Sebastian Brenner

Summary

Country: Germany

Publications

  1. ncbi request reprint The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe combined immunodeficient mice
    Sebastian Brenner
    Laboratory of Host Defences, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA
    Stem Cells 25:1807-13. 2007
  2. ncbi request reprint Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Ther 14:202-11. 2006
  3. ncbi request reprint CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 22:1128-33. 2004
  4. ncbi request reprint Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 11N112, 10 Center Dr, MSC 1886, Bethesda, MD 20892 1886, USA
    Blood 102:2789-97. 2003
  5. ncbi request reprint Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome
    Toshinao Kawai
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1456, USA
    Exp Hematol 33:460-8. 2005
  6. ncbi request reprint NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes
    Miklos Geiszt
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:299-306. 2003
  7. ncbi request reprint Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo
    Takahiro Ueda
    Molecular and Clinical Hematology Branch, NIDDK, National Instiutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:991-8. 2005
  8. ncbi request reprint Progress toward effective gene therapy for chronic granulomatous disease
    Harry L Malech
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Jpn J Infect Dis 57:S27-8. 2004
  9. ncbi request reprint Third-generation, self-inactivating gp91(phox) lentivector corrects the oxidase defect in NOD/SCID mouse-repopulating peripheral blood-mobilized CD34+ cells from patients with X-linked chronic granulomatous disease
    Joachim Roesler
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Blood 100:4381-90. 2002
  10. ncbi request reprint Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation
    Mindy Anderson-Cohen
    Laboratory of Host Defenses, NIAID, Department of Laboratory Medicine, Bethesda, MD, USA
    Clin Immunol 109:308-17. 2003

Collaborators

  • H L Malech
  • Joachim Roesler
  • Elizabeth M Kang
  • Mitchell E Horwitz
  • Thomas J MacVittie
  • Thomas L Leto
  • A M Farese
  • Toshihiro Nanki
  • A Lun
  • Lysann Mauch
  • Jack J Bleesing
  • Takahiro Ueda
  • Toshinao Kawai
  • Thomas A Fleisher
  • Mindy Anderson-Cohen
  • Miklos Geiszt
  • Uta Oelschlagel
  • Tobias Fuchs
  • John S Harris
  • Dolphe Kutter
  • Angela Rosen-Wolff
  • Ilka Schulze
  • Arturo Zychlinsky
  • Maurice R G O'Gorman
  • Peter E Lipsky
  • William J Savage
  • Cynthia Martinez
  • Margarida M Souto-Carneiro
  • Richard M Siegel
  • Sule Yavuz
  • Margaret R Brown
  • Philip M Murphy
  • Gilda F Linton
  • Joan M G Sechler
  • Martha Kirby
  • John F Tisdale
  • Narda L Whiting-Theobald
  • Allen E Krouse
  • Oswald A Phang
  • Robert E Donahue
  • Uimook Choi
  • Shira Perl
  • Saskia M Langemeijer
  • Li Ding
  • Kristen Lekstrom
  • Doug B Kuhns
  • Raya Dana
  • Stephen M Hewitt
  • Steve M Holland

Detail Information

Publications14

  1. ncbi request reprint The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe combined immunodeficient mice
    Sebastian Brenner
    Laboratory of Host Defences, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA
    Stem Cells 25:1807-13. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  2. ncbi request reprint Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Ther 14:202-11. 2006
    ..Some inserts landed in the vicinity of genes controlling cell cycle and proliferation. Statistical analyses of insertion sites 1 year posttransplant suggest a high diversity of insertion sites despite low marking...
  3. ncbi request reprint CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 22:1128-33. 2004
    ..We conclude that transduction-mediated overexpression of CXCR4 significantly improves marrow engraftment of cultured PBSCs...
  4. ncbi request reprint Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 11N112, 10 Center Dr, MSC 1886, Bethesda, MD 20892 1886, USA
    Blood 102:2789-97. 2003
    ..Our data demonstrate the highest reported level of functional correction of any inherited metabolic disorder in human cells in vivo with the NOD/SCID mouse system using onco-retrovirus vector...
  5. ncbi request reprint Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome
    Toshinao Kawai
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1456, USA
    Exp Hematol 33:460-8. 2005
    ....
  6. ncbi request reprint NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes
    Miklos Geiszt
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:299-306. 2003
    ....
  7. ncbi request reprint Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo
    Takahiro Ueda
    Molecular and Clinical Hematology Branch, NIDDK, National Instiutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:991-8. 2005
    ....
  8. ncbi request reprint Progress toward effective gene therapy for chronic granulomatous disease
    Harry L Malech
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Jpn J Infect Dis 57:S27-8. 2004
    ..These maneuvers might result in clinical benefit to CGD patients from gene therapy...
  9. ncbi request reprint Third-generation, self-inactivating gp91(phox) lentivector corrects the oxidase defect in NOD/SCID mouse-repopulating peripheral blood-mobilized CD34+ cells from patients with X-linked chronic granulomatous disease
    Joachim Roesler
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Blood 100:4381-90. 2002
    ....
  10. ncbi request reprint Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation
    Mindy Anderson-Cohen
    Laboratory of Host Defenses, NIAID, Department of Laboratory Medicine, Bethesda, MD, USA
    Clin Immunol 109:308-17. 2003
    ..Our conclusion: A presumed autosomal form of CGD has been excluded. Instead, a spontaneous mutation in gp91-phox coinciding with an extreme X chromosome inactivation ratio resulted in X-linked CGD in this young woman...
  11. ncbi request reprint Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy
    Sebastian Brenner
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1640:1-24. 2003
    ..Engl. J. Med. 346 (2002) 1185]. These achievements of prolonged clinical benefit from gene therapy were tempered by the finding of insertional mutageneses in two of the treated X-SCID patients [N. Engl. J. Med. 348 (2003) 255]...
  12. ncbi request reprint Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established
    Elizabeth M Kang
    LHD NIAID, National Institutes of Health DHHS, Bethesda, MD 20895, USA
    Exp Hematol 33:699-705. 2005
    ....
  13. ncbi request reprint Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment
    Jack J Bleesing
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 176:7096-103. 2006
    ..These results suggest a role for NADPH in the process of memory B cell formation, inviting further exploration of secondary Ab responses in CGD patients...
  14. ncbi request reprint Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD
    Lysann Mauch
    University Clinic Carl Gustav Carus, Department of Pediatrics, Dresden, Germany
    Clin Chem 53:890-6. 2007
    ..Our aim was to devise simple laboratory methods to differentiate MPO deficiency (false positive for CGD) and NADPH oxidase abnormalities (true CGD)...