Bruno Bulic

Summary

Affiliation: Center of Advanced European Studies and Research
Country: Germany

Publications

  1. pmc Presenilin is the molecular target of acidic γ-secretase modulators in living cells
    Thorsten Jumpertz
    Department of Neuropathology, Heinrich Heine University, Duesseldorf, Germany
    PLoS ONE 7:e30484. 2012
  2. doi request reprint Tau protein and tau aggregation inhibitors
    Bruno Bulic
    Center for Advanced European Studies and Research, Bonn, Germany
    Neuropharmacology 59:276-89. 2010
  3. doi request reprint Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure
    Stefanie Hahn
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    J Neurochem 116:385-95. 2011
  4. ncbi request reprint Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening
    Heiko Zettl
    Department of Neuropathology, Heinrich Heine University, D 40225 Duesseldorf, Germany
    ACS Chem Biol 7:1488-95. 2012

Collaborators

Detail Information

Publications4

  1. pmc Presenilin is the molecular target of acidic γ-secretase modulators in living cells
    Thorsten Jumpertz
    Department of Neuropathology, Heinrich Heine University, Duesseldorf, Germany
    PLoS ONE 7:e30484. 2012
    ..These findings indicate that potent acidic GSMs target presenilin to modulate the enzymatic activity of the γ-secretase complex...
  2. doi request reprint Tau protein and tau aggregation inhibitors
    Bruno Bulic
    Center for Advanced European Studies and Research, Bonn, Germany
    Neuropharmacology 59:276-89. 2010
    ....
  3. doi request reprint Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure
    Stefanie Hahn
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    J Neurochem 116:385-95. 2011
    ..However, we also provide evidence that additional compound screens could discover GSMs that are able to break the attenuating effects of PSEN mutations...
  4. ncbi request reprint Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening
    Heiko Zettl
    Department of Neuropathology, Heinrich Heine University, D 40225 Duesseldorf, Germany
    ACS Chem Biol 7:1488-95. 2012
    ..We describe the identification of a series of 4-hydroxypyridin-2-one derivatives, which display a novel type of γ-secretase modulation with equipotent inhibition of Aβ42 and Aβ38 peptide species...