JURGEN BROSIUS

Summary

Country: Germany

Publications

  1. ncbi request reprint Genomes were forged by massive bombardments with retroelements and retrosequences
    J Brosius
    Institute of Experimental Pathology Molecular Neurobiology, ZMBE, University of Munster, Germany
    Genetica 107:209-38. 1999
  2. ncbi request reprint Waste not, want not--transcript excess in multicellular eukaryotes
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Trends Genet 21:287-8. 2005
  3. ncbi request reprint Echoes from the past--are we still in an RNP world?
    J Brosius
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster, Germany
    Cytogenet Genome Res 110:8-24. 2005
  4. doi request reprint Rodent evolution: back to the root
    Gennady Churakov
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 27:1315-26. 2010
  5. pmc Genomic impact of eukaryotic transposable elements
    Irina R Arkhipova
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster D 48149, Germany
    Mob DNA 3:19. 2012
  6. pmc Retrocopy contributions to the evolution of the human genome
    Robert Baertsch
    Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA
    BMC Genomics 9:466. 2008
  7. ncbi request reprint Gene duplication and other evolutionary strategies: from the RNA world to the future
    JURGEN BROSIUS
    Institute of Experimental Pathology, Center for Molecular Biology of Inflammation, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    J Struct Funct Genomics 3:1-17. 2003
  8. ncbi request reprint The contribution of RNAs and retroposition to evolutionary novelties
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Genetica 118:99-116. 2003
  9. ncbi request reprint From Eden to a hell of uniformity? Directed evolution in humans
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Bioessays 25:815-21. 2003
  10. pmc Neuronal untranslated BC1 RNA: targeted gene elimination in mice
    Boris V Skryabin
    Institute of Experimental Pathology ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Mol Cell Biol 23:6435-41. 2003

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Genomes were forged by massive bombardments with retroelements and retrosequences
    J Brosius
    Institute of Experimental Pathology Molecular Neurobiology, ZMBE, University of Munster, Germany
    Genetica 107:209-38. 1999
    ..Finally the paradox of evolution's lack of foresight and the future exaptive use of retronuons is being dealt with by referring to W.F. Doolittle's 'Hierarchical Approaches to Genome Evolution'...
  2. ncbi request reprint Waste not, want not--transcript excess in multicellular eukaryotes
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Trends Genet 21:287-8. 2005
    ..Nevertheless, analogous to 'superfluous' genomic DNA, aberrant transcripts or processing products embody evolutionary potential and provide novel RNAs that natural selection can act on...
  3. ncbi request reprint Echoes from the past--are we still in an RNP world?
    J Brosius
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster, Germany
    Cytogenet Genome Res 110:8-24. 2005
    ..Apart from the impact of such RNA-mediated processes as retroposition, the role of RNA in a wide variety of cellular functions has only recently become more widely appreciated...
  4. doi request reprint Rodent evolution: back to the root
    Gennady Churakov
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 27:1315-26. 2010
    ....
  5. pmc Genomic impact of eukaryotic transposable elements
    Irina R Arkhipova
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster D 48149, Germany
    Mob DNA 3:19. 2012
    ..The success of the meeting reflects the important role of Repbase in comparative genomic studies, and emphasizes the need for close interactions between experimental and computational biologists in the years to come...
  6. pmc Retrocopy contributions to the evolution of the human genome
    Robert Baertsch
    Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA
    BMC Genomics 9:466. 2008
    ..A subset of retroposed mRNAs (retrocopies) shows strong evidence of expression in primates, often yielding functional retrogenes...
  7. ncbi request reprint Gene duplication and other evolutionary strategies: from the RNA world to the future
    JURGEN BROSIUS
    Institute of Experimental Pathology, Center for Molecular Biology of Inflammation, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    J Struct Funct Genomics 3:1-17. 2003
    ..At the dawn of the most recent transformation, a fast evolutionary transition that we will be witnessing in our life times, a form of Lamarckism is raising its head...
  8. ncbi request reprint The contribution of RNAs and retroposition to evolutionary novelties
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Genetica 118:99-116. 2003
    ..It is obvious that retroposition has, thus far, contributed numerous useful novelties to genomes...
