Stefan Schreiber

Summary

Affiliation: Campus Kiel
Country: Germany

Publications

  1. doi request reprint Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn's disease
    S Schreiber
    Department of Medicine I, University Hospital Schleswig Holstein, Kiel, Christian Albrechts University, Germany
    J Crohns Colitis 7:213-21. 2013
  2. ncbi request reprint [Microbiome and nutrition : The way to a future therapy for chronic inflammatory bowel diseases?]
    S Schreiber
    Klinik fur Innere Medizin I, Universitatsklinikum Schleswig Holstein, Christian Albrechts Universitat zu Kiel, Schittenhelmstr 12, 24105, Kiel, Deutschland
    Internist (Berl) 55:889-97. 2014
  3. pmc Systematic association mapping identifies NELL1 as a novel IBD disease gene
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    PLoS ONE 2:e691. 2007
  4. ncbi request reprint [New biologics for treatment of chronic inflammatory bowel diseases]
    S Schreiber
    Klinik fur Innere Medizin I, Universitatsklinikum Schleswig Holstein, Christian Albrechts Universitat zu Kiel, Schittenhelmstr 12, 24105, Kiel, Deutschland
    Internist (Berl) 55:367-76. 2014
  5. doi request reprint [Genetic etiology of chronic inflammatory bowel disease]
    S Schreiber
    Klinik fur Innere Medizin I, Universitatsklinikum Schleswig Holstein, Campus Kiel, Christian Albrechts Universitat zu Kiel, Schittenhelmstr 12, 24105, Kiel, Deutschland
    Internist (Berl) 55:156-64. 2014
  6. pmc Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
    BMC Med Genet 13:31. 2012
  7. pmc Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing
    Abdou ElSharawy
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    BMC Genomics 13:417. 2012
  8. pmc Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing
    Abdou ElSharawy
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    BMC Genomics 13:500. 2012
  9. doi request reprint National differences in ulcerative colitis experience and management among patients from five European countries and Canada: an online survey
    Stefan Schreiber
    Department of Medicine I, University Hospital Schleswig Holstein, Christian Albrechts University, Schittenhelmstr 12, 24105 Kiel, Germany
    J Crohns Colitis 7:497-509. 2013
  10. pmc Perception gaps between patients with ulcerative colitis and healthcare professionals: an online survey
    Stefan Schreiber
    Department of Medicine I, University Hospital Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    BMC Gastroenterol 12:108. 2012

Detail Information

Publications195 found, 100 shown here

  1. doi request reprint Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn's disease
    S Schreiber
    Department of Medicine I, University Hospital Schleswig Holstein, Kiel, Christian Albrechts University, Germany
    J Crohns Colitis 7:213-21. 2013
    ..We examined the impact of disease duration on clinical outcomes and safety in a post hoc analysis of a remission maintenance trial with adalimumab in patients with moderate to severe CD...
  2. ncbi request reprint [Microbiome and nutrition : The way to a future therapy for chronic inflammatory bowel diseases?]
    S Schreiber
    Klinik fur Innere Medizin I, Universitatsklinikum Schleswig Holstein, Christian Albrechts Universitat zu Kiel, Schittenhelmstr 12, 24105, Kiel, Deutschland
    Internist (Berl) 55:889-97. 2014
    ....
  3. pmc Systematic association mapping identifies NELL1 as a novel IBD disease gene
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    PLoS ONE 2:e691. 2007
    ..Several associations were replicated in at least one independent sample, point to an involvement of ITGB6 (upstream), GRM8 (downstream), OR5V1 (downstream), PPP3R2 (downstream), NM_152575 (upstream) and HNF4G (intron)...
  4. ncbi request reprint [New biologics for treatment of chronic inflammatory bowel diseases]
    S Schreiber
    Klinik fur Innere Medizin I, Universitatsklinikum Schleswig Holstein, Christian Albrechts Universitat zu Kiel, Schittenhelmstr 12, 24105, Kiel, Deutschland
    Internist (Berl) 55:367-76. 2014
    ..However, there are several unmet needs which warrant the development of additional biologics for a better and complete control of the inflammatory process...
  5. doi request reprint [Genetic etiology of chronic inflammatory bowel disease]
    S Schreiber
    Klinik fur Innere Medizin I, Universitatsklinikum Schleswig Holstein, Campus Kiel, Christian Albrechts Universitat zu Kiel, Schittenhelmstr 12, 24105, Kiel, Deutschland
    Internist (Berl) 55:156-64. 2014
    ..Endpoints should include the avoidance of co-morbidities, which may be a limiting factor for patients with chronically active disease. ..
