Herta Flor

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples
    S Ridder
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Psychol Med 42:2325-35. 2012
  2. pmc The importance of synchrony and temporal order of visual and tactile input for illusory limb ownership experiences - an FMRI study applying virtual reality
    Robin Bekrater-Bodmann
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    PLoS ONE 9:e87013. 2014
  3. doi request reprint The neural basis of phantom limb pain
    Herta Flor
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany
    Trends Cogn Sci 17:307-8. 2013
  4. doi request reprint New developments in the understanding and management of persistent pain
    Herta Flor
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany
    Curr Opin Psychiatry 25:109-13. 2012
  5. ncbi request reprint Maladaptive plasticity, memory for pain and phantom limb pain: review and suggestions for new therapies
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Expert Rev Neurother 8:809-18. 2008
  6. ncbi request reprint Sensorimotor training and cortical reorganization
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    NeuroRehabilitation 25:19-27. 2009
  7. ncbi request reprint Phantom limb pain: a case of maladaptive CNS plasticity?
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Nat Rev Neurosci 7:873-81. 2006
  8. ncbi request reprint Altered pain processing in children with migraine: an evoked potential study
    Katrin Zohsel
    Department of Clinical and Cognitive Neuroscience, Ruprecht Karls University of Heidelberg, Central Institute of Mental Health, Square J5 D 68159 Mannheim, Germany
    Eur J Pain 12:1090-101. 2008
  9. ncbi request reprint The startle reflex in alcohol-dependent patients: changes after cognitive-behavioral therapy and predictive validity for drinking behavior. A pilot study
    Sabine Loeber
    Department of Addictive Behavior and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Psychother Psychosom 76:385-90. 2007
  10. doi request reprint Do burn injuries during infancy affect pain and sensory sensitivity in later childhood?
    Iris Wollgarten-Hadamek
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, Mannheim, Germany
    Pain 141:165-72. 2009

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. pmc Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples
    S Ridder
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Psychol Med 42:2325-35. 2012
    ..Enhanced acquisition and delayed extinction of fear conditioning are viewed as major determinants of anxiety disorders, which are often characterized by a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis...
  2. pmc The importance of synchrony and temporal order of visual and tactile input for illusory limb ownership experiences - an FMRI study applying virtual reality
    Robin Bekrater-Bodmann
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    PLoS ONE 9:e87013. 2014
    ..These results underline the temporal limits of the induction of limb ownership related to multisensory body-related input. ..
  3. doi request reprint The neural basis of phantom limb pain
    Herta Flor
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany
    Trends Cogn Sci 17:307-8. 2013
    ..These findings add valuable information on cortical reorganization after amputation. We suggest further lines of research to clarify the mechanisms that underlie phantom pain. ..
  4. doi request reprint New developments in the understanding and management of persistent pain
    Herta Flor
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany
    Curr Opin Psychiatry 25:109-13. 2012
    ..It is proposed that central rather than peripheral factors may be important in pain chronicity. We review recent empirical findings on these processes and discuss implications for treatment and prevention...
  5. ncbi request reprint Maladaptive plasticity, memory for pain and phantom limb pain: review and suggestions for new therapies
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Expert Rev Neurother 8:809-18. 2008
    ....
  6. ncbi request reprint Sensorimotor training and cortical reorganization
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    NeuroRehabilitation 25:19-27. 2009
    ..Further research must elucidate the mechanisms of these plastic changes and relate them to disorders and treatments...
  7. ncbi request reprint Phantom limb pain: a case of maladaptive CNS plasticity?
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Nat Rev Neurosci 7:873-81. 2006
    ..We cite both animal and human studies and derive suggestions for innovative interventions aimed at alleviating phantom pain...
  8. ncbi request reprint Altered pain processing in children with migraine: an evoked potential study
    Katrin Zohsel
    Department of Clinical and Cognitive Neuroscience, Ruprecht Karls University of Heidelberg, Central Institute of Mental Health, Square J5 D 68159 Mannheim, Germany
    Eur J Pain 12:1090-101. 2008
    ..Consistent with the psychobiological perspective of chronic pain, such an attentional bias could constitute an important mechanism for migraine becoming a chronic problem...
