V Butterweck

Summary

Country: Germany

Publications

  1. ncbi request reprint Mechanism of action of St John's wort in depression : what is known?
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Munster, Germany
    CNS Drugs 17:539-62. 2003
  2. ncbi request reprint Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats
    V Butterweck
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Germany
    Planta Med 69:189-92. 2003
  3. ncbi request reprint Long-term effects of an Apocynum venetum extract on brain monoamine levels and beta-AR density in rats
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster, Domagkstrasse 12, 48149 Munster, Germany
    Pharmacol Biochem Behav 75:557-64. 2003
  4. ncbi request reprint In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Westfälische Wilhelms Universität Muenster, Domagkstrasse 12, 48149 Muenster, Germany
    Psychopharmacology (Berl) 162:193-202. 2002
  5. ncbi request reprint Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Domagkstrasse 12, 48149 Muenster, Germany
    Brain Res 930:21-9. 2002
  6. ncbi request reprint Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment
    V Butterweck
    Institute of Pharmacology and Toxicology, Munster, Germany
    Pharmacopsychiatry 34:S2-7. 2001
  7. ncbi request reprint Antidepressant effects of apocynum venetum leaves in a forced swimming test
    V Butterweck
    Institute of Pharmacology and Toxicology, WWU Muenster, Germany
    Biol Pharm Bull 24:848-51. 2001
  8. ncbi request reprint Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster, Domagkstrasse 12, 48149 Muenster, Germany
    Life Sci 73:627-39. 2003
  9. ncbi request reprint St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats
    V Butterweck
    Institute of Pharmacology and Toxicology, Domagkstrasse 12, 48149 Munster, Germany
    Mol Psychiatry 6:547-64. 2001
  10. ncbi request reprint Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex
    K Simbrey
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Domagkstrasse 12, 48149 Munster, Germany
    Life Sci 74:1027-38. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Mechanism of action of St John's wort in depression : what is known?
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Munster, Germany
    CNS Drugs 17:539-62. 2003
    ..This review integrates new findings of possible mechanisms that may underlie the antidepressant action of St John's wort and its active constituents with a large body of existing literature...
  2. ncbi request reprint Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats
    V Butterweck
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Germany
    Planta Med 69:189-92. 2003
    ..It can be speculated that, when administered together with these compounds, a significant accumulation of hypericin in rat plasma in the presence of both polyphenols might be responsible for the observed increased in vivo activity...
  3. ncbi request reprint Long-term effects of an Apocynum venetum extract on brain monoamine levels and beta-AR density in rats
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster, Domagkstrasse 12, 48149 Munster, Germany
    Pharmacol Biochem Behav 75:557-64. 2003
    ..125I]CYP binding to beta-adrenergic receptors was found to be decreased after 8 weeks treatment with imipramine, whereas AV-extract had no effect on beta-receptor binding...
  4. ncbi request reprint In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Westfälische Wilhelms Universität Muenster, Domagkstrasse 12, 48149 Muenster, Germany
    Psychopharmacology (Berl) 162:193-202. 2002
    ..Hypericum perforatum L. (St. John's wort; SJW) is one of the leading psychotherapeutic phytomedicines and great effort has been devoted to clarifying its mechanism of action...
  5. ncbi request reprint Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Domagkstrasse 12, 48149 Muenster, Germany
    Brain Res 930:21-9. 2002
    ..01). Our data clearly show that long-term, but not short-term administration of St. John's wort and its active constituent hypericin modify levels of neurotransmitters in brain regions involved in the pathophysiology of depression...
  6. ncbi request reprint Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment
    V Butterweck
    Institute of Pharmacology and Toxicology, Munster, Germany
    Pharmacopsychiatry 34:S2-7. 2001
    ..From our present data, we propose that cooperative effects of hypericin and procyanidin B2 are of important relevance for the acute, but not for the chronic effects of this polycylic quinone...
  7. ncbi request reprint Antidepressant effects of apocynum venetum leaves in a forced swimming test
    V Butterweck
    Institute of Pharmacology and Toxicology, WWU Muenster, Germany
    Biol Pharm Bull 24:848-51. 2001
    ..Further, it can be speculated that this effect might be related to hyperoside and isoquercitrin which are major flavonoids in the extract...
