Gabriele Ende

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression
    Gabriele Ende
    Division Neuroimaging, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 257:36-9. 2007
  2. ncbi request reprint Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
  3. ncbi request reprint The biochemistry of dysfunctional emotions: proton MR spectroscopic findings in major depressive disorder
    Gabriele Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Prog Brain Res 156:481-501. 2006
  4. ncbi request reprint Further evidence for altered cerebellar neuronal integrity in schizophrenia
    Gabriele Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:790-2. 2005
  5. ncbi request reprint Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter
    Gabriele Ende
    Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 37:1643-9. 2013
  6. doi request reprint Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010
  7. doi request reprint Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain
    Alexander Sartorius
    Central Institute of Mental Health, J5, Mannheim, Germany
    J Neurosci Methods 172:215-9. 2008
  8. doi request reprint Experience of social discrimination correlates with neurometabolism: a pilot study in heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, P O Box 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:197-203. 2013
  9. doi request reprint Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
  10. doi request reprint Effects of alcoholism and continued abstinence on brain volumes in both genders
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 35:1678-85. 2011

Detail Information

Publications40

  1. ncbi request reprint Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression
    Gabriele Ende
    Division Neuroimaging, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 257:36-9. 2007
    ..Abnormal levels of choline-containing compounds most likely reflect altered membrane phospholipid metabolism. A reduced level in the hippocampus and an increased level in the putamen suggest regionally opponent membrane abnormalities...
  2. ncbi request reprint Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
    ..Cannabinoids present neurotoxic and neuroprotective properties in in vitro studies, inconsistent alterations in human neuroimaging studies, neuropsychological deficits, and an increased risk for psychotic episodes...
  3. ncbi request reprint The biochemistry of dysfunctional emotions: proton MR spectroscopic findings in major depressive disorder
    Gabriele Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Prog Brain Res 156:481-501. 2006
    ..This review summarizes the literature about biochemical changes quantified via 1H MRS in MDD patients in brain regions that play an important role for the communication and processing of emotions...
  4. ncbi request reprint Further evidence for altered cerebellar neuronal integrity in schizophrenia
    Gabriele Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:790-2. 2005
    ....
  5. ncbi request reprint Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter
    Gabriele Ende
    Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 37:1643-9. 2013
    ..This study investigated magnetic resonance spectroscopy (MRS)-detectable Glu levels in frontal WM of non-treatment-seeking heavy drinkers and its associations with AUD symptoms...
  6. doi request reprint Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010
    ..Impulsivity is a key feature of BPD and can be related to anterior cingulate cortex function...
  7. doi request reprint Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain
    Alexander Sartorius
    Central Institute of Mental Health, J5, Mannheim, Germany
    J Neurosci Methods 172:215-9. 2008
    ..An influence of tCr on the brain's energy regulating system seems plausible...
  8. doi request reprint Experience of social discrimination correlates with neurometabolism: a pilot study in heroin addicts
    Ulrich Frischknecht
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, P O Box 12 21 20, 68072 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 263:197-203. 2013
    ..Further research is needed to elucidate factors associated with chronic stigmatization...
  9. doi request reprint Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
    ..4 T animal system seems a promising tool to study underlying mechanisms since it allows for an accurate quantification of metabolites with distinction of glutamate, GABA and glutamine, as well as separation of taurine from choline...
  10. doi request reprint Effects of alcoholism and continued abstinence on brain volumes in both genders
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 35:1678-85. 2011
    ....
  11. doi request reprint Diminished brain functional magnetic resonance imaging activation in patients on opiate maintenance despite normal spatial working memory task performance
    Patrick Bach
    Department Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Clin Neuropharmacol 35:153-60. 2012
    ..The objective of the study at hand was to investigate the effect of buprenorphine and methadone maintenance therapy on visuospatial working memory performance...
  12. ncbi request reprint Increased activation of the ACC during a spatial working memory task in alcohol-dependence versus heavy social drinking
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 34:771-6. 2010
    ..To transfer these results into adults, we used the same task in adults...
  13. doi request reprint MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex
    Derik Hermann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Germany
    Addict Biol 17:659-67. 2012
    ..Increased Cho concentrations in fWM corroborate findings of WM abnormalities in opioid-dependent subjects...
  14. ncbi request reprint Alcohol consumption significantly influences the MR signal of frontal choline-containing compounds
    Gabriele Ende
    Department of Neuroimaging and Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, PO Box 12 21 20, D 68072 Mannheim, Germany
    Neuroimage 32:740-6. 2006
    ....
  15. doi request reprint MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia
    Nuran Tunc-Skarka
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 48:525-31. 2009
    ..Furthermore, they elucidate why reports of a reduced N-acetylaspartate concentration in schizophrenia were not always corroborated...
  16. ncbi request reprint Long-term follow-up of magnetic resonance-detectable choline signal changes in the hippocampus of patients treated with electroconvulsive therapy
    Thomas Obergriesser
    Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychiatry 64:775-80. 2003
    ..The purpose of this investigation was to monitor the long-term course of the hippocampal metabolite signals post-ECT treatment...
  17. ncbi request reprint Multiregional 1H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia
    Gabriele Ende
    NMR Research in Psychiatry, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 253:9-15. 2003
    ..The hippocampus, thalamus and basal ganglia are among the brain regions of major interest in schizophrenia...
  18. doi request reprint Metabolic alterations in the amygdala in borderline personality disorder: a proton magnetic resonance spectroscopy study
