W Bruck

Summary

Country: Germany

Publications

  1. pmc Effects of pulmonary acid aspiration on the lungs and extra-pulmonary organs: a randomized study in pigs
    Jan Florian Heuer
    Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical Center, Robert Koch Straße 40, 37075 Gottingen, Germany
    Crit Care 16:R35. 2012
  2. pmc Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons
    Shailender Singh
    Department of Neuropathology, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Acta Neuropathol 125:595-608. 2013
  3. doi request reprint Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Ann Neurol 72:385-94. 2012
  4. doi request reprint Laquinimod, a once-daily oral drug in development for the treatment of relapsing-remitting multiple sclerosis
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center Gottingen, Robert Koch Street 40, 37075 Gottingen, Germany
    Expert Rev Clin Pharmacol 5:245-56. 2012
  5. pmc Advances in multiple sclerosis research in 2009
    Stefan Nessler
    Department of Neuropathology, University Medical Center Gottingen, Robert Koch Str 40, Gottingen, Germany
    J Neurol 257:1590-3. 2010
  6. pmc Acute effects of intracranial hypertension and ARDS on pulmonary and neuronal damage: a randomized experimental study in pigs
    Jan Florian Heuer
    Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical Center, Gottingen, Germany
    Intensive Care Med 37:1182-91. 2011
  7. ncbi request reprint Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis
    Wolfgang Bruck
    Dept of Neuropathology, University Hospital Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 252:v10-5. 2005
  8. ncbi request reprint The spectrum of multiple sclerosis: new lessons from pathology
    Wolfgang Bruck
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Curr Opin Neurol 18:221-4. 2005
  9. ncbi request reprint Clinical implications of neuropathological findings in multiple sclerosis
    Wolfgang Bruck
    Institute of Neuropathology, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Neurol 252:iii10-iii14. 2005
  10. ncbi request reprint The role of macrophages in Wallerian degeneration
    W Bruck
    Department of Neuropathology, University of Gottingen, Germany
    Brain Pathol 7:741-52. 1997

Detail Information

Publications94

  1. pmc Effects of pulmonary acid aspiration on the lungs and extra-pulmonary organs: a randomized study in pigs
    Jan Florian Heuer
    Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical Center, Robert Koch Straße 40, 37075 Gottingen, Germany
    Crit Care 16:R35. 2012
    ..The aim of this study was to determine the effects of acid aspiration pneumonitis (AAP) on extrapulmonary organs and to test the hypothesis that these could be due to circulatory depression or hypoxemia...
  2. pmc Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons
    Shailender Singh
    Department of Neuropathology, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Acta Neuropathol 125:595-608. 2013
    ..In addition, we show that early MS microglial nodules exhibit both pro- and antiinflammatory phenotypes...
  3. doi request reprint Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Ann Neurol 72:385-94. 2012
    ..The aim of our study was to compare the histological characteristics of early active demyelinating NMO and MS brain lesions...
  4. doi request reprint Laquinimod, a once-daily oral drug in development for the treatment of relapsing-remitting multiple sclerosis
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center Gottingen, Robert Koch Street 40, 37075 Gottingen, Germany
    Expert Rev Clin Pharmacol 5:245-56. 2012
    ..In conclusion, preclinical studies show that laquinimod's unique mechanisms of action, including its immunomodulatory and CNS-protective effects, translate into clinical benefits in relapsing-remitting multiple sclerosis patients...
  5. pmc Advances in multiple sclerosis research in 2009
    Stefan Nessler
    Department of Neuropathology, University Medical Center Gottingen, Robert Koch Str 40, Gottingen, Germany
    J Neurol 257:1590-3. 2010
    ..The following review summarizes the progress in multiple sclerosis research published in the Journal of Neurology in 2009...
  6. pmc Acute effects of intracranial hypertension and ARDS on pulmonary and neuronal damage: a randomized experimental study in pigs
    Jan Florian Heuer
    Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical Center, Gottingen, Germany
    Intensive Care Med 37:1182-91. 2011
    ..To determine reciprocal and synergistic effects of acute intracranial hypertension and ARDS on neuronal and pulmonary damage and to define possible mechanisms...