  8. ncbi request reprint Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster, Domagkstrasse 12, 48149 Muenster, Germany
    Life Sci 73:627-39. 2003
    ..We also could show that hyperforin contributes to the beneficial properties of SJW extract, confirming the hypothesis that the crude SJW extract contains several constituents with antidepressant activity...
  9. ncbi request reprint St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats
    V Butterweck
    Institute of Pharmacology and Toxicology, Domagkstrasse 12, 48149 Munster, Germany
    Mol Psychiatry 6:547-64. 2001
    ..However, imipramine appears to be more effective in blocking stress effects on the HPA axis than the plant extract...
  10. ncbi request reprint Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex
    K Simbrey
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Domagkstrasse 12, 48149 Munster, Germany
    Life Sci 74:1027-38. 2004
    ..Compared to the SJW extracts and single compounds the effect of imipramine on beta-AR-binding was more pronounced in both treatment paradigms...
  11. ncbi request reprint Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test
    V Butterweck
    Institute of Pharmacology and Toxicology, Westfalische Wilhelms Universitat, Munster, Germany
    Planta Med 66:3-6. 2000
    ..Except for quercetin, quercitrin and astilbin all compounds were active. To exclude false positive results in the FST the validity was checked in open field experiments and in the FST after 12 days of daily treatment...
  12. ncbi request reprint [Pharmacologic and clinical studies using Cimicifuga racemosa in climacteric complaints]
    H Winterhoff
    Institut für Pharmakologie und Toxikologie des Universitätsklinikums Münster, Deutschland
    Wien Med Wochenschr 152:360-3. 2002
    ..In addition pronounced effects on the central nervous system were shown. Taking these relevant therapeutic properties into account further experimental and clinical studies seem to be necessary and promising...
  13. doi request reprint Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application
    Sasiporn Sarawek
    College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Planta Med 74:221-7. 2008
    ..In conclusion, an aqueous ALE, caffeic acid derivatives and flavones exerted XO inhibitory effects in vitro but a hypouricemic activity could not be confirmed after oral administration...
  14. ncbi request reprint St. John's wort: role of active compounds for its mechanism of action and efficacy
    Veronika Butterweck
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32608, USA
    Wien Med Wochenschr 157:356-61. 2007
    ..Although there are some open questions, the bulk of data suggests that several groups of active compounds are contributing to the antidepressant efficacy of the plant extract...
  15. ncbi request reprint Potential of pharmacokinetic profiling for detecting herbal interactions with drugs
    Veronika Butterweck
    Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Clin Pharmacokinet 47:383-97. 2008
    ..Effective screening tools that accurately predict metabolic herb-drug interactions would offer a tremendous advantage because it is not possible to study all potential herb-drug interactions in clinical trials...
  16. ncbi request reprint Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test
    Oliver Grundmann
    College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesvilla, FL 32610, USA
    J Ethnopharmacol 110:406-11. 2007
    ..These results indicate that AV extract is an effective anxiolytic agent, and suggest that the anxiolytic-like activities of this plant are mainly mediated via the GABAergic system...
  17. ncbi request reprint Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice
    Oliver Grundmann
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Planta Med 72:1366-71. 2006
    ..1 mg/kg. In conclusion, using open field stress as a psychological stressor to induce hyperthermia in mice we were able to detect putative anxiolytic effects of SJW extract and single consituents...
  18. ncbi request reprint Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models
    Hiroyuki Sakakibara
    Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Biol Pharm Bull 29:1767-70. 2006
    ..The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models...
  19. ncbi request reprint Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella Colla
    Marcos J Salvador
    Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida dos Bandeirantes, 3900, 14040 901 Ribeirao Preto, Sao Paulo, Brasil
    Z Naturforsch C 61:19-25. 2006
    ..Moreover, the total soluble phenolic contents of the extract and fractions were measured using the Folin-Ciocalteau reagent and the quantitative analysis of flavone C-glycosides major constituents was performed by HPLC...
