Research Topics
Genomes and GenesSpecies | Michael DeuschleSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Detail Information
Publications
Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatmentMichael Deuschle
Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
Psychiatry Res 136:1-6. 2005..Serum SP concentrations were not related to treatment response or the class of antidepressant administered. Our data do not support the hypothesis that changes in SP levels in serum or CSF are related to antidepressant response...- Resistin and adiponectin in major depression: the association with free cortisol and effects of antidepressant treatmentBettina Weber-Hamann
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
J Psychiatr Res 41:344-50. 2007..03). In conclusion, the present data revealed resistin but not adiponectin to be related to free cortisol concentrations and to decline in remitters to antidepressive treatment... 
Venlafaxine and mirtazapine treatment lowers serum concentrations of dehydroepiandrosterone-sulfate in depressed patients remitting during the course of treatmentGeorgios Paslakis
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159 Mannheim, Germany
J Psychiatr Res 44:556-60. 2010....- Antidepressant treatment with mirtazapine, but not venlafaxine, lowers cortisol concentrations in saliva: a randomised open trialBarbara Scharnholz
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Psychiatry Res 177:109-13. 2010..Thus, mirtazapine and venlafaxine show different effects on HPA system activity as measured by saliva cortisol. This may be of relevance with regard to physical sequelae of depression... - Salivary cortisol in a middle-aged community sample: results from 990 men and women of the KORA-F3 Augsburg studyFlorian Lederbogen
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Eur J Endocrinol 163:443-51. 2010..The aim of this study was to evaluate the concentrations of salivary cortisol in a large middle-aged community sample and to identify major factors associated with altered hormone levels... - Pituitary-adrenal and sympathetic nervous system responses to stress in women remitted from recurrent major depressionThorben Ahrens
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Psychosom Med 70:461-7. 2008..We characterized these systems at baseline and in response to a psychosocial stressor in a cohort of women remitted from recurrent major depression as well as in never-depressed healthy female controls... - A single DEX/CRH test in male drug-free depressed patients is associated with the clinical response to treatment with fluoxetineGeorgios Paslakis
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
J Psychiatr Res 44:1154-7. 2010..The DEX/CRH test has been proposed to be suitable as a biomarker for the prediction of treatment response in depression... - Restless legs syndrome: evidence for nocturnal hypothalamic-pituitary-adrenal system activationClaudia Schilling
Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Mov Disord 25:1047-52. 2010..Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable... - Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetineBettina Weber-Hamann
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
J Clin Psychiatry 67:1856-61. 2006..Therefore, the aim of the present study was to examine whether insulin sensitivity improves during anti-depressive treatment in depressed patients with declining HPA system activity... - Searching for responders to acamprosate and naltrexone in alcoholism treatment: rationale and design of the PREDICT studyKarl Mann
Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Alcohol Clin Exp Res 33:674-83. 2009..The study follows the assessment methods, treatments, and medications used in the U.S. based COMBINE study, which will allow for a direct comparison between this U.S. study trial and a study performed in Europe... - Cortisol metabolism in depressed patients and healthy controlsBenedikt Römer
Central Institute of Mental Health, J5, Mannheim, Germany
Neuroendocrinology 90:301-6. 2009.... - Antagonism of the serotonin (5-HT)-2 receptor and insulin sensitivity: implications for atypical antipsychoticsMaria Gilles
Central Institute of Mental Health, Mannheim, Germany
Psychosom Med 67:748-51. 2005..We tested the hypothesis that antagonism of the serotonin (5-HT)-2 receptor impairs insulin sensitivity... - The effect of a 4-week treatment with reboxetine on metabolic parameters of depressed inpatientsGeorgios Paslakis
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 261:173-7. 2011..Due to the preliminary character of the present investigation, no conclusions about the clinical efficacy of reboxetine can be drawn... 