  7. ncbi request reprint Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis
    Wolfgang Bruck
    Dept of Neuropathology, University Hospital Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 252:v10-5. 2005
    ..Cumulative tissue loss in the grey and white matter, especially of axons, is important and probably the principal determinant of accumulation of irreversible neurological disability and of conversion to a progressive disease course...
  8. ncbi request reprint The spectrum of multiple sclerosis: new lessons from pathology
    Wolfgang Bruck
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Curr Opin Neurol 18:221-4. 2005
    ....
  9. ncbi request reprint Clinical implications of neuropathological findings in multiple sclerosis
    Wolfgang Bruck
    Institute of Neuropathology, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Neurol 252:iii10-iii14. 2005
    ..However, axon-protective therapy is yet to be established and the mechanisms and effector molecules involved in axonal degeneration are still to be defined...
  10. ncbi request reprint The role of macrophages in Wallerian degeneration
    W Bruck
    Department of Neuropathology, University of Gottingen, Germany
    Brain Pathol 7:741-52. 1997
    ..The relevance of these findings for immune-mediated demyelination are discussed since the definition of the role of macrophages might lead to a better understanding of the pathogenesis of demyelination...
  11. doi request reprint Insight into the mechanism of laquinimod action
    W Bruck
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    J Neurol Sci 306:173-9. 2011
    ..In conclusion, treatment with laquinimod is effective in reducing inflammation, demyelination and axonal damage...
  12. ncbi request reprint The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage
    Wolfgang Bruck
    Dept of Neuropathology, University Hospital Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 252:v3-9. 2005
    ..Different soluble or cellular mediators of the immune response have been shown to damage axons in experimental systems, and these may be responsible for neurodegeneration in human disease...
  13. doi request reprint Gender differences in the histopathology of MS?
    T Kuhlmann
    Institute of Neuropathology, University Hospital Munster, 48149 Munster, Germany
    J Neurol Sci 286:86-91. 2009
    ....
  14. doi request reprint Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    T Kuhlmann
    Institute of Neuropathology, University Hospital Munster, Munster, Domagkstr 19, 48149 Munster, Germany
    Brain 131:1749-58. 2008
    ..In summary, we provide evidence that a differentiation block of oligodendroglial progenitors is a major determinant of remyelination failure in chronic multiple sclerosis lesions...
  15. ncbi request reprint Follistatin (FS) in human cerebrospinal fluid and regulation of FS expression in a mouse model of meningitis
    U Michel
    Laboratory of Neurobiology, Department of Neurology and Psychiatry, University of Gottingen, Germany
    Eur J Endocrinol 143:809-16. 2000
    ..Furthermore, a mouse pneumococcal meningitis model was used to localise the cellular sources of FS in brains of normal and meningitic mice...
  16. ncbi request reprint The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system
    H Siebert
    Department of Neuropathology, Charite, Humboldt University, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    J Neuroimmunol 110:177-85. 2000
    ..These data demonstrate the involvement of the chemokine receptor CCR2 in macrophage recruitment to the injured nervous system...
  17. ncbi request reprint Granulocytes in the subarachnoid space of humans and rabbits with bacterial meningitis undergo apoptosis and are eliminated by macrophages
    R Nau
    Department of Neurology, University of Gottingen, Germany
    Acta Neuropathol 96:472-80. 1998
    ..These granulocytes are removed by phagocytosis by macrophages. Apoptosis is more frequent in granulocytes floating in the CSF than in adherent cells...
  18. ncbi request reprint Differential regulation of myelin phagocytosis by macrophages/microglia, involvement of target myelin, Fc receptors and activation by intravenous immunoglobulins
    Tanja Kuhlmann
    Department of Neuropathology, Charite, Humboldt Universitat, Berlin, Germany
    J Neurosci Res 67:185-90. 2002
    ..Local factors within the CNS or PNS may affect this process by modulating the surface receptor profile and activation state of the phagocytic cell or the structure of the myelin sheath...
  19. doi request reprint Remyelination capacity of the MS brain decreases with disease chronicity
    T Goldschmidt
    Department of Neuropathology, University Medical Center, Gottingen, Germany
    Neurology 72:1914-21. 2009
    ..However, no studies have been published that have quantified and compared the extent of remyelination in early and chronic MS lesions...
