Andrew C B Cato

Summary

Country: Germany

Publications

  1. ncbi request reprint Rapid actions of steroid receptors in cellular signaling pathways
    Andrew C B Cato
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Post Office Box 3640, D 76021 Karlsruhe, Germany
    Sci STKE 2002:re9. 2002
  2. pmc A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity
    J Schneikert
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, D 76021 Karlsruhe, Germany
    J Cell Biol 146:929-40. 1999
  3. pmc A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death
    Danilo Maddalo
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein Leopoldshafen, Germany
    PLoS ONE 7:e45690. 2012
  4. doi request reprint Depletion of the cellular levels of Bag-1 proteins attenuates phorbol ester-induced downregulation of IκBα and nuclear accumulation of NF-κB
    Jana V Maier
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, D 76344 Eggenstein Leopoldshafen, Germany
    Biochem Biophys Res Commun 401:406-11. 2010
  5. pmc The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor
    Liubov Shatkina
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, D 76021 Karlsruhe, Germany
    Mol Cell Biol 23:7189-97. 2003
  6. doi request reprint Specific N-terminal mutations in the human androgen receptor induce cytotoxicity
    Sarah F Funderburk
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, D 76021 Karlsruhe, Germany
    Neurobiol Aging 30:1851-64. 2009
  7. pmc Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis
    Anja Bruchmann
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, Eggenstein Leopoldshafen 76344, Germany
    BMC Cancer 13:96. 2013
  8. ncbi request reprint Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids
    Jana V Maier
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, D 76021 Karlsruhe, Germany
    Mol Endocrinol 21:2663-71. 2007
  9. ncbi request reprint Interdigital apoptosis and downregulation of BAG-1 expression in mouse autopods
    Alexander Crocoll
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, 76021, Karlsruhe, Germany
    Mech Dev 111:149-52. 2002
  10. doi request reprint Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures
    Tobias Jochum
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, D 76344 Eggenstein Leopoldshafen, Germany
    Biochim Biophys Acta 1822:1070-8. 2012

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Rapid actions of steroid receptors in cellular signaling pathways
    Andrew C B Cato
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Post Office Box 3640, D 76021 Karlsruhe, Germany
    Sci STKE 2002:re9. 2002
    ....
  2. pmc A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity
    J Schneikert
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, D 76021 Karlsruhe, Germany
    J Cell Biol 146:929-40. 1999
    ..These studies identify the [EEX(4)](8) sequence as a signature motif for inhibition of GR-mediated transactivation and demonstrate a specific nuclear action of a eukaryotic cochaperone in the regulation of GR activity...
  3. pmc A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death
    Danilo Maddalo
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein Leopoldshafen, Germany
    PLoS ONE 7:e45690. 2012
    ..This sequence therefore represents a candidate lead peptide for anti-tumor therapy...
  4. doi request reprint Depletion of the cellular levels of Bag-1 proteins attenuates phorbol ester-induced downregulation of IκBα and nuclear accumulation of NF-κB
    Jana V Maier
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, D 76344 Eggenstein Leopoldshafen, Germany
    Biochem Biophys Res Commun 401:406-11. 2010
    ..Thus Bag-1 proteins function as regulators of the action of selective transcription factors...
  5. pmc The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor
    Liubov Shatkina
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, D 76021 Karlsruhe, Germany
    Mol Cell Biol 23:7189-97. 2003
    ..These studies demonstrate the regulation of transcriptional activity of androgen receptor by a molecular chaperone-cochaperone complex...
  6. doi request reprint Specific N-terminal mutations in the human androgen receptor induce cytotoxicity
    Sarah F Funderburk
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, D 76021 Karlsruhe, Germany
    Neurobiol Aging 30:1851-64. 2009
    ..The response of the receptors to inhibitors of polyglutamine toxicity is altered by the amino acid exchanges suggesting that careful consideration is needed in the choice of potential therapies of disorders involving toxic polyQ species...
  7. pmc Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis
    Anja Bruchmann
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, Eggenstein Leopoldshafen 76344, Germany
    BMC Cancer 13:96. 2013
    ..Bag proteins like Bag1 and Bag3 have been implicated in tumor growth and survival but it is not known whether Bag5 also exhibits this function...
  8. ncbi request reprint Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids
    Jana V Maier
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, D 76021 Karlsruhe, Germany
    Mol Endocrinol 21:2663-71. 2007
    ..Thus GC-mediated antiinflammatory action is largely independent of DUSP1...
  9. ncbi request reprint Interdigital apoptosis and downregulation of BAG-1 expression in mouse autopods
    Alexander Crocoll
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, 76021, Karlsruhe, Germany
    Mech Dev 111:149-52. 2002
    ..On the contrary, the expression of BAG-1 remains unaltered in autopods of RARbeta(-/-)/RARgamma(-/-) mice which show severe interdigital webbing due to a marked decrease in interdigital apoptosis...
  10. doi request reprint Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures
    Tobias Jochum
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, D 76344 Eggenstein Leopoldshafen, Germany
    Biochim Biophys Acta 1822:1070-8. 2012
    ..Further comparative investigation of these reproducibly distinct toxic and non-toxic oligomers could advance our understanding of the molecular basis of the polyQ pathologies...
  11. ncbi request reprint Localization and dynamics of glucocorticoid receptor at the plasma membrane of activated mast cells
    Emmanuel Oppong
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, 76344, Eggenstein Leopoldshafen, Germany
    Small 10:1991-8. 2014
    ..These results demonstrate a membrane localization and function of the GR in mast cell signaling. ..
  12. ncbi request reprint The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy
    Andrew C B Cato
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, D 76021 Karlsruhe, Germany
    Curr Drug Targets Inflamm Allergy 3:347-53. 2004
    ..These will provide invaluable source of information for the search of glucocorticoid receptor agonists with potent anti-inflammatory but reduced side effects...