Gerard Drewes

Summary

Affiliation: Cellzome AG
Country: Germany

Publications

  1. pmc Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics
    Armin Haupt
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    BMC Cancer 12:38. 2012
  2. ncbi request reprint MARKing tau for tangles and toxicity
    Gerard Drewes
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Trends Biochem Sci 29:548-55. 2004
  3. ncbi request reprint Global approaches to protein-protein interactions
    Gerard Drewes
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Opin Cell Biol 15:199-205. 2003
  4. ncbi request reprint The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth
    Gerard Drewes
    Cell Cycle Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    FEBS Lett 554:45-9. 2003
  5. doi request reprint Chemical proteomics in drug discovery
    Gerard Drewes
    Cellzome AG, Heidelberg, Germany
    Methods Mol Biol 803:15-21. 2012
  6. ncbi request reprint Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
    Pierre Olivier Angrand
    Cellzome AG and the European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell Proteomics 5:2211-27. 2006
  7. ncbi request reprint Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Biotechnol 25:1035-44. 2007
  8. doi request reprint Mass spectrometry approaches to monitor protein-drug interactions
    Nico Zinn
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Methods 57:430-40. 2012
  9. doi request reprint Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
    Marcus Bantscheff
    Cellzome AG, Heidelberg, Germany
    Nat Biotechnol 29:255-65. 2011
  10. doi request reprint The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains
    Antje Dittmann
    Cellzome GmbH, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    ACS Chem Biol 9:495-502. 2014

Detail Information

Publications22

  1. pmc Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics
    Armin Haupt
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    BMC Cancer 12:38. 2012
    ..However, its inhibition in healthy cells could also lead to severe side effects. This is the first comprehensive analysis of the response to Hsp90 inhibition at the kinome level...
  2. ncbi request reprint MARKing tau for tangles and toxicity
    Gerard Drewes
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Trends Biochem Sci 29:548-55. 2004
    ..Toxic consequences for the neuron might be exacerbated by tangle formation but are already evident during the early steps of the process...
  3. ncbi request reprint Global approaches to protein-protein interactions
    Gerard Drewes
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Opin Cell Biol 15:199-205. 2003
    ..Several large-scale proteomics technologies have been developed to generate comprehensive, cellular protein-protein interaction maps...
  4. ncbi request reprint The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth
    Gerard Drewes
    Cell Cycle Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    FEBS Lett 554:45-9. 2003
    ..Overexpression of kin1 results in a loss of polarity, with partially or fully rounded cells. From these results we suggest that kin1 is required to direct the growth machinery to the cell ends...
  5. doi request reprint Chemical proteomics in drug discovery
    Gerard Drewes
    Cellzome AG, Heidelberg, Germany
    Methods Mol Biol 803:15-21. 2012
    ..This chapter discusses examples of drug discovery processes where chemical proteomics-based assays using native endogenous proteins should have substantial impact...
  6. ncbi request reprint Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
    Pierre Olivier Angrand
    Cellzome AG and the European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell Proteomics 5:2211-27. 2006
    ....
  7. ncbi request reprint Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Biotechnol 25:1035-44. 2007
    ..The data suggest that our approach is a valuable tool for drug discovery...
  8. doi request reprint Mass spectrometry approaches to monitor protein-drug interactions
    Nico Zinn
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Methods 57:430-40. 2012
    ..This review provides an overview of current methods for the characterization of drug-target interactions by mass spectrometry and describes a protocol for chemoproteomic target binding studies using immobilized bioactive molecules...
  9. doi request reprint Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
    Marcus Bantscheff
    Cellzome AG, Heidelberg, Germany
    Nat Biotechnol 29:255-65. 2011
    ..Our approach enables the discovery of novel targets and inhibitors and suggests that the selectivity of HDAC inhibitors should be evaluated in the context of HDAC complexes and not purified catalytic subunits...
  10. doi request reprint The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains
    Antje Dittmann
    Cellzome GmbH, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    ACS Chem Biol 9:495-502. 2014
    ....
  11. doi request reprint Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP
    Isabelle Becher
    Cellzome GmbH, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    ACS Chem Biol 8:599-607. 2013
    ..This extensive and consistent data set of kinase-nucleotide affinities, determined for native enzymes under defined experimental conditions, will represent a useful resource for kinase drug discovery...
  12. ncbi request reprint Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
    Miro Brajenovic
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Biol Chem 279:12804-11. 2004
    ..Our findings suggest co-regulation and/or signaling events between the distinct Par complexes and provide a basis for further elucidation of the molecular mechanisms that govern cell polarity...
  13. ncbi request reprint Functional organization of the yeast proteome by systematic analysis of protein complexes
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 415:141-7. 2002
    ..This higher-order map contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery...
  14. doi request reprint Chemoproteomic approaches to drug target identification and drug profiling
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Bioorg Med Chem 20:1973-8. 2012
    ....
  15. doi request reprint A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation
    Giovanna Bergamini
    Cellzome AG, Heidelberg, Germany
    Nat Chem Biol 8:576-82. 2012
    ....
  16. doi request reprint Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care
    Ulrich Kruse
    Deptartment of Discovery Technology, Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell Proteomics 7:1887-901. 2008
    ..Moreover we highlight the emerging utility of pathway and chemical proteomics techniques for translational research in patient tissue...
  17. ncbi request reprint Proteome survey reveals modularity of the yeast cell machinery
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
    ..This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling...
  18. ncbi request reprint Pathway proteomics and chemical proteomics team up in drug discovery
    Carsten Hopf
    Cellzome AG, Department of Discovery Research, Heidelberg, Germany
    Neurodegener Dis 4:270-80. 2007
    ..The present review discusses some of the current experimental strategies, with a focus on applications in neurobiology...
  19. pmc Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson's Disease-Related Toxicity in Human Neurons
    Nigel Ramsden
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    ACS Chem Biol 6:1021-8. 2011
    ..These precise chemical probes further validate this emerging therapeutic strategy. They will enable more detailed studies of LRRK2-dependent signaling and pathogenesis and accelerate drug discovery...
  20. ncbi request reprint A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    Tewis Bouwmeester
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 6:97-105. 2004
    ..This systems approach provides significant insight into the logic of the TNF-alpha/NF-kappa B pathway and is generally applicable to other pathways relevant to human disease...
  21. ncbi request reprint MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes
    Bernhard Trinczek
    Department of Medicinal Chemistry, University of Kansas, Malott Hall, Lawrence, Kansas 66045, USA
    J Biol Chem 279:5915-23. 2004
    ....
  22. doi request reprint Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008