  20. ncbi request reprint Concentration-dependent effects of the esterase inhibitor BNPP on macrophage migration and myelin phagocytosis
    H Siebert
    Institute of Neuropathology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Brain Res 916:159-64. 2001
    ..The therapeutical use of this inhibitor for treatment of autoimmune diseases such as multiple sclerosis or Guillain-Barré syndrome remains to be investigated...
  21. ncbi request reprint Central nervous system TNFalpha-mRNA expression during rabbit experimental pneumococcal meningitis
    A Bitsch
    Department of Neurology, University of Gottingen, Germany
    Neurosci Lett 237:105-8. 1997
    ..After monocyte depletion, no TNFalpha-mRNA positive cells were detected in the CNS. These findings suggest that TNFalpha in pneumococcal meningitis is produced in the CNS mainly by blood-derived, infiltrating monocytes...
  22. ncbi request reprint Serum levels of macrophage-derived protein MRP-8/14 are elevated in active multiple sclerosis
    T Bogumil
    Department of Neurology, University of Gottingen, Germany
    Neurosci Lett 247:195-7. 1998
    ..These results may indicate an early activation of macrophages in the formation of demyelinating MS plaques. In addition, increased serum levels of MRP-8/14 may prove to be a useful paraclinical disease activity parameter in MS patients...
  23. ncbi request reprint Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
    A L Siren
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Acta Neuropathol 101:271-6. 2001
    ....
  24. ncbi request reprint Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions
    D Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Mult Scler 12:369-74. 2006
    ..MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS...
  25. ncbi request reprint Mechanisms of macrophage recruitment in Wallerian degeneration
    W Bruck
    Department of Neuropathology, University of Gottingen, Germany
    Acta Neuropathol 89:363-7. 1995
    ..The differences observed between the in vivo and in vitro situations suggest that axonal breakdown plays an important role in the initiation of macrophage recruitment to degenerating peripheral nerves...
  26. ncbi request reprint The role of TNF-alpha during Wallerian degeneration
    M Liefner
    Department of Neuropathology, Georg August Universitat, Gottingen, Germany
    J Neuroimmunol 108:147-52. 2000
    ..These data indicate that the main function of TNF-alpha during Wallerian degeneration is the induction of macrophage recruitment from the periphery without affecting myelin damage or phagocytosis...
  27. ncbi request reprint Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis
    Imke Metz
    Department of Neuropathology, Georg August University, Gottingen, Germany
    Brain 130:1254-62. 2007
    ....
  28. doi request reprint In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
    Amke Hesse
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Neurobiol Dis 37:362-9. 2010
    ..However, mice lacking FAS in oligodendrocytes are not protected against cuprizone-induced oligodendroglial cell death, showing that FAS is dispensable for oligodendroglial cell death in the cuprizone model...
  29. ncbi request reprint Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat
    F K van Landeghem
    Institute of Neuropathology, Charite, Humboldt University, Berlin, Germany
    Glia 35:167-79. 2001
    ..Ramified microglia may play an important compensatory role in the early regulation of extracellular glutamate after CCII...
  30. ncbi request reprint Immunopathology of primary hypophysitis: implications for pathogenesis
    A Gutenberg
    Department Neuropathology, Georg August University, Gottingen, Germany
    Am J Surg Pathol 29:329-38. 2005
    ....
  31. ncbi request reprint A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain 129:1972-83. 2006
    ..Our data thus suggest that cortical inflammation is a transient phenomenon, and that remyelination of cortical inflammatory-demyelinating lesions may occur rapidly...
  32. doi request reprint Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant
    Hauke Schmidt
    Institute of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Exp Neurol 216:306-11. 2009
    ..Finally, myelin recovery was found to be independent from endogenous IFNAR signalling, indicating a redundant role of this receptor for non-inflammatory myelin damage and repair...
  33. ncbi request reprint The role of cytokines and adhesion molecules in axon degeneration after peripheral nerve axotomy: a study in different knockout mice
    Heike Siebert
    Institute of Neuropathology, Georg August Universitat Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Brain Res 960:152-6. 2003
    ....
