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Genomes and GenesSpecies | Martin BruneSummaryCountry: Germany Publications
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Publications
Theory of mind in schizophrenia: the role of clinical symptomatology and neurocognition in understanding other people's thoughts and intentionsMona Abdel-Hamid
Department of Psychiatry, Psychotherapy, Psychosomatics and Preventative Medicine, University of Bochum, LWL Hospital, Germany
Psychiatry Res 165:19-26. 2009..This study lends further support to the assumption of differential associations of ToM deficits with individual symptoms and symptom clusters in schizophrenia...
[The relevance of ethology for psychiatry]M Brune
Zentrum für Psychiatrie und Psychotherapie, Ruhr Universitat Bochum
Fortschr Neurol Psychiatr 66:296-302. 1998....
Schizophrenia-an evolutionary enigma?Martin Brune
Centre for Psychiatry and Psychotherapy, University of Bochum, Alexandrinenstr, Bochum, Germany
Neurosci Biobehav Rev 28:41-53. 2004..In the present article, I therefore discuss the evolutionary hypotheses of schizophrenia, arguing that a symptom-based approach to psychotic disorders in evolutionary perspective may improve upon the existing models of schizophrenia...
Erotomania variants in dementiaMartin Brune
Center for Psychiatry and Psychotherapy, University of Bochum, Bochum, Germany
J Geriatr Psychiatry Neurol 16:232-4. 2003....
Erotomanic stalking in evolutionary perspectiveMartin Brune
Center for Psychiatry and Psychotherapy, University of Bochum, Alexandrinenstrasse 1, D 44791 Bochum, Germany
Behav Sci Law 21:83-8. 2003..The evolutionary perspective may provide additional insights into the nature of sex-specific behaviors and may improve our understanding of forensically relevant behaviors...
Theory of mind and the role of IQ in chronic disorganized schizophreniaMartin Brune
Department of Psychiatry and Psychotherapy, Ruhr University of Bochum, Alexandrinenstr 1 3, D 44791 Bochum, Germany
Schizophr Res 60:57-64. 2003..Several studies have suggested a theory of mind (ToM) deficit in schizophrenic disorders. However, the role of interfering variables such as IQ, attention, memory, and severity of the disorder has remained ambiguous...
"Theory of mind" in schizophrenia: a review of the literatureMartin Brune
Center for Psychiatry and Psychotherapy, University of Bochum, Alexandrinenstr 1 3, D 44791 Bochum, Germany
Schizophr Bull 31:21-42. 2005..In addition to these potential research areas, future studies may also address whether patients could benefit from cognitive training in this domain...
Toward an integration of interpersonal and biological processes: evolutionary psychiatry as an empirically testable framework for psychiatric researchMartin Brune
Department of Psychiatry and Psychotherapy, Ruhr University of Bochum, Alexandrinenstr 1 3, 44791 Bochum, Germany
Psychiatry 65:48-57. 2002....
Evolutionary fallacies of Nazi psychiatry. Implications for current researchM Brune
Department of Psychiatry and Psychotherapy, Ruhr University of Bochum, Alexandrinenstr 1, D 44791 Bochum, Germany
Perspect Biol Med 44:426-33. 2001....
[Neuropsychological follow-up of attention deficit/hyperactive disorder in adulthood before and after treatment with methylphenidate]M Brune
Zentrum für Psychiatrie und Psychotherapie, Ruhr Universitat Bochum
Psychiatr Prax 28:198-200. 2001..ADHD may be treated efficiently even after primary diagnosis in adulthood. Differential diagnosis of ADHD should be considered in disorders associated with motor hyperactivity, impulsivity, stress intolerance and conduct disorders...
[A case of delusional jealousy in Parkinson disease ]M Brune
Zentrum für Psychiatrie u Psychotherapie der Ruhr Universität Bochum, Alexandrinenstr 1 3, 44791 Bochum
Nervenarzt 72:224-6. 2001..A case of a 49-year-old man suffering from this pathology in the course of Parkinson's disease is presented as to clinical picture, therapy, course, and outcome...
Social cognition and psychopathology in an evolutionary perspective. Current status and proposals for researchM Brune
Department of Psychiatry and Psychotherapy, Ruhr University of Bochum, Germany
Psychopathology 34:85-94. 2001..Systematic studies on social reasoning processes in psychiatric disorders may provide new insights also useful for the development of coping strategies in cognitive-behavioural therapy...
The incidence of akathisia in bipolar affective disorder treated with neuroleptics--a preliminary reportM Brune
Department of Psychiatry and Psychotherapy, Ruhr University of Bochum, Germany
J Affect Disord 53:175-7. 1999..Investigations of akathisia in neuroleptic treated patients suffering from bipolar disorder are lacking...