  6. pmc Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
    BMC Med Genet 13:31. 2012
    ..Recently, we identified the mitochondrial oxidative phosphorylation chain as a consistently overrepresented category in the published gene expression profiling (GEP) studies on CRC prognosis...
  7. pmc Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing
    Abdou ElSharawy
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    BMC Genomics 13:417. 2012
    ..To generate our own test model, we combined a sequence capture method with NGS in three experimental stages of increasing complexity (E. coli genes, multiplexed E. coli, and multiplexed HapMap BRCA1/2 regions)...
  8. pmc Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing
    Abdou ElSharawy
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    BMC Genomics 13:500. 2012
    ..Three of these samples were also preamplified by WGA and evaluated. We tested sample pooling or multiplexing strategies at different stages of the tested targeted NGS (T-NGS) workflow...
  9. doi request reprint National differences in ulcerative colitis experience and management among patients from five European countries and Canada: an online survey
    Stefan Schreiber
    Department of Medicine I, University Hospital Schleswig Holstein, Christian Albrechts University, Schittenhelmstr 12, 24105 Kiel, Germany
    J Crohns Colitis 7:497-509. 2013
    ..This study explored national differences in patients' and physicians' experiences, expectations, and beliefs about ulcerative colitis...
  10. pmc Perception gaps between patients with ulcerative colitis and healthcare professionals: an online survey
    Stefan Schreiber
    Department of Medicine I, University Hospital Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    BMC Gastroenterol 12:108. 2012
    ..The purpose of this study was to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs)...
  11. doi request reprint A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1
    Annegret Fischer
    Christian Albrechts University, Institute of Clinical Molecular Biology, Schittenhelmstrasse 12, Kiel, Germany
    Am J Respir Crit Care Med 186:877-85. 2012
    ..Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known...
  12. pmc Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine
    Ateequr Rehman
    Department of Environmental Health Sciences, University Medical Center, Breisacher Str 115B, D 79106 Freiburg, Germany
    BMC Microbiol 12:47. 2012
    ..Microbial metabolites (short chain fatty acids, lactate, branched chain fatty acids, and ammonia) and the intestinal microbiota were analyzed...
  13. pmc Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study
    J Herrmann
    Department of Physiology and Biochemistry of Nutrition, Max Rubner Institut, Federal Research Institute of Nutrition and Food, Karlsruhe and Kiel, Germany
    Lipids Health Dis 8:35. 2009
    ..After each intervention biopsies were taken, whole genome expression microarrays were applied, and genes of interest were verified by realtime PCR...
  14. pmc Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns
    Karol Szafranski
    Genome Analysis, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr, 07745 Jena, Germany
    Genome Biol 8:R154. 2007
    ..Intrigued by anecdotal evidence for functional non-AG 3' splice sites, we carried out a human genome-wide screen...
  15. pmc Phylogenetically widespread alternative splicing at unusual GYNGYN donors
    Michael Hiller
    Institute of Computer Science, Albert Ludwigs University Freiburg, Georges Koehler Allee 106, 79110 Freiburg, Germany
    Genome Biol 7:R65. 2006
    ..Here, we focus on unusual donor sites with the motif GYNGYN (Y stands for C or T; N stands for A, C, G, or T)...
  16. pmc NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner
    Marcel Kramer
    Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    BMC Res Notes 3:224. 2010
    ..NOD2 displays a tandem caspase recruitment domain (CARD) architecture, which is unique within the NLR family...
  17. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
    ..A substantial proportion of the inter-individual variability in S CR level is explicable by genetic factors...
  18. pmc Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study
    Marlo Möller
    Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, PO Box 19063, Stellenbosch University, Tygerberg 7505, South Africa
    BMC Infect Dis 10:154. 2010
    ..tuberculosis. Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis susceptibility, we investigated polymorphisms in eight candidate genes...
  19. pmc The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis
    Nadine Steubesand
    Department of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    BMC Immunol 10:36. 2009
    ..albicans. We used the esophageal cell line OE21 and analysed the role of paracrine signals from polymorphonuclear leukocytes (PMN) in an in vitro model of esophageal candidiasis...
  20. pmc A tissue-specific landscape of sense/antisense transcription in the mouse intestine
    Ulrich C Klostermeier
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    BMC Genomics 12:305. 2011
    ..With the advent of next generation sequencing and its utilization for the analysis of the RNA sequence space, the level of detail on the global architecture of the transcriptome reached a new order of magnitude compared to microarrays...