  34. ncbi request reprint Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination--possible markers for an antibody-mediated process
    W Bruck
    Department of Neuropathology, Charite, Humboldt Universitat, Berlin, Germany
    Mult Scler 7:173-7. 2001
    ..Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case...
  35. ncbi request reprint The pathology of primary progressive multiple sclerosis
    W Bruck
    Department of Neuropathology, Charite, Berlin, Germany
    Mult Scler 8:93-7. 2002
    ....
  36. doi request reprint Wallerian degeneration: a major component of early axonal pathology in multiple sclerosis
    Tomasz Dziedzic
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Brain Pathol 20:976-85. 2010
    ..It may contribute to radiological changes observed in early MS and most likely plays a major role in the development of disability...
  37. ncbi request reprint Lessons from the neuropathology of atypical forms of multiple sclerosis
    C Stadelmann
    Institute of Neuropathology, Georg August Universitat, Robert Koch Str 40, D 37075 Gottingen, Germany
    Neurol Sci 25:S319-22. 2004
    ..Acute disseminated encephalomyelitis (ADEM) may be regarded as a related condition lacking extensive demyelination. Thus, atypical MS forms may help to elucidate pathogenic mechanisms in MS...
  38. ncbi request reprint Inflammation and degeneration in multiple sclerosis
    W Bruck
    Department of Neuropathology, Georg August Universitat Gottingen, Robert Koch Strasse 40, D 37075, Gottingen, Germany
    Neurol Sci 24:S265-7. 2003
    ..The exact mechanisms and effector molecules of axonal degeneration, however, are not yet defined, and an axon-protective therapy has not yet been established...
  39. doi request reprint Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles
    Frank K H van Landeghem
    Institute of Neuropathology, Charite Universitatsmedizin Berlin, CVK, 13353 Berlin, Germany
    Biomaterials 30:52-7. 2009
    ..Furthermore, all patients did not present any clinical symptoms related to possible adverse effects of MFH...
  40. ncbi request reprint Myelin basic protein induces cell death of mature pig oligodendrocytes in vitro and produces demyelination in vivo
    H H Althaus
    Max Planck Institute for Experimental Medicine, AG Neural Regeneration, H Reinstrasse 3, 37075, Gottingen, Germany
    Neurosci Lett 283:77-80. 2000
    ..Thus, this type of lesion might present an alternative option for studying the fate of transplanted myelinating cells...
  41. doi request reprint Cerebral involvement in axonal Charcot-Marie-Tooth neuropathy caused by mitofusin2 mutations
    Knut Brockmann
    Dept of Pediatrics and Pediatric Neurology, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    J Neurol 255:1049-58. 2008
    ..The present findings indicate an enhanced cellular density in cerebral white matter of MFN2 neuropathy which is primarily due to a reactive gliosis without axonal damage and possibly accompanied by mild demyelination...
  42. ncbi request reprint Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    Alexander Mildner
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    Nat Neurosci 10:1544-53. 2007
    ..Our results identify Ly-6C(hi)CCR2(+) monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment...
  43. doi request reprint Interplay between mechanisms of damage and repair in multiple sclerosis
    Christine Stadelmann
    Georg August Universitat Gottingen, Abteilung Neuropathologie, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 255:12-8. 2008
    ..There is important heterogeneity between patients in terms of the extent of remyelination, which may reflect underlying differences in pathogenetic mechanisms between patients...
  44. doi request reprint Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
    ..In contrast, absence of IFNAR on myeloid cells led to severe disease with an enhanced effector phase and increased lethality, indicating a distinct protective function of type I IFNs during autoimmune inflammation of the CNS...
  45. ncbi request reprint Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
    Denise van Rossum
    Institute for Neuropathology, University of Gottingen, D 37075, Gottingen, Germany
    Glia 56:271-83. 2008
    ..Nerve-exposed macrophages thus commit to a unique functional orientation...
  46. ncbi request reprint Spontaneous adrenal hemorrhage: a little-known complication of intracranial tumor surgery. Case report
    Angelika Gutenberg
    Departments of Neurosurgery, Georg August University, Gottingen, Germany
    J Neurosurg 106:1086-8. 2007
    ..In this brief report they seek to draw attention to this rare but life-threatening complication, because rapid diagnosis can be life-saving...