  9. ncbi request reprint From Eden to a hell of uniformity? Directed evolution in humans
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Bioessays 25:815-21. 2003
    ....
  10. pmc Neuronal untranslated BC1 RNA: targeted gene elimination in mice
    Boris V Skryabin
    Institute of Experimental Pathology ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Mol Cell Biol 23:6435-41. 2003
    ..Behavioral analyses, to be reported separately, indicate that the lack of BC1 RNA appears to reduce exploratory activity...
  11. ncbi request reprint RNomenclature
    JURGEN BROSIUS
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster, Germany
    RNA Biol 1:81-3. 2004
    ..Class II RNAs comprise the familiar mRNAs, including peptide-coding RNAs. Class I RNAs, we suggest, are most fittingly called utRNAs (untranslated RNAs). The term npcRNAs (non-peptide/protein coding) can be used synonymously...
  12. ncbi request reprint Reverse transcriptase: mediator of genomic plasticity
    J Brosius
    Institute for Experimental Pathology, ZMBE University of Münster, Germany
    Virus Genes 11:163-79. 1995
    ..J. and Vrba E., Paleobiology 8, 4-15, 1982] and punctuated equilibrium [Elredge N. and Gould S.J. in Schopf T.J.M. (ed). Models in Paleobiology. Freeman, Cooper, San Francisco, 1972, pp. 82-115]...
  13. ncbi request reprint RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements
    J Brosius
    Institute of Experimental Pathology Molecular Neurobiology, ZMBE, University of Munster, Germany
    Gene 238:115-34. 1999
    ..BC1 is the first identified master gene generating a subclass of ID repetitive elements, and BC200 is the only known Alu element (monomeric) that was exapted as a novel small RNA encoding gene...
  14. ncbi request reprint tRNAs in the spotlight during protein biosynthesis
    J Brosius
    Institute of Experimental Pathology Molecular Neurobiology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Trends Biochem Sci 26:653-6. 2001
    ..Yet, this translational apparatus must have developed from a much more primitive structure. Throughout the evolution of this apparatus, tRNAs have been, and still are, key players in the translation process...
  15. ncbi request reprint Birth of a gene: locus of neuronal BC200 snmRNA in three prosimians and human BC200 pseudogenes as archives of change in the Anthropoidea lineage
    V Y Kuryshev
    Institute of Experimental Pathology Molecular Neurobiology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, D 48149, Germany
    J Mol Biol 309:1049-66. 2001
    ....
  16. ncbi request reprint The fragmented gene
    JURGEN BROSIUS
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Ann N Y Acad Sci 1178:186-93. 2009
    ..Such consideration favors not only a more complex view of the gene as an entity composed of many more or less conserved subgenic modules, but also a concept of modular evolution of genes and entire genomes...
  17. pmc RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing
    Thean Hock Tang
    Institut für Experimentelle Pathologie Molekulare Neurobiologie ZMBE, Universitat Munster, D 48149 Munster, Germany
    Nucleic Acids Res 30:921-30. 2002
    ..This supports the notion that it might have an important but still unknown role in pre-rRNA biogenesis or might even target RNA molecules other than rRNA...
  18. pmc Mosaic retroposon insertion patterns in placental mammals
    Gennady Churakov
    Institute of Experimental Pathology, Center for Molecular Biology of Inflammation, University of Munster, Munster, Germany
    Genome Res 19:868-75. 2009
    ....
  19. pmc Two primate-specific small non-protein-coding RNAs in transgenic mice: neuronal expression, subcellular localization and binding partners
    Tasneem Khanam
    Institute of Experimental Pathology ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Nucleic Acids Res 35:529-39. 2007
    ..These observations strongly support the possibility that the independently exapted npcRNAs have similar functions, perhaps in translational regulation of dendritic protein biosynthesis in neurons of the respective primates...
  20. pmc Evolution of small nucleolar RNAs in nematodes
    Anja Zemann
    Institute of Experimental Pathology ZMBE, University of Munster, D 48149 Munster, Germany
    Nucleic Acids Res 34:2676-85. 2006
    ..Some target sites modified by snoRNAs were changed, added or lost, documenting a high degree of evolutionary plasticity of npcRNAs...