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, 68159 Mannheim, Germany
    Biol Psychiatry 67:399-405. 2010
    ..0 T in which we acquire data within only the small amygdala. The purpose of this study was to determine alterations of the metabolism in the amygdala in BPD patients...
  19. ncbi request reprint Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 7:246-50. 2006
    ..Our data show a significant inverse correlation (p = 0.018) between PLA2 protein levels and MRS Cho/NAA levels suggesting a possible downregulation of PLA2 in compensation for an upregulation of other phospholipases...
  20. ncbi request reprint Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia
    Dieter F Braus
    NMR Research and Clinic for Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Eur Neuropsychopharmacol 12:145-52. 2002
    ..These results suggest that atypical antipsychotics modify the function of anterior cingulate neurons in a specific manner...
  21. ncbi request reprint Abnormal amygdala activation profile in pedophilia
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 258:271-7. 2008
    ..More extensive research in this field would be of benefit for both the victims and the offenders...
  22. ncbi request reprint Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol
    Nuran Tunc-Skarka
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty of Mannheim Heidelberg University, Germany
    NMR Biomed 27:228-34. 2014
    ..Our results corroborated the age-related changes in metabolite concentrations, and found evidence for a link between SCN1A and frontal white matter mI in healthy subjects...
  23. doi request reprint Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Drug Alcohol Depend 114:242-5. 2011
    ..Chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (THC) and cannabidiol (CBD)...
  24. doi request reprint Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum
    Sabine Vollstädt-Klein
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Addiction 105:1741-9. 2010
    ..In this study we address this hypothesis in the context of alcohol dependence...
  25. doi request reprint Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions
    Heike Tost
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Affect Disord 120:54-61. 2010
    ..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities...
  26. ncbi request reprint Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Neuroreport 14:2199-201. 2003
    ..A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed...
  27. ncbi request reprint Monitoring the effects of chronic alcohol consumption and abstinence on brain metabolism: a longitudinal proton magnetic resonance spectroscopy study
    Gabriele Ende
    Nuclear Magnetic Resonance Research in Psychiatry and Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 58:974-80. 2005
    ..This study focused on metabolic brain alterations in recently detoxified alcohol-dependent patients (S1) and their possible reversibility after 3 (S2) and 6 months (S3) of abstinence...
  28. doi request reprint SCN1A affects brain structure and the neural activity of the aging brain
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
    Biol Psychiatry 72:677-83. 2012
    ..rs10930201 was further observed to be related to differences in neural activity during a working memory task...
  29. doi request reprint In vivo voxel based morphometry: detection of increased hippocampal volume and decreased glutamate levels in exercising mice
    Sarah Biedermann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim, Germany
    Neuroimage 61:1206-12. 2012
    ..An inverse correlation of hippocampal gray matter volume and glutamate concentration indicates a possible implication of the glutamatergic system for hippocampal volume...
  30. ncbi request reprint Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Neuroreport 18:1469-73. 2007
    ..Our results corroborate previous findings of an amino-acid influence on the pathomechanisms of mood disorders...
  31. doi request reprint 3D RINEPT {1H}-31P CSI: a feasible approach for the study of membrane turnover in the human brain
    Tim Wokrina
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Magn Reson Med 59:999-1004. 2008
    ..5T. The 3D sequence design allows covering the whole brain in a single measurement, while scan times are compliant with clinical routine protocols...
  32. doi request reprint Altered phospholipid metabolism in schizophrenia: a phosphorus 31 nuclear magnetic resonance spectroscopy study
    Wolfgang Weber-Fahr
    Department of Neuroimaging, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Psychiatry Res 214:365-73. 2013
    ....
  33. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  34. ncbi request reprint D2 antidopaminergic modulation of frontal lobe function in healthy human subjects
    Heike Tost
    Department of Psychiatry and Psychotherapy, University of Heidelberg, Germany
    Biol Psychiatry 60:1196-205. 2006
    ..Two major neurophysiological models propose segregated functional circuits on the systems level as well as D(1) and D(2) receptor-dependent processing states on the cellular level (two-state model)...
  35. pmc Overlapping neural correlates of reading emotionally positive and negative adjectives
    Traute Demirakca
    Heidelberg Academy of Science, Department Neuroimaging, J5, 68159 Mannheim, Germany
    Open Neuroimag J 3:54-7. 2009
    ..The overlap of activated regions and lack of pronounced distinct regions supports the assumption that the processing of negative and positive words mainly takes place in overlapping brain regions...
  36. ncbi request reprint MR spectroscopy in Alzheimer's disease: gender differences in probabilistic learning capacity
    Michael Colla
    Central Institute of Mental Health, J 5, 68159, Mannheim, Germany
    Neurobiol Aging 24:545-52. 2003
    ..04). The altered metabolite signals and ratios in combination with the cognitive performance might suggest gender-related neuronal degeneration and dysfunction within subcortical regions in AD...
  37. ncbi request reprint Alcoholic neurobiology: changes in dependence and recovery
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 29:1504-13. 2005
    ....
  38. ncbi request reprint Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times
    Michael Colla
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    J Psychiatr Res 42:587-95. 2008
    ..The combination of performance deficits and elevated Ch levels in the ACC supports the hypothesis that subtle structural abnormalities underlie the functional alterations in ACC activation previously observed in ADHD patients...
  39. ncbi request reprint A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe
    Frank Träber
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur Radiol 16:1096-103. 2006
    ..This is the basis for applying (1)H-MRS in large-scale early recognition and treatment studies in MTL affecting disorders...
  40. ncbi request reprint Diffusion weighted MRI in the early phase after electroconvulsive therapy
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Neurol Res 29:256-9. 2007
    ..These findings are in line with previous negative studies using conventional MRI. Higher resolution DWI and serial imaging may be necessary to visualize possible minimal signal changes after ECT...