A Heinz

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations
    A Heinz
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Psychiatry Res 89:97-106. 1999
  2. ncbi request reprint Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems
    A Heinz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Neurochem Int 37:425-32. 2000
  3. ncbi request reprint Serotonergic dysfunction, negative mood states, and response to alcohol
    A Heinz
    Central Institute of Mental Health, University of Heidelberg, Germany
    Alcohol Clin Exp Res 25:487-95. 2001
  4. ncbi request reprint Dopaminergic dysfunction in alcoholism and schizophrenia--psychopathological and behavioral correlates
    A Heinz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Psychiatry 17:9-16. 2002
  5. ncbi request reprint Relationship between cortisol and serotonin metabolites and transporters in alcoholism [correction of alcolholism]
    A Heinz
    Intramural Research Program, Clinical Brain Disorders Branch NIMH, Bethesda, MD, USA
    Pharmacopsychiatry 35:127-34. 2002
  6. ncbi request reprint Serotonin transporter availability correlates with alcohol intake in non-human primates
    A Heinz
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD, USA
    Mol Psychiatry 8:231-4. 2003
  7. ncbi request reprint Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics
    D F Braus
    Central Institute of Mental Health, Mannheim, Federal Republic of Germany
    J Neural Transm 108:887-94. 2001
  8. doi request reprint [Neurobiology of behavioral addictions]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Germany
    Nervenarzt 84:557-62. 2013
  9. pmc Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents
    F Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 38:2081-9. 2013
  10. ncbi request reprint [The NMDA receptor system: genetic risk factor for alcoholism]
    G Schumann
    Molekulargenetisches Labor, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg, Mannheim
    Nervenarzt 76:1355-62. 2005

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations
    A Heinz
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Psychiatry Res 89:97-106. 1999
    ....
  2. ncbi request reprint Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems
    A Heinz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Neurochem Int 37:425-32. 2000
    ....
  3. ncbi request reprint Serotonergic dysfunction, negative mood states, and response to alcohol
    A Heinz
    Central Institute of Mental Health, University of Heidelberg, Germany
    Alcohol Clin Exp Res 25:487-95. 2001
    ..Serotonergic dysfunction may be associated with three behavior patterns relevant for alcoholism: impulsive aggression, negative mood states, and a low response to alcohol intake...
  4. ncbi request reprint Dopaminergic dysfunction in alcoholism and schizophrenia--psychopathological and behavioral correlates
    A Heinz
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Psychiatry 17:9-16. 2002
    ..Studies in humans and non-human primates emphasize the role of dopaminergic neurotransmission in reward anticipation and its dysfunction in different neuropsychiatric diseases...
  5. ncbi request reprint Relationship between cortisol and serotonin metabolites and transporters in alcoholism [correction of alcolholism]
    A Heinz
    Intramural Research Program, Clinical Brain Disorders Branch NIMH, Bethesda, MD, USA
    Pharmacopsychiatry 35:127-34. 2002
    ..We assessed the interaction between stress hormone activation, serotonin transporters, monoamine metabolites in the cerebrospinal fluid (CSF), and mood states in male and female alcoholics and healthy control subjects...
  6. ncbi request reprint Serotonin transporter availability correlates with alcohol intake in non-human primates
    A Heinz
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD, USA
    Mol Psychiatry 8:231-4. 2003
    ..81, P=0.006). These observations indicate that there may be a direct relationship between serotonin transporter availability and alcohol intake after controlling for aggression and alcohol response on first exposure...
  7. ncbi request reprint Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics
    D F Braus
    Central Institute of Mental Health, Mannheim, Federal Republic of Germany
    J Neural Transm 108:887-94. 2001
    ..This observation supports the hypothesis that alcohol use affects areas involved in brain reward circuits and that their stimulus-induced activation may be associated with an increased risk for relapse...
  8. doi request reprint [Neurobiology of behavioral addictions]
    F Kiefer
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Germany
    Nervenarzt 84:557-62. 2013
    ..The main focuses are on changes in neurocognitive processes, such as cue reactivity, reward and punishment processing and behavioral control...
  9. pmc Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents
    F Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 38:2081-9. 2013
    ..Thus, it seems to have a major role in the processing of and behavioral adaptation to changing reward outcomes. ..
