Stefan R Bornstein

Summary

Country: Germany

Publications

  1. ncbi request reprint The clinically inapparent adrenal mass: update in diagnosis and management
    Georg Mansmann
    Department of Endocrinology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Endocr Rev 25:309-40. 2004
  2. pmc Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase
    Janine Schmid
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 108:13722-7. 2011
  3. doi request reprint Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells
    Kuei Fang Chung
    Medical Clinic III, Carl Gustav Carus University Medical School, Dresden University of Technology, Dresden, Germany
    Mol Cell Endocrinol 336:141-8. 2011
  4. pmc Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 107:12623-8. 2010
  5. doi request reprint The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes
    Peter E H Schwarz
    Medical Faculty Carl Gustav Carus of Technical University Dresden, Medical Clinic III, Building 10, Room 108, Fetscherstrasse 74, 01309 Dresden, Germany
    J Clin Endocrinol Metab 94:920-6. 2009
  6. pmc Structured health care for subjects with diabetic foot ulcers results in a reduction of major amputation rates
    Matthias Weck
    Department of Diabetes, Interdisciplinary Diabetic Foot Unit, Weisseritztal Kliniken, Freital, Germany
    Cardiovasc Diabetol 12:45. 2013
  7. doi request reprint Chromaffin cells: the peripheral brain
    S R Bornstein
    Department of Medicine III, University of Dresden, Dresden, Germany
    Mol Psychiatry 17:354-8. 2012
  8. pmc Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients
    Alexander Koch
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, JW Goethe University Hospital, Theodor Stern Kai 7, Frankfurt am Main 60590, Germany
    Crit Care 15:R109. 2011
  9. pmc Transcriptional regulatory program in wild-type and retinoblastoma gene-deficient mouse embryonic fibroblasts during adipocyte differentiation
    Robab Hakim-Weber
    Biocenter, Division of Bioinformatics, Innsbruck Medical University, Austria
    BMC Res Notes 4:157. 2011
  10. pmc Consumption of alcohol, cigarettes and illegal substances among physicians and medical students in Brandenburg and Saxony (Germany)
    Karen Voigt
    Department of General Medicine Medical Clinic III, Dresden Medical School, Dresden University of Technology, Dresden, Germany
    BMC Health Serv Res 9:219. 2009

