Peter J Gebicke-Haerter

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint DNA microarrays and expression profiling in drug abuse research
    Peter J Gebicke-Haerter
    Addict Biol 10:1-3. 2005
  2. ncbi request reprint Expression profiling in brain disorders and beyond
    Peter J Gebicke-Haerter
    Central Institute for Mental Health J5, 68159 Mannheim, Germany
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:1-10. 2006
  3. ncbi request reprint Expression profiling methods used in drug abuse research
    Peter Gebicke-Haerter
    Department of Psychopharmacology, Central Institute for Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 10:37-46. 2005
  4. ncbi request reprint Microarrays and expression profiling in microglia research and in inflammatory brain disorders
    Peter J Gebicke-Haerter
    Department of Psychopharmacology, Central Institute for Mental Health, Mannheim, Germany
    J Neurosci Res 81:327-41. 2005
  5. doi request reprint Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain
    Nina Peselmann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:285-97. 2013
  6. doi request reprint Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain
    Nina Segnitz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, P O Box 122120, 68072 Mannheim, Germany
    Psychopharmacology (Berl) 217:127-42. 2011
  7. doi request reprint Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice
    Peter Gass
    RG Behavioral Biology, University of Heidelberg, Mannheim, Germany
    J Neurosci Res 86:3184-93. 2008
  8. ncbi request reprint Reduced expression of complexins I and II in rats bred for learned helplessness
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, PO Box 12 21 20, D 68072 Mannheim, Germany
    Brain Res 1144:202-8. 2007
  9. doi request reprint Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, PO Box 12 21 20, D 68072 Mannheim, Germany
    Eur J Neurosci 34:457-68. 2011
  10. ncbi request reprint Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, 68072, Mannheim, Germany
    Psychopharmacology (Berl) 181:560-5. 2005

Collaborators

Detail Information

Publications16

  1. ncbi request reprint DNA microarrays and expression profiling in drug abuse research
    Peter J Gebicke-Haerter
    Addict Biol 10:1-3. 2005
  2. ncbi request reprint Expression profiling in brain disorders and beyond
    Peter J Gebicke-Haerter
    Central Institute for Mental Health J5, 68159 Mannheim, Germany
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:1-10. 2006
    ..They show that even without good software programs it is possible to come up with reasonable biological hypotheses to be evaluated in subsequent more detailed experiments...
  3. ncbi request reprint Expression profiling methods used in drug abuse research
    Peter Gebicke-Haerter
    Department of Psychopharmacology, Central Institute for Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 10:37-46. 2005
    ..These new techniques have also been applied in drug abuse research recently and some examples of such approaches are described...
  4. ncbi request reprint Microarrays and expression profiling in microglia research and in inflammatory brain disorders
    Peter J Gebicke-Haerter
    Department of Psychopharmacology, Central Institute for Mental Health, Mannheim, Germany
    J Neurosci Res 81:327-41. 2005
    ..Finally, some general remarks are made about pivotal issues when beginning to use microarray technology...
  5. doi request reprint Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain
    Nina Peselmann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:285-97. 2013
    ..The findings might be explained by regulatory connections between serotonergic, GABAergic, and dopaminergic neurotransmission and should be validated in behavioral animal models of psychotic disorders...
  6. doi request reprint Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain
    Nina Segnitz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, P O Box 122120, 68072 Mannheim, Germany
    Psychopharmacology (Berl) 217:127-42. 2011
    ..Within the second-generation antipsychotics, the partial dopaminergic and serotonergic agonist aripiprazole (APZ) was able to counteract the behavioral effects of NMDA-R antagonists...
  7. doi request reprint Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice
    Peter Gass
    RG Behavioral Biology, University of Heidelberg, Mannheim, Germany
    J Neurosci Res 86:3184-93. 2008
    ..This approach may also be useful to find new targets for pharmacotherapy in affective disorders...
  8. ncbi request reprint Reduced expression of complexins I and II in rats bred for learned helplessness
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, PO Box 12 21 20, D 68072 Mannheim, Germany
    Brain Res 1144:202-8. 2007
    ..The experimental data fit well into current pathogenetic concepts of mood disorders and support the hypothesis, that complexins are pivotal players in the pathophysiology of depression and tentative targets of antidepressants...
  9. doi request reprint Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, PO Box 12 21 20, D 68072 Mannheim, Germany
    Eur J Neurosci 34:457-68. 2011
    ..We therefore conclude that perinatal ethanol toxicity alters the plasticity of neurodevelopment and the regulation of glutamatergic gene expression, which may result in specific hippocampus-dependent learning deficits in adulthood...
  10. ncbi request reprint Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, 68072, Mannheim, Germany
    Psychopharmacology (Berl) 181:560-5. 2005
    ..Previous post-mortem findings reporting on downregulation of complexins cannot be explained as mere effects of psychotropic drug treatment...
  11. doi request reprint The systems view in addiction research
    Peter J Gebicke-Haerter
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 13:449-54. 2008
    ..Using a molecular oscillator model where levels of oscillations are changed by repetitive drug administration, changes in set point adjustment are described that underlay allostatic shifts in drug reinforcement processes...
  12. ncbi request reprint Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia
    Fernando Leonardi-Essmann
    Central Institute for Mental Health, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    J Neuroimmunol 160:92-101. 2005
    ..Two of them-integrin alpha(2) and integrin beta(5)-were upregulated as well. These data provide a much closer look into molecular mechanisms involved in apoptosis of neurons and their removal by microglia...
  13. ncbi request reprint Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  14. ncbi request reprint Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Sci 92:115-23. 2003
    ..These results suggest that WAVE and Rac1 participate in the phagocytosis of A beta 42 by microglia...
  15. ncbi request reprint Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    J Pharmacol Sci 91:330-3. 2003
    ..These results suggest that small oligomers, rather than large molecular aggregates, mediate microglial activation induced by Abeta peptides...
  16. ncbi request reprint Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins
    Jun ichi Kakimura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    FASEB J 16:601-3. 2002
    ..These observations suggest that HSP-induced microglial activation may serve a neuroprotective role by facilitating Abeta clearance and cytokine production..