  9. ncbi request reprint The startle reflex in alcohol-dependent patients: changes after cognitive-behavioral therapy and predictive validity for drinking behavior. A pilot study
    Sabine Loeber
    Department of Addictive Behavior and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Psychother Psychosom 76:385-90. 2007
    ..Further, we examined whether the affect-modulated startle reflex is a predictor of treatment success...
  10. doi request reprint Do burn injuries during infancy affect pain and sensory sensitivity in later childhood?
    Iris Wollgarten-Hadamek
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, Mannheim, Germany
    Pain 141:165-72. 2009
    ..Most importantly, our findings suggest that early traumatic and painful injuries, such as burns, can induce global, long-term alterations in sensory and pain processing...
  11. doi request reprint Cerebral processing of pain in school-aged children with neonatal nociceptive input: an exploratory fMRI study
    Johanna Hohmeister
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, Mannheim, Ruprecht Karls University Heidelberg, Germany
    Pain 150:257-67. 2010
    ..In highly vulnerable children such as preterms, neonatal nociceptive input may, aside from other neurodevelopmental consequences, persistently increase the gain within pain pathways...
  12. pmc Emotional learning during dissociative states in borderline personality disorder
    Ulrich W Ebner-Priemer
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Germany
    J Psychiatry Neurosci 34:214-22. 2009
    ..The aim of our study was to determine whether high states of dissociative experience would specifically alter emotional learning, but not declarative knowledge...
  13. ncbi request reprint Peripheral and electrocortical responses to painful and non-painful stimulation in chronic pain patients, tension headache patients and healthy controls
    Herta Flor
    Department of Clinical and Cognitive Neuroscience at the University of Heidelberg, Central Institute of Mental Health, Square J5, D 68159 Mannheim, Germany
    Neurosci Lett 361:147-50. 2004
    ..The observed lack of habituation may contribute to the persistence of chronic pain...
  14. doi request reprint A risk variant for alcoholism in the NMDA receptor affects amygdala activity during fear conditioning in humans
    Raffaele Cacciaglia
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Biol Psychol 94:74-81. 2013
    ..Carriers of the risk variant additionally exhibit dampened insula activation, a finding that further strengthens our data, given the importance of this brain region in fear conditioning. ..
  15. doi request reprint Fear conditioning in psychopaths: event-related potentials and peripheral measures
    Yvonne Rothemund
    Department of Psychosomatic Medicine, University Medicine Charité, Berlin, Germany
    Biol Psychol 90:50-9. 2012
    ....
  16. doi request reprint Treatment-related changes in brain activation in patients with fibromyalgia syndrome
    Martin Diers
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Exp Brain Res 218:619-28. 2012
    ..Future studies should compare responders and non-responders for differential treatment effects and examine in more detail the mechanisms underlying these changes...
  17. doi request reprint Pain ratings and somatosensory evoked responses to repetitive intramuscular and intracutaneous stimulation in fibromyalgia syndrome
    Martin Diers
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    J Clin Neurophysiol 25:153-60. 2008
    ..These results indicate lower pain thresholds in the fibromyalgia syndrome patients after electrical stimulation and a higher N80 amplitude both indicative of enhanced sensory processing in this group...
  18. doi request reprint Do school-aged children with burn injuries during infancy show stress-induced activation of pain inhibitory mechanisms?
    Iris Wollgarten-Hadamek
    Department of Clinical and Cognitive Neuroscience, Ruprecht Karls University Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Eur J Pain 15:423.e1-10. 2011
    ....
  19. doi request reprint Exposure to uncontrollable stress and the postimperative negative variation (PINV): prior control matters
    Carsten Diener
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Biol Psychol 80:189-95. 2009
    ..We conclude that cortical activation changes are linked to the evaluation of instrumental contingencies. However, the exact determination of brain regions involved in the processing of uncontrollable stress needs further investigation...
  20. doi request reprint Cortico-subcortical activation patterns for itch and pain imagery
    Hideki Mochizuki
    Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan Electronic address
    Pain 154:1989-98. 2013
    ..These differences in brain networks may explain why motor responses to itch are more socially contagious than those related to pain. ..
  21. doi request reprint Deficient modulation of pain by a positive emotional context in fibromyalgia patients
    Sandra Kamping
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Pain 154:1846-55. 2013
    ..Our results suggest that fibromyalgia patients are less efficient in modulating pain by positive affect and may benefit less from appetitive events than healthy control subjects. ..
