Michael Deuschle

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatment
    Michael Deuschle
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Psychiatry Res 136:1-6. 2005
  2. ncbi request reprint Resistin and adiponectin in major depression: the association with free cortisol and effects of antidepressant treatment
    Bettina Weber-Hamann
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    J Psychiatr Res 41:344-50. 2007
  3. doi request reprint Venlafaxine and mirtazapine treatment lowers serum concentrations of dehydroepiandrosterone-sulfate in depressed patients remitting during the course of treatment
    Georgios Paslakis
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159 Mannheim, Germany
    J Psychiatr Res 44:556-60. 2010
  4. doi request reprint Antidepressant treatment with mirtazapine, but not venlafaxine, lowers cortisol concentrations in saliva: a randomised open trial
    Barbara Scharnholz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychiatry Res 177:109-13. 2010
  5. ncbi request reprint Heart rate variability during antidepressant treatment with venlafaxine and mirtazapine
    Johannes Terhardt
    Central Institute of Mental Health, University of Heidelberg, Faculty of Medicine Mannheim, Mannheim, Germany and Department of Psychiatry and Psychotherapy, University Medical Center, University of Freiburg, Freiburg, Germany
    Clin Neuropharmacol 36:198-202. 2013
  6. doi request reprint Salivary cortisol in a middle-aged community sample: results from 990 men and women of the KORA-F3 Augsburg study
    Florian Lederbogen
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur J Endocrinol 163:443-51. 2010
  7. doi request reprint Pituitary-adrenal and sympathetic nervous system responses to stress in women remitted from recurrent major depression
    Thorben Ahrens
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychosom Med 70:461-7. 2008
  8. doi request reprint A single DEX/CRH test in male drug-free depressed patients is associated with the clinical response to treatment with fluoxetine
    Georgios Paslakis
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    J Psychiatr Res 44:1154-7. 2010
  9. ncbi request reprint Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine
    Bettina Weber-Hamann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychiatry 67:1856-61. 2006
  10. pmc Association between a serotonin transporter length polymorphism and primary insomnia
    Michael Deuschle
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Sleep 33:343-7. 2010

Detail Information

Publications39

  1. ncbi request reprint Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatment
    Michael Deuschle
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Psychiatry Res 136:1-6. 2005
    ..Serum SP concentrations were not related to treatment response or the class of antidepressant administered. Our data do not support the hypothesis that changes in SP levels in serum or CSF are related to antidepressant response...
  2. ncbi request reprint Resistin and adiponectin in major depression: the association with free cortisol and effects of antidepressant treatment
    Bettina Weber-Hamann
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    J Psychiatr Res 41:344-50. 2007
    ..03). In conclusion, the present data revealed resistin but not adiponectin to be related to free cortisol concentrations and to decline in remitters to antidepressive treatment...
  3. doi request reprint Venlafaxine and mirtazapine treatment lowers serum concentrations of dehydroepiandrosterone-sulfate in depressed patients remitting during the course of treatment
    Georgios Paslakis
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159 Mannheim, Germany
    J Psychiatr Res 44:556-60. 2010
    ....
  4. doi request reprint Antidepressant treatment with mirtazapine, but not venlafaxine, lowers cortisol concentrations in saliva: a randomised open trial
    Barbara Scharnholz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychiatry Res 177:109-13. 2010
    ..Thus, mirtazapine and venlafaxine show different effects on HPA system activity as measured by saliva cortisol. This may be of relevance with regard to physical sequelae of depression...
  5. ncbi request reprint Heart rate variability during antidepressant treatment with venlafaxine and mirtazapine
    Johannes Terhardt
    Central Institute of Mental Health, University of Heidelberg, Faculty of Medicine Mannheim, Mannheim, Germany and Department of Psychiatry and Psychotherapy, University Medical Center, University of Freiburg, Freiburg, Germany
    Clin Neuropharmacol 36:198-202. 2013
    ..The widely used antidepressants venlafaxine and mirtazapine led to further decline in HRV. Clinicians should consider HRV effects in the selection of antidepressants. ..
  6. doi request reprint Salivary cortisol in a middle-aged community sample: results from 990 men and women of the KORA-F3 Augsburg study
    Florian Lederbogen
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur J Endocrinol 163:443-51. 2010
    ..The aim of this study was to evaluate the concentrations of salivary cortisol in a large middle-aged community sample and to identify major factors associated with altered hormone levels...
  7. doi request reprint Pituitary-adrenal and sympathetic nervous system responses to stress in women remitted from recurrent major depression
    Thorben Ahrens
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychosom Med 70:461-7. 2008
    ..We characterized these systems at baseline and in response to a psychosocial stressor in a cohort of women remitted from recurrent major depression as well as in never-depressed healthy female controls...
