A Buchmann

Summary

Country: Germany

Publications

  1. ncbi request reprint Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
    Albrecht Buchmann
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Mutat Res 638:66-74. 2008
  2. ncbi request reprint Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity
    A Buchmann
    Institute of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Cell Death Differ 6:190-200. 1999
  3. ncbi request reprint Transforming growth factor-beta1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells
    C L Buenemann
    Institute of Toxicology, , Wilhelmstrabetae 56, , Germany
    Carcinogenesis 22:447-52. 2001
  4. ncbi request reprint p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions
    A Kalkuhl
    Institute of Toxicology, University of Tubingen, Germany
    Hepatology 27:1081-8. 1998
  5. ncbi request reprint Ah receptor ligands and tumor promotion: survival of neoplastic cells
    M Schwarz
    Institute of Toxicology, University of Tubingen, Wilhelmstr 56, D 72074, Tubingen, Germany
    Toxicol Lett 112:69-77. 2000
  6. doi request reprint Tumor promotion in liver of mice with a conditional Cx26 knockout
    Philip Marx-Stoelting
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Toxicol Sci 103:260-7. 2008
  7. ncbi request reprint Effect of the tumor promoter phenobarbital on the pattern of global gene expression in liver of connexin32-wild-type and connexin32-deficient mice
    Sabine Stahl
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Germany
    Int J Cancer 115:861-9. 2005
  8. ncbi request reprint Genotype-phenotype relationships in hepatocellular tumors from mice and man
    Sabine Stahl
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstrasse 56, 72074 Tubingen, Germany
    Hepatology 42:353-61. 2005
  9. ncbi request reprint Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas
    Albert Braeuning
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Wilhelmstr 56, 72074 Tuebingen, Germany
    Drug Metab Dispos 35:503-7. 2007
  10. ncbi request reprint Global gene expression in Ha-ras and B-raf mutated mouse liver tumors
    Maike Jaworski
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Int J Cancer 121:1382-5. 2007

Collaborators

  • M Schwarz
  • Frank Gaunitz
  • Howard P Glauert
  • Wilfried Bursch
  • R Gebhardt
  • P Bannasch
  • Brett Spear
  • Albert Braeuning
  • Carina Ittrich
  • Christoph Kohle
  • Maike Jaworski
  • Sabine Stahl
  • Sandra Loeppen
  • Philip Marx-Stoelting
  • Julia Strathmann
  • Stephan Hailfinger
  • Oliver Moennikes
  • Michael Bonin
  • Thomas Ott
  • Klaus E Appel
  • E Georg Luebeck
  • Olaf Riess
  • C L Buenemann
  • Veit Simon Eckle
  • Ines Wanke
  • Daniela Schneider
  • Johanna Mahr
  • Sandra Schreiber
  • Thomas Knorpp
  • Markus F Templin
  • Krisztina Paal
  • Naomoto Harada
  • Eberhard Krause
  • Yoshitaka Tamai
  • Eva Maria Kleinschnitz
  • Moritz Menzel
  • Job C Tharappel
  • Larry W Robertson
  • A Kalkuhl
  • Christoph Koehle
  • Ozge Altug-Teber
  • Peter Bauer
  • Suresh H Moolgavkar
  • Stephan Kaiser
  • Jürgen Jobst
  • Lorenz Poellinger
  • Rolf Schulte-Hermann
  • Patrik Andersson
  • Raffael Kurek
  • C Willy
  • A Schmiechen
  • S Stinchcombe
  • J Troppmair
  • K Kaestner
  • U R Rapp