  22. doi request reprint A target sample of adolescents and reward processing: same neural and behavioral correlates engaged in common paradigms?
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Exp Brain Res 223:429-39. 2012
    ....
  23. ncbi request reprint Retrieval and emotional processing of traumatic memories in posttraumatic stress disorder: peripheral and central correlates
    Michele Wessa
    Department of Clinical and Cognitive Neuroscience at the University of Heidelberg, Central Institute of Mental Health, J 5, 68159 Mannheim, Germany
    Neuropsychologia 44:1683-96. 2006
    ..These findings are discussed in the context of current models of the role of declarative memory in the development and maintenance of PTSD...
  24. ncbi request reprint Pavlovian conditioning of muscular responses in chronic pain patients: central and peripheral correlates
    Christoph Schneider
    Department of Neuropsychology, University of Heidelberg, Central Institute of Mental Health, J 5, D 68159 Mannheim, Germany
    Pain 112:239-47. 2004
    ....
  25. ncbi request reprint Failure of extinction of fear responses in posttraumatic stress disorder: evidence from second-order conditioning
    Michele Wessa
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Square J 5, 68159 Mannheim, Germany
    Am J Psychiatry 164:1684-92. 2007
    ..The extinction of the traumatic response might be impeded if trauma reminders maintain fear responses by their association with the original trauma through second-order conditioning...
  26. ncbi request reprint Effects of repeated withdrawal from alcohol on recovery of cognitive impairment under abstinence and rate of relapse
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Alcohol 45:541-7. 2010
    ..The aim of the present study was to investigate whether repeated withdrawal from alcohol affects recovery of cognitive function and is related to relapse...
  27. doi request reprint A cross-over study of effects on the hypothalamus-pituitary-adrenal (HPA) axis and the sympathoadrenergic system in magnetic field strength exposure from 0 to 7 T
    Maria Gilles
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, Medical Faculty Mannheim, Heidelberg University, Germany
    Stress 16:172-80. 2013
    ..Our study suggests that the results of MRI studies using stress-paradigms are not influenced by the static magnetic field itself...
  28. ncbi request reprint Aversive Pavlovian conditioning in psychopaths: peripheral and central correlates
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Psychophysiology 39:505-18. 2002
    ..These data indicate a deficit in association formation in psychopaths that may be related to deficient interaction of limbic-subcortical and cortical structures...
  29. pmc Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex
    Simone Lang
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Eur J Neurosci 29:823-32. 2009
    ..These data are consistent with theoretical models that propose an inhibitory effect of the mPFC on the amygdala. The interaction of the mPFC with the hippocampus may reflect the context-specificity of extinction learning...
  30. ncbi request reprint Somatic pain sensitivity in children with recurrent abdominal pain
    Katrin Zohsel
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Am J Gastroenterol 103:1517-23. 2008
    ..However, it is not known whether somatic sensitivity is altered as well. Therefore, the aim of our study was to assess somatic pain sensitivity in children with RAP and healthy controls at the abdomen and a distal site (thenar)...
  31. ncbi request reprint Central and peripheral psychophysiological responses to trauma-related cues in subclinical posttraumatic stress disorder: a pilot study
    Michele Wessa
    Department of Neuropsychology and Clinical Psychology at the University of Heidelberg, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Exp Brain Res 167:56-65. 2005
    ....
  32. doi request reprint Enhanced stress analgesia to a cognitively demanding task in patients with posttraumatic stress disorder
    Slawomira J Diener
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    J Affect Disord 136:1247-51. 2012
    ..In posttraumatic stress disorder (PTSD) exaggerated stress-induced analgesia to trauma reminders was proposed. The present study investigated whether enhanced analgesia occurs in response to a trauma-unrelated cognitive stressor in PTSD...
  33. doi request reprint The role of context in the processing of alcohol-relevant cues
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Addict Biol 17:441-51. 2012
    ..These data have not only important implications for our understanding of the role of learning in drug dependence but also for treatment, which needs to take these factors into account...
  34. ncbi request reprint Psychophysiological responses in patients with fibromyalgia syndrome
    Kati Thieme
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    J Psychosom Res 61:671-9. 2006
    ..Several potential mechanisms for these psychophysiological responses are discussed...