  8. doi request reprint A single DEX/CRH test in male drug-free depressed patients is associated with the clinical response to treatment with fluoxetine
    Georgios Paslakis
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    J Psychiatr Res 44:1154-7. 2010
    ..The DEX/CRH test has been proposed to be suitable as a biomarker for the prediction of treatment response in depression...
  9. ncbi request reprint Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine
    Bettina Weber-Hamann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychiatry 67:1856-61. 2006
    ..Therefore, the aim of the present study was to examine whether insulin sensitivity improves during anti-depressive treatment in depressed patients with declining HPA system activity...
  10. pmc Association between a serotonin transporter length polymorphism and primary insomnia
    Michael Deuschle
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Sleep 33:343-7. 2010
    ..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia...
  11. ncbi request reprint Antagonism of the serotonin (5-HT)-2 receptor and insulin sensitivity: implications for atypical antipsychotics
    Maria Gilles
    Central Institute of Mental Health, Mannheim, Germany
    Psychosom Med 67:748-51. 2005
    ..We tested the hypothesis that antagonism of the serotonin (5-HT)-2 receptor impairs insulin sensitivity...
  12. doi request reprint Searching for responders to acamprosate and naltrexone in alcoholism treatment: rationale and design of the PREDICT study
    Karl Mann
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 33:674-83. 2009
    ..The "reward drinker/craver" is mainly associated with alterations in the dopaminergic and opioidergic system and responds to naltrexone...
  13. ncbi request reprint Restless legs syndrome: evidence for nocturnal hypothalamic-pituitary-adrenal system activation
    Claudia Schilling
    Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Mov Disord 25:1047-52. 2010
    ..Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable...
  14. ncbi request reprint Cortisol metabolism in depressed patients and healthy controls
    Benedikt Römer
    Central Institute of Mental Health, J5, Mannheim, Germany
    Neuroendocrinology 90:301-6. 2009
    ....
  15. doi request reprint The effect of a 4-week treatment with reboxetine on metabolic parameters of depressed inpatients
    Georgios Paslakis
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 261:173-7. 2011
    ..Due to the preliminary character of the present investigation, no conclusions about the clinical efficacy of reboxetine can be drawn...
  16. ncbi request reprint Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans
    Michael Deuschle
    Central Institute of Mental Health, Mannheim, Germany
    Neuropsychopharmacology 28:379-83. 2003
    ..7+/-4.6 nmol/l), but not in the young subgroup (pre: 15.6+/-11.3; post: 27.7+/-9.4 nmol/l). We thus conclude that the treatment of healthy controls with steroid-synthesis inhibitors does not lead to a major increase in CRH secretion...
  17. ncbi request reprint Antidepressive treatment with amitriptyline and paroxetine: effects on saliva cortisol concentrations
    Michael Deuschle
    Central Institute of Mental Health, Mannheim, and dagger Department of Psychiatry, Free University of Berlin, Berlin, Germany
    J Clin Psychopharmacol 23:201-5. 2003
    ..In hypercortisolemically depressed patients, treatment with AMI may be preferable to PAROX in order to lower HPA system activity...
  18. ncbi request reprint Circadian blood pressure regulation in hospitalized depressed patients and non-depressed comparison subjects
    Florian Lederbogen
    Central Institute of Mental Health, Mannheim, Germany
    Blood Press Monit 8:71-6. 2003
    ..Neuroendocrine dysregulation and disturbed sleep, frequently seen in major depression, may interfere with circadian blood pressure regulation...
  19. ncbi request reprint Effect of ambulatory blood pressure measurement on sleep in patients with a major depressive episode
    Florian Lederbogen
    Central Institute of Mental Health, Mannheim, Germany
    Blood Press Monit 8:187-90. 2003
    ..To assess the effects of ambulatory blood pressure measurement (ABPM) upon sleep in mentally depressed patients with near absence of deep (stage 3 and 4) sleep...
  20. ncbi request reprint Antidepressant treatment and dehydroepiandrosterone sulfate: different effects of amitriptyline and paroxetine
    Michael Deuschle
    Central Institute of Mental Health, Mannheim, Germany
    Neuropsychobiology 50:252-6. 2004
    ..However, there is only limited information about the effect of different classes of antidepressants on the course of adrenal androgens...
  21. ncbi request reprint Metabolic changes in elderly patients with major depression: evidence for increased accumulation of visceral fat at follow-up
    Bettina Weber-Hamann
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 31:347-54. 2006
    ..02; 11.5 +/- 2.7 vs. 7.8 +/- 1.9 mmol/l, p = 0.01). The larger proportion of visceral fat accumulation in patients may constitute a link for explaining the increased cardiovascular mortality in patients suffering from major depression...
  22. doi request reprint Impact of early parental child-rearing behavior on young adults' cardiometabolic risk profile: a prospective study
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
    Psychosom Med 72:156-62. 2010
    ..Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile...
  23. doi request reprint Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults
    Michael Deuschle
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Germany
    Curr Opin Psychiatry 26:60-5. 2013
    ..This review is an overview on antidepressant treatment and its potential metabolic risks...