  21. ncbi request reprint A universal method for the study of CR1 retroposons in nonmodel bird genomes
    Alexander Suh
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 29:2899-903. 2012
    ..Five markers appear to be species-specific insertions, including the hitherto first evidence in birds for biallelic CR1 insertions that could be useful in future population genetic studies...
  22. ncbi request reprint Automated scanning for phylogenetically informative transposed elements in rodents
    Astrid Farwick
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, 48149 Munster, Germany
    Syst Biol 55:936-48. 2006
    ..All loci were amplifiable and ultimately contributed 31 phylogenetically informative markers distributed throughout the major groups of Rodentia...
  23. ncbi request reprint Evolutionary history of 7SL RNA-derived SINEs in Supraprimates
    Jan Ole Kriegs
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    Trends Genet 23:158-61. 2007
    ..As well as new elements in Tupaia and primates, we also found that the purported ancestral fossil Alu monomer was restricted to Primates, and provide here the first description of a potential chimeric promoter box region in SINEs...
  24. ncbi request reprint A novel abundant family of retroposed elements (DAS-SINEs) in the nine-banded armadillo (Dasypus novemcinctus)
    Gennady Churakov
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 22:886-93. 2005
    ....
  25. pmc RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs
    Guozhong Yuan
    Institute for Experimental Pathology ZMBE, Universitat Munster, D 48149 Munster, Germany
    Nucleic Acids Res 31:2495-507. 2003
    ..Surprisingly, a few snmRNA sequences could not be found on the published D.melanogaster genome, which might suggest that more snmRNA genes (as well as mRNAs) are hidden in unsequenced regions of the genome...
  26. doi request reprint Exonization of transposed elements: A challenge and opportunity for evolution
    Jürgen Schmitz
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Biochimie 93:1928-34. 2011
    ....
  27. pmc Can ID repetitive elements serve as cis-acting dendritic targeting elements? An in vivo study
    Tasneem Khanam
    Institute of Experimental Pathology, University of Munster, Munster, Germany
    PLoS ONE 2:e961. 2007
    ..Other mRNAs containing naturally inserted ID elements are also not found in neuronal dendrites. We conclude that the 5' ID domain from BC1 RNA is not a sufficient dendritic targeting element for mRNAs in vivo...
  28. pmc Tracking marsupial evolution using archaic genomic retroposon insertions
    Maria A Nilsson
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    PLoS Biol 8:e1000436. 2010
    ..The now firmly established phylogeny can be used to determine the direction of genomic changes and morphological transitions within marsupials...
  29. doi request reprint Beyond DNA: RNA editing and steps toward Alu exonization in primates
    Maren Möller-Krull
    Institute of Experimental Pathology ZMBE, University of Munster, Von Esmarch Str 56, 48149 Munster, Germany
    J Mol Biol 382:601-9. 2008
    ..The gorilla, chimpanzee, and human nuclear prelamin A recognition factor genes exemplify the versatile interplay of pre- and posttranscriptional modifications leading to novel genetic potential...
  30. pmc Retroposed elements as archives for the evolutionary history of placental mammals
    Jan Ole Kriegs
    Institute of Experimental Pathology, Center for Molecular Biology of Inflammation, University of Munster, Munster, Germany
    PLoS Biol 4:e91. 2006
    ....
  31. ncbi request reprint Retroposed elements and their flanking regions resolve the evolutionary history of xenarthran mammals (armadillos, anteaters, and sloths)
    Maren Möller-Krull
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 24:2573-82. 2007
    ..The data provide a stable phylogenetic framework for further evolutionary investigations of xenarthrans and important information for defining conservation priorities to save the diversity of one of the most curious groups of mammals...
  32. pmc Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs)
    Maren Krull
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Genome Res 17:1139-45. 2007
    ....
  33. pmc Retroposed SNOfall--a mammalian-wide comparison of platypus snoRNAs
    Jürgen Schmitz
    Institute of Experimental Pathology ZMBE, University of Munster, Munster 48149, Germany
    Genome Res 18:1005-10. 2008
    ..High-copy retroposition via multiple host gene-promoted transcription units is a novel pathway for combining housekeeping function and SINE-like dispersal and reveals a new dimension in the evolution of novel snoRNA function...