  35. ncbi request reprint The assessment of pain coping and pain-related cognitions in children and adolescents: current methods and further development
    Christiane Hermann
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    J Pain 8:802-13. 2007
    ..Catastrophizing was associated with dysphoric mood, trait anxiety, and current pain activity. Subgroups of pain patients differed with regard to catastrophizing and positive self-statements...
  36. ncbi request reprint Reliability and validity of neuroelectric source imaging in primary somatosensory cortex of human upper limb amputees
    Michael Schaefer
    Department of Clinical and Cognitive Neuroscience at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Brain Topogr 15:95-106. 2002
    ....
  37. doi request reprint Functional and structural aspects of tinnitus-related enhancement and suppression of auditory cortex activity
    Eugen Diesch
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Neuroimage 50:1545-59. 2010
    ..Direction and extent of this alteration are modulated by musicality and auditory cortex volume...
  38. doi request reprint An MR-compatible device for automated and safe application of laser stimuli in experiments employing nociceptive stimulation
    Peter P Pott
    Laboratory for Biomechanics and Experimental Orthopedics, Orthopedic and Trauma Surgery Center OUZ, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurosci Methods 186:1-7. 2010
    ..Finally, the reliability and validity of the device were tested and demonstrated. It permits easy and investigator-independent use of laser stimulation in the MR scanner...
  39. ncbi request reprint Impairment of cognitive abilities and decision making after chronic use of alcohol: the impact of multiple detoxifications
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, 68159 Mannheim, Germany
    Alcohol Alcohol 44:372-81. 2009
    ..In the present study, the effect of previous detoxifications on prefrontal function and decision making was examined in alcohol-dependent patients. Further, we examined whether the length of abstinence affects cognitive function...
  40. doi request reprint Attentional bias in alcohol-dependent patients: the role of chronicity and executive functioning
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:194-203. 2009
    ..Our results indicate that differences with regard to drinking-related variables as well as cognitive functioning seem to modulate attentional bias and need to be taken into account in models of drinking maintenance...
  41. ncbi request reprint An augmented reality home-training system based on the mirror training and imagery approach
    Jorg Trojan
    Department of Cognitive und Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Behav Res Methods 46:634-40. 2014
    ..This suggests that the system is well suited to maintain motivation in patients, especially when it is used for a prolonged period of time. ..
  42. doi request reprint From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits
    Angela Heinrich
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, 68159, Germany Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Eur J Neurosci 38:2941-5. 2013
    ..Our findings support the hypothesis that the schizophrenia-related risk variant of rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral as well as an imaging genetics level. ..
  43. pmc Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism
    Jelka Tzschoppe
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 39:875-84. 2014
    ..This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders. ..
  44. doi request reprint Activation of the ventral striatum during aversive contextual conditioning in humans
    Sebastian T Pohlack
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    Biol Psychol 91:74-80. 2012
    ..Our data suggest the involvement of the ventral striatum during contextual fear conditioning, and underline its role in the processing of salient stimuli in general, not only during reward processing...
  45. doi request reprint A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression
    Carsten Diener
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    Neuroimage 61:677-85. 2012
    ....
  46. ncbi request reprint Localization of the human female breast in primary somatosensory cortex
    Yvonne Rothemund
    Department of Clinical and Cognitive Neuroscience at the University of Heidelberg, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Exp Brain Res 164:357-64. 2005
    ..Despite an extensive body of research on the topography of the primary somatosensory cortex (S1) little is known about the representation of the trunk...
  47. doi request reprint Mirrored, imagined and executed movements differentially activate sensorimotor cortex in amputees with and without phantom limb pain
    Martin Diers
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, D 68159 Mannheim, Germany
    Pain 149:296-304. 2010
    ..Further research must identify the causal mechanisms related to mirror treatment, imagined movements or movements of the other hand and associated changes in pain perception...
  48. doi request reprint Dimensions of pain-related parent behavior: development and psychometric evaluation of a new measure for children and their parents
    Christiane Hermann
    Department of Cognitive and Clinical Neuroscience, Ruprecht Karls University Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Pain 137:689-99. 2008
    ....
  49. doi request reprint Responses to pain in school-aged children with experience in a neonatal intensive care unit: cognitive aspects and maternal influences
    Johanna Hohmeister
    Department of Clinical and Cognitive Neuroscience, Ruprecht Karls University Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Eur J Pain 13:94-101. 2009
    ....