  21. pmc Comprehensive assessment of sequence variation within the copy number variable defensin cluster on 8p23 by target enriched in-depth 454 sequencing
    Stefan Taudien
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    BMC Genomics 12:243. 2011
    ..g. by the 1000 Genomes Project is confined by an affordable sequence depth. Combining target enrichment with NGS may represent a feasible approach...
  22. pmc Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing
    Stefan Taudien
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    BMC Genomics 11:252. 2010
    ..Here, we demonstrate that amplicon sequencing of pooled individual PCR products by the 454 technology allows in-depth determination of MSV haplotypes and estimation of DEFB CNs in parallel...
  23. pmc Functional characterization of two novel 5' untranslated exons reveals a complex regulation of NOD2 protein expression
    Philip Rosenstiel
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    BMC Genomics 8:472. 2007
    ..Tissue specific constitutive and inducible expression patterns of NOD2 have been described that result from complex regulatory events for which the molecular mechanisms are not yet fully understood...
  24. pmc Genetic diversity of the obligate intracellular bacterium Chlamydophila pneumoniae by genome-wide analysis of single nucleotide polymorphisms: evidence for highly clonal population structure
    Thomas Rattei
    Institute of Medical Microbiology and Hygiene, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Genomics 8:355. 2007
    ..Four published genomes revealed an identity of > 99 %. This remarkable finding raised questions about the existence of distinguishable genotypes in correlation with geographical and anatomical origin...
  25. pmc Recent transfer of an iron-regulated gene from the plastid to the nuclear genome in an oceanic diatom adapted to chronic iron limitation
    Markus Lommer
    Leibniz Institute of Marine Sciences at Kiel University IFM GEOMAR, Kiel, Germany
    BMC Genomics 11:718. 2010
    ..oceanica has been attributed to a decrease in the photosynthetic components that are rich in iron. Genomic information on T. oceanica may shed light on the genetic basis of the physiological differences between the two species...
  26. pmc Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Genet 9:38. 2008
    ..However, comprehensive genetic information about the TPI1 locus is still lacking...
  27. pmc Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model
    Rainer Noth
    Department of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    BMC Gastroenterol 11:109. 2011
    ..Because surveillance and biopsies of human gastrointestinal GvHD are difficult to perform, rare information of the alterations of the gastrointestinal barrier exists resulting in a need for systematic animal models...
  28. pmc Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
    Clemens Schafmayer
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
    BMC Gastroenterol 6:36. 2006
    ..This study aimed to define patterns of gallstone composition and identify demographic predictors of gallstone composition in a large sample of symptomatic gallstones from Northern Germany...
  29. pmc GMFilter and SXTestPlate: software tools for improving the SNPlex genotyping system
    Markus Teuber
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Arnold Heller Str, 3, D 24105 Kiel, Germany
    BMC Bioinformatics 10:81. 2009
    ..The high level of automation and the large amount of data produced in a high-throughput laboratory require advanced software tools for quality control and workflow management...
  30. pmc Can Zipf's law be adapted to normalize microarrays?
    Tim Lu
    Department of Medicine, Christian Albrechts University, Kiel, Germany
    BMC Bioinformatics 6:37. 2005
    ..A computationally simple and intuitively appealing technique based on this observation is presented...
  31. ncbi request reprint Genetics of Crohn disease, an archetypal inflammatory barrier disease
    Stefan Schreiber
    Institute for Clinical Molecular Biology, Center for Conservative Medicine, Christian Albrechts University Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Rev Genet 6:376-88. 2005
    ..These will probably target the molecular interaction on the mucosal surface between the products of the genome and the microbial metagenome of a patient...
  32. doi request reprint Randomised clinical trial: certolizumab pegol for fistulas in Crohn's disease - subgroup results from a placebo-controlled study
    S Schreiber
    Department of Medicine I, Christian Albrechts University, University Hospital Schleswig Holstein, Kiel, Germany
    Aliment Pharmacol Ther 33:185-93. 2011
    ..Treatment options for fistulizing Crohn's disease (CD) are limited...
  33. ncbi request reprint Mesalamine with MMX technology for the treatment of ulcerative colitis
    Stefan Schreiber
    Medicine and Gastroenterology, Institute for Clinical Molecular Biology, Center for Conservative Medicine, Schittenhelmstr 12, 24105, Kiel, Germany
    Expert Rev Gastroenterol Hepatol 2:299-314. 2008
    ....