  34. doi request reprint Ancestry of the Australian termitivorous numbat
    Anja Zemann
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 30:1041-5. 2013
    ....
  35. pmc A novel web-based TinT application and the chronology of the Primate Alu retroposon activity
    Gennady Churakov
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str, 56, 48149 Munster, Germany
    BMC Evol Biol 10:376. 2010
    ....
  36. pmc Waves of genomic hitchhikers shed light on the evolution of gamebirds (Aves: Galliformes)
    Jan Ole Kriegs
    Institute of Experimental Pathology ZMBE University of Münster, Von Esmarch Str, 56, D 48149 Munster, Germany
    BMC Evol Biol 7:190. 2007
    ..Ascertaining the fixation patterns of CR1 elements would help unravel the phylogeny of gamebirds and other poorly resolved avian clades...
  37. ncbi request reprint Does the AD7c-NTP locus encode a protein?
    Jan Ole Kriegs
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, Munster, Germany
    Biochim Biophys Acta 1727:1-4. 2005
    ..We come to the conclusion that the existence of the gene and in particular the predicted protein is inconsistent with EST and genomic data. Previously published data need to be reassessed...
  38. pmc Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus
    Thean Hock Tang
    Institute of Experimental Pathology, Von Esmarch Strasse 56, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 99:7536-41. 2002
    ..Our study further supports the importance of snmRNAs in all three domains of life...
  39. doi request reprint The genome of a Mesozoic paleovirus reveals the evolution of hepatitis B viruses
    Alexander Suh
    Institute of Experimental Pathology ZMBE, University of Munster, Von Esmarch Straße 56, D 48149 Munster, Germany
    Nat Commun 4:1791. 2013
    ..Our study reveals previously undiscovered and multi-faceted insights into prehistoric hepatitis B virus evolution and provides valuable resources for future studies, such as in-vitro resurrection of Mesozoic hepadnaviruses...
  40. doi request reprint Retroposon insertions and the chronology of avian sex chromosome evolution
    Alexander Suh
    Institute of Experimental Pathology, University of Munster, Munster, Germany
    Mol Biol Evol 28:2993-7. 2011
    ..Additionally, three of our investigated loci can be utilized as universal, easy-to-use independent tools for molecular sexing of Neoaves or Neognathae...
  41. pmc Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation
    Boris V Skryabin
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    PLoS Genet 3:e235. 2007
    ..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype...
  42. pmc Mesozoic retroposons reveal parrots as the closest living relatives of passerine birds
    Alexander Suh
    Institute of Experimental Pathology ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Nat Commun 2:443. 2011
    ..This includes insights of relevance to human neuroscience, as vocal learning (that is, birdsong) probably evolved in the psittacopasseran ancestor, >30 million years earlier than previously assumed...
  43. pmc Retrophylogenomics place tarsiers on the evolutionary branch of anthropoids
    Gerrit Hartig
    Institute of Experimental Pathology, University of Munster, 48149 Munster, Germany
    Sci Rep 3:1756. 2013
    ..Thus, tarsiers are clearly the sister group to anthropoids in the clade Haplorrhini...
  44. ncbi request reprint Alu-SINE exonization: en route to protein-coding function
    Maren Krull
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 22:1702-11. 2005
    ..The course of these paths can probably be generalized to the exonization of other elements as well...
  45. pmc Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea
    Timofey S Rozhdestvensky
    Institut für Experimentelle Pathologie Molekulare Neurobiologie ZMBE, Universitat Munster, D 48149 Munster, Germany
    Nucleic Acids Res 31:869-77. 2003
    ..These findings suggest a triple role for L7Ae protein in Archaea, e.g. in ribosomes as well as H/ACA and C/D box sRNP biogenesis and function by binding to the K-turn motif...
  46. ncbi request reprint Inhibitory effect of naked neural BC1 RNA or BC200 RNA on eukaryotic in vitro translation systems is reversed by poly(A)-binding protein (PABP)
    Alexander V Kondrashov
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    J Mol Biol 353:88-103. 2005
    ....