  50. doi request reprint Cortical correlates of an attentional bias to painful and innocuous somatic stimuli in children with recurrent abdominal pain
    Christiane Hermann
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Square J5, D 68159 Mannheim, Germany
    Pain 136:397-406. 2008
    ..This may represent an important mechanism not only for the maintenance of RAP, but also for the development of psychosomatic symptoms...
  51. ncbi request reprint The impact of chronic pain in children and adolescents: Development and initial validation of a child and parent version of the Pain Experience Questionnaire
    Christiane Hermann
    Department of Clinical and Cognitive Neuroscience, Ruprecht Karls University Heidelberg, Central Institute of Mental Health, Square J5, D 68159 Mannheim, Germany
    Pain 135:251-61. 2008
    ..Despite the preliminary nature of the psychometric evaluation, the child and parent PEQ seem promising for a comprehensive assessment of pediatric pain...
  52. ncbi request reprint Responder criteria for operant and cognitive-behavioral treatment of fibromyalgia syndrome
    Kati Thieme
    University of Heidelberg, Mannheim, Germany
    Arthritis Rheum 57:830-6. 2007
    ..To predict the effects of cognitive-behavioral therapy (CBT) and operant-behavioral therapy (OBT) in fibromyalgia syndrome (FMS)...
  53. ncbi request reprint Central processing of acute muscle pain in chronic low back pain patients: an EEG mapping study
    Martin Diers
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg Central Institute of Mental Health, Mannheim, Germany
    J Clin Neurophysiol 24:76-83. 2007
    ..The lower P260 component in the patients may be explained in terms of tonic pain inhibiting phasic pain or may be related to the affective distress observed in this patient group...
  54. ncbi request reprint A simultaneous EEG-fMRI study of painful electric stimulation
    Christoph Christmann
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Neuroimage 34:1428-37. 2007
    ..The BOLD signal change decreased in SI over time. Dipole strength of the ACC source decreased over the experiment and increased during the stimulation block suggesting sensitization and habituation effects in these areas...
  55. doi request reprint Voluntary exercise does not ameliorate context memory and hyperarousal in a mouse model for post-traumatic stress disorder (PTSD)
    Raffaele Cacciaglia
    Institute of Neuropsychology and Clinical Psychology, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 14:403-9. 2013
    ..However, studies that have tried to link physical exercise and contextual conditioning in an animal model of PTSD, revealed mixed findings...
  56. doi request reprint Increased BOLD sensitivity in the orbitofrontal cortex using slice-dependent echo times at 3 T
    Sebastian Domsch
    Department of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Magn Reson Imaging 31:201-11. 2013
    ..3 when the modified EPI was used. We conclude that an EPI with slice-dependent echo times may be a valuable tool to mitigate susceptibility artifacts in event-related whole-brain fMRI studies with a focus on the orbitofrontal cortex...
  57. doi request reprint Cognition and sensation in very high static magnetic fields: a randomized case-crossover study with different field strengths
    Angela Heinrich
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, D 68159 Mannheim, Germany
    Radiology 266:236-45. 2013
    ..To establish the extent to which representative cognitive functions in subjects undergoing magnetic resonance (MR) imaging are acutely impaired by static magnetic fields of varying field strengths...
  58. pmc Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:986-95. 2012
    ....
  59. doi request reprint Hippocampal but not amygdalar volume affects contextual fear conditioning in humans
    Sebastian T Pohlack
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim D 68159, Germany
    Hum Brain Mapp 33:478-88. 2012
    ..This study shows the relevance of hippocampal volume for contextual fear conditioning in healthy volunteers and may have important implications for anxiety disorders...
  60. ncbi request reprint Auditory discrimination training for the treatment of tinnitus
    Herta Flor
    Department of Cognitive and Clinical Neuroscience, University of Heidelberg, Central Institute of Mental Health, Quadrat J5, 68159 Mannheim, Germany
    Appl Psychophysiol Biofeedback 29:113-20. 2004
    ..For more substantial changes in multiple variables an extended training period with additional consideration of emotional variables would be necessary. In addition, controls for nonspecific training effects need to be implemented...
  61. doi request reprint Differential central pain processing following repetitive intramuscular proton/prostaglandin E₂ injections in female fibromyalgia patients and healthy controls
    Martin Diers
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Eur J Pain 15:716-23. 2011
    ..While the etiology of fibromyalgia syndrome (FMS) remains unclear, it is assumed that both peripheral and central components are involved...