  34. pmc The complicated path to true causes of disease: role of nuclear factor kappaB in inflammatory bowel disease
    S Schreiber
    Hospital for General Internal Medicine and Institute for Clinical Molecular Biology, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Gut 54:444-5. 2005
  35. ncbi request reprint A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease
    Stefan Schreiber
    Hospital for General Internal Medicine, Christian Albrechts University, Klinik für Allgemeine Innere Medizin, Kiel, Germany
    Gastroenterology 129:807-18. 2005
    ..To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease...
  36. doi request reprint Increased response and remission rates in short-duration Crohn's disease with subcutaneous certolizumab pegol: an analysis of PRECiSE 2 randomized maintenance trial data
    Stefan Schreiber
    Department of General Internal Medicine, Christian Albrechts University, Klinik für Allgemeine Innere Medizin, Universitätsklinicum Schleswig Holstein, Schittenhelmstrasse 12, Kiel 24105, Germany
    Am J Gastroenterol 105:1574-82. 2010
    ..We sought to analyze the efficacy (response and remission) and safety data from the PRECiSE 2 trial of certolizumab pegol according to duration of Crohn's disease since diagnosis at baseline...
  37. ncbi request reprint [Crohn's disease--infliximab, adalimumab and certolizumab-pegol: clinical value of anti-TNF-alpha treatment]
    S Schreiber
    Klinik für Allgemeine Innere Medizin und Institut für Klinische Molekularbiologie, Christian Albrechts Universitat, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Dtsch Med Wochenschr 132:1770-4. 2007
    ..An abscess has to be excluded. Due to the high risk of infection any symptoms which might be a sign of complications during therapy should result in a thorough diagnostic examination. Patients should be documented in registries...
  38. ncbi request reprint Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
    Stefan Schreiber
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Christian Aldrechb University, Kiel, Germany
    Clin Gastroenterol Hepatol 4:325-34. 2006
    ..This study investigated the efficacy and safety of BIRB 796, a highly potent inhibitor of p38 MAPK, in chronic active CD...
  39. ncbi request reprint Review article: exploration of the genetic aetiology of inflammatory bowel disease--implications for diagnosis and therapy
    S Schreiber
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Aliment Pharmacol Ther 20:1-8. 2004
    ..It can be anticipated that genomic findings will profoundly influence the future therapy of inflammatory bowel disease...
  40. ncbi request reprint Inflammatory bowel disease: immunologic concepts
    S Schreiber
    1st Department of Medicine, Christian Albrechts University, Kiel, Germany
    Hepatogastroenterology 47:15-28. 2000
    ..The exploration of the genetic etiology of inflammatory bowel disease holds great future promises...
  41. ncbi request reprint Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease
    S Schreiber
    First Medical Department, University Hospital Kiel, Germany
    Gastroenterology 120:1339-46. 2001
    ..The aim of this study was to investigate safety and efficacy of ISIS-2302 in chronic active Crohn's disease (CACD)...
  42. ncbi request reprint Use of anti-tumour necrosis factor agents in inflammatory bowel disease. European guidelines for 2001-2003
    S Schreiber
    Department of Medicine I, University Hospital Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Int J Colorectal Dis 16:1-11; discussion 12-3. 2001
    ..Biological agents will be followed by smaller and more stable, orally available compounds. These guidelines will be succeeded by a formal public consensus in 2002/2003...
  43. ncbi request reprint Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease
    S Schreiber
    1st Medical Department, Christian Albrechts University, Kiel, Germany
    Lancet 353:459-61. 1999
    ..We investigated the relation between production of TNF alpha and interleukin 1beta by mononuclear cells of the colonic lamina propria in patients with remitting Crohn's disease and the risk of relapse...
  44. ncbi request reprint Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group
    S Schreiber
    Charite University Hospital, Fourth Medical Department, Humboldt University, Berlin, Germany
    Gastroenterology 119:1461-72. 2000
    ..Interleukin (IL)-10 is a cytokine with potent anti-inflammatory properties. We investigated the safety and efficacy of different doses of human recombinant (rhu)IL-10 in patients with Crohn's disease (CD)...
  45. ncbi request reprint Maintenance therapy with certolizumab pegol for Crohn's disease
    Stefan Schreiber
    Hospital for General Internal Medicine, Christian Albrechts University, Kiel, Germany
    N Engl J Med 357:239-50. 2007
    ..Certolizumab pegol is a pegylated humanized Fab' fragment with a high binding affinity for tumor necrosis factor alpha that does not induce apoptosis of T cells or monocytes...
  46. pmc Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease
    S Schreiber
    1st Department of Medicine, Christian Albrechts University, Schittenhelmstrasse 12, Kiel, Germany
    Gut 51:379-85. 2002
    ....
