Tewis Bouwmeester

Summary

Affiliation: Cellzome AG
Country: Germany

Publications

  1. ncbi Functional organization of the yeast proteome by systematic analysis of protein complexes
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 415:141-7. 2002
  2. ncbi A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    Tewis Bouwmeester
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 6:97-105. 2004
  3. ncbi Modular decomposition of protein-protein interaction networks
    Julien Gagneur
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Genome Biol 5:R57. 2004
  4. ncbi Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
    Pierre Olivier Angrand
    Cellzome AG and the European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell Proteomics 5:2211-27. 2006
  5. ncbi Proteome survey reveals modularity of the yeast cell machinery
    Anne-Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
  6. ncbi Global approaches to protein-protein interactions
    Gerard Drewes
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Opin Cell Biol 15:199-205. 2003
  7. ncbi Human protein-protein interaction networks and the value for drug discovery
    Heinz Ruffner
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Drug Discov Today 12:709-16. 2007
  8. ncbi Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Biotechnol 25:1035-44. 2007
  9. ncbi Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
    Miro Brajenovic
    Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
    J Biol Chem 279:12804-11. 2004
  10. ncbi Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization
    Amaury Fernandez-Montalvan
    Expertise Platform Proteases, Novartis Institutes for BioMedical Research, Basel, Switzerland
    FEBS J 274:4256-70. 2007

Collaborators

Detail Information

Publications11

  1. ncbi Functional organization of the yeast proteome by systematic analysis of protein complexes
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 415:141-7. 2002
    ..This higher-order map contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery...
  2. ncbi A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    Tewis Bouwmeester
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 6:97-105. 2004
    ..This systems approach provides significant insight into the logic of the TNF-alpha/NF-kappa B pathway and is generally applicable to other pathways relevant to human disease...
  3. ncbi Modular decomposition of protein-protein interaction networks
    Julien Gagneur
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Genome Biol 5:R57. 2004
    ..The method is applied to experimental data on the pro-inflammatory tumor necrosis factor-alpha (TNF-alpha)/NFkappaB transcription factor pathway...
  4. ncbi Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
    Pierre Olivier Angrand
    Cellzome AG and the European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell Proteomics 5:2211-27. 2006
    ....
  5. ncbi Proteome survey reveals modularity of the yeast cell machinery
    Anne-Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
    ..This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling...
  6. ncbi Global approaches to protein-protein interactions
    Gerard Drewes
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Opin Cell Biol 15:199-205. 2003
    ..Several large-scale proteomics technologies have been developed to generate comprehensive, cellular protein-protein interaction maps...
  7. ncbi Human protein-protein interaction networks and the value for drug discovery
    Heinz Ruffner
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Drug Discov Today 12:709-16. 2007
    ....
  8. ncbi Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Biotechnol 25:1035-44. 2007
    ..The data suggest that our approach is a valuable tool for drug discovery...
  9. ncbi Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
    Miro Brajenovic
    Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
    J Biol Chem 279:12804-11. 2004
    ..Our findings suggest co-regulation and/or signaling events between the distinct Par complexes and provide a basis for further elucidation of the molecular mechanisms that govern cell polarity...
  10. ncbi Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization
    Amaury Fernandez-Montalvan
    Expertise Platform Proteases, Novartis Institutes for BioMedical Research, Basel, Switzerland
    FEBS J 274:4256-70. 2007
    ....
  11. ncbi Phosphorylation-dependent interaction of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (YWHA) with PADI6 following oocyte maturation in mice
    Alan J Snow
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA
    Biol Reprod 79:337-47. 2008
    ..These results indicate that phosphorylation and/or YWHA binding may serve as a means of intracellular PADI6 regulation...