P Gass

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi Dopamine receptor 3 (D3) knockout mice show regular emotional behaviour
    S Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Mannheim, Germany
    Pharmacol Res 58:302-7. 2008
  2. ncbi Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP
    Peter Gass
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5 D 68159 Mannheim, Germany
    Brain Res Mol Brain Res 130:16-22. 2004
  3. ncbi Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety?
    P Gass
    Central Institute of Mental Health ZI, J5, Mannheim D 68159, Germany
    Physiol Behav 73:811-25. 2001
  4. ncbi Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal degeneration and early induction of transcription factor genes in the hippocampus
    B W Böttiger
    Department of Anesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
    Brain Res Mol Brain Res 65:135-42. 1999
  5. ncbi mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning
    M Zueger
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    J Neural Transm 113:347-56. 2006
  6. ncbi Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping
    M A Vogt
    Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
    Exp Neurol 211:25-33. 2008
  7. ncbi Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    Sabine Chourbaji
    Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
    Brain Res Mol Brain Res 121:28-36. 2004
  8. ncbi AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression
    S Chourbaji
    Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
    FASEB J 22:3129-34. 2008
  9. ncbi Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurosci Res 83:525-31. 2006
  10. ncbi Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus
    T Strekalova
    Central Institut of Mental Health CIMA, University of Heidelberg, Mannheim, Germany
    Genes Brain Behav 2:3-10. 2003

Collaborators

Detail Information

Publications75

  1. ncbi Dopamine receptor 3 (D3) knockout mice show regular emotional behaviour
    S Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Mannheim, Germany
    Pharmacol Res 58:302-7. 2008
    ..Hence, these results do not indicate an evident involvement of the D3 receptor in the development of a depression-like syndrome in mice for now. This does, however, not exclude the D3 receptor as a potential target for pharmacotherapy...
  2. ncbi Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP
    Peter Gass
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5 D 68159 Mannheim, Germany
    Brain Res Mol Brain Res 130:16-22. 2004
    ..These findings suggest that different c-Fos target genes are involved in LTP, contextual learning, and spatial reference memory formation...
  3. ncbi Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety?
    P Gass
    Central Institute of Mental Health ZI, J5, Mannheim D 68159, Germany
    Physiol Behav 73:811-25. 2001
    ....
  4. ncbi Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal degeneration and early induction of transcription factor genes in the hippocampus
    B W Böttiger
    Department of Anesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
    Brain Res Mol Brain Res 65:135-42. 1999
    ..This appears to be a good model which should be useful in evaluating the role of various genes in transgenic and knockout mice following global ischemia...
  5. ncbi mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning
    M Zueger
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    J Neural Transm 113:347-56. 2006
    ..None of these learning types were affected by the mutations, suggesting that mPer1 and mPer2 do not play a major role in the regulation of hippocampus-dependent learning and memory...
  6. ncbi Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping
    M A Vogt
    Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
    Exp Neurol 211:25-33. 2008
    ....
  7. ncbi Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    Sabine Chourbaji
    Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
    Brain Res Mol Brain Res 121:28-36. 2004
    ..Thus, a chronic reduction of BDNF protein content in adult mice is not sufficient to induce neurochemical or behavioral alterations that are reminiscent of depressive symptoms in humans...
  8. ncbi AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression
    S Chourbaji
    Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
    FASEB J 22:3129-34. 2008
    ....
  9. ncbi Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurosci Res 83:525-31. 2006
    ..J. Neurosci. 16:2434-2440), we suggest that the memory and cognitive decline in the context of aging may be accompanied by rather subtle anatomical changes, such as numbers and morphology of dendritic spines...
  10. ncbi Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus
    T Strekalova
    Central Institut of Mental Health CIMA, University of Heidelberg, Mannheim, Germany
    Genes Brain Behav 2:3-10. 2003
    ..The specific activation of CA1 neurons during the retrieval of contextual fear associations supports the postulated concept of a mnemonic role of this hippocampal subsector during the retrieval of contextual informations...
  11. ncbi Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive"
    Björn Zörner
    Central Institute of Mental Health Mannheim, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 54:972-82. 2003
    ..We investigated the hypothesis that mice with a forebrain-specific knockout of the trkB receptor, the main mediator of BDNF signaling, represent a genetic animal model for depression...
  12. ncbi The suitability of 129SvEv mice for studying depressive-like behaviour: both males and females develop learned helplessness
    Sabine Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Behav Brain Res 211:105-10. 2010
    ....