  24. doi request reprint City living and urban upbringing affect neural social stress processing in humans
    Florian Lederbogen
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
    Nature 474:498-501. 2011
    ....
  25. ncbi request reprint Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease
    Solveig Horstmann
    Department of Neurology, Medical School, University of Heidelberg, Heidelberg, Germany
    Int Psychogeriatr 22:966-72. 2010
    ....
  26. ncbi request reprint Effect of mental and physical stress on platelet activation markers in depressed patients and healthy subjects: a pilot study
    Florian Lederbogen
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychiatry Res 127:55-64. 2004
    ..These preliminary results lend partial support to the hypothesis of an exaggerated platelet reactivity after physical activity in depression, thus possibly contributing to an increased cardiovascular risk in this disorder...
  27. ncbi request reprint MR spectroscopy in Alzheimer's disease: gender differences in probabilistic learning capacity
    Michael Colla
    Central Institute of Mental Health, J 5, 68159, Mannheim, Germany
    Neurobiol Aging 24:545-52. 2003
    ..04). The altered metabolite signals and ratios in combination with the cognitive performance might suggest gender-related neuronal degeneration and dysfunction within subcortical regions in AD...
  28. doi request reprint How depression may increase cardiac risk: effect of hypercortisolism on platelet activation markers: preliminary data
    Reka Baranyai
    Central Institute of Mental Health, Mannheim, Germany
    Neuropsychobiology 57:146-50. 2008
    ..Hypercortisolism, as seen in the majority of patients with major depression, may be associated with the generation of platelets that show signs of increased activation...
  29. ncbi request reprint Hypercortisolemic depression is associated with increased intra-abdominal fat
    Bettina Weber-Hamann
    Central Institute of Mental Health, Mannheim, Germany
    Psychosom Med 64:274-7. 2002
    ..Interestingly, both disorders share a specific endocrine syndrome that promotes the accumulation of visceral fat, which again is considered a marker of increased cardiovascular morbidity and mortality...
  30. ncbi request reprint Increased concentration of corticosteroid-binding globulin due to antidepressant treatment with amitritpyline, but not paroxetine
    Michael Deuschle
    J Psychiatr Res 37:85-7. 2003
  31. ncbi request reprint Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment
    Daniel Kopf
    Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychopharmacol 24:527-31. 2004
    ..Although uncontrolled, our data suggest that treatment of depression exerts a mainly beneficial effect on lipid regulation...
  32. ncbi request reprint Chronic but not acute hydrocortisone treatment shifts the response to an orthostatic challenge towards parasympathetic activity
    Annemarie Nonell
    Central Institute of Mental Health, Mannheim, Germany
    Neuroendocrinology 81:63-8. 2005
    ..Our data suggest that prolonged but not acute hydrocortisone administration shifts the autonomic response to an orthostatic challenge towards parasympathetic activity...
  33. ncbi request reprint Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients
    Bettina Weber-Hamann
    Central Institute of Mental Health, Mannheim, Campus Benjamin Franklin, Department of Psychiatry, Berlin, Germany
    Neuroendocrinology 81:200-4. 2005
    ..25, p < 0.04). These findings support the hypothesis that hypercortisolemia may lead to disturbed glucose utilization in depressed patients...
  34. ncbi request reprint Hippocampal volume reduction and HPA-system activity in major depression
    Michael Colla
    Department of Psychiatry, Charite, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    J Psychiatr Res 41:553-60. 2007
    ..Finally, we observed a trend for higher hippocampal volumes in those patients who showed a subsequent decrease in cortisol levels under pharmacotherapy...
  35. ncbi request reprint Effect of single-dose sertraline on the hypothalamus-pituitary-adrenal system, autonomic nervous system, and platelet function
    Thorben Ahrens
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychopharmacol 27:602-6. 2007
    ..We compared the reaction of these systems to physical stress with single-dose SSRI treatment (100 mg) with that of placebo treatment...
  36. ncbi request reprint Amitriptyline and paroxetine: effects upon peripheral nervous system (PNS)
    Oliver Henning
    J Clin Psychopharmacol 22:229-30. 2002
  37. ncbi request reprint Characterization of the neuronal dopamine transporter DAT in human blood platelets
    Pascal Frankhauser
    Department Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Neurosci Lett 399:197-201. 2006
    ....
  38. ncbi request reprint Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times
    Michael Colla
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    J Psychiatr Res 42:587-95. 2008
    ..The combination of performance deficits and elevated Ch levels in the ACC supports the hypothesis that subtle structural abnormalities underlie the functional alterations in ACC activation previously observed in ADHD patients...
  39. ncbi request reprint [Stabilizing affective symptoms without adverse cardiac effects. Myocardial infarct risk after depression--and vice versa]
    Michael Deuschle
    Zentralinstitut fur Seelische Gesundheit, J 5, D 68159 Mannheim
    MMW Fortschr Med 144:54-5. 2002