Research Topics
| A BuchmannSummaryCountry: Germany Publications
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Detail Information
Publications
Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesisAlbrecht Buchmann
Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
Mutat Res 638:66-74. 2008....- Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activityA Buchmann
Institute of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
Cell Death Differ 6:190-200. 1999.... - Transforming growth factor-beta1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cellsC L Buenemann
Institute of Toxicology, , Wilhelmstrabetae 56, , Germany
Carcinogenesis 22:447-52. 2001.... - p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesionsA Kalkuhl
Institute of Toxicology, University of Tubingen, Germany
Hepatology 27:1081-8. 1998.... - Ah receptor ligands and tumor promotion: survival of neoplastic cellsM Schwarz
Institute of Toxicology, University of Tubingen, Wilhelmstr 56, D 72074, Tubingen, Germany
Toxicol Lett 112:69-77. 2000..The present paper reviews some of the effects of TCDD on liver cell homeostasis that have been observed under diverse experimental settings and discusses some of the possible underlying mechanisms... 
Tumor promotion in liver of mice with a conditional Cx26 knockoutPhilip Marx-Stoelting
Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
Toxicol Sci 103:260-7. 2008..Altogether our present data show that elimination of Cx26 has only minor effects on chemically induced mouse hepatocarcinogenesis, in striking contrast to the effects seen in Cx32 KO mice...- Effect of the tumor promoter phenobarbital on the pattern of global gene expression in liver of connexin32-wild-type and connexin32-deficient miceSabine Stahl
Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Germany
Int J Cancer 115:861-9. 2005.... - Genotype-phenotype relationships in hepatocellular tumors from mice and manSabine Stahl
, Abteilung Toxikologie, , Wilhelmstrasse 56, , Germany
Hepatology 42:353-61. 2005..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index/html)... - Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomasAlbert Braeuning
Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Wilhelmstr 56, 72074 Tuebingen, Germany
Drug Metab Dispos 35:503-7. 2007..These findings favor the hypothesis that gene expression patterns in periportal and perivenous hepatocytes are regulated, at least in part, by Ras- and beta-catenin-dependent signaling pathways... - Global gene expression in Ha-ras and B-raf mutated mouse liver tumorsMaike Jaworski
Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
Int J Cancer 121:1382-5. 2007..The similarity in the patterns of global gene expression of Ha-ras and B-raf mutated liver tumors suggests that mutational activation of the 2 oncogenes results in activation of a common set of transcriptional regulators... - B-raf and Ha-ras mutations in chemically induced mouse liver tumorsMaike Jaworski
1Institut für Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
Oncogene 24:1290-5. 2005..These fundamental differences between the biology of liver tumors in mice and man may be of toxicological relevance... - A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumorsSandra Loeppen
Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tuebingen, Wilhelmstrasse 56, 72074 Tuebingen, Germany
Carcinogenesis 26:239-48. 2005.... - Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbitalSandra Loeppen
, , Germany
Cancer Res 62:5685-8. 2002..These data suggest that promotion of hepatocarcinogenesis by PB confers beta-catenin-mutated tumor cells with a selective advantage by up-regulation of GS expression... - Role of connexin32 and beta-catenin in tumor promotion in mouse liverMichael Schwarz
Institut fur Pharmakologie und Toxikologie, Universitat Tubingen, Tubingen, Germany
Toxicol Pathol 31:99-102. 2003..The link between beta-catenin-signaling and Cx32-dependent gap junctional intercellular communication, if existent, remains obscure... - WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null miceOliver Moennikes
Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstr 56, D 72074 Tubingen, Germany
Carcinogenesis 24:1561-5. 2003..Our results demonstrate significant differences between mouse liver lesions of differing phenotype and genotype in their response towards selection by Wy-14,643 during the promotional phase of hepatocarcinogenesis... - Proteome analysis of chemically induced mouse liver tumors with different genotypeJulia Strathmann
Department of Toxicology, University of Tubingen, Tubingen, Germany
Proteomics 7:3318-31. 2007..Our data suggest that GS(+) and GS(-) tumor cells show a completely different biology and use divergent evolutionary strategies to gain a selective advantage over normal hepatocytes... - Serum components and activated Ha-ras antagonize expression of perivenous marker genes stimulated by beta-catenin signaling in mouse hepatocytesAlbert Braeuning
Institute of Pharmacology und Toxicology, Department of Toxicology, University of Tuebingen, Germany
FEBS J 274:4766-77. 2007..These data suggest that activation of the Ras/mitogen-activated protein kinase (extracellular signal-regulated kinase) pathway favors periportal gene expression while simultaneously antagonizing a perivenous phenotype of hepatocytes... - Differential gene expression in periportal and perivenous mouse hepatocytesAlbert Braeuning
Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Germany
FEBS J 273:5051-61. 2006..Our results confirm previous findings on metabolic zonation in liver, and extend our knowledge of the regulatory mechanisms at the transcriptional level... - PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumorsJulia Strathmann
Department of Toxicology, University of Tuebingen, 72074 Tuebingen, Germany
Toxicol Sci 93:34-40. 2006..These results clearly indicate that PCB 153 strongly selects for Catnb-mutated, GS-positive liver tumors, which is similar to the known action of PB, a prototypical tumor promoter in rodent liver... - Zonal gene expression in murine liver: lessons from tumorsStephan Hailfinger
Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Germany
Hepatology 43:407-14. 2006..In conclusion, gradients of opposing signaling molecules along the portocentral axis determine the pattern of enzymes and other proteins expressed in hepatocytes of the periportal and pericentral domains of the liver lobule... - Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liverVeit-Simon Eckle
Institute of Pharmacology and Toxicology, Department of Toxicology, , Wilhelmstr. 56, , Germany
Toxicol Pathol 32:9-15. 2004..In summary, this study demonstrates that cleaved caspase-positive apoptotic hepatocytes could be reliably identified and quantified both in normal and neoplastically transformed liver tissue... - A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in miceOliver Moennikes
Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstrasse 56, 72074 Tubingen, Germany
Cancer Res 64:4707-10. 2004.... - Insulin and dexamethasone inhibit TGF-beta-induced apoptosis of hepatoma cells upstream of the caspase activation cascadeInes Wanke
Department of Toxicology, Institute of Pharmacology and Toxicology, , Wilhelmstr. 56, , Germany
Toxicology 204:141-54. 2004..Thus, both anti-apoptotic compounds exert their inhibitory effects through modulation of anti-apoptotic signalling pathways involved in regulation of cytochrome c release and activation of the caspase machinery... - Modulation of liver tumorigenesis in Connexin32-deficient mouseE Georg Luebeck
Fred Hutchinson Cancer Research Center, Public Health Sciences Division, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Mutat Res 570:33-47. 2005..Our findings also underscore the importance of the timing (6 weeks versus 2 weeks) of the genotoxic insult in relation to the developmental stage of the liver and the importance of clonal selection during tumor promotion...