  62. ncbi request reprint Long-term alteration of pain sensitivity in school-aged children with early pain experiences
    Christiane Hermann
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Pain 125:278-85. 2006
    ..Our findings suggest that repeated pain experiences in neonates may induce activity-induced changes in the functioning of pain pathways that persist well beyond infancy...
  63. ncbi request reprint Quantitative sensory testing in children with migraine: preliminary evidence for enhanced sensitivity to painful stimuli especially in girls
    Katrin Zohsel
    Department of Neuropsychology and Clinical Psychology at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Pain 123:10-8. 2006
    ..Girls with migraine were more prone to such sensitization, which may increase their risk for continuing to suffer from migraine throughout adulthood...
  64. pmc Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments
    Kati Thieme
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, J5, 68169 Mannheim, Germany
    Arthritis Res Ther 8:R121. 2006
    ..The AP group showed that unstructured discussion of FMS-related problems may be detrimental...
  65. ncbi request reprint Alteration in the response properties of primary somatosensory cortex related to differential aversive Pavlovian conditioning
    Eugen Diesch
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Square J5, 68159 Mannheim, Germany
    Pain 131:171-80. 2007
    ..Pavlovian conditioning of tactile responses might be important in the altered processing of painful stimuli in chronic pain patients where enhanced conditioning has been demonstrated...
  66. doi request reprint Site-specific visual feedback reduces pain perception
    Martin Diers
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Pain 154:890-6. 2013
    ..These findings suggest novel intervention modes for chronic back pain based on visualization of body parts by augmented reality applications...
  67. doi request reprint Simultaneous EEG and fMRI reveals a causally connected subcortical-cortical network during reward anticipation
    Michael M Plichta
    Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg, Department of Psychiatry and Psychotherapy, 68159 Mannheim, Germany
    J Neurosci 33:14526-33. 2013
    ..Collectively, these findings represent a likely neurobiological mechanism mapping a primarily subcortical process, i.e., reward anticipation, onto a cortical signature. ..
  68. doi request reprint SCN1A affects brain structure and the neural activity of the aging brain
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
    Biol Psychiatry 72:677-83. 2012
    ..rs10930201 was further observed to be related to differences in neural activity during a working memory task...
  69. ncbi request reprint The perceptual and neuronal stability of the rubber hand illusion across contexts and over time
    Robin Bekrater-Bodmann
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, D 68159 Mannheim, Germany
    Brain Res 1452:130-9. 2012
    ..The functional magnetic resonance imaging data suggest temporally stable ventral premotor cortex processing. These results indicate that dynamic changes in perceived limb ownership by the induction of the RHI are trait-like...
  70. doi request reprint Brain correlates of stress-induced analgesia
    Pinar Yilmaz
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Pain 151:522-9. 2010
    ..SIA seems to activate similar brain networks as placebo analgesia or analgesia mediated by diffuse noxious inhibitory controls and involved sensory, affective and cognitive modulatory circuits...
  71. doi request reprint Loss of control during instrumental learning: a source localization study
    Carsten Diener
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 50:717-26. 2010
    ..These results provide further evidence for the role of the ACC in detecting response conflict and its involvement in the generation of the PINV...
  72. doi request reprint Cardiac awareness and autonomic cardiac reactivity during emotional picture viewing and mental stress
    Beate M Herbert
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Psychophysiology 47:342-54. 2010
    ..The results suggest that cardiac awareness is related to greater responsivity of the autonomic nervous system during situations evoking autonomic reactivity...
  73. ncbi request reprint Blockade of cue-induced brain activation of abstinent alcoholics by a single administration of amisulpride as measured with fMRI
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 30:1349-54. 2006
    ..We tested the effects of the atypical dopamine D(2/3) blocker amisulpride on cue-induced brain activation in a functional magnetic resonance imaging (fMRI) paradigm...
  74. ncbi request reprint Cue exposure in the treatment of alcohol dependence: effects on drinking outcome, craving and self-efficacy
    Sabine Loeber
    Department of Addictive Behaviour and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Br J Clin Psychol 45:515-29. 2006
    ..We hypothesized that cue exposure treatment is associated with a stronger decline of craving, a stronger increase in self-efficacy and has beneficial effects on drinking behaviour after discharge...