  47. ncbi request reprint [Genetics and the environment. Has the picture become clearer?]
    S Schreiber
    Klinik für Allgemeine Innere Medizin, Christian Albrechts Universitat zu Kiel, Schittenhelmstrasse 12, 24105 Kiel
    Internist (Berl) 43:1335-41. 2002
  48. pmc Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling
    Oliver von Kampen
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D 24105, Germany
    J Biol Chem 285:19921-6. 2010
    ..Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells...
  49. doi request reprint A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians
    Almut Nebel
    Institute of Clinical Molecular Biology, the Christian Albrechts University, Kiel, Germany
    Mech Ageing Dev 130:691-9. 2009
    ..Given the survival advantage that is associated with the C allele of rs1776180, EXO1 can be considered a candidate for a novel longevity-enabling gene...
  50. ncbi request reprint Genetic variation in DLG5 is associated with inflammatory bowel disease
    Monika Stoll
    First Department of Medicine, University Hospital Schleswig Holstein, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Genet 36:476-80. 2004
    ..This is suggestive of a complex pattern of gene-gene interaction between DLG5 and CARD15, reflecting the complex nature of polygenic diseases. Further functional studies will evaluate the biological significance of DLG5 variants...
  51. ncbi request reprint Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection
    Philip Rosenstiel
    Institut für Klinische Molekularbiologie, Christian Albrechts Universitat, Kiel, Germany
    Cell Microbiol 8:1188-98. 2006
    ..6; P < 0.044]. H. pylori-induced upregulation of NOD1 and NOD2 in vivo may play a critical role in the recognition of this common pathogen. A missense mutation in the leucine-rich region of CARD15 is associated with gastric lymphoma...
  52. ncbi request reprint Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Gastroenterology 135:1207-15. 2008
    ..Crohn's disease (CD) and sarcoidosis (SA) are chronic inflammatory barrier diseases that share several clinical and immunological features, including the occurrence of granulomas...
  53. ncbi request reprint A functional promotor polymorphism of TNF-alpha is associated with primary gastric B-Cell lymphoma
    Stephan Hellmig
    Department of General Internal Medicine, University Clinics of Schleswig Holstein, Campus Kiel, Germany
    Am J Gastroenterol 100:2644-9. 2005
    ..We investigated four functional promotor polymorphisms in the TNF-alpha gene for association with the development of primary gastric B-cell lymphoma...
  54. pmc Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays
    Christine M Costello
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University of Kiel, Kiel, Germany
    PLoS Med 2:e199. 2005
    ..cDNA microarrays can be used to decipher gene regulation events at a genome-wide level and to identify novel unknown genes that might be involved in perpetuating inflammatory disease progression...
  55. pmc Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
    Athena Chalaris
    Institute of Biochemistry, Christian Albrechts University Kiel, D 24098 Kiel, Germany
    J Exp Med 207:1617-24. 2010
    ..Thus, our mouse model will help investigate ADAM17 as a potential drug target...
  56. ncbi request reprint Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations
    Valentina Medici
    Department of General and Internal Medicine, Institute for Clinical Molecular Biology, Christian Albrechts University, Schittenhelmstrasse 12, Kiel 24105, Germany
    Eur J Hum Genet 14:459-68. 2006
    ..035). The present results are consistent with an emerging pattern of a low frequency of the CARD15 variants in Northern countries where the prevalence of IBD is greatest...
  57. ncbi request reprint The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10
    Gregor Bochenek
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Hum Mol Genet 22:4516-27. 2013
    ..001 upon adjustment for sex and age. Our results give evidence that specific isoforms of ANRIL regulate key genes of glucose and fatty acid metabolism. ..
  58. ncbi request reprint Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
    Peter J P Croucher
    1st Department of Medicine, Christian Albrechts University, Kiel, Germany
    Eur J Hum Genet 11:6-16. 2003
    ..This approach, in conjunction with the examination of the mutational steps in a haplotype network, allows unambiguous identification of the potentially causative mutations...
  59. pmc Role of NOD2/CARD15 in coronary heart disease
    Nour Eddine El Mokhtari
    Department of Cardiology, University Hospital Schleswig Holstein, Kiel, Germany
    BMC Genet 8:76. 2007
    ....
  60. doi request reprint Fungi and inflammatory bowel diseases: Alterations of composition and diversity
    Stephan J Ott
    Institute for Clinical Molecular Biology, Christian Albrechts University CAU, Kiel, Germany
    Scand J Gastroenterol 43:831-41. 2008
    ..While a reduced bacterial diversity has been reported in IBD, little is known about the fungal microbiota. The aim of this study was to carry out a systematic analysis of intestinal fungal microbiota in IBD...
