- Presenilin is the molecular target of acidic γ-secretase modulators in living cellsThorsten Jumpertz
Department of Neuropathology, Heinrich Heine University, Duesseldorf, Germany
PLoS ONE 7:e30484. 2012..These findings indicate that potent acidic GSMs target presenilin to modulate the enzymatic activity of the γ-secretase complex...
- Tau protein and tau aggregation inhibitorsBruno Bulic
Center for Advanced European Studies and Research, Bonn, Germany
Neuropharmacology 59:276-89. 2010....
- Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structureStefanie Hahn
Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
J Neurochem 116:385-95. 2011..However, we also provide evidence that additional compound screens could discover GSMs that are able to break the attenuating effects of PSEN mutations...
- Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screeningHeiko Zettl
Department of Neuropathology, Heinrich Heine University, D 40225 Duesseldorf, Germany
ACS Chem Biol 7:1488-95. 2012..We describe the identification of a series of 4-hydroxypyridin-2-one derivatives, which display a novel type of γ-secretase modulation with equipotent inhibition of Aβ42 and Aβ38 peptide species...