  75. ncbi request reprint Psychometric qualities of the German version of the Posttraumatic Diagnostic Scale (PTDS)
    Dorothee Griesel
    Department of Cognitive and Clinical Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Psychol Assess 18:262-8. 2006
    ..The findings are discussed with respect to their equivalency to the original PTDS, core symptoms of PTSD, and desirable future research...
  76. doi request reprint Phantom limb pain after lower limb trauma: origins and treatments
    Jens Foell
    University of Heidelberg, Mannheim, Germany
    Int J Low Extrem Wounds 10:224-35. 2011
    ..This article describes the current state of research in regard to the demographics, causal factors, and treatments of phantom limb pain...
  77. ncbi request reprint Pavlovian conditioning of opioid and nonopioid pain inhibitory mechanisms in humans
    Herta Flor
    Department of Neuropsychology at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Eur J Pain 6:395-402. 2002
    ..Learning processes also influence pain inhibitory processes in humans and this effect might play a role in the development of chronic pain...
  78. ncbi request reprint Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    Michael N Smolka
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Neurosci 25:836-42. 2005
    ....
  79. doi request reprint Reduced volume of Heschl's gyrus in tinnitus
    Peter Schneider
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 45:927-39. 2009
    ..The volume changes observed may represent antecedents or consequences of tinnitus and tinnitus-associated hearing loss and also raise the possibility that small cortical volume constitutes a vulnerability factor...
  80. ncbi request reprint Remapping somatosensory cortex after injury
    Herta Flor
    Department of Neuropsychology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Adv Neurol 93:195-204. 2003
    ....
  81. ncbi request reprint Altered cortisol awakening response in posttraumatic stress disorder
    Michele Wessa
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 31:209-15. 2006
    ..The findings are discussed in light of the hypothesis of a counterregulation of hyper-arousal symptoms and chronic stress in PTSD...
  82. ncbi request reprint The modification of cortical reorganization and chronic pain by sensory feedback
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Appl Psychophysiol Biofeedback 27:215-27. 2002
    ..We show that cortical plasticity related to chronic pain can be reduced by behavioral interventions that provide feedback to the brain areas that were altered by somatosensory pain memories...
  83. ncbi request reprint Enhancement of steady-state auditory evoked magnetic fields in tinnitus
    Eugen Diesch
    Department of Neuropsychology, University of Heidelberg, Central Institute of Mental Health, Square J5, D 68159, Mannheim, Germany
    Eur J Neurosci 19:1093-104. 2004
    ..The relationship of tinnitus to auditory cortex hyperexcitability and its independence of hearing loss is discussed with reference to loss of surround inhibition in and map reorganization of primary auditory cortex...
  84. ncbi request reprint The role of operant conditioning in chronic pain: an experimental investigation
    Herta Flor
    Department of Neuropsychology, Ruprecht Karls University of Heidelberg, Central Institute of Mental Health, J 5, D 68159 Mannheim, Germany
    Pain 95:111-8. 2002
    ..These data suggest that CBP patients are more easily influenced by operant conditioning factors than healthy controls and this susceptibility may add to the maintenance of the chronic pain problem...
  85. ncbi request reprint Operant behavioral treatment of fibromyalgia: a controlled study
    Kati Thieme
    Department of Psychosomatic and Psychotherapeutic Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Arthritis Rheum 49:314-20. 2003
    ..To evaluate the efficacy of operant pain treatment for fibromyalgia syndrome (FMS) in an inpatient setting...
  86. ncbi request reprint Covariation bias for ambiguous social stimuli in generalized social phobia
    Christiane Hermann
    Department of Neuropsychology, University of Heidelberg, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    J Abnorm Psychol 113:646-53. 2004
    ..Hence, illusory correlations--possibly resulting from acquired associations between social cues and negative consequences--may contribute to a negative interpretation bias in GSP...
  87. ncbi request reprint Psychophysiological and subjective indicators of aversive pavlovian conditioning in generalized social phobia
    Christiane Hermann
    Department of Neuropsychology at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 52:328-37. 2002
    ..Furthermore, delayed extinction of the conditioned response seems to contribute to the etiology and maintenance of generalized social phobia...
  88. ncbi request reprint Phantom phenomena in mastectomized patients and their relation to chronic and acute pre-mastectomy pain
    Yvonne Rothemund
    Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Pain 107:140-6. 2004
    ....