  47. doi request reprint Cortical pathology in multiple sclerosis
    Christine Stadelmann
    Institute of Neuropathology, University Medical Centre, Gottingen, Germany
    Curr Opin Neurol 21:229-34. 2008
    ..Lately, evidence has accumulated that large areas of grey matter are affected in multiple sclerosis patients...
  48. doi request reprint Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease
    Oliver Wirths
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 31:747-57. 2010
    ..These data add further evidence to the assumption that inflammatory processes are tightly associated with axonal degeneration and neuron loss, as is evident in the APP/PS1KI mouse model...
  49. doi request reprint Persistence of immunopathological and radiological traits in multiple sclerosis
    Fatima B König
    Department of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    Arch Neurol 65:1527-32. 2008
    ....
  50. doi request reprint Inflammation, demyelination, and degeneration - recent insights from MS pathology
    Christine Stadelmann
    Institute of Neuropathology, University Medical Center, Gottingen, Germany
    Biochim Biophys Acta 1812:275-82. 2011
    ..This review summarizes current knowledge on the interrelation between inflammation, demyelination, and neurodegeneration derived from the study of human autopsy and biopsy brain tissue and experimental models of MS...
  51. doi request reprint CNS tumor 22 years after spinal neuroblastoma IV: diagnostic dilemma between recurrence and secondary malignancy
    Angelika Gutenberg
    Department of Neurosurgery, Georg August University, Gottingen, Germany
    Pediatr Neurosurg 45:61-8. 2009
    ....
  52. doi request reprint Propagation of spreading depression inversely correlates with cortical myelin content
    Doron Merkler
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Ann Neurol 66:355-65. 2009
    ..However, the functional implication of cortical demyelination remains elusive. In this study, we investigated whether cortical myelin influences cortical spreading depression (CSD)...
  53. doi request reprint High chromosomal instability in brain metastases of colorectal carcinoma
    Angelika Gutenberg
    Department of Neurosurgery, Georg August University, Gottingen, D 37099, Germany
    Cancer Genet Cytogenet 198:47-51. 2010
    ..The prevalently altered genomic regions in the metastases of this study are likely to harbor genes that play an important role in the genesis of brain-specific metastasis...
  54. doi request reprint Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain
    Heike Siebert
    Institute of Neuropathology, University Medical Centre Goettingen, Goettingen, Germany
    J Neurochem 114:1007-18. 2010
    ..alpha-Synuclein transgenic mice represent an appropriate model for investigations on axonal transport in neurodegenerative diseases...
  55. ncbi request reprint Multicontrast MRI of remyelination in the central nervous system
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Germany
    NMR Biomed 18:395-403. 2005
    ..With a correct assignment of 95% of all animals examined, the procedure will allow for the survey of new therapeutic approaches aiming at improved remyelination...
  56. ncbi request reprint Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis
    Simone C Tauber
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neuropathol Exp Neurol 64:806-15. 2005
    ..004). No significant changes in GDNF expression were observed. In conclusion, increased synthesis of BDNF and TrkB suggests a contribution of this neurotrophic factor to neurogenesis after bacterial meningitis...
  57. pmc Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
    Marco Prinz
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    J Clin Invest 116:456-64. 2006
    ..Our data clearly demonstrate that both TLR9 and MyD88 are essential modulators of the autoimmune process during the effector phase of disease and suggest that endogenous "danger signals" modulate the disease pathogenesis...
  58. ncbi request reprint Fas (CD95/Apo-1)/Fas ligand expression in neonates with pontosubicular neuron necrosis
    Frank K H van Landeghem
    Institute of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Pediatr Res 51:129-35. 2002
    ..There was no significant difference between cases with and without PSN. We conclude that in the developing human brain, cells expressing the Fas receptor may be susceptible to undergoing apoptosis in response to hypoxic-ischemic injury...
  59. ncbi request reprint Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain Pathol 16:117-23. 2006
    ..Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain...
