Research Topics
| Peter J Gebicke-HaerterSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
| Collaborators
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Detail Information
Publications
DNA microarrays and expression profiling in drug abuse researchPeter J Gebicke-Haerter
Addict Biol 10:1-3. 2005- Expression profiling in brain disorders and beyondPeter J Gebicke-Haerter
Central Institute for Mental Health J5, 68159 Mannheim, Germany
Nihon Shinkei Seishin Yakurigaku Zasshi 26:1-10. 2006..They show that even without good software programs it is possible to come up with reasonable biological hypotheses to be evaluated in subsequent more detailed experiments... - Microarrays and expression profiling in microglia research and in inflammatory brain disordersPeter J Gebicke-Haerter
Department of Psychopharmacology, Central Institute for Mental Health, Mannheim, Germany
J Neurosci Res 81:327-41. 2005..Finally, some general remarks are made about pivotal issues when beginning to use microarray technology... - Expression profiling methods used in drug abuse researchPeter Gebicke-Haerter
Department of Psychopharmacology, Central Institute for Mental Health, University of Heidelberg, Mannheim, Germany
Addict Biol 10:37-46. 2005..These new techniques have also been applied in drug abuse research recently and some examples of such approaches are described... 
Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brainNina Segnitz
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, P O Box 122120, 68072 Mannheim, Germany
Psychopharmacology (Berl) 217:127-42. 2011..Within the second-generation antipsychotics, the partial dopaminergic and serotonergic agonist aripiprazole (APZ) was able to counteract the behavioral effects of NMDA-R antagonists...- Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized micePeter Gass
RG Behavioral Biology, University of Heidelberg, Mannheim, Germany
J Neurosci Res 86:3184-93. 2008..This approach may also be useful to find new targets for pharmacotherapy in affective disorders... - Reduced expression of complexins I and II in rats bred for learned helplessnessMathias Zink
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, PO Box 12 21 20, D 68072 Mannheim, Germany
Brain Res 1144:202-8. 2007..The experimental data fit well into current pathogenetic concepts of mood disorders and support the hypothesis, that complexins are pivotal players in the pathophysiology of depression and tentative targets of antidepressants... - Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampusMathias Zink
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, PO Box 12 21 20, D 68072 Mannheim, Germany
Eur J Neurosci 34:457-68. 2011..We therefore conclude that perinatal ethanol toxicity alters the plasticity of neurodevelopment and the regulation of glutamatergic gene expression, which may result in specific hippocampus-dependent learning deficits in adulthood... - Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampusMathias Zink
Central Institute of Mental Health, P O Box 12 21 20, 68072, Mannheim, Germany
Psychopharmacology (Berl) 181:560-5. 2005..Previous post-mortem findings reporting on downregulation of complexins cannot be explained as mere effects of psychotropic drug treatment... - The systems view in addiction researchPeter J Gebicke-Haerter
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Germany
Addict Biol 13:449-54. 2008..Using a molecular oscillator model where levels of oscillations are changed by repetitive drug administration, changes in set point adjustment are described that underlay allostatic shifts in drug reinforcement processes... - Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microgliaFernando Leonardi-Essmann
Central Institute for Mental Health, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
J Neuroimmunol 160:92-101. 2005..Two of them-integrin alpha(2) and integrin beta(5)-were upregulated as well. These data provide a much closer look into molecular mechanisms involved in apoptosis of neurons and their removal by microglia... - Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microgliaRavi Shankar Akundi
Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
Glia 51:199-208. 2005..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents... - Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microgliaYoshihisa Kitamura
Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
J Pharmacol Sci 92:115-23. 2003..These results suggest that WAVE and Rac1 participate in the phagocytosis of A beta 42 by microglia... - Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activationKazuyuki Takata
Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan
J Pharmacol Sci 91:330-3. 2003..These results suggest that small oligomers, rather than large molecular aggregates, mediate microglial activation induced by Abeta peptides... - Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteinsJun-Ichi Kakimura
Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan
FASEB J 16:601-3. 2002..These observations suggest that HSP-induced microglial activation may serve a neuroprotective role by facilitating Abeta clearance and cytokine production..