Alexander Buchberger

Summary

Country: Germany

Publications

  1. ncbi request reprint From UBA to UBX: new words in the ubiquitin vocabulary
    Alexander Buchberger
    Dept of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Trends Cell Biol 12:216-21. 2002
  2. ncbi request reprint Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation
    Christian Schuberth
    Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Cell Biol 7:999-1006. 2005
  3. doi request reprint UBXD1 binds p97 through two independent binding sites
    Maximilian Kern
    Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Biochem Biophys Res Commun 380:303-7. 2009
  4. doi request reprint Imbalances in p97 co-factor interactions in human proteinopathy
    Vanesa Fernández-Sáiz
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    EMBO Rep 11:479-85. 2010
  5. pmc Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation
    Christian Schuberth
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    EMBO Rep 5:818-24. 2004
  6. pmc A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein
    Claudia Bex
    Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nucleic Acids Res 35:e142. 2007
  7. pmc VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL
    Katja Knauth
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Biol Chem 284:10514-22. 2009
  8. ncbi request reprint The PUB domain functions as a p97 binding module in human peptide N-glycanase
    Mark D Allen
    Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 281:25502-8. 2006

Collaborators

  • Vanesa Fernández-Sáiz
  • Christian Schuberth
  • Katja Knauth
  • Maximilian Kern
  • Mark Bycroft
  • Claudia Bex
  • Mark D Allen
  • Stefan Freund
  • Edward Cartwright
  • Zasie Schäfer
  • Silvia Dambacher
  • Holger Richly
  • Sebastian Rumpf

Detail Information

Publications8

  1. ncbi request reprint From UBA to UBX: new words in the ubiquitin vocabulary
    Alexander Buchberger
    Dept of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Trends Cell Biol 12:216-21. 2002
    ..Here, I give an overview of important ubiquitin-related protein motifs, including the UBA, UIM, UBD and UBX domains, and propose a model for the role of subclasses of UBA-domain-containing proteins in ubiquitin-mediated proteolysis...
  2. ncbi request reprint Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation
    Christian Schuberth
    Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Cell Biol 7:999-1006. 2005
    ..Lack of Ubx2 causes defects in ERAD that are exacerbated under stress conditions. These findings are consistent with a model in which Ubx2 coordinates the assembly of a highly efficient ERAD machinery at the ER membrane...
  3. doi request reprint UBXD1 binds p97 through two independent binding sites
    Maximilian Kern
    Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Biochem Biophys Res Commun 380:303-7. 2009
    ..This novel, bipartite binding mode suggests that UBXD1 could be an efficient regulator of p97 cofactor interactions...
  4. doi request reprint Imbalances in p97 co-factor interactions in human proteinopathy
    Vanesa Fernández-Sáiz
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    EMBO Rep 11:479-85. 2010
    ..Our results suggest that imbalanced co-factor binding to p97 is a key pathological feature of IBMPFD and potentially of other proteinopathies involving p97...
  5. pmc Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation
    Christian Schuberth
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    EMBO Rep 5:818-24. 2004
    ..Our data suggest that Shp1 and Ubx2 are adaptors for Cdc48-dependent protein degradation through the ubiquitin/proteasome pathway...
  6. pmc A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein
    Claudia Bex
    Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nucleic Acids Res 35:e142. 2007
    ..Additional future applications may include structure/function analyses of pVHL-HIF1/2alpha binding and screens for therapeutically relevant compounds that either stabilize or disrupt this interaction...
  7. pmc VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL
    Katja Knauth
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Biol Chem 284:10514-22. 2009
    ..Together, our data reveal unexpectedly strong structural defects of type 2C-associated pVHL mutant proteins that are likely to affect both HIF-1/2alpha-related and -unrelated pVHL functions in the pathogenesis of pheochromocytomas...
  8. ncbi request reprint The PUB domain functions as a p97 binding module in human peptide N-glycanase
    Mark D Allen
    Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 281:25502-8. 2006
    ..Furthermore, we show that the PUB and UBX domains do not bind to p97 in a mutually exclusive manner. Our results suggest that PUB domain-containing proteins constitute a widespread family of diverse p97 cofactors...