Birgitta C Burckhardt

Summary

Country: Germany

Publications

  1. request reprint
    Burckhardt B, Henjakovic M, Hagos Y, Burckhardt G. Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). Pflugers Arch. 2016;468:1909-1918 pubmed
  2. Schweikhard E, Kempson S, Ziegler C, Burckhardt B. Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress. Am J Physiol Renal Physiol. 2014;307:F107-15 pubmed publisher
    ..T40A, however, cannot be phosphorylated, as revealed using a specific anti-phosphoantibody, and, therefore, T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane. ..
  3. Schwob E, Hagos Y, Burckhardt G, Burckhardt B. Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency. Am J Physiol Renal Physiol. 2014;307:F1373-9 pubmed publisher
    ..Efflux of NCG across the luminal membrane into the tubular lumen probably occurs by OAT4 completing renal secretion of this drug. ..
  4. Burckhardt B, Henjakovic M, Hagos Y, Burckhardt G. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. J Pharmacol Exp Ther. 2017;362:450-458 pubmed publisher
    ..At OAT1, more than one binding site must be assumed to explain substrate and drug-dependent stimulation and inhibition of transport activity. ..
  5. Henjakovic M, Hagos Y, Krick W, Burckhardt G, Burckhardt B. Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function. Am J Physiol Renal Physiol. 2015;309:F843-51 pubmed publisher
    ..These experiments suggest that OAT2-mediated cGMP uptake does not occur via exchange with monocarboxylates, dicarboxylates, and hydroxyl ions. The counter anion for electroneutral cGMP uptake remains to be identified. ..

Collaborators