  10. ncbi request reprint [The NMDA receptor system: genetic risk factor for alcoholism]
    G Schumann
    Molekulargenetisches Labor, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg, Mannheim
    Nervenarzt 76:1355-62. 2005
    ..Candidate gene studies, including association studies and animal models, are powerful and sensitive for detecting oligogenic effects and thus important to alcoholism research...
  11. doi request reprint Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
    F Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Pharmacogenomics J 11:368-74. 2011
    ..These results could help to identify those alcohol-dependent patients who may be at an increased risk of relapse and who may better respond to treatment with acamprosate...
  12. ncbi request reprint Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
    J Treutlein
    Molecular Genetics Laboratory and Department of Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Mol Psychiatry 11:594-602. 2006
    ..Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene-environment effects in alcohol use disorders...
  13. doi request reprint [The concept of behavioral addiction and limits of the term addiction]
    K Mann
    Zentralinstitut fur Seelische Gesundheit, Klinik für Abhängiges Verhalten und Suchtmedizin, Mannheim, Germany
    Nervenarzt 84:548-56. 2013
    ..In specific cases the addiction model can also be applied for excessive sexual behavior, compulsive buying and obesity...
  14. pmc How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
    A Kobiella
    Department of Psychiatry and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Transl Psychiatry 1:e37. 2011
    ..Our findings stress the role of genetic effects during neurodevelopment...
  15. ncbi request reprint The influence of gender and emotional valence of visual cues on FMRI activation in humans
    S Klein
    Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 36:S191-4. 2003
    ..In men fMRI activation was independent of stimulus valence. These results suggest to take gender differences into account when emotional paradigms are tested in functional brain imaging...
  16. ncbi request reprint Anhedonia, self-experience in schizophrenia, and implications for treatment
    G Juckel
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S176-80. 2003
    ..Understanding the neurobiological correlates of motivation and pleasure may provide new options to treat anhedonia in patients with schizophrenia...
  17. ncbi request reprint Psychopathological correlates of reduced dopamine receptor sensitivity in depression, schizophrenia, and opiate and alcohol dependence
    K Schmidt
    , Germany
    Pharmacopsychiatry 34:66-72. 2001
    ..These findings indicate that patients with dopaminergic dysfunction are not unable to experience pleasure, but may fail to be motivated by environmental stimuli to seek reward...
  18. ncbi request reprint Neurobiological correlates of the disposition and maintenance of alcoholism
    A Heinz
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S255-8. 2003
    ..New treatment options include pharmacological approaches and indicate that behavior or motivational therapy and the attendance of patient groups may equally reduce the relapse risk...
  19. ncbi request reprint [Aggressive and impulsive behavior: neurobiological models explain how affectregulation might work and social skills develop]
    T Kienast
    Klinik für Psychiatrie und Psychotherapie der Charité, CCM, Universitatsmedizin Berlin
    MMW Fortschr Med 149:29-32. 2007
    ..The serotonin turnover of an individual is controlled by environmental influences in interaction with genetic factors. In this article, impulse control disorders will be discussed with regard to their origin and social effects...
  20. ncbi request reprint Memantine-associated reversal of clozapine-induced weight gain
    M Schaefer
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 40:149-51. 2007
    ..Weight gain is a frequently observed adverse event in the treatment with atypical antipsychotics that significantly affects the patients' physical health and treatment compliance...
  21. doi request reprint [Structural and functional brain changes in schizophrenic disorders. Indications of early neuronal developmental disturbances?]
    P Kalus
    Psychiatrische Universitätsklinik der Charité im St Hedwig Krankenhaus, Grosse Hamburger Strasse 5 11, 10115 Berlin
    Nervenarzt 79:275-87. 2008
    ..With modern neuroimaging techniques microstructural changes and alterations in cerebral activation can be exactly demonstrated and related to the specific psychopathologic features of schizophrenia...
  22. doi request reprint Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients
    I Puls
    Department of Psychiatry and Psychotherapy, CCM, Charite University Medicine, Berlin, Germany
    Biol Psychol 79:126-36. 2008
    ..These data are in line with prior studies supporting a role for dopamine-glutamate interaction in modulation of alcohol disease...