Theory of mind--evolution, ontogeny, brain mechanisms and psychopathologyMartin Brune
Center for Psychiatry and Psychotherapy, University of Bochum, Alexandrinenstr 1 3, 44791 Bochum, Germany
Neurosci Biobehav Rev 30:437-55. 2006..This article reviews the evolutionary psychology of theory of mind including its ontogeny and representation in the central nervous system, and studies of theory of mind in psychopathological conditions...
Hippocampal subdivision and amygdalar volumes in patients in an at-risk mental state for schizophreniaHenning Witthaus
Early Recognition and Therapy Centre for Beginning Psychoses Bochum, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, Bochum, Germany
J Psychiatry Neurosci 35:33-40. 2010..Furthermore, no subregions of the hippocampus have been investigated in people at UHR...
Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophreniaGeorg Juckel
Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
Neuropsychobiology 66:50-6. 2012....
Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controlsHenning Witthaus
Early Recognition and Therapy Centre for Psychoses Bochum BoFit, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, Alexandrinenstrasse 1, 44791, Germany
Psychiatry Res 173:163-9. 2009..This study provides further evidence that gray matter brain volume, especially in the anterior cingulate cortex, is already reduced in the prodromal state of schizophrenia...
Social cognition in "pure" delusional disorderIsabel Bömmer
University of Bochum, Germany
Cogn Neuropsychiatry 11:493-503. 2006..Difficulties in metaphorical speech comprehension and executive functioning could, however, indicate more subtle social cognitive deficits in these patients...
Neuroanatomical correlates of suicide in psychosis: the possible role of von Economo neuronsMartin Brune
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, University Hospital Bochum, Bochum, Germany
PLoS ONE 6:e20936. 2011..VEN density in the ACC seems to be increased in suicide victims with psychosis. This finding may support the assumption that VEN have a special role in emotion processing and self-evaluation, including negative self-appraisal...
An fMRI study of theory of mind in schizophrenic patients with "passivity" symptomsMartin Brune
Department of Psychiatry, Ruhr University Bochum, LWL Hospital, Alexandrinenstr 1, 44791 Bochum, Germany
Neuropsychologia 46:1992-2001. 2008..These findings suggest abnormal activation of those brain areas involved in the evaluation of self-reference during mental state attribution...
Proverb comprehension impairments in schizophrenia are related to executive dysfunctionPatrizia Thoma
Dept of Neuropsychology, Ruhr University of Bochum, 44780 Bochum, Germany
Psychiatry Res 170:132-9. 2009....
Intrinsic motivation and metacognition as predictors of learning potential in patients with remitted schizophreniaCumhur Taş
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventative Medicine, Ruhr University Bochum, Alexandrinenstrasse 1, Bochum, Germany
J Psychiatr Res 46:1086-92. 2012..We hypothesized that metacognition and intrinsic motivation would have a strong relationship and independently predict learning potential...
Comparison of self- and clinician's ratings of Personal and Social Performance in patients with schizophrenia: the role of insightDaniela Schaub
Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Bochum, Germany
Psychopathology 45:109-16. 2012....
Nonverbal behavior during standardized interviews in patients with schizophrenia spectrum disordersMartin Brune
Centre for Psychiatry, Psychotherapy, Psychosomatics and Preventative Medicine, University of Bochum, Germany
J Nerv Ment Dis 196:282-8. 2008..Culture-specific nonverbal expressivity seems to play an additional (minor) role in distinguishing patients from healthy controls...
Cooperation and deception recruit different subsets of the theory-of-mind networkSilke Lissek
Department of Neurology, Ruhr University Bochum, BG Kliniken Bergmannsheil, Bochum, Germany
PLoS ONE 3:e2023. 2008..These results indicate an important role for prefrontal cortex in processing a mismatch between a character's intention and another's expectations as required in complex social interactions...
Nonverbal behavior during clinical interviews: similarities and dissimilarities among schizophrenia, mania, and depressionSigrid Annen
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Department of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr University of Bochum, LWL University Hospital Bochum, Alexandrinenstrasse 1, Bochum, Germany
J Nerv Ment Dis 200:26-32. 2012..Patients with schizophrenia, depression, and mania differ in nonverbal behavior. Nonverbal communication seems to be a significant contributor to clinicians' intuitive ratings...
Rules of social exchange: game theory, individual differences and psychopathologyJulia Wischniewski
Department of Psychiatry, University of Bochum, LWL University Hospital, Alexandrinenstr 1, D 44791 Bochum, Germany
Neurosci Biobehav Rev 33:305-13. 2009....
The illness and everyday living: close interplay of psychopathological syndromes and psychosocial functioning in chronic schizophreniaDaniela Schaub
LWL University Hospital, Department of Psychiatry, Psychotherapy, Psychosomatics and Preventive Medicine, Ruhr University Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
Eur Arch Psychiatry Clin Neurosci 261:85-93. 2011..Findings prove the close interplay between social functioning and psychopathology in the chronic course of schizophrenia...