  47. pmc A novel class of mammalian-specific tailless retropseudogenes
    Jürgen Schmitz
    Institute of Experimental Pathology ZMBE, University of Muenster, D 48149 Muenster, Germany
    Genome Res 14:1911-5. 2004
    ..Thus, tailless retropseudogenes point to a novel, variant mechanism for the biogenesis of retrosequences...
  48. ncbi request reprint Retroposon insertion patterns of neoavian birds: strong evidence for an extensive incomplete lineage sorting era
    Andreas Matzke
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 29:1497-501. 2012
    ....
  49. doi request reprint Identification of differentially expressed small non-protein-coding RNAs in Staphylococcus aureus displaying both the normal and the small-colony variant phenotype
    Luay F Abu-Qatouseh
    University Hospital of Munster, Institute of Medical Microbiology, Domagkstr 10, 48149, Munster, Germany
    J Mol Med (Berl) 88:565-75. 2010
    ..aureus phenotype-specific expression of four novel npcRNAs was documented. Thus, the presence of differentially expressed npcRNAs in S. aureus may help to understand the phenotypic variation and its associated pathogenicity...
  50. pmc RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse
    A Huttenhofer
    Institute of Experimental Pathology Molecular Neurobiology, ZMBE, 48149 Munster, Max Planck Institute of Molecular Genetics, 14195 Berlin Dahlem, Germany
    EMBO J 20:2943-53. 2001
    ..It is likely that at least some of the latter will represent novel, unclassified snmRNAS:..
  51. ncbi request reprint Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana
    Claudia Marker
    Institute of Experimental Pathology, ZMBE, Von Esmarch Str 56, 48149 Munster, Germany
    Curr Biol 12:2002-13. 2002
    ..Genomes from all organisms known to date express two types of RNA molecules: messenger RNAs (mRNAs), which are translated into proteins, and non-messenger RNAs, which function at the RNA level and do not serve as templates for translation...
  52. ncbi request reprint An unusual primate locus that attracted two independent Alu insertions and facilitates their transcription
    A Ludwig
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    J Mol Biol 350:200-14. 2005
    ..Thus, the BC200 RNA gene locus attracted two independent Alu insertions during its evolutionary history and provided upstream promoter elements required for their transcription...
  53. ncbi request reprint Isolation and posttranscriptional modification analysis of native BC1 RNA from mouse brain
    Timofey S Rozhdestvensky
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    RNA Biol 4:11-5. 2007
    ....
  54. pmc Neuronal BC1 RNA structure: evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure
    T S Rozhdestvensky
    Institute of Experimental Pathology Molecular Neurobiology, , Germany
    RNA 7:722-30. 2001
    ..The three distinct structural domains reflect evolutionary legacies of BC1 RNA...
  55. ncbi request reprint RNomics: identification and function of small, non-messenger RNAs
    Alexander Huttenhofer
    Institute of Experimental Pathology, ZMBE, Von Esmarch Str 56, 48149, Munster, Germany
    Curr Opin Chem Biol 6:835-43. 2002
    ..Many other RNAs were identified by RNomics studies lacking known sequence and structure motifs. Future challenges in the field of RNomics include identification of the novel snmRNA's biological roles in the cell...
  56. ncbi request reprint Identification of human autoantigen La/SS-B as BC1/BC200 RNA-binding protein
    J Kremerskothen
    Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, , Germany
    DNA Cell Biol 17:751-9. 1998
    ..The fact that La binds both BC1 and BC200 RNAs further supports the notion that the RNAs are functional analogs despite the fact that they arose from two separate retroposition events in two different mammalian lineages...
  57. ncbi request reprint Role of a neuronal small non-messenger RNA: behavioural alterations in BC1 RNA-deleted mice
    L Lewejohann
    Department of Behavioural Biology, University of Munster, D 48149 Munster, Germany
    Behav Brain Res 154:273-89. 2004
    ..In the outdoor pen, the survival rates of BC1-depleted mice were lower than in controls. Thus, we conclude that the neuron-specific non-messenger BC1 RNA contributes to the aptive modulation of behaviour...