  61. ncbi request reprint Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection
    Stephan Hellmig
    Department of General Internal Medicine, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    Am J Gastroenterol 101:29-35. 2006
    ..The aim of this study was to investigate if genetic variants in MMPs involved in the inflammatory response to H. pylori could predispose patients with chronic H. pylori infection to develop gastric ulcer disease...
  62. ncbi request reprint Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome
    Inka Lindner
    Institute of Human Nutrition and Food Science, Molecular Nutrition, Christian Albrecht University, Kiel, Germany
    Mol Nutr Food Res 51:1447-51. 2007
    ..BMI tended to show lower values in His-allele carriers, (p = 0.067). In conclusion, risk-reducing effects of the minor His allele of the PTGES2 Arg298His polymorphism could be mediated partly by lowered BMI...
  63. doi request reprint mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease
    Stefanie Derer
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Gut 62:376-86. 2013
    ..The aim of this study was to analyse transcriptomal responses of reverse signalling induced by the TNFα binding agents infliximab (IFX) and CZP in myelomonocytic cells...
  64. doi request reprint Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis
    Sylvia Hofmann
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Eur Respir J 41:888-900. 2013
    ..Expression analyses of OS9 mRNA provide evidence for a functional mechanism underlying the detected association signal...
  65. ncbi request reprint Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus
    Oliver von Kampen
    Department of Internal Medicine I, Hospital Schleswig Holstein, Kiel, Germany
    Hepatology 57:2407-17. 2013
    ..2-fold, P = 0.003) only for the ABCG8-19H variant, which was also superior in nested logistic regression models in German (P = 0.018), Chilean (P = 0.030), and Chinese (P = 0.040) patient samples...
  66. doi request reprint Female-specific association of C-C chemokine receptor 5 gene polymorphisms with Löfgren's syndrome
    Annegret Fischer
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Schittenhelmstrasse 12, 24105, Kiel, Germany
    J Mol Med (Berl) 86:553-61. 2008
    ....
  67. doi request reprint Germline variations of the MALT1 gene as risk factors in the development of primary gastric B-cell lymphoma
    Stephan Hellmig
    Department of General Internal Medicine, University Hospital of Schleswig Holstein, Kiel, Germany
    Eur J Cancer 45:1865-70. 2009
    ..This is the first genetic association study that investigated polymorphisms of MALT1 as genetic risk factors in the development of primary gastric lymphoma...
  68. ncbi request reprint Postprandial plasma adiponectin decreases after glucose and high fat meal and is independently associated with postprandial triacylglycerols but not with -- 11388 promoter polymorphism
    Diana Rubin
    Institute of Physiology and Biochemistry of Nutrition, Federal Research Center of Nutrition and Food, Kiel, Germany
    Br J Nutr 99:76-82. 2008
    ..Our findings favour the interpretation that postprandial adiponectin has the strongest and independent associations to postprandial TAG metabolism...
  69. ncbi request reprint Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease
    Clemens Schafmayer
    Department of General Surgery and Thoracic Surgery, Christian Albrechts University Kiel, Kiel, Germany
    Liver Int 27:910-9. 2007
    ..Two attractive positional and functional candidate genes in apolipoprotein B mRNA-editing protein (APOBEC1) and peroxisome proliferator-activated receptor gamma (PPARG) are located in this interval...
  70. doi request reprint LINGO1 polymorphisms are associated with essential tremor in Europeans
    Sandra Thier
    Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Mov Disord 25:717-23. 2010
    ..Our study gives further evidence that LINGO1 acts as a susceptibility gene for ET...
  71. doi request reprint A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion
    Andreas Till
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 12, Kiel, Germany
    J Cell Sci 121:487-95. 2008
    ..We propose that the CD147-NOD2 interaction serves as a molecular guide to regulate NOD2 function at sites of pathogen invasion...
  72. ncbi request reprint Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity
    Mike Ufer
    University Hospital Schleswig Holstein, Arnold Heller Str 3 Hs 30 D 24105 Kiel, Germany
    Pharmacogenomics 10:1941-53. 2009
    ..Here, we compared the intestinal expression of drug transporters, metabolizing enzymes and putative regulatory genes between inflamed and noninflamed tissue and studied their modulation by disease activity...