White matter abnormalities in subjects at ultra high-risk for schizophrenia and first-episode schizophrenic patientsHenning Witthaus
Early Recognition and Therapy Centre for beginning psychosis Bochum BoFit, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, 44791 Bochum, Germany
Schizophr Res 102:141-9. 2008..Furthermore, white matter abnormalities seem to progress after transition into schizophrenia...
Mental state attribution, neurocognitive functioning, and psychopathology: what predicts poor social competence in schizophrenia best?Martin Brune
Center for Psychiatry, Psychotherapy, Psychosomatics and Preventative Medicine, University of Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
Schizophr Res 92:151-9. 2007..We sought to determine whether mental state attribution in schizophrenia predicts poor social competence better than "non-social" cognitive factors or psychopathology...
Theory of mind and neurocognitive functioning in patients with bipolar disorderFrederike Wolf
Research Department of Cognitive Neuropsychiatryand Psychiatric Preventive Medicine, University of Bochum, LWL University Hospital, Germany
Bipolar Disord 12:657-66. 2010..Results have been mixed so far, mainly due to possible confounding effects of neurocognition, as well as clinical factors such as acuity and current mood. Here, we explored ToM and its associations with neurocognitive functioning in BPD...
Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophreniaMartin Brune
Research Department for Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
Acta Neuropathol 119:771-8. 2010..These findings suggest that VENs in the ACC are involved in neurodevelopmental and perhaps neurodegenerative processes specific to schizophrenia...
"Theory of mind" is impaired in Huntington's diseaseMartin Brune
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Bochum, Germany
Mov Disord 26:671-8. 2011..Schizophrenia patients are frequently impaired in "theory of mind" (ToM), that is, the ability to reflect on the mental states of self and others, with mixed evidence for a ToM deficit in HD...
Impairment of probabilistic reward-based learning in schizophreniaJulia A Weiler
Institute of Cognitive Neuroscience, Department of Neuropsychology, Ruhr University Bochum, Bochum, Germany
Neuropsychology 23:571-80. 2009..In summary, although there was evidence of intact basic processing of reward magnitudes, individuals with schizophrenia were impaired at using this feedback for the adaptive guidance of behavior...
"Theory of mind" and executive functioning in forensic patients with schizophreniaKarina Majorek
Department of Psychiatry, University of Bochum, LWL University Hospital, Germany
J Forensic Sci 54:469-73. 2009....
An rTMS study into self-face recognition using video-morphing techniqueChristine Heinisch
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, University of Bochum, LWL University Hospital, Alexandrinenstr 1, D 44791 Bochum, Germany
Soc Cogn Affect Neurosci 6:442-9. 2011..The transition from an unfamiliar face to one's own face indicated a left frontal lateralization...
Empathy moderates the effect of repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex on costly punishmentMartin Brune
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Landschaftsverband Westfalen Lippe University Hospital, Ruhr University Bochum, Bochum, Germany
PLoS ONE 7:e44747. 2012....
Psychopathology in great apes: concepts, treatment options and possible homologies to human psychiatric disordersMartin Brune
Center for Psychiatry, Psychotherapy and Psychosomatics, University of Bochum, Germany
Neurosci Biobehav Rev 30:1246-59. 2006..This article proposes the need to expand research into ape psychopathology, which would require an essentially interdisciplinary approach of primatology and psychiatry, ultimately to the benefit of both...
Emotion recognition, 'theory of mind,' and social behavior in schizophreniaMartin Brune
Center for Psychiatry and Psychotherapy, University of Bochum, Alexandrinenstrasse 1 3, Bochum, D 44791 Germany
Psychiatry Res 133:135-47. 2005..Considering impaired social perception and social cognition significantly contributes to the understanding of social behavioral problems in schizophrenia...
Neuropsychological aspects of delusional disorderMona Abdel-Hamid
Department of Psychiatry, University of Bochum, LWL University Hospital, Alexandrinenstr 1, 44791, Bochum, Germany
Curr Psychiatry Rep 10:229-34. 2008..Future research may help to clarify the question of gene-environment interaction involvement in the formation of delusional beliefs...
Machiavellianism and executive functioning in patients with delusional disorderMartin Brune
Department of Psychiatry, LWL University Hospital, Ruhr University of Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
Psychol Rep 106:205-15. 2010..This finding indicates that frontal lobe dysfunction may influence interpersonal attitudes and personality in Delusional Disorder...