Detail Information

Publications24

  1. ncbi request reprint Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
    Albrecht Buchmann
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Mutat Res 638:66-74. 2008
    ....
  2. ncbi request reprint Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity
    A Buchmann
    Institute of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Cell Death Differ 6:190-200. 1999
    ....
  3. ncbi request reprint Transforming growth factor-beta1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells
    C L Buenemann
    Institute of Toxicology, , Wilhelmstrabetae 56, , Germany
    Carcinogenesis 22:447-52. 2001
    ....
  4. ncbi request reprint p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions
    A Kalkuhl
    Institute of Toxicology, University of Tubingen, Germany
    Hepatology 27:1081-8. 1998
    ....
  5. ncbi request reprint Ah receptor ligands and tumor promotion: survival of neoplastic cells
    M Schwarz
    Institute of Toxicology, University of Tubingen, Wilhelmstr 56, D 72074, Tubingen, Germany
    Toxicol Lett 112:69-77. 2000
    ..The present paper reviews some of the effects of TCDD on liver cell homeostasis that have been observed under diverse experimental settings and discusses some of the possible underlying mechanisms...
  6. doi request reprint Tumor promotion in liver of mice with a conditional Cx26 knockout
    Philip Marx-Stoelting
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Toxicol Sci 103:260-7. 2008
    ..Altogether our present data show that elimination of Cx26 has only minor effects on chemically induced mouse hepatocarcinogenesis, in striking contrast to the effects seen in Cx32 KO mice...
  7. ncbi request reprint Effect of the tumor promoter phenobarbital on the pattern of global gene expression in liver of connexin32-wild-type and connexin32-deficient mice
    Sabine Stahl
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Germany
    Int J Cancer 115:861-9. 2005
    ....
  8. ncbi request reprint Genotype-phenotype relationships in hepatocellular tumors from mice and man
    Sabine Stahl
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstrasse 56, 72074 Tubingen, Germany
    Hepatology 42:353-61. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index/html)...
  9. ncbi request reprint Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas
    Albert Braeuning
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Wilhelmstr 56, 72074 Tuebingen, Germany
    Drug Metab Dispos 35:503-7. 2007
    ..These findings favor the hypothesis that gene expression patterns in periportal and perivenous hepatocytes are regulated, at least in part, by Ras- and beta-catenin-dependent signaling pathways...
  10. ncbi request reprint Global gene expression in Ha-ras and B-raf mutated mouse liver tumors
    Maike Jaworski
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Int J Cancer 121:1382-5. 2007
    ..The similarity in the patterns of global gene expression of Ha-ras and B-raf mutated liver tumors suggests that mutational activation of the 2 oncogenes results in activation of a common set of transcriptional regulators...
  11. ncbi request reprint B-raf and Ha-ras mutations in chemically induced mouse liver tumors
    Maike Jaworski
    1Institut für Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Oncogene 24:1290-5. 2005
    ..These fundamental differences between the biology of liver tumors in mice and man may be of toxicological relevance...
  12. ncbi request reprint A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors
    Sandra Loeppen
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tuebingen, Wilhelmstrasse 56, 72074 Tuebingen, Germany
    Carcinogenesis 26:239-48. 2005
    ....
  13. ncbi request reprint Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital
    Sandra Loeppen
    Institut fur Toxikologie, Universitat Tubingen, Germany
    Cancer Res 62:5685-8. 2002
    ..These data suggest that promotion of hepatocarcinogenesis by PB confers beta-catenin-mutated tumor cells with a selective advantage by up-regulation of GS expression...
  14. ncbi request reprint Role of connexin32 and beta-catenin in tumor promotion in mouse liver
    Michael Schwarz
    Institut fur Pharmakologie und Toxikologie, Universitat Tubingen, Tubingen, Germany
    Toxicol Pathol 31:99-102. 2003
    ..The link between beta-catenin-signaling and Cx32-dependent gap junctional intercellular communication, if existent, remains obscure...
  15. ncbi request reprint WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice
    Oliver Moennikes
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstr 56, D 72074 Tubingen, Germany
    Carcinogenesis 24:1561-5. 2003
    ..Our results demonstrate significant differences between mouse liver lesions of differing phenotype and genotype in their response towards selection by Wy-14,643 during the promotional phase of hepatocarcinogenesis...
  16. ncbi request reprint Proteome analysis of chemically induced mouse liver tumors with different genotype
    Julia Strathmann
    Department of Toxicology, University of Tubingen, Tubingen, Germany
    Proteomics 7:3318-31. 2007
    ..Our data suggest that GS(+) and GS(-) tumor cells show a completely different biology and use divergent evolutionary strategies to gain a selective advantage over normal hepatocytes...
  17. ncbi request reprint Serum components and activated Ha-ras antagonize expression of perivenous marker genes stimulated by beta-catenin signaling in mouse hepatocytes
    Albert Braeuning
    Institute of Pharmacology und Toxicology, Department of Toxicology, University of Tuebingen, Germany
    FEBS J 274:4766-77. 2007
    ..These data suggest that activation of the Ras/mitogen-activated protein kinase (extracellular signal-regulated kinase) pathway favors periportal gene expression while simultaneously antagonizing a perivenous phenotype of hepatocytes...
  18. ncbi request reprint Differential gene expression in periportal and perivenous mouse hepatocytes
    Albert Braeuning
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Germany
    FEBS J 273:5051-61. 2006
    ..Our results confirm previous findings on metabolic zonation in liver, and extend our knowledge of the regulatory mechanisms at the transcriptional level...
  19. ncbi request reprint PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors
    Julia Strathmann
    Department of Toxicology, University of Tuebingen, 72074 Tuebingen, Germany
    Toxicol Sci 93:34-40. 2006
    ..These results clearly indicate that PCB 153 strongly selects for Catnb-mutated, GS-positive liver tumors, which is similar to the known action of PB, a prototypical tumor promoter in rodent liver...
  20. ncbi request reprint Zonal gene expression in murine liver: lessons from tumors
    Stephan Hailfinger
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, Germany
    Hepatology 43:407-14. 2006
    ..In conclusion, gradients of opposing signaling molecules along the portocentral axis determine the pattern of enzymes and other proteins expressed in hepatocytes of the periportal and pericentral domains of the liver lobule...
  21. ncbi request reprint Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver
    Veit Simon Eckle
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Toxicol Pathol 32:9-15. 2004
    ..In summary, this study demonstrates that cleaved caspase-positive apoptotic hepatocytes could be reliably identified and quantified both in normal and neoplastically transformed liver tissue...
  22. ncbi request reprint A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice
    Oliver Moennikes
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstrasse 56, 72074 Tubingen, Germany
    Cancer Res 64:4707-10. 2004
    ....
  23. ncbi request reprint Insulin and dexamethasone inhibit TGF-beta-induced apoptosis of hepatoma cells upstream of the caspase activation cascade
    Ines Wanke
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Toxicology 204:141-54. 2004
    ..Thus, both anti-apoptotic compounds exert their inhibitory effects through modulation of anti-apoptotic signalling pathways involved in regulation of cytochrome c release and activation of the caspase machinery...
  24. ncbi request reprint Modulation of liver tumorigenesis in Connexin32-deficient mouse
    E Georg Luebeck
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mutat Res 570:33-47. 2005
    ..Our findings also underscore the importance of the timing (6 weeks versus 2 weeks) of the genotoxic insult in relation to the developmental stage of the liver and the importance of clonal selection during tumor promotion...