Association between a serotonin transporter length polymorphism and primary insomniaMichael Deuschle
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
Sleep 33:343-7. 2010..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia...- Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humansMichael Deuschle
Central Institute of Mental Health, Mannheim, Germany
Neuropsychopharmacology 28:379-83. 2003..7+/-4.6 nmol/l), but not in the young subgroup (pre: 15.6+/-11.3; post: 27.7+/-9.4 nmol/l). We thus conclude that the treatment of healthy controls with steroid-synthesis inhibitors does not lead to a major increase in CRH secretion... - Antidepressive treatment with amitriptyline and paroxetine: effects on saliva cortisol concentrationsMichael Deuschle
Central Institute of Mental Health, Mannheim, and dagger Department of Psychiatry, Free University of Berlin, Berlin, Germany
J Clin Psychopharmacol 23:201-5. 2003..In hypercortisolemically depressed patients, treatment with AMI may be preferable to PAROX in order to lower HPA system activity... - Effect of ambulatory blood pressure measurement on sleep in patients with a major depressive episodeFlorian Lederbogen
Central Institute of Mental Health, Mannheim, Germany
Blood Press Monit 8:187-90. 2003..To assess the effects of ambulatory blood pressure measurement (ABPM) upon sleep in mentally depressed patients with near absence of deep (stage 3 and 4) sleep... - Circadian blood pressure regulation in hospitalized depressed patients and non-depressed comparison subjectsFlorian Lederbogen
Central Institute of Mental Health, Mannheim, Germany
Blood Press Monit 8:71-6. 2003..Neuroendocrine dysregulation and disturbed sleep, frequently seen in major depression, may interfere with circadian blood pressure regulation... - Antidepressant treatment and dehydroepiandrosterone sulfate: different effects of amitriptyline and paroxetineMichael Deuschle
Central Institute of Mental Health, Mannheim, Germany
Neuropsychobiology 50:252-6. 2004..However, there is only limited information about the effect of different classes of antidepressants on the course of adrenal androgens... - Metabolic changes in elderly patients with major depression: evidence for increased accumulation of visceral fat at follow-upBettina Weber-Hamann
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Psychoneuroendocrinology 31:347-54. 2006..02; 11.5 +/- 2.7 vs. 7.8 +/- 1.9 mmol/l, p = 0.01). The larger proportion of visceral fat accumulation in patients may constitute a link for explaining the increased cardiovascular mortality in patients suffering from major depression... - Impact of early parental child-rearing behavior on young adults' cardiometabolic risk profile: a prospective studyArlette F Buchmann
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
Psychosom Med 72:156-62. 2010..Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile... - Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's diseaseSolveig Horstmann
Department of Neurology, Medical School, University of Heidelberg, Heidelberg, Germany
Int Psychogeriatr 22:966-72. 2010.... - City living and urban upbringing affect neural social stress processing in humansFlorian Lederbogen
Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, 68159 Mannheim, Germany
Nature 474:498-501. 2011.... - Effect of mental and physical stress on platelet activation markers in depressed patients and healthy subjects: a pilot studyFlorian Lederbogen
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Psychiatry Res 127:55-64. 2004..These preliminary results lend partial support to the hypothesis of an exaggerated platelet reactivity after physical activity in depression, thus possibly contributing to an increased cardiovascular risk in this disorder... - MR spectroscopy in Alzheimer's disease: gender differences in probabilistic learning capacityMichael Colla
Central Institute of Mental Health, J 5, 68159, Mannheim, Germany
Neurobiol Aging 24:545-52. 2003..04). The altered metabolite signals and ratios in combination with the cognitive performance might suggest gender-related neuronal degeneration and dysfunction within subcortical regions in AD... - Effect of single-dose sertraline on the hypothalamus-pituitary-adrenal system, autonomic nervous system, and platelet functionThorben Ahrens
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
J Clin Psychopharmacol 27:602-6. 2007..We compared the reaction of these systems to physical stress with single-dose SSRI treatment (100 mg) with that of placebo treatment... - Hypercortisolemic depression is associated with increased intra-abdominal fatBettina Weber-Hamann
Central Institute of Mental Health, Mannheim, Germany
Psychosom Med 64:274-7. 2002..The fact that hypercortisolemia reverses depression-related fat loss, particularly in the visceral area, might partially explain why major depression can be considered a risk factor for cardiovascular disorders... - Increased concentration of corticosteroid-binding globulin due to antidepressant treatment with amitritpyline, but not paroxetineMichael Deuschle
J Psychiatr Res 37:85-7. 2003 - Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatmentDaniel Kopf
Central Institute of Mental Health, Mannheim, Germany
J Clin Psychopharmacol 24:527-31. 2004..Although uncontrolled, our data suggest that treatment of depression exerts a mainly beneficial effect on lipid regulation... - Chronic but not acute hydrocortisone treatment shifts the response to an orthostatic challenge towards parasympathetic activityAnnemarie Nonell
Central Institute of Mental Health, Mannheim, Germany
Neuroendocrinology 81:63-8. 2005..Our data suggest that prolonged but not acute hydrocortisone administration shifts the autonomic response to an orthostatic challenge towards parasympathetic activity... - Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patientsBettina Weber-Hamann
Central Institute of Mental Health, Mannheim, Campus Benjamin Franklin, Department of Psychiatry, Berlin, Germany
Neuroendocrinology 81:200-4. 2005..25, p < 0.04). These findings support the hypothesis that hypercortisolemia may lead to disturbed glucose utilization in depressed patients... - Hippocampal volume reduction and HPA-system activity in major depressionMichael Colla
Department of Psychiatry, Charite, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
J Psychiatr Res 41:553-60. 2007..Finally, we observed a trend for higher hippocampal volumes in those patients who showed a subsequent decrease in cortisol levels under pharmacotherapy... - How depression may increase cardiac risk: effect of hypercortisolism on platelet activation markers: preliminary dataReka Baranyai
Central Institute of Mental Health, Mannheim, Germany
Neuropsychobiology 57:146-50. 2008..Hypercortisolism, as seen in the majority of patients with major depression, may be associated with the generation of platelets that show signs of increased activation... - Amitriptyline and paroxetine: effects upon peripheral nervous system (PNS)Oliver Henning
J Clin Psychopharmacol 22:229-30. 2002 - Characterization of the neuronal dopamine transporter DAT in human blood plateletsPascal Frankhauser
Department Psychiatry, Central Institute of Mental Health, Mannheim, Germany
Neurosci Lett 399:197-201. 2006.... - [Stabilizing affective symptoms without adverse cardiac effects. Myocardial infarct risk after depression--and vice versa]Michael Deuschle
, J 5, D-68159 Mannheim
MMW Fortschr Med 144:54-5. 2002 - Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction timesMichael Colla
Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
J Psychiatr Res 42:587-95. 2008..The combination of performance deficits and elevated Ch levels in the ACC supports the hypothesis that subtle structural abnormalities underlie the functional alterations in ACC activation previously observed in ADHD patients...