Ethological approaches to psychiatric disorders: focus on depression and schizophreniaErwin Geerts
Department of Psychiatry, Psychotherapy, Psychosomatics and Preventative Medicine, University of Bochum, LWL University Hospital, Alexandrinenstrasse 1, Bochum, Germany
Aust N Z J Psychiatry 43:1007-15. 2009..A full appreciation of psychiatric disorders may require answers to questions to the proximate causes and evolutionary (Darwinian) trajectories of behaviour, an approach that may well be expanded to maladaptive cognition and emotion...
Proverb comprehension reconsidered--'theory of mind' and the pragmatic use of language in schizophreniaMartin Brune
Center for Psychiatry and Psychotherapy, University of Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
Schizophr Res 75:233-9. 2005....
Obsessive compulsive disorder in huntington disease: a case of isolated obsessions successfully treated with sertralineTanja Patzold
Department Neurology, Psychiatry, Ruhr University, Bochum, Germany
Neuropsychiatry Neuropsychol Behav Neurol 15:216-9. 2002..To report about a patient with Huntington disease (HD) in combination with obsessions who was successfully treated with a selective serotonin reuptake inhibitor...
Does the oxytocin receptor (OXTR) polymorphism (rs2254298) confer 'vulnerability' for psychopathology or 'differential susceptibility'? Insights from evolutionMartin Brune
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, University of Bochum, LWL University Hospital, Bochum, Germany
BMC Med 10:38. 2012..Seeing genetic variation at the core of developmental plasticity can explain, in contrast to the diathesis-stress perspective, why evolution by natural selection has maintained such 'risk' alleles in the gene pool of a population...
Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosiAndreas Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Bull 37:S111-21. 2011..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...
Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication studyGeorg Juckel
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
Psychiatry Res 158:79-82. 2008..Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia...
Linking social cognition with social interaction: Non-verbal expressivity, social competence and "mentalising" in patients with schizophrenia spectrum disordersMartin Brune
Department of Psychiatry, LWL University Hospital, University of Bochum, Bochum, Germany
Behav Brain Funct 5:6. 2009..abstract:..
Psychosurgery and deep brain stimulation as ultima ratio treatment for refractory depressionGeorg Juckel
Department of Psychiatry Psychotherapy and Psychosomatic Medicine, Ruhr University, Alexandrinenstr 1, Bochum 44791, Germany
Eur Arch Psychiatry Clin Neurosci 259:1-7. 2009..In this review, we suggest possible standard criteria for the application of deep brain stimulation on patients suffering from otherwise treatment-resistant depression...
Auditory mismatch negativity deficits in long-term heavy cannabis usersPatrik Roser
Department of Psychiatry, Ruhr University Bochum, Alexandrinenstr 1, 44791, Bochum, Germany
Eur Arch Psychiatry Clin Neurosci 260:491-8. 2010..The results indicate that chronic cannabis use may cause a specific impairment of auditory information processing. In particular, duration and quantity of cannabis use could be identified as important factors of deficient MMN generation...
Impaired facial emotion recognition in a ketamine model of psychosisAndreas Ebert
Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Bochum, Germany
Psychiatry Res 200:724-7. 2012..Given the role of glutamatergic neurotransmission in schizophrenia-related cognitive impairments, we investigated the effects of the glutamatergic NMDA receptor antagonist ketamine on facial emotion recognition...
The evolutionary psychology of obsessive-compulsive disorder: the role of cognitive metarepresentationMartin Brune
Center for Psychiatry, Psychotherapy and Psychosomatics, University of Bochum, Bochum, Germany
Perspect Biol Med 49:317-29. 2006..The costly side of the adaptive ability to anticipate future needs or threats could be that etiologically heterogeneous affections of the underlying striatal-frontal brain circuits may render an individual vulnerable to develop OCD...
On human self-domestication, psychiatry, and eugenicsMartin Brune
Department of Psychiatry, University of Bochum, LWL Hospital, Germany
Philos Ethics Humanit Med 2:21. 2007....
Stress induces a functional asymmetry in an emotional attention taskMartin Brune
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital Bochum, Bochum, Germany
Cogn Emot 27:558-66. 2013..This could suggest that stress influences interhemispheric transfer of information that is relevant for emotion processing...
Interaction of recalled parental ADHD symptoms and rearing behavior with current attachment and emotional dysfunction in adult offspring with ADHDMarc Andreas Edel
Dept of Psychiatry and Psychotherapy, Ruhr University Bochum, LWL University Hospital Bochum, Alexandrinenstr 1, Bochum, Germany
Psychiatry Res 178:137-41. 2010..ADHD symptoms in parents of children with ADHD may present a risk factor for attachment problems and poor emotion regulation when ADHD children are grown...
Smoking reduces language lateralization: a dichotic listening study with control participants and schizophrenia patientsConstanze Hahn
Institute for Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany
Brain Cogn 76:300-9. 2011..Possible neurobiological mechanisms with which smoking may alter auditory microcircuits and thereby diminish left-right differences are discussed...