  13. ncbi Ambiguous-cue interpretation is biased under stress- and depression-like states in rats
    Thomas Enkel
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 35:1008-15. 2010
    ..The behavioral paradigm described constitutes a useful tool to study the neuronal basis of decision making under ambiguous conditions and may promote innovative pharmaco- and psychotherapy for depression...
  14. ncbi Learned helplessness: validity and reliability of depressive-like states in mice
    S Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany, J 5, D 68159 Mannheim, Germany
    Brain Res Brain Res Protoc 16:70-8. 2005
    ..Here, we present a mouse model with good face and predictive validity that can be used for transgenic, behavioral, and pharmacological studies...
  15. ncbi The impact of environmental enrichment on sex-specific neurochemical circuitries - effects on brain-derived neurotrophic factor and the serotonergic system
    S Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Neuroscience 220:267-76. 2012
    ..Only in male BDNF(+/-) mice the rescue is related to an increase in hippocampal BDNF expression suggesting that enrichment triggers different neuronal systems in a gender-specific manner...
  16. ncbi Finasteride treatment inhibits adult hippocampal neurogenesis in male mice
    B Romer
    RG Behavioural Biology, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Pharmacopsychiatry 43:174-8. 2010
    ..As neurosteroids metabolized by 5-alpha-reductase influence neural plasticity, we investigated whether finasteride treatment alters adult hippocampal neurogenesis, implicated in the pathophysiology of depression...
  17. ncbi Olfactory bulbectomy in mice induces alterations in exploratory behavior
    M Zueger
    Central Institute of Mental Health Mannheim (ZI, University of Heidelberg, J5, D-68159 Mannheim, Germany
    Neurosci Lett 374:142-6. 2005
    ..The extended behavioral characterization of the murine OBX model may contribute in particular to the increasing need to test transgenic mice for the presence of depression-like behaviors...
  18. ncbi Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice
    M S Cowen
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health CIMH, J5, 68159, Mannheim, Germany
    Neuropharmacology 45:325-33. 2003
    ..However, changes observed in activity patterns may be related to the putative role of AMPA receptors in attention deficit hyperactivity disorder...
  19. ncbi [Cyberstalking]
    H Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, J 5, 68159, Mannheim
    Nervenarzt 80:833-6. 2009
    ..The need for a scientific definition of cyberstalking and for future studies is presented. Since it is likely that psychiatrists will encounter victims of cyberstalking they should have knowledge of this phenomenon...
  20. ncbi [Stalking--what does the family doctor need to know?]
    H Dressing
    Zentralinstitut für seelische Gesundheit J5, Mannheim
    MMW Fortschr Med 148:41-3. 2006
    ..In the light of the above, it is of great importance that the physician should thoroughly familiarize himself with the problems associated with stalking...
  21. ncbi [Are journalists more frequently victims of stalking? Results of first empirical examinations]
    H Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg
    Gesundheitswesen 69:699-703. 2007
    ..Since stalking may cause severe psychological distress in the victims and, in some cases, puts them in severe risk of aggressive violence, preventive strategies should be considered...
  22. ncbi [Psychiatric significance of stalking]
    H Dressing
    Zentralinstitut fur Seelische Gesundheit, Mannheim
    Gesundheitswesen 67:869-71. 2005
    ..To provide an overview on the psychiatric significance of stalking and the implications for the health care system...
  23. ncbi [Stalking--from psychoterror to murder]
    H Dressing
    Zentralinstitut fur Seelische Gesundheit, Mannheim, Germany
    Nervenarzt 73:1112-5. 2002
    ..Members of the medical profession and other socially exposed people are especially potential victims of stalkers. Therefore, information on this topic is necessary in order to deal with it in a professional manner...
  24. ncbi [Multiaxial classification of stalking. Guidelines for the assessment of criminal liability and prognosis]
    H Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, J 5, Mannheim
    Nervenarzt 78:764, 766-8, 770-2. 2007
    ..The central components of the forensic psychiatric assessment remain the known diagnostic categories, the effects of which on behaviour can be analysed...
  25. ncbi Differential expression of glutamate transporters EAAT1 and EAAT2 in mice deficient for PACAP-type I receptor
    M Zink
    Central Institute of Mental Health, Mannheim, Germany
    J Neural Transm 111:1537-42. 2004
    ..Our data confirm the previously reported in-vitro-regulation of EAAT1 in the adult nervous system in vivo. EAAT2 expression, however, is unchanged in PAC1 knockout mice, most likely due to counterbalancing factors...
  26. ncbi Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 42:270-6. 2009
    ..An increasing number of studies uses serum BDNF levels as a potential indicator for central nervous system alterations...
