Elke Butt

Summary

Country: Germany

Publications

  1. pmc Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation
    T G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Grombuehlstr 12, D 97080 Wurzburg, Germany
    Br J Cancer 96:296-305. 2007
  2. pmc Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer
    J J Frietsch
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstr 12, 97080 Wuerzburg, Germany
    Br J Cancer 102:1645-53. 2010
  3. pmc Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides
    Katharina Werner
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstrasse 12, Wuerzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 384:169-76. 2011
  4. pmc The LIM and SH3 domain protein family: structural proteins or signal transducers or both?
    Thomas G P Grunewald
    Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Pediatric Oncology Center, Kolner Platz 1, D 80804 Munich, Germany
    Mol Cancer 7:31. 2008
  5. ncbi request reprint Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
    E Butt
    Medical University Clinic, Institute of Clinical Biochemistry and Pathobiochemistry, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 275:5179-87. 2000
  6. ncbi request reprint Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146
    Elke Butt
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 278:15601-7. 2003
  7. ncbi request reprint Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants
    E Butt
    Institute of Clinical Biochemistry and Pathochemistry, Medical University Clinic, Wurzburg, Germany
    J Biol Chem 276:7108-13. 2001
  8. ncbi request reprint Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
    Christian Keicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 324:308-16. 2004
  9. doi request reprint Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase
    Julia Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Thromb Haemost 102:520-8. 2009
  10. ncbi request reprint Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Endocrinol Metab 290:E423-33. 2006

Collaborators

Detail Information

Publications20

  1. pmc Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation
    T G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Grombuehlstr 12, D 97080 Wurzburg, Germany
    Br J Cancer 96:296-305. 2007
    ..The data provide evidence for an essential role of LASP-1 in tumour cell growth and migration, possibly through influencing zyxin localization...
  2. pmc Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer
    J J Frietsch
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstr 12, 97080 Wuerzburg, Germany
    Br J Cancer 102:1645-53. 2010
    ..This current study analysed the prognostic significance of LASP-1 on overall survival (OS) in 177 breast cancer patients and addressed the suggested mechanisms of LASP-1-regulation...
  3. pmc Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides
    Katharina Werner
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstrasse 12, Wuerzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 384:169-76. 2011
    ....
  4. pmc The LIM and SH3 domain protein family: structural proteins or signal transducers or both?
    Thomas G P Grunewald
    Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Pediatric Oncology Center, Kolner Platz 1, D 80804 Munich, Germany
    Mol Cancer 7:31. 2008
    ..The increased expression of LASP-1 in breast tumours correlates with high rates of nodal-metastasis and refers to a possible relevance as a prognostic marker...
  5. ncbi request reprint Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
    E Butt
    Medical University Clinic, Institute of Clinical Biochemistry and Pathobiochemistry, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 275:5179-87. 2000
    ....
  6. ncbi request reprint Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146
    Elke Butt
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 278:15601-7. 2003
    ..Taken together, these data suggest that phosphorylation of LASP by cGK and cAK may be involved in cytoskeletal organization and cell motility...
  7. ncbi request reprint Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants
    E Butt
    Institute of Clinical Biochemistry and Pathochemistry, Medical University Clinic, Wurzburg, Germany
    J Biol Chem 276:7108-13. 2001
    ..These data suggest that phosphorylation of Hsp27 and Hsp27-dependent regulation of actin microfilaments contribute to the inhibitory effects of cGK on platelet function...
  8. ncbi request reprint Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
    Christian Keicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 324:308-16. 2004
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1...
  9. doi request reprint Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase
    Julia Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Thromb Haemost 102:520-8. 2009
    ..Concomitant with adhesion, LASP-1 translocated from the cytosol along the arms of the pseudopodia into the leading lamellae of the spreading platelets, indicating a crucial role of the protein in platelet cytoskeleton rearrangement...
  10. ncbi request reprint Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Endocrinol Metab 290:E423-33. 2006
    ..Our results suggest that ZG cells, in addition to PKA and Epac/Rap proteins, contain other as yet unidentified cAMP mediator(s) involved in regulating CaMK activity and aldosterone secretion...
  11. pmc Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma
    Thomas G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstr, 12, D 97080 Wuerzburg, Germany
    BMC Cancer 7:198. 2007
    ....
  12. ncbi request reprint Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Germany
    Blood 103:2593-600. 2004
    ..One explanation for these discrepancies is the novel finding that extracellular cGMP analogs potently and rapidly inhibit thrombin-, thromboxane-, and VWF-induced human platelet signaling and activation by a cGK-independent mechanism...
  13. ncbi request reprint cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry Medical University Clinic Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    J Biol Chem 278:29640-8. 2003
    ..The results presented indicate that PKG II activity in ZG cells is important for maintaining basal aldosterone production...
  14. ncbi request reprint Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells
    Thomas G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Grombühlstr 12, D 97080 Wurzburg, Germany
    Exp Cell Res 312:974-82. 2006
    ..The data provide evidence for an essential role of LASP-1 in tumor cell growth and migration, possibly by influencing the localization of zyxin...
  15. doi request reprint Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma
    Christopher Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Wuerzburg, Germany
    Cancer Res 70:8003-14. 2010
    ....
  16. pmc Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation
    Gaby Wangorsch
    Department of Bioinformatics, Biocenter, University of Wurzburg, Germany
    BMC Syst Biol 5:178. 2011
    ..Modeling of pharmacodynamics allows understanding this intricate signaling and supports the precise description of these pivotal targets for pharmacological modulation...
  17. ncbi request reprint Dynamic interaction between Src and C-terminal Src kinase in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton
    Martin Vielreicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, D 97080 Wurzburg, Germany
    J Biol Chem 282:33623-31. 2007
    ..The novel experimental FRET approach reported here for the inactivation of Src can be readily applied to other integrin and signaling pathways, including closely related Src family kinase members...
  18. doi request reprint Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays
    Semjon Willier
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Biol Cell 105:317-33. 2013
    ..Finally, we discuss current approaches to specifically target the LPA/LPAR circuits in experimental cancer therapy. ..
  19. pmc The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Wuerzburg, Germany
    Br J Pharmacol 167:826-38. 2012
    ..As it has been shown that Rp-cGMPS and KT5823 have numerous non-specific effects, we analysed the pharmacological properties of the oligopeptide (D)-DT-2 described as a highly specific, membrane-permeable, PKG inhibitor...
  20. doi request reprint Defining the role of TRIP6 in cell physiology and cancer
    Semjon Willier
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Grombühlstrasse 12, 97080 Wurzburg, Germany
    Biol Cell 103:573-91. 2011
    ....