  20. ncbi request reprint Hyperforin in St. John's wort drug interactions
    Rajanikanth Madabushi
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O 100494, Gainesville, 32610, USA
    Eur J Clin Pharmacol 62:225-33. 2006
    ..In the present paper clinical significant SJW interactions are critically evaluated against the background of hyperforin...
  21. ncbi request reprint Effects of forced swimming stress on rat brain function
    Hiroyuki Sakakibara
    Department of Food Science, The University of Tokushima Graduate School, Japan
    J Med Invest 52:300-1. 2005
    ..These phenomena may be included in key mechanisms of the development of depression...
  22. ncbi request reprint Apocynum venetum extract does not induce CYP3A and P-glycoprotein in rats
    Michiya Kobayashi
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Biol Pharm Bull 27:1649-52. 2004
    ..These results suggest that, unlike SJW, the recommended dose of AV (3.3 mg/kg/d) would not influence hepatic CYP3A and intestinal P-gp in rats...
  23. ncbi request reprint Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?
    Veronika Butterweck
    Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
    Planta Med 70:784-91. 2004
    ..Efforts to identify all possible interactions will lead to limitless investigations and to inconsistent decisions...
  24. ncbi request reprint The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice
    Veronika Butterweck
    Institute of Pharmacology and Toxicology, Universitaetsklinikum Muenster, Domagkstrasse 12, Muenster 48149, Germany
    Behav Brain Res 144:49-56. 2003
    ..These data suggest that IL-6 plays an important role in the control of emotionality, but not in the regulation of body temperature after psychological stress...
  25. ncbi request reprint Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity
    Hilke Winterhoff
    Institute for Pharmacology and Toxicology, Central Clinic, University of Munster, Domagkstrasse 12, 48149 Munster, Germany
    Maturitas 44:S51-8. 2003
    ..These findings in pharmacological tests-a reduction of the frequency of hot flush equivalents and hints on antidepressant activity of Cimicifuga extracts-are in good agreement with the therapeutical responses in climacteric women...
  26. ncbi request reprint [What is known about St. John's wort? Phytochemistry and pharmacology]
    Veronika Butterweck
    Institut für Pharmazeutische Biologie und Phytochemie Westf Wilhelms Universität Hittorfstr 56 48149 Münster
    Pharm Unserer Zeit 32:212-9. 2003
  27. ncbi request reprint Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats
    Veronika Butterweck
    Section on Functional Neuroanatomy, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:2160-8. 2003
    ..These data suggest that hyperforin and hyperforin derivatives are not involved in the regulation of genes that control HPA axis function...
  28. ncbi request reprint Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies
    Whocely Victor De Castro
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O BOX 100494, Gainesville, Florida 32610 0494, USA
    J Agric Food Chem 54:249-55. 2006
    ..The concentration of potentially contributing compounds may crucially influence the magnitude of observed interaction and impair direct comparison of studies in which different juices have been used...
  29. ncbi request reprint Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodology
    Oliver Grundmann
    College of Pharmacy, Department of Pharmaceutics, University of Florida, FL 32608, USA
    Planta Med 73:1039-46. 2007
    ..divinorum...
  30. ncbi request reprint Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice
    Veronika Butterweck
    College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, PO Box 100494, FL 32610, USA
    J Pharm Pharmacol 59:549-52. 2007
    ..Thus, our data suggests that the hypothermic--and therefore the sleep-inducing--effects of hops extract are possibly mediated through activation of melatonin receptors...
  31. ncbi request reprint Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells
    Susanne U Mertens-Talcott
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O BOX 100494, Gainesville, FL 32610, USA
    J Agric Food Chem 55:2563-8. 2007
    ..Based on their relatively low concentrations (< or =3 microg/mL) in citrus, the clinical relevance of these interactions needs to be further elucidated in in vivo studies...
  32. doi request reprint Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats
    Whocely Victor De Castro
    Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, P O BOX 100494, Gainesville, FL 32610, USA
    J Agric Food Chem 56:4840-5. 2008
    ..5- to 1.8-fold, respectively. In conclusion, the effect of GFJ on P-gp activity seems to depend on the variety, the concentration of compounds in the juice, and the composition of different ingredients...