  27. ncbi Evaluation of effects of previous exposure to an acute stressor before testing for depression-like behaviours in mice
    Sabine Chourbaji
    Department of Behavioural Biology, Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Mannheim, Germany
    Stress 11:170-5. 2008
    ..On the behavioural level, no test interactions could be detected, which suggests, that in general, combining these test conditions in experiments with a restricted availability of animals seems to be rather unproblematic...
  28. ncbi CREB-regulated diurnal activity patterns are not indicative for depression-like symptoms in mice and men
    Sabine Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Med Hypotheses 70:117-21. 2008
    ..Thus it is reasonable to assume that CREB Ser142 represents a molecular switch in mice and men, which is responsible for the (dys)regulation of circadian rhythms...
  29. ncbi Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice
    Peter Gass
    RG Behavioral Biology, University of Heidelberg, Mannheim, Germany
    J Neurosci Res 86:3184-93. 2008
    ..This approach may also be useful to find new targets for pharmacotherapy in affective disorders...
  30. ncbi Increased risk of mental disorders among lifetime victims of stalking--findings from a community study
    Christine Kuehner
    Central Institute of Mental Health, Research Group Longitudinal and Intervention Research, P O Box 122120, 68072 Mannheim, University of Heidelberg, Germany
    Eur Psychiatry 22:142-5. 2007
    ..The aim of the present study was to assess associations between stalking victimization and specific DSM-IV mental disorders in a community sample...
  31. ncbi The epidemiology and characteristics of stalking
    Harald Dressing
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Mannheim, Germany
    Curr Opin Psychiatry 19:395-9. 2006
    ..This article summarizes major results in the field of epidemiology and characteristics of stalking, as published in literature between 2003 and October 2005...
  32. ncbi [Mental health impact of stalking in men and women]
    Christine Kuehner
    AG Verlaufs und Interventionsforschung, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Psychother Psychosom Med Psychol 56:336-41. 2006
    ..In contrast, the associations of stalking victimization with poor mental health, psychosocial functioning, and use of medication were largely comparable across gender...
  33. ncbi IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors
    Sabine Chourbaji
    Central Institute of Mental Health ZI, J5, Mannheim D 68159, Germany
    Neurobiol Dis 23:587-94. 2006
    ..IL-6(-/-) mice represent tools to study IL-6-dependent signaling pathways in the pathophysiology of depression in vivo. Moreover, these mice may support the screening of compounds for depression by altering cytokine-mediated signaling...
  34. ncbi Nature vs. nurture: can enrichment rescue the behavioural phenotype of BDNF heterozygous mice?
    Sabine Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Behav Brain Res 192:254-8. 2008
    ....
  35. ncbi What can we learn from the first community-based epidemiological study on stalking in Germany?
    Harald Dressing
    Central Institute of Mental Health Mannheim ZI J 5 D 68159 Mannheim, University of Heidelberg, Germany
    Int J Law Psychiatry 30:10-7. 2007
    ..Implications for forensic psychiatric assessment and treatment of stalkers as well as for management of stalking victims are discussed...
  36. ncbi CREB, neurogenesis and depression
    Peter Gass
    Central Institute of Mental Health Mannheim, University of Heidelberg, Germany
    Bioessays 29:957-61. 2007
    ..It also outlines some crucial experiments and lines of future research that could clarify some of the pending questions...
  37. ncbi Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68072 Mannheim, Germany
    J Neurosci 26:1231-8. 2006
    ..In conclusion, AMPA receptors seem to be involved in the neuroplastic changes underlying alcohol seeking behavior and relapse. Thus, AMPA receptors represent a novel therapeutic target in preventing relapse...
  38. ncbi Prevalence of stalking in a psychiatric hospital population
    Harald Dressing
    Zentralinstitut fur Seelische Gesundheit, Mannheim, Germany
    Aust N Z J Psychiatry 44:736-41. 2010
    ..Study of the lifetime prevalence of stalking and types of stalking in a sample of psychiatric inpatients...
  39. ncbi Stalking behavior - an overview of the problem and a case report of male-to-male stalking during delusional disorder
    Harald Dressing
    Central Institute of Mental Health Mannheim, Mannheim, Germany
    Psychopathology 35:313-8. 2002
    ..Special gender aspects are discussed by presenting a case history of male-to-male stalking...
  40. ncbi [Prevalence and impact of stalking in psychiatric patients]
    Harald Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, 68159 Mannheim
    Psychiatr Prax 36:334-7. 2009
    ..The present study was designed to to investigate lifetime prevalence and types of stalking victimization in a sample of psychiatric in-patients...