  60. ncbi request reprint Primary hypophysitis: clinical-pathological correlations
    Angelika Gutenberg
    Department of Neurosurgery, Georg August University Gottingen, Gottingen, Germany
    Eur J Endocrinol 155:101-7. 2006
    ..Primary hypophysitis comprises of three distinct histomorphological entities: lymphocytic, granulomatous and xanthomatous. Clinical features of the three subtypes for diagnostic and treatment strategies have yet not been well characterized...
  61. pmc Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2
    Isabel Herrmann
    Department of Neurology, Georg August University, Robert Koch Str 40, D 37075 Gottingen, Germany
    Infect Immun 74:4841-8. 2006
    ..In conclusion, infection with S. pneumoniae worsens EAE probably by elevation of proinflammatory cytokines and activation of dendritic cells in the systemic circulation via TLR2 and cross talk through the blood-brain barrier...
  62. ncbi request reprint The relative number of macrophages/microglia expressing macrophage colony-stimulating factor and its receptor decreases in multiple sclerosis lesions
    Katrin Werner
    Department of Neuropathology, Charite, Humboldt Universitat, Campus Virchow Klinikum, Berlin, Germany
    Glia 40:121-9. 2002
    ..Nevertheless, the differences in the relative number of cells expressing the M-CSF/M-CSFR pathway implicate that this pathway may be an important contributory factor in different forms of MS pathology...
  63. ncbi request reprint Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice
    Marija Djukic
    Department of Neurology, Georg August University, Gottingen, Germany
    Brain 129:2394-403. 2006
    ..Thus, circulating cells entering the brain such as monocytes/macrophages might provide a potential cellular target for the treatment of the tissue damage following meningitis via peripheral cell therapy...
  64. ncbi request reprint Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    Tanja Kuhlmann
    Department of Neuropathology, Charite, Humboldt Universitat, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Brain 125:2202-12. 2002
    ..Our results indicate that a putative axon-protective treatment should start as early as possible and include strategies preventing T cell/macrophage-mediated axon destruction and leading to remyelination of axons...
  65. ncbi request reprint Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions
    Tanja Kuhlmann
    Department of Neuropathology, University of Gottingen, Gottingen, Germany
    J Neuropathol Exp Neurol 66:238-46. 2007
    ..Nogo-A strongly and reliably labeled oligodendrocytes in the adult CNS as well as in demyelinating lesions and thus represents a valuable tool for the identification of oligodendrocytes in human and mouse CNS tissue...
  66. ncbi request reprint Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease?
    H Tumani
    Department of Neurology, University of Gottingen, Germany
    Arch Neurol 56:1241-6. 1999
    ..To determine whether the glutamine synthetase (GS) level in cerebrospinal fluid (CSF) is a useful biochemical marker in the diagnosis of Alzheimer disease (AD), and to assess the source of GS (brain vs. blood derived) in CSF...
  67. ncbi request reprint No evidence of hSNF5/INI1 point mutations in choroid plexus papilloma
    W Mueller
    Institute of Neuropathology, Charite, Humboldt University, Berlin, Germany
    Neuropathol Appl Neurobiol 30:304-7. 2004
    ..No alterations in migratory patterns were detected. These data indicate that somatic point mutations of hSNF5/INI1 do not play a role in the pathogenesis of CPP and that CPP and CPC may arise by two different molecular pathways...
  68. doi request reprint Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
    Christiane Wegner
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    J Neuroimmunol 227:133-43. 2010
    ..Laquinimod might thus protect myelin and axons by decreasing pro-inflammatory cytokines and impairing the migratory capacity of lymphocytes...
  69. doi request reprint CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Brain 132:2487-500. 2009
    ..Collectively, these data indicate a disease-promoting role of CCR2+Ly-6Chi monocytes during autoimmune inflammation of the central nervous system...
  70. ncbi request reprint Erythropoietin: a candidate compound for neuroprotection in schizophrenia
    H Ehrenreich
    Max Planck Institute for Experimental Medicine and Department of Psychiatry, Georg August University, Goettingen, Germany
    Mol Psychiatry 9:42-54. 2004
    ....
