 2001
    ..This may explain the lack of adaptive responses in this strain...
  16. ncbi request reprint Cortical response to motor stimulation in neuroleptic-naive first episode schizophrenics
    D F Braus
    Central Institute of Mental Health ZI, NMR Research, P O Box 122 120, D 68072, Mannheim, Germany
    Psychiatry Res 98:145-54. 2000
    ..In contrast to data previously reported for chronic disorganized medicated patients, these results suggest that motor dysfunction is not part of the phenomenology of acute paranoid first episode patients...
  17. doi request reprint Reduced expression of GABA transporter GAT3 in helpless rats, an animal model of depression
    M Zink
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Neurochem Res 34:1584-93. 2009
    ..Reduced GABA transporter expression is well in concert with the behavioural phenotypes of knockout animals and strengthens the hypothesis of impaired glial functions in depression...
  18. ncbi request reprint Genome polymorphism and alcoholism
    J Thome
    Laboratory of Biochemistry, Central Institute of Mental Health, Mannheim, Germany
    Pharmacogenomics 1:63-71. 2000
    ..However, further research is required before these developments will considerably change today's clinical handling of alcoholism...
  19. ncbi request reprint Functional imaging research in schizophrenia
    H Tost
    Central Institute of Mental Health, NMR Research in Psychiatry, Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68072 Mannheim, Germany
    Int Rev Neurobiol 67:95-118. 2005
  20. ncbi request reprint Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain
    A Schmitt
    Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 36:292-6. 2003
    ..As most patients had been treated with antipsychotics, medication effects cannot be excluded as a possible explanation for these results...
  21. ncbi request reprint A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia
    W Weber-Fahr
    NMR Research in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 16:49-60. 2002
    ..These results are in good agreement with neuropathological and previous MR spectroscopy studies of the hippocampus in schizophrenic patients...
  22. ncbi request reprint Differential regulation of synaptic vesicle proteins by antidepressant drugs
    S Rapp
    Central Institute of Mental Health, Mannheim, Germany
    Pharmacogenomics J 4:110-3. 2004
    ..Additionally, synapsin I-mRNA levels in the hippocampus and cerebral cortex are significantly reduced in tranylcypromine-treated animals. This identifies SVP genes as target genes of antidepressant treatment...
  23. doi request reprint Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: implications for schizophrenia
    M Fendt
    Animal Physiology, Zoological Institute, Faculty of Biology, University of Tubingen, Tubingen, Germany
    Pharmacopsychiatry 41:138-45. 2008
    ..The present study investigated the effects of weak chronic neonatal hypoxia in rats on different behavioural animal models of schizophrenia...
  24. ncbi request reprint [Effect of antipsychotics on glutaminergic neural transmission in the animal model]
    A Schmitt
    Zentralinstitut fur Seelische Gesundheit, Universit├Ąt Mannheim, Germany
    Nervenarzt 75:16-22. 2004
    ..The results suggest that post-mortem findings in patients with schizophrenia may at least partially be explained by drug effects and plasticity changes induced by long-term medication with antipsychotics...
  25. ncbi request reprint Promoter polymorphism of the 5-HT transporter and Alzheimer's disease
    M Hu
    Laboratory of Biochemistry, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Neurosci Lett 294:63-5. 2000
    ..However, given the reported negative findings, we are presently trying to identify diagnostic subgroups for which the 5-HTT promoter polymorphism represents a susceptibility locus...
  26. ncbi request reprint [One decade of functional imaging in schizophrenia research. From visualisation of basic information processing steps to molecular-genetic oriented imaging]
    H Tost
    NMR Forschung in der Psychiatrie, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Radiologe 45:113-8, 120-3. 2005
    ..Special emphasis is given to new methodological approaches, such as the visualisation of medication effects and the functional characterisation of risk genes...
  27. ncbi request reprint Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease
    J Thome
    Laboratory of Biochemistry, Central Institute of Mental Health, Mannheim, Federal Republic of Germany
    J Neural Transm 108:1175-80. 2001
    ..These polymorphisms probably do not represent major genetic risk factors of AD. However, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in AD...
  28. ncbi request reprint ECT anesthesia: the lighter the better?
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 39:201-4. 2006
    ..Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated...
  29. ncbi request reprint Bispectral index monitoring for more effective electroconvulsive therapy?
    A Sartorius
    Br J Anaesth 96:806-7. 2006
  30. ncbi request reprint [Treating depressive disorders with continuation electroconvulsive therapy]
    A Sartorius
    Zentralinstitut fur Seelische Gesundheit, J5, Mannheim
    Nervenarzt 76:1363-9. 2005
    ..Today, cECT is underindicated as a result of assumed problems, fears, and stigmas. We would therefore recommend broader use of this proven treatment tool for keeping major depression in remission...
  31. ncbi request reprint Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law
    C Sanchis-Segura
    Department of Psychopharmacology, CIMH, Mannheim, Germany
    Behav Pharmacol 16:267-70. 2005
    ..Moreover, our data are in agreement with the proposed relationship between helplessness and sucrose preference, and support the usefulness of the cLH and cNLH rats as a model of depression...
  32. ncbi request reprint No association of alcohol dependence with a NMDA-receptor 2B gene variant
    G Schumann
    Mol Psychiatry 8:11-2. 2003
  33. ncbi request reprint [Molecular aspects of antidepressive therapy. Transsynaptic effects on signal transduction, gene expression and neuronal plasticity]
    J Thome
    Biochemisches Labor, Zentralinstitut fur Seelische Gesundheit
    Nervenarzt 73:595-9. 2002
    ....
  34. ncbi request reprint [Current overview of structural magnetic resonance imaging in schizophrenia]
    A Schmitt
    , Mannheim
    Fortschr Neurol Psychiatr 69:105-15. 2001
    ..Based on these findings future longitudinal studies should examine to what extent such a progressive decrease in volume might be influenced by treatment with modern antipsychotics...
  35. ncbi request reprint Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study
    W Guenther
    Psychiatric University Hospital, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 244:115-25. 1994
    ..The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions...