- Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicates SEC63 as potential target gene in hepatocarcinogenesisMarkus Casper
Department of Medicine II, Saarland University Medical Center, Homburg, Germany
Scand J Gastroenterol 48:344-51. 2013..Hepatocellular carcinoma (HCC) has not been considered part of the tumor spectrum. The aim was to provide a detailed molecular characterization of an HCC associated with Lynch Syndrome (Muir-Torre variant)...
- MUTYH hotspot mutations in unselected colonoscopy patientsM Casper
Department of Medicine II, Saarland University Medical Centre, Homburg, Germany
Colorectal Dis 14:e238-44. 2012..Y179C and p.G396D account for the majority of pathogenic variants of MUTYH in Caucasians. Our aim was to evaluate the prevalence of MUTYH mutations in a prospective cohort of unselected patients with different colorectal diseases...