  23. doi request reprint [Patient-oriented management of aggression and violence in psychiatry. Description of a training program and first results]
    Z Zala
    Max Planck Institut fur Psychiatrie, Munchen
    Nervenarzt 79:827-31. 2008
    ....
  24. doi request reprint Genes and neuroimaging: advances in psychiatric research
    J Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Neurodegener Dis 5:277-85. 2008
    ..Furthermore, recently identified putative susceptibility genes for schizophrenia (neuregulin 1, dysbindin, G72) are briefly discussed...
  25. ncbi request reprint Self-reported empathic abilities in schizophrenia
    C Montag
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Schizophr Res 92:85-9. 2007
    ..e. cognitive aspects of mental state attribution, the ability to infer emotional experiences of others, i.e. affective empathy, has not been investigated so far...
  26. ncbi request reprint [Alcohol-related disorders: etiopathology and therapeutic considerations]
    J Hein
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Berlin, Germany
    Fortschr Neurol Psychiatr 75:10-7. 2007
    ..The understanding of these neurobiological principles of alcohol-related disorders should contribute to enhance and improve their therapeutic options...
  27. ncbi request reprint Development of alcohol-associated cues and cue-induced brain activation in alcoholics
    J Wrase
    Department of Psychiatry of the Charité, Humboldt University of Berlin, Schumannstr 20 21, 10117, Berlin, Germany
    Eur Psychiatry 17:287-91. 2002
    ..These observations suggest that standardized pictures of alcoholic beverages can be used to assess brain circuits involved in the processing and evaluation of alcohol cues...
  28. ncbi request reprint [Outpatient alcohol detoxification]
    T Scherle
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Nervenarzt 74:219-25. 2003
    ..This article provides an overview on outpatient alcohol detoxification and discusses its transfer to practical application...
  29. ncbi request reprint Molecular brain imaging and the neurobiology and genetics of schizophrenia
    A Heinz
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S152-7. 2003
    ..Molecular brain imaging can help to unravel the complex interactions between genes and environment and its association with neuronal network dysfunction in schizophrenia...
  30. ncbi request reprint Neurotransmitter changes by interferon-alpha and therapeutic implications
    M Schaefer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S203-6. 2003
    ..We review recent research about IFN-associated neurotransmitter changes in the central nervous system and discuss treatment strategies...
  31. ncbi request reprint Oxcarbazepine in alcohol relapse prevention--a case series
    B Croissant
    Pharmacopsychiatry 37:306-7. 2004
  32. ncbi request reprint Stimulus-induced craving and startle potentiation in abstinent alcoholics and controls
    S M Grusser
    Department of Psychology, Clinical Psychology and Behavioral Neuroscience Unit, Humboldt University, Hausvogteiplatz 5 7, 10117 Berlin, Germany
    Eur Psychiatry 17:188-93. 2002
    ..These findings indicate that alcohol-related stimuli may have appetitive incentive salience for alcoholics in spite of verbal reports of craving and valence to the opposite...
  33. ncbi request reprint Combination of multimodal imaging and molecular genetic information to investigate complex psychiatric disorders
    J Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Pharmacopsychiatry 39:S76-9. 2006
    ..To overcome the limitations of standard statistical methods, new approaches in machine learning have to be adapted to handle multiple parameters obtained from brain imaging and genetic measurements...
  34. ncbi request reprint [Cue-induced alcohol craving. Neurobiological correlates and clinical relevance]
    J Wrase
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Germany
    Nervenarzt 77:1051-2, 1055-8, 1060-3. 2006
    ..These findings point to specific indications for psychotherapeutic and additive pharmacological treatment options...
  35. ncbi request reprint Dopamine and the diseased brain
    T Kienast
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Schumannstrasse 20 21, 10117 Berlin, Germany
    CNS Neurol Disord Drug Targets 5:109-31. 2006
    ....
  36. ncbi request reprint [Addiction as loss of self-control? Current concepts on the development and treatment of addictive behaviors]
    A Heinz
    Fortschr Neurol Psychiatr 75:1-4. 2007
  37. ncbi request reprint No association of alcohol dependence with a NMDA-receptor 2B gene variant
    G Schumann
    Mol Psychiatry 8:11-2. 2003