  73. doi request reprint CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection
    Arne S Schaefer
    Christian Albrechts University Kiel, Institute for Clinical Molecular Biology, Kiel, Germany
    J Med Genet 48:38-47. 2011
    ..003) and GECs (p=0.004), respectively. Considering the global importance of CDKN2BAS in the disease risk of CHD, this observation supports the theory of inflammatory components in the disease physiology of CHD...
  74. ncbi request reprint Sarcoidosis is associated with a truncating splice site mutation in BTNL2
    Ruta Valentonyte
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Genet 37:357-64. 2005
    ..The resulting protein lacks the C-terminal IgC domain and transmembrane helix, thereby disrupting the membrane localization of the protein, as shown in experiments using green fluorescent protein and V5 fusion proteins...
  75. ncbi request reprint Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    J Clin Endocrinol Metab 92:3183-8. 2007
    ..On the basis of its chromosomal localization and its role in the synthesis of the antilipolytic compound prostaglandin E(2), the prostaglandin E synthase 2 (PTGES2) is a candidate gene for type 2 diabetes...
  76. ncbi request reprint Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease
    Rainer Noth
    Department of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Crohns Colitis 6:464-9. 2012
    ..The aim of the present study was to investigate the influence of anti-TNF-α antibody (infliximab) treatment on the intestinal barrier function of patients with active Crohn's disease...
  77. pmc A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology
    Katherine L Helbig
    Institute for Experimental Medicine, Section of Epidemiology, Christian Albrechts University of Kiel, Arnold Heller Strasse 3, Haus 3, 24105 Kiel, Germany
    BMC Med Genet 13:14. 2012
    ..However, little is known about a potential interaction between these risk factors. We investigated gene-environment interactions between CD-associated NOD2 alleles and cigarette smoking in a large sample of patients with CD...
  78. pmc Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB
    Christian Sina
    Institute of Clinical Molecular Biology, UKSH Campus Kiel, Kiel, Germany
    Inflamm Bowel Dis 16:320-31. 2010
    ..Addressing the potential role of gly96/iex-1 in the regulation of NF-kappaB in IBD, we used the dextran sodium sulfate (DSS) colitis model in mice in which the gly96/iex-1 gene had been deleted...
  79. ncbi request reprint Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
    Inke Nitz
    Department of Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University, Kiel, Germany
    Mol Nutr Food Res 51:1046-52. 2007
    ..03). In conclusion, we identified a common splice site mutation (rs2291726) of the GIP gene which results in a truncated protein and provide preliminary evidence for an association of the heterozygous GIPR Glu354Gln genotype with CVD...
  80. ncbi request reprint Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms
    Annegret Auinger
    Max Rubner Institut, Federal Research Institute of Nutrition and Food, Department of Physiology and Biochemistry of Nutrition, Kiel, Karlsruhe, Germany
    J Nutr 140:1411-7. 2010
    ..41; P < 0.01). Our data indicate that FABP2 expression depends on (n-3) FA intake and FABP2 genotypes. FABP2 might be involved in regulating food intake and intestinal FA utilization...
  81. ncbi request reprint Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion
    Philip Rosenstiel
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstrache 12, Kiel, Germany
    J Immunol 178:8203-11. 2007
    ..Dysregulated intestinal DMBT1 expression due to mutations in the NOD2/CARD15 gene may be part of the complex pathophysiology of barrier dysfunction in Crohn's disease...
  82. ncbi request reprint Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
    Andre Franke
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    Nat Genet 42:292-4. 2010
    ..81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively)...
  83. pmc A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways
    Philip Rosenstiel
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Kiel, Germany
    Proc Natl Acad Sci U S A 103:3280-5. 2006
    ..These data unveil another level of complexicity in the regulation of intracellular innate immunity and may have important implications for the molecular understanding of NOD/NALP protein-driven disease pathophysiology...
  84. doi request reprint The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses
    Sven Kuenzel
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Immunol 184:1990-2000. 2010
    ..We conclude that NLRC5 may represent a molecular switch of IFN-gamma activation sequence/IFN-specific response element signaling pathways contributing to antiviral defense mechanisms...
  85. doi request reprint Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease
    Tanja Kuehbacher
    1Clinic for General Internal Medicine, I Medical Department, University Hospital Schleswig Holstein UKSH, Campus Kiel, Brunswiker Str 10, D 24105 Kiel, Germany
    J Med Microbiol 57:1569-76. 2008
    ..g. as a promoter of inflammation at early stages of disease...
  86. pmc Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    Am J Hum Genet 90:636-47. 2012
    ..Our results show the usefulness of joint analyses of clinically distinct immune-mediated diseases and enlarge the map of shared genetic risk loci...