  41. ncbi Perinatal exposure to alcohol reduces the expression of complexins I and II
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, Mannheim, Germany
    Neurotoxicol Teratol 31:400-5. 2009
    ..Further investigations should focus on other synaptic vesicle protein genes in order to unravel the molecular basis of ethanol-induced neurocognitive disabilities...
  42. ncbi Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning
    Barbara Vollmayr
    Department of Psychiatry, Central Institute of Mental Health J5, D 68159 Mannheim, Germany
    Behav Brain Res 150:217-21. 2004
    ....
  43. ncbi Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Neurosci Lett 360:106-8. 2004
    ..Our data demonstrate that even in vivo PAC1-mediated signaling seems to play a pivotal role for the transcriptional regulation of BDNF...
  44. ncbi [Increased prevalence of problematic alcohol consumption in university students]
    Josef Bailer
    Zentralinstitut fur Seelische Gesundheit, Mannheim
    Psychother Psychosom Med Psychol 59:376-9. 2009
    ..To compare the prevalence rates of problematic alcohol consumption in students and in the general population...
  45. ncbi Prevalence of stalking victimization in journalists: an E-mail survey of German journalists
    Peter Gass
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Violence Vict 24:163-71. 2009
    ..Primary and secondary preventive strategies should be considered...
  46. ncbi [Prevalence of stalking in Germany]
    Harald Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg
    Psychiatr Prax 32:73-8. 2005
    ..The present study aimed at gathering information on the lifetime prevalence and impact of stalking on victims in a German community...
  47. ncbi Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice
    Sabine Chourbaji
    Department of Behavioural Biology, Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Behav Brain Res 164:100-6. 2005
    ..These results suggest that housing conditions significantly influence the outcome of learned helplessness studies...
  48. ncbi Lifetime prevalence and impact of stalking in a European population: epidemiological data from a middle-sized German city
    Harald Dressing
    Central Institute of Mental Health Mannheim ZI, J 5, D 68159 Mannheim, Germany
    Br J Psychiatry 187:168-72. 2005
    ..There is a lack of community-based studies on prevalence rates of stalking and the impact of stalking on victims in European countries...
  49. ncbi Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review
    Dragos Inta
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Neurosci Biobehav Rev 34:285-94. 2010
    ..They may provide insight into the pathophysiology of schizophrenia and prove useful in the development of new therapeutics...
  50. ncbi Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications
    Dragos Inta
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Int J Neuropsychopharmacol 12:1133-6. 2009
    ..Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research...
  51. ncbi Imaging new neurons in vivo: a pioneering tool to study the cellular biology of depression?
    Benedikt Römer
    Central Institute of Mental Health Mannheim, University of Heidelberg, Germany
    Bioessays 30:806-10. 2008
    ..This makes it possible to study the role of neural progenitor cells in a wide variety of human brain disorders...
  52. ncbi Glucocorticoid receptor transgenic mice as models for depression
    Sabine Chourbaji
    Central Institute of Mental Health ZI, J5, Mannheim, D 68159, Germany
    Brain Res Rev 57:554-60. 2008
    ..In this review we summarize different approaches used to alter or eliminate glucocorticoid receptor expression and function, and discuss their relevance as models for depression...
  53. ncbi Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
    Tatyana Strekalova
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 29:2007-17. 2004
    ..Thus, behavioral correlates of stress-induced anhedonia and of chronic stress alone can be separated in the present model...
  54. ncbi Mutant mouse models of depression: candidate genes and current mouse lines
    Alexandre Urani
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, D-68159 Mannheim, Germany
    Neurosci Biobehav Rev 29:805-28. 2005
    ..This approach would correspond to the new concept of 'endophenotypes' in human depression research trying to identify behavioral traits which are thought to be encoded by a limited set of genes...
  55. ncbi Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice
    M H Schwab
    Zentrum für Molekulare Biologie ZMBH, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 18:1408-18. 1998
    ....
  56. ncbi Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
    R Brusa
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Germany
    Science 270:1677-80. 1995
    ..These mice developed seizures and died by 3 weeks of age, showing that GluR-B pre-mRNA editing is essential for brain function...
  57. ncbi Corticosteroid receptor transgenic mice: models for depression?
    Alexandre Urani
    Central Institute of Mental Health CIMA, University of Heidelberg, D 68159 Mannheim, Germany
    Ann N Y Acad Sci 1007:379-93. 2003
    ..The corticosteroid receptor-regulated target genes to be identified in these models may code for proteins that could represent new drug-targets for the treatment of affective disorders...