  71. ncbi request reprint Myelinopathia centralis diffusa (vanishing white matter disease): evidence of apoptotic oligodendrocyte degeneration in early lesion development
    W Bruck
    Department of Neuropathology, University of Gottingen, Germany
    Ann Neurol 50:532-6. 2001
    ..In an active demyelinating lesion in the brainstem, oligodendrocytes showed typical signs of apoptosis. We suggest that death of mature oligodendrocytes is the critical event in the disease...
  72. ncbi request reprint Progress in neuropathology of the neuronal ceroid lipofuscinoses
    H H Goebel
    Department of Neuropathology, Johannes Gutenberg University, Mainz, Germany
    Mol Genet Metab 66:367-72. 1999
    ..A European Tissue Registry established within the framework of a European Concerted Action on Neuronal Ceroid-Lipofuscinosis may form the basis for additional collaborative studies on NCL, including both biopsy and autopsy tissues...
  73. ncbi request reprint Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis
    T Kuhlmann
    Department of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt Universitat, Augustenburger Platz 1, 13353, Berlin, Germany
    J Neuroimmunol 129:154-60. 2002
    ..No significant differences in the frequency of gene sequence variations were found between MS patients and controls. The apoptosis genes studied here therefore appear less likely to be important effector genes in MS...
  74. pmc Wallerian degeneration in ICAM-1-deficient mice
    V I Vougioukas
    Department of Neuropathology, University of Gottingen, Germany
    Am J Pathol 152:241-9. 1998
    ..These data indicate that ICAM-1 is involved in macrophage recruitment to injured peripheral nerves as well as in the proliferative and phagocytic response of Schwann cells after peripheral nerve transection...
  75. pmc Mechanisms of acute axonal degeneration in the optic nerve in vivo
    Johanna Knöferle
    Departments of Neurology and Neuropathology, University Medicine, Georg August University, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 107:6064-9. 2010
    ..Both processes are proposed to be major targets for the manipulation of axonal degeneration in future therapeutic settings...
  76. ncbi request reprint Increased neurogenesis after experimental Streptococcus pneumoniae meningitis
    Joachim Gerber
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neurosci Res 73:441-6. 2003
    ..This suggests that endogenous repair mechanisms may limit consequences of neuronal destruction after meningitis...
  77. pmc Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach
    Tanja Kuhlmann
    Department of Neuropathology, University Medical Centre Göttingen, Robert Koch Str 40, 37075, Gottingen, Germany
    Acta Neuropathol 115:275-87. 2008
    ..Here, we summarize the histological hallmarks and most important neuropathological differential diagnoses of early MS, and provide practical guidelines for the diagnosis of inflammatory demyelinating diseases...
  78. doi request reprint Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo
    Steve Klopfleisch
    Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    J Neurosci 28:13609-14. 2008
    ..Our findings may have significant implications for the application of statins in MS patients and in other demyelinating diseases of the CNS...
  79. doi request reprint Substantial early, but nonprogressive neuronal loss in multiple sclerosis (MS) spinal cord
    Lucas Schirmer
    Department of Neuropathology, University Medical Centre Göttingen, Gottingen, Germany
    Ann Neurol 66:698-704. 2009
    ....
  80. ncbi request reprint Molecular genetic diagnosis of a primary central nervous system T cell lymphoma
    A Harder
    Institute of Neuropathology, Charite, Humboldt University, Berlin, Germany
    Acta Neuropathol 105:65-8. 2003
    ....
  81. doi request reprint MGMT promoter methylation status and prognosis of patients with primary or recurrent glioblastoma treated with carmustine wafers
    A Gutenberg
    Department of Neurosurgery, Georg August University Gottingen, Gottingen, Germany
    Br J Neurosurg 27:772-8. 2013
    ..Owing to the small number of patients investigated, however, these findings would need to be corroborated in larger patient cohorts...
  82. ncbi request reprint How a neuropsychiatric brain bank should be run: a consensus paper of Brainnet Europe II
    A Schmitt
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    J Neural Transm 114:527-37. 2007
    ..These guidelines may be of value for future implementations of additional neuropsychiatric brain banks world-wide...
