Anne Claude Gavin

Summary

Affiliation: Cellzome AG
Country: Germany

Publications

  1. ncbi Functional organization of the yeast proteome by systematic analysis of protein complexes
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 415:141-7. 2002
  2. ncbi Proteome survey reveals modularity of the yeast cell machinery
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
  3. doi Interaction networks for systems biology
    Samuel Bader
    EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    FEBS Lett 582:1220-4. 2008
  4. ncbi Protein complexes and proteome organization from yeast to man
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1 69117 Heidelberg, Germany
    Curr Opin Chem Biol 7:21-7. 2003
  5. doi The social network of a cell: recent advances in interactome mapping
    Sebastian Charbonnier
    EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Biotechnol Annu Rev 14:1-28. 2008
  6. ncbi Keystone symposia: proteomics and bioinformatics and systems and biology
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Expert Rev Proteomics 2:291-3. 2005
  7. ncbi Structure-based assembly of protein complexes in yeast
    Patrick Aloy
    European Molecular Biology Laboratory, Structural and Computational Biology Programme, 1, 69117 Heidelberg, Germany
    Science 303:2026-9. 2004
  8. doi Recent advances in charting protein-protein interaction: mass spectrometry-based approaches
    Anne Claude Gavin
    EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Curr Opin Biotechnol 22:42-9. 2011
  9. doi Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins
    Kenji Maeda
    European Molecular Biology Laboratory, EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nature 501:257-61. 2013
  10. doi Proteome organization in a genome-reduced bacterium
    Sebastian Kühner
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 326:1235-40. 2009

Collaborators

Detail Information

Publications20

  1. ncbi Functional organization of the yeast proteome by systematic analysis of protein complexes
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 415:141-7. 2002
    ..This higher-order map contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery...
  2. ncbi Proteome survey reveals modularity of the yeast cell machinery
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
    ..This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling...
  3. doi Interaction networks for systems biology
    Samuel Bader
    EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    FEBS Lett 582:1220-4. 2008
    ..The aim of this review is to provide a short overview of the most promising contributions of interaction networks to human biology, structural biology and human genetics...
  4. ncbi Protein complexes and proteome organization from yeast to man
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1 69117 Heidelberg, Germany
    Curr Opin Chem Biol 7:21-7. 2003
    ..Recent proteome-wide studies provide insight into the properties of cellular protein complexes, their modular nature, their interaction with other complexes and the resulting preliminary organization chart of the proteome...
  5. doi The social network of a cell: recent advances in interactome mapping
    Sebastian Charbonnier
    EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Biotechnol Annu Rev 14:1-28. 2008
    ..The adaptation of these technologies to the large-scale measurement of biomolecular interactions in (semi-)quantitative terms represents an important challenge...
  6. ncbi Keystone symposia: proteomics and bioinformatics and systems and biology
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Expert Rev Proteomics 2:291-3. 2005
  7. ncbi Structure-based assembly of protein complexes in yeast
    Patrick Aloy
    European Molecular Biology Laboratory, Structural and Computational Biology Programme, 1, 69117 Heidelberg, Germany
    Science 303:2026-9. 2004
    ..We also consider interactions between complexes (cross-talk) and use these to construct a structure-based network of molecular machines in the cell...
  8. doi Recent advances in charting protein-protein interaction: mass spectrometry-based approaches
    Anne Claude Gavin
    EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Curr Opin Biotechnol 22:42-9. 2011
    ..In this review, we focus on recent developments in a suite of methods that enable the purification of protein complexes under native conditions and, in conjunction with protein mass spectrometry, identification of their constituents...
  9. doi Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins
    Kenji Maeda
    European Molecular Biology Laboratory, EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nature 501:257-61. 2013
    ....
  10. doi Proteome organization in a genome-reduced bacterium
    Sebastian Kühner
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 326:1235-40. 2009
    ..The data set provides a blueprint of the minimal cellular machinery required for life...
  11. pmc Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC
    Nicholas M I Taylor
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    J Biol Chem 288:15110-20. 2013
    ..Our results identify τ55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities, and provide a small set of regulated phosphosite targets in vivo...
  12. ncbi 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors
    Paola Grandi
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Mol Cell 10:105-15. 2002
    ..We conclude that the 40S synthesis machinery predominately associates with the 35S pre-rRNA factors, whereas factors required for 60S subunit synthesis largely bind later, showing an unexpected dichotomy in binding...
  13. ncbi A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    Tewis Bouwmeester
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 6:97-105. 2004
    ..This systems approach provides significant insight into the logic of the TNF-alpha/NF-kappa B pathway and is generally applicable to other pathways relevant to human disease...
  14. doi Drug target identification using side-effect similarity
    Monica Campillos
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 321:263-6. 2008
    ..Nine of these were tested and confirmed in cell assays, documenting the feasibility of using phenotypic information to infer molecular interactions and hinting at new uses of marketed drugs...
  15. doi Meeting report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome Biology
    Anne Claude Gavin
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell Proteomics 7:2288-91. 2008
    ..More than 60 nationalities were represented at the meeting...
  16. pmc A complex prediction: three-dimensional model of the yeast exosome
    Patrick Aloy
    EMBL, Meyerhofstrasse, Heidelberg, Germany
    EMBO Rep 3:628-35. 2002
    ..The model suggests numerous experiments to probe exosome function, particularly with respect to subunits making direct atomic contacts and conserved, possibly functional residues within the predicted central pore of the complex...
  17. ncbi The minimum information required for reporting a molecular interaction experiment (MIMIx)
    Sandra Orchard
    European Molecular Biology Laboratory EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Biotechnol 25:894-8. 2007
    ....
  18. ncbi Towards quantitative analysis of proteome dynamics
    Sebastian Kühner
    Nat Biotechnol 25:298-300. 2007
  19. pmc Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction
    Tatiana Cheusova
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Genes Dev 20:1800-16. 2006
    ..This is the first description of a regulatory cross-talk between MuSK and CK2 and of a role for the KI of the receptor tyrosine kinase MuSK for the development of subsynaptic specializations...
  20. pmc New perspectives on an old disease: proteomics in cancer research
    Oriol Gallego
    Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
    Genome Biol 8:303. 2007