  58. ncbi Endocannabinoids and voluntary activity in mice: runner's high and long-term consequences in emotional behaviors
    Johannes Fuss
    RG Behavioral Biology, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health ZI, University of Heidelberg, Mannheim, Germany
    Exp Neurol 224:103-5. 2010
    ....
  59. ncbi The cerebral 'no-reflow' phenomenon after cardiac arrest in rats--influence of low-flow reperfusion
    B W Böttiger
    Department of Anesthesiology, University of Heidelberg, Germany
    Resuscitation 34:79-87. 1997
    ..We investigated the influence of prolonged cardiac arrest and basic life support (BLS) procedures on the quality of cerebral microcirculatory reperfusion...
  60. ncbi Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
    ..As a first potential molecular correlate for such changes, we identified a downregulation of BDNF protein content in the hippocampus of GR+/- mice, which is in agreement with the so-called neurotrophin hypothesis of depression...
  61. ncbi Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder
    Sabine Chourbaji
    Central Institute of Mental Health, J 5, D 68159, Mannheim, Germany
    Prog Brain Res 167:65-77. 2008
    ....
  62. ncbi Corticosteroid receptors in the brain: gene targeting studies
    Christoph Kellendonk
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Brain Res Bull 57:73-83. 2002
    ..Because an imbalance in glucocorticoid levels is associated with cognitive impairments and mental disorders, the described mouse lines will aid in understanding the mechanisms involved in the pathology of these disorders...
  63. ncbi A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning
    Yann Humeau
    Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    J Neurosci 27:10947-56. 2007
    ....
  64. ncbi Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment
    Sebastian Bisler
    C and O Vogt Institut für Hirnforschung, Heinrich Heine Universitat, Universitatsstr 1, D 40225 Dusseldorf, Germany
    J Chem Neuroanat 23:187-98. 2002
    ....
  65. ncbi Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock
    Daniel Gau
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Neuron 34:245-53. 2002
    ..Our findings provide genetic evidence that CREB Ser142 phosphorylation is involved in the entrainment of the mammalian clock and reveal a novel phosphorylation-dependent regulation of CREB activity...
  66. ncbi Fibronectin domains of extracellular matrix molecule tenascin-C modulate hippocampal learning and synaptic plasticity
    Tatyana Strekalova
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Mol Cell Neurosci 21:173-87. 2002
    ..In summary, our data show that TN-C is involved in hippocampus-dependent contextual memory and synaptic plasticity and identify the FN6-8 domain as one of molecular determinants mediating these functions...
  67. ncbi Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?
    Detlef Balschun
    Department of Neurophysiology, Leibniz Institute for Neurobiology, 39108 Magdeburg, Germany
    J Neurosci 23:6304-14. 2003
    ..This implies either a species-specific or regionally restricted role of CREB in the brain and/or a compensatory upregulation of the cAMP response element modulator (CREM) and other as yet unidentified transcription factors...
  68. ncbi Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS
    Alexander Fleischmann
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Neurosci 23:9116-22. 2003
    ..In summary, our data suggest a role for c-Fos in hippocampus-dependent learning and memory as well as in NMDA receptor-dependent LTP formation...
  69. ncbi Differential regulation of neurotrophins and serotonergic function in mice with genetically reduced glucocorticoid receptor expression
    Olaf Schulte-Herbrüggen
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Neurol 204:307-16. 2007
    ....
  70. ncbi Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness
    Barbara Vollmayr
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1035-40. 2003
    ..Further studies will have to clarify if during learned helpless behavior neurogenesis is impaired by altered differentiation or survival of cells...
  71. ncbi Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function
    Olaf Schulte-Herbrüggen
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Psychoneuroendocrinology 31:1266-77. 2006
    ..In conclusion, GR overexpression-dependent increases of hippocampal and amygdala BDNF content presumably represent a dynamic correlate of enhanced stress resistance...
  72. ncbi Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice
    Olga Valverde
    Laboratori de Neurofarmacologia, , Universitat Pompeu Fabra, Barcelona, Spain
    Neuropsychopharmacology 29:1122-33. 2004
    ..Our results emphasize the selective role played by neuronal CREB in emotional-like behavior and the somatic expression morphine withdrawal, without participating in the rewarding properties induced by morphine and cocaine...
  73. ncbi Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas
    Rainer Hellweg
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Neurobiol Dis 25:1-7. 2007
    ....
  74. ncbi Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  75. ncbi Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye
    Thorsten Belz
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    Eur J Neurosci 26:2222-7. 2007
    ....