Collaborators

Detail Information

Publications163 found, 100 shown here

  1. ncbi request reprint The clinically inapparent adrenal mass: update in diagnosis and management
    Georg Mansmann
    Department of Endocrinology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Endocr Rev 25:309-40. 2004
    ..Based on the statements of the conference, the available literature, and ongoing studies, our aim is to provide practical recommendations for the management of this common entity and to highlight areas for future studies and research...
  2. pmc Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase
    Janine Schmid
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 108:13722-7. 2011
    ..Agonists of CRHR1 and GHRH-receptor, therefore, may play an important role as novel therapeutic tools in the treatment of diabetes mellitus...
  3. doi request reprint Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells
    Kuei Fang Chung
    Medical Clinic III, Carl Gustav Carus University Medical School, Dresden University of Technology, Dresden, Germany
    Mol Cell Endocrinol 336:141-8. 2011
    ..Furthermore, the high dehydroepiandrosterone concentrations present in the fetal and adult adrenal may play an important role in adrenomedullary cell proliferation and differentiation...
  4. pmc Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 107:12623-8. 2010
    ..In conclusion, our study provides evidence that agonists of GHRH represent a promising pharmacological therapy aimed at promoting islet graft growth and proliferation in diabetic patients...
  5. doi request reprint The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes
    Peter E H Schwarz
    Medical Faculty Carl Gustav Carus of Technical University Dresden, Medical Clinic III, Building 10, Room 108, Fetscherstrasse 74, 01309 Dresden, Germany
    J Clin Endocrinol Metab 94:920-6. 2009
    ..In this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes risk...
  6. pmc Structured health care for subjects with diabetic foot ulcers results in a reduction of major amputation rates
    Matthias Weck
    Department of Diabetes, Interdisciplinary Diabetic Foot Unit, Weisseritztal Kliniken, Freital, Germany
    Cardiovasc Diabetol 12:45. 2013
    ..We tested the effects of structured health care for the diabetic foot in one region in Germany aiming to reduce the number of major amputations...
  7. doi request reprint Chromaffin cells: the peripheral brain
    S R Bornstein
    Department of Medicine III, University of Dresden, Dresden, Germany
    Mol Psychiatry 17:354-8. 2012
    ....
  8. pmc Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients
    Alexander Koch
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, JW Goethe University Hospital, Theodor Stern Kai 7, Frankfurt am Main 60590, Germany
    Crit Care 15:R109. 2011
    ..To investigate the link to systemic inflammation in this context, we additionally measured 10 different cytokines in the serum...
  9. pmc Transcriptional regulatory program in wild-type and retinoblastoma gene-deficient mouse embryonic fibroblasts during adipocyte differentiation
    Robab Hakim-Weber
    Biocenter, Division of Bioinformatics, Innsbruck Medical University, Austria
    BMC Res Notes 4:157. 2011
    ..abstract:..
  10. pmc Consumption of alcohol, cigarettes and illegal substances among physicians and medical students in Brandenburg and Saxony (Germany)
    Karen Voigt
    Department of General Medicine Medical Clinic III, Dresden Medical School, Dresden University of Technology, Dresden, Germany
    BMC Health Serv Res 9:219. 2009
    ..The aim of this study was to assess consumption of alcohol, cigarettes and illegal substances among physicians and medical students in two German states: Brandenburg and Saxony...
  11. ncbi request reprint Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions
    S R Bornstein
    Department of Medicine, University of Dresden, Carl Gustav Carus, Dresden, Germany
    Mol Psychiatry 11:892-902. 2006
    ....
  12. doi request reprint Is the worldwide epidemic of obesity a communicable feature of globalization?
    S R Bornstein
    Department of Medicine, University of Dresden, Carl Gustav Carus, Dresden, Germany
    Exp Clin Endocrinol Diabetes 116:S30-2. 2008
    ..Understanding obesity in the light of globalization as a communicable disorder will allow outlining better avenues of prevention and treatment...
  13. ncbi request reprint The role of toll-like receptors in the immune-adrenal crosstalk
    S R Bornstein
    Department of Anesthesiology, Heinrich Heine University, Dusseldorf, Germany
    Ann N Y Acad Sci 1088:307-18. 2006
    ..In conclusion, TLRs play a crucial role in the immune-adrenal crosstalk. This close functional relationship needs to be considered in the treatment of inflammatory diseases requiring an intact adrenal stress response...
  14. doi request reprint Dissociation of ACTH and glucocorticoids
    Stefan R Bornstein
    Medical Faculty Carl Gustav Carus of the Technical University Dresden, Dresden, Germany
    Trends Endocrinol Metab 19:175-80. 2008
    ..The separation of adrenocorticotropic hormone and corticosteroid secretion is of clinical relevance and should be incorporated into our view on endocrine stress regulation...
  15. ncbi request reprint From Neuroendocrinology to Neuroimmunomodulation - a tribute to Prof. Dr. Samuel McCann
    Stefan R Bornstein
    Department of Medicine, University of Dresden, Carl Gustav Carus, Dresden, Gemany
    Neuroimmunomodulation 14:122-5. 2007
    ....
  16. pmc Impaired adrenal stress response in Toll-like receptor 2-deficient mice
    Stefan R Bornstein
    Department of Medicine, Carl Gustav Carus University Hospital, University of Dresden, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 101:16695-700. 2004
    ..Our data demonstrate a link between the innate immune system and the endocrine stress response. The critical role of TLR-2 in adrenal glucocorticoid regulation needs to be considered in patients with inflammatory disease...