  83. ncbi request reprint Expression of the beta-trace protein in human pachymeninx as revealed by in situ hybridization and immunocytochemistry
    B Blödorn
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neurosci Res 57:730-4. 1999
    ..The major ones are the fibroblasts of the pachymeninx, and as previously shown, the epithelial layer of the choroid plexus...
  84. ncbi request reprint Multiple sclerosis - remyelination failure as a cause of disease progression
    Karin Hagemeier
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Histol Histopathol 27:277-87. 2012
    ..We will also summarize a selected number of inhibitory pathways and non-disease related factors which may contribute to remyelination failure in chronic MS...
  85. ncbi request reprint Endothelin b receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus
    H Ehrenreich
    Max Planck Institute for Experimental Medicine and Department of Neurology, Gottingen, Germany
    Neuroscience 95:993-1001. 2000
    ..In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions...
  86. ncbi request reprint Expression of tyrosine kinases FAK and Pyk2 in 331 human astrocytomas
    A Gutenberg
    Department of Neuropathology, Georg August University, Robert Koch Str 40, 37099 Gottingen, Germany
    Acta Neuropathol 108:224-30. 2004
    ..This connection and the roles of these two tyrosine kinases in the progression of tumors should be confirmed by further studies...
  87. ncbi request reprint Evidence for frequent focal and diffuse acute axonal injury in human bacterial meningitis
    J Gerber
    Department of Neurology, University of Gottingen, Germany
    Clin Neuropathol 28:33-9. 2009
    ..We aimed at quantifying acute axonal injury in victims of bacterial meningitis...
  88. ncbi request reprint Axonal injury, a neglected cause of CNS damage in bacterial meningitis
    Roland Nau
    Department of Neurology, University of Gottingen, Germany
    Neurology 62:509-11. 2004
    ..This suggests a substantial contribution of axonal pathology to neurologic sequelae after bacterial meningitis...
  89. doi request reprint Diagnostic pitfall: optic neuritis mimicking optic nerve glioma
    Markus Bergmann
    Department of Neuropathology, Klinikum Bremen Mitte, Bremen, Germany
    Neuropathology 29:450-3. 2009
    ....
  90. ncbi request reprint Neuronal injury in bacterial meningitis: mechanisms and implications for therapy
    Roland Nau
    Dept of Neurology, University of Gottingen, University Hospital, Robert Koch Str 40, D 37075, Gottingen, Germany
    Trends Neurosci 25:38-45. 2002
    ....
  91. ncbi request reprint Neuronal apoptosis in the dentate gyrus in humans with subarachnoid hemorrhage and cerebral hypoxia
    Roland Nau
    Department of Neurology, Georg August University, Gottingen, Germany
    Brain Pathol 12:329-36. 2002
    ..001). Apoptosis appears to be the predominant mechanism of death in dentate granule cells irrespective of the underlying disease, whereas neuronal death in the hippocampus generally is of necrotic morphology...
  92. ncbi request reprint Intradural, extramedullary spinal sarcoidosis: report of a rare case and review of the literature
    Bernhard Schaller
    Department of Neurosurgery, University of Gottingen, Robert Koch Strasse 40, Gottingen 37075, Germany
    Spine J 6:204-10. 2006
    ..Most spinal sarcoid lesions are intramedullary, and only eight cases of intradural, extramedullary sarcoid lesions have been reported hitherto. We describe the complete entity of intradural, extramedullary spinal sarcoidosis...
  93. doi request reprint Increased neurogenesis after hypoxic-ischemic encephalopathy in humans is age related
    Wulf Rainer C Mattiesen
    Department of Neurology, Georg August University, Gottingen, Germany
    Acta Neuropathol 117:525-34. 2009
    ..Whether neurogenesis can contribute to recovery after HIE remains to be determined. The stimulation of adult neurogenesis may be less efficient in older victims of HIE...
  94. ncbi request reprint Extensive cortical remyelination in patients with chronic multiple sclerosis
    Monika Albert
    Institute of Neuropathology, University of Goettingen, Goettingen, Germany
    Brain Pathol 17:129-38. 2007
    ..Our data confirm the high prevalence of cortical demyelination in chronic MS and imply that the propensity to remyelinate is high in cortical MS lesions...