  87. ncbi request reprint GENOMIZER: an integrated analysis system for genome-wide association data
    Andre Franke
    Institute of Clinical Molecular Biology, Kiel Center of the German National Genotyping Platform, Christian Albrechts University, Kiel, Germany
    Hum Mutat 27:583-8. 2006
    ..We suggest that the use of this software will facilitate the handling and interpretation of the currently emerging genome-wide association data...
  88. pmc Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer
    Nikolaus Möckelmann
    Department of General Internal Medicine Christian Albrechts University, Kiel, Germany
    BMC Gastroenterol 9:79. 2009
    ....
  89. ncbi request reprint A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
    Almut Nebel
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Mech Ageing Dev 132:324-30. 2011
    ..A recent GWAS in Dutch LLI independently confirmed the APOE-longevity association, thus strengthening the conclusion that this locus is a very, if not the most, important genetic factor influencing longevity...
  90. ncbi request reprint Ulcerative colitis: conservative management and long-term effects
    Tanja Kühbacher
    I Medizinische Klinik, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Langenbecks Arch Surg 389:350-3. 2004
    ..v. can be used. If no response to treatment is seen, proctocolectomy should be considered. Biological agents such as beta-Interferon seem to be effective in mild to moderately ulcerative colitis, but further studies have to be performed...
  91. doi request reprint Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis
    Patricia Lepage
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    Gastroenterology 141:227-36. 2011
    ..We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional interaction between microbiota and mucosal epithelium...
  92. doi request reprint Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
    Sylvia Hofmann
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D 24105, Germany
    Nat Genet 40:1103-6. 2008
    ..Annexin A11 has complex and essential functions in several biological pathways, including apoptosis and proliferation...
  93. doi request reprint DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses
    Simone Lipinski
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    J Cell Sci 122:3522-30. 2009
    ..Our results demonstrate a new role of ROS as effector molecules of protective cellular signalling in response to a defined danger signal carried out by a mammalian intracellular NLR system...
  94. ncbi request reprint SNPSplicer: systematic analysis of SNP-dependent splicing in genotyped cDNAs
    Abdou ElSharawy
    Institute of Clinical Molecular Biology at the Christian Albrechts University, Kiel, Germany
    Hum Mutat 27:1129-34. 2006
    ..We anticipate that this methodology may help in the functional annotation of SNPs in a more high-throughput fashion...
  95. doi request reprint A comprehensive evaluation of SNP genotype imputation
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Kiel, Germany
    Hum Genet 125:163-71. 2009
    ..We nevertheless recommend either MACH or BEAGLE for practical use because these two programs are more user-friendly and generally require less memory than IMPUTE...
  96. ncbi request reprint A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels
    Diana Rubin
    Institute of Physiology and Biochemistry of Nutrition, Federal Research Center of Nutrition and Food, Hermann Weigmann Str 1, 24103, Kiel, Germany
    J Hum Genet 51:567-74. 2006
    ..007). These results suggest that the rare allele of the MTP I128T polymorphism may be protective against impaired glucose tolerance, type 2 diabetes and other parameters of the metabolic syndrome...
  97. doi request reprint Systematic evaluation of the effect of common SNPs on pre-mRNA splicing
    Abdou ElSharawy
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Kiel, Germany
    Hum Mutat 30:625-32. 2009
    ..The results highlight the need for a better understanding of the sequence characteristics of functional splice-sites to improve our ability to predict in silico the splicing relevance of empirically observed DNA sequence variants...
  98. ncbi request reprint A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    Jochen Hampe
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:207-11. 2007
    ..039). Together with the lack of association between rs2241880 and ulcerative colitis (P > 0.4), these data suggest that the underlying biological process may be specific to Crohn disease...
  99. doi request reprint Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC
    Susanne Billmann-Born
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    J Immunol 186:4027-38. 2011
    ..Lack of these regulatory events due to the L1007fsinsC variant may pivotally contribute to the induction and perpetuation of chronic inflammation...
  100. doi request reprint A genome-wide linkage analysis in 181 German sarcoidosis families using clustered biallelic markers
    Annegret Fischer
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Chest 138:151-7. 2010
    ..To reveal susceptibility variants with low frequencies but strong effects, we performed a genome-wide linkage scan in a large sample of SA families...
  101. ncbi request reprint Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel 24105, Germany
    Nat Genet 40:1319-23. 2008
    ..17 (1.01-1.34)). IL10 is an immunosuppressive cytokine that has long been proposed to influence IBD pathophysiology. Our findings strongly suggest that defective IL10 function is central to the pathogenesis of the UC subtype of IBD...