  17. ncbi request reprint Genetic testing in pheochromocytoma: increasing importance for clinical decision making
    Stefan R Bornstein
    Department of Medicine, Carl Gustav Carus University Hospital, Dresden, Germany
    Ann N Y Acad Sci 1073:94-103. 2006
    ..This algorithm will need to be validated by further genetic analysis, multicenter studies, and long-term observations...
  18. ncbi request reprint 150 years of Sigmund Freud: What would Freud have said about the obesity epidemic?
    S R Bornstein
    Department of Medicine, University of Dresden, Dresden, Germany
    Mol Psychiatry 11:1070-2. 2006
    ..In this perspective, we attempt to write on his behalf an updated version of a Freudian way of thinking focused on the current high rates of obesity and depression...
  19. doi request reprint Direct effect of dehydroepiandrosterone sulfate (DHEAS) on PC-12 cell differentiation processes
    Christian G Ziegler
    Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 336:149-55. 2011
    ..Furthermore, employing membrane-impermeable dehydroepiandrosterone-BSA indicates the involvement of plasma-membrane bound receptors...
  20. ncbi request reprint Dehydroepiandrosterone induces a neuroendocrine phenotype in nerve growth factor-stimulated chromaffin pheochromocytoma PC12 cells
    Christian G Ziegler
    University Hospital Carl Gustav Carus, Medical Clinic III, University of Dresden, 01307 Dresden, Germany
    Endocrinology 149:320-8. 2008
    ..DHEA drives NGF-stimulated cells toward a neuroendocrine phenotype, suggesting that the interaction of intraadrenal steroids and growth factors is required for the maintenance of an intact adrenal medulla...
  21. doi request reprint Differentiation of chromaffin progenitor cells to dopaminergic neurons
    Vladimir Vukicevic
    Molecular Endocrinology, Medical Clinic III, University Clinic Dresden, Dresden University of Technology, Fetscherstrasse 74, Dresden, Germany
    Cell Transplant 21:2471-86. 2012
    ..In summary, this study elucidates the capacity of chromaffin progenitor cells to generate functional dopaminergic neurons, indicating their potential use in cell replacement therapies...
  22. doi request reprint Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla
    Kuei Fang Chung
    Carl Gustav Carus University Medical School, Medical Clinic III, Dresden University of Technology, Dresden, Germany
    Stem Cells 27:2602-13. 2009
    ....
  23. pmc Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation
    Waldemar Kanczkowski
    Department of Medicine III, Technical University Dresden, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 110:14801-6. 2013
    ..Thus, our data suggest an important role of immune cell rather than adrenocortical MyD88 for adrenal inflammation and HPA-axis activation mediated by LPS. ..
  24. pmc Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, University of Dresden, Dresden, Germany
    Eur J Cancer 48:1739-49. 2012
    ..There are currently no reliable biomarkers for malignant pheochromocytomas and paragangliomas (PPGLs). This study examined whether measurements of catecholamines and their metabolites might offer utility for this purpose...
  25. pmc Age at diagnosis of pheochromocytoma differs according to catecholamine phenotype and tumor location
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine III, University of Dresden, 01307 Dresden, Germany
    J Clin Endocrinol Metab 96:375-84. 2011
    ..Pheochromocytomas and paragangliomas (PPGLs) are diagnosed earlier in patients with hereditary than sporadic disease. Whether other factors influence age at diagnosis is unclear...
  26. doi request reprint Characterization of the LPS-induced inflammation of the adrenal gland in mice
    Waldemar Kanczkowski
    Department of Medicine III, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 371:228-35. 2013
    ..Our results performed in mice, suggest that LPS-induced adrenal gland inflammation and cell death might be mechanisms potentially involved in the adrenal gland dysfunction in patients with sepsis...
  27. pmc Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine III, University of Dresden, Dresden, Germany
    Clin Chem 57:411-20. 2011
    ..This study assessed whether measurements of plasma metanephrine, normetanephrine, and methoxytyramine, the O-methylated metabolites of catecholamines, might help to distinguish different hereditary forms of the tumor...
  28. doi request reprint Lipoprotein apheresis of hypercholesterolemic patients mediates vasoprotective gene expression in human endothelial cells
    Henning Morawietz
    Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Clinical Center, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Atheroscler Suppl 14:107-13. 2013
    ..The underlying molecular mechanisms are not well-understood. In this study, we analyzed the impact of lipoprotein apheresis on gene expression in human endothelial cells...
  29. pmc Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone
    Undine Schubert
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 110:2288-93. 2013
    ..Our studies demonstrated that the adrenal may be an attractive site for islet transplantation and that GHRH analogs might allow reduction of the islet mass needed to reverse a diabetic status...
  30. pmc Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate
    Flavie Sicard
    Department of Medicine, Carl Gustav Carus University Medical School, University of Technology, Dresden, Germany
    Proc Natl Acad Sci U S A 104:2007-12. 2007
    ..In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors...
  31. ncbi request reprint Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice
    Valeria Lamounier-Zepter
    Department of Internal Medicine III, University Medical Center, University of Dresden, 01307 Dresden, Germany
    Mol Cell Endocrinol 280:39-46. 2008
    ..In conclusion, lipodystrophy in A-ZIP/F-1 mice is associated with hypertension, possibly due to hypercorticosteronemia and/or others metabolic-vascular changes...
  32. doi request reprint Modified high-density lipoprotein modulates aldosterone release through scavenger receptors via extra cellular signal-regulated kinase and Janus kinase-dependent pathways
    Sarama Saha
    Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Fetscherstraße 74, 01307 Dresden, Germany
    Mol Cell Biochem 366:1-10. 2012
    ..This significant influence on multiple signaling mechanisms could be targeted for future research to implement novel therapeutic trials...
  33. pmc LipidXplorer: a software for consensual cross-platform lipidomics
    Ronny Herzog
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS ONE 7:e29851. 2012
    ..mpi-cbg.de/wiki/lipidx/index.php/Main_Page...
  34. doi request reprint Type 2 diabetes in octogenarians is associated with decreased low molecular weight adiponectin
    Juergen Graessler
    Department of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany
    Gerontology 57:316-26. 2011
    ..We examined whether adiponectin oligomer distribution is associated with aging and type 2 diabetes (T2D) in octogenarians without characteristic features of metabolic syndrome...
  35. doi request reprint Endothelial factors mediate aldosterone release via PKA-independent pathways
    Ishrath Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 300:66-70. 2009
    ..These results provide evidence for the existence of a cAMP-dependent but PKA-independent pathway in mediating the ECM-induced aldosterone release and the significant influence of more than one signaling mechanism...
  36. doi request reprint Dehydroepiandrosterone-sulphate (DHEA-S) promotes neuroendocrine differentiation of chromaffin pheochromocytoma PC12 cells
    Alexander W Krug
    Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Germany
    Mol Cell Endocrinol 300:126-31. 2009
    ..Our study provides support for the notion that adrenocortical-derived DHEA-S impacts adrenomedullary chromaffin cells during development and differentiation...
  37. doi request reprint Chromaffin progenitor cells from the adrenal medulla
    Monika Ehrhart-Bornstein
    University Clinic Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Cell Mol Neurobiol 30:1417-23. 2010
    ..We therefore aim to establish protocols for the efficient isolation, enrichment and differentiation of chromaffin progenitor cells to dopaminergic neurons in culture...
  38. doi request reprint Abrogation of TLR4 and CD14 expression and signaling in human adrenocortical tumors
    Waldemar Kanczkowski
    Department of Medicine III, Technical University of Dresden, Dresden, Germany
    J Clin Endocrinol Metab 95:E421-9. 2010
    ....
  39. doi request reprint Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells
    Claudia Goettsch
    Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University of Technology Dresden, Fetscherstrasse 74, Dresden, Germany
    Basic Res Cardiol 106:551-61. 2011
    ..This novel mechanism may be involved in the flow-dependent downregulation of endothelial superoxide anion formation...
  40. doi request reprint Is there still a place for adrenal venous sampling in the diagnostic localization of pheochromocytoma?
    Roland Därr
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Dresden Technical University Medical Center, Fetscherstr 74, 01307, Dresden, Germany
    Endocrine 40:75-9. 2011
    ..This case highlights a scenario where a combination of (68)Ga-DOTATOC-PET/CT and AVS with measurement of the metanephrine to normetanephrine ratio was crucial for the preoperative assessment of a patient with bilateral pheochromocytoma...
  41. doi request reprint Prediabetic and diabetic in vivo modification of circulating low-density lipoprotein attenuates its stimulatory effect on adrenal aldosterone and cortisol secretion
    Steffi Kopprasch
    Department of Internal Medicine 3, Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology Dresden, Dresden, Germany
    J Endocrinol 200:45-52. 2009
    ..We conclude that LDL modifications in IGT and DM2 subjects may have significant clinical benefits by counteracting prediabetic and diabetic overactivity of the renin-angiotensin-aldosterone system and enhanced cortisol generation...
  42. doi request reprint Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease
    Valeria Lamounier-Zepter
    Medical Clinic III, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Circ Res 105:326-34. 2009
    ..We have recently reported that secretory products from human adipocytes directly and acutely depressed cardiac contractile function...
  43. pmc Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, University of Dresden, 01307 Dresden, Germany
    Endocr Relat Cancer 18:97-111. 2011
    ..The data further suggest developmental origins of PPGLs from different populations of chromaffin cell progenitors...
  44. pmc Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome
    Kai Zacharowski
    Molecular Cardioprotection and Inflammation Group, Department of Anesthesia, Heinrich Heine University, Dusseldorf 40225, Germany
    Proc Natl Acad Sci U S A 103:6392-7. 2006
    ..Furthermore, TLR polymorphisms could contribute to the underlying mechanisms of impaired adrenal stress response in patients with bacterial sepsis...
  45. ncbi request reprint Corticotropin-releasing hormone receptor expression on normal and tumorous human adrenocortical cells
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University of Dusseldorf, Dusseldorf, Germany
    Neuroendocrinology 82:274-81. 2005
    ..The data support the assertion of a direct action of CRH on human adrenocortical cells in addition to an intra-adrenal CRH receptor/adrenocorticotropin system. Enhanced CRH1R expression may be involved in adrenocortical tumorigenesis...
  46. pmc Optimizing orthotopic cell transplantation in the mouse adrenal