Braeuning A, Vetter S, Orsetti S, Schwarz M. Paradoxical cytotoxicity of tert-butylhydroquinone in vitro: What kills the untreated cells?. Arch Toxicol. 2012;86:1481-7 pubmed publisher
..This might lead to an underestimation of the effects observed on the Nrf2 signaling pathway, where tBHQ is frequently used as an inductor in vitro. ..
Braeuning A. Interplay of ?-catenin with xenobiotic-sensing receptors and its role in glutathione S-transferase expression. Curr Drug Metab. 2012;13:203-14 pubmed
..In addition, the crosstalk of ?-catenin signaling with nuclear receptors involved in the regulation of glutathione S-transferases will be discussed. ..
Muche S, Kirschnick M, Schwarz M, Braeuning A. Synergistic effects of Î²-catenin inhibitors and sorafenib in hepatoma cells. Anticancer Res. 2014;34:4677-83 pubmed
..In vitro data suggest that the combination of sorafenib and Î²-catenin inhibition might be a promising approach for HCC treatment. ..
Braeuning A, Bucher P, Hofmann U, Buchmann A, Schwarz M. Chemically induced mouse liver tumors are resistant to treatment with atorvastatin. BMC Cancer. 2014;14:766 pubmed publisher
..In summary, the present data provide substantial evidence that atorvastatin does not beneficially influence tumor growth in mouse liver and thereby challenge the hypothesis that statin use might protect against hepatocellular cancer. ..
Braeuning A, Buchmann A. The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor. Drug Metab Dispos. 2009;37:1576-80 pubmed publisher
..Instead, SB216763 induces Cyp1a1 by activation of AhR-mediated transcription. The present results suggest that SB216763 acts as a partial agonist of the AhR. ..
Braeuning A, Vetter S. The nuclear factor ?B inhibitor (E)-2-fluoro-4'-methoxystilbene inhibits firefly luciferase. Biosci Rep. 2012;32:531-7 pubmed publisher
..The in vitro use of trans-stilbenes such as (E)-2-fluoro-4'-methoxystilbene or resveratrol compromises firefly luciferase reporter assays as well as ATP/luciferase-based cell viability assays...
Braeuning A, Gavrilov A, Brown S, Wolf C, Henderson C, Schwarz M. Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Toxicol Sci. 2014;140:259-70 pubmed publisher
..In conclusion, the present findings demonstrate that human CAR and PXR support tumor promotion by PB in mouse liver, but to a significantly lesser extent than the WT murine receptors. ..
Vaas S, Kreft L, Schwarz M, Braeuning A. Cooperation of structurally different aryl hydrocarbon receptor agonists and Î²-catenin in the regulation of CYP1A expression. Toxicology. 2014;325:31-41 pubmed publisher