  89. ncbi request reprint Simultaneous electroencephalography and functional magnetic resonance imaging of primary and secondary somatosensory cortex in humans after electrical stimulation
    Christoph Christmann
    Department of Clinical and Cognitive Neuroscience at the University of Heidelberg, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Neurosci Lett 333:69-73. 2002
    ..7 mm (SD = 3.5) for S2 cortex. fMRI constrained dipole searches lead to higher residual variances. The data show that simultaneous EEG and fMRI measurements of somatosensory activity are feasible and yield reliable and valid results...
  90. ncbi request reprint Phantom-limb pain: characteristics, causes, and treatment
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Lancet Neurol 1:182-9. 2002
    ..The prevention of phantom-limb pain by peripheral analgesia has not yielded consistent results. Additional measures that reverse or prevent the formation of central memory processes might be more effective...
  91. ncbi request reprint Reproducibility and stability of neuroelectric source imaging in primary somatosensory cortex
    Michael Schaefer
    Department of Clinical and Cognitive Neuroscience at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Brain Topogr 14:179-89. 2002
    ..BEM was not found to be superior to a 4-shell model. These data support the use of multi-electrode EEG recordings combined with MRI as an adequate method for the investigation of the functional organization of the somatosensory cortex...
  92. pmc Painful memories. Can we train chronic pain patients to 'forget' their pain?
    Herta Flor
    Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Mannheim, Germany
    EMBO Rep 3:288-91. 2002
  93. ncbi request reprint [Posttraumatic stress disorder and trauma memory--a psychobiological perspective]
    Michele Wessa
    Lehrstuhl für Neuropsychologie an der Ruprecht Karls Universität Heidelberg, Zentralinstitut fur Seelische Gesundheit, J 5, D 68159 Mannheim, Germany
    Z Psychosom Med Psychother 48:28-37. 2002
    ..This dissociation of implicit and explicit memory prevents the extinction of the emotional response to the trauma and perpetuates the disorder. First empirical results based on this model confirm the main hypotheses...
  94. ncbi request reprint Emotional modulation of pain: a clinical perspective
    Iris Klossika
    Department of Psychosomatic Medicine and Psychotherapy, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Pain 124:264-8. 2006
  95. ncbi request reprint Predictors of pain behaviors in fibromyalgia syndrome
    Kati Thieme
    Department of Anesthesiology, University of Washington, Seattle 98195 6450, USA
    Arthritis Rheum 53:343-50. 2005
    ..To evaluate the contributions of physical, pain-related, cognitive, stress-related, affective, and spouse-related variables to differences in pain behaviors in subgroups of patients with fibromyalgia syndrome (FMS)...
  96. ncbi request reprint Comorbid depression and anxiety in fibromyalgia syndrome: relationship to somatic and psychosocial variables
    Kati Thieme
    Department of Anesthesiology at the University of Washington, 1959 NE Pacific Street, Box 356540, Seattle, WA 98195 6540, USA
    Psychosom Med 66:837-44. 2004
    ..The prevalence as well as predictors of psychiatric disorders (Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV] axis I and II) in patients with fibromyalgia syndrome (FMS) was evaluated...
  97. ncbi request reprint Deficient fear conditioning in psychopathy: a functional magnetic resonance imaging study
    Niels Birbaumer
    Institute of Medical Psychology and Behavioral Neurobiology and Section of Experimental Resonance Imaging of the CNS, Department of Neuroradiology, University of Tubingen, Tubingen, Germany
    Arch Gen Psychiatry 62:799-805. 2005
    ..It was hypothesized that this behavior might be the consequence of deficient fear conditioning...
  98. ncbi request reprint Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
    ..As a first potential molecular correlate for such changes, we identified a downregulation of BDNF protein content in the hippocampus of GR+/- mice, which is in agreement with the so-called neurotrophin hypothesis of depression...
  99. ncbi request reprint Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans
    Ralf Veit
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Gartenstrasse 29, 72074, Tubingen, Germany
    Neurosci Lett 328:233-6. 2002
    ..Thus, a hypoactive frontolimbic circuit may represent the neural correlate of psychopathic behavior, whereas an overactive frontolimbic system may underly social fear...
  100. ncbi request reprint Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
    Biol Psychiatry 61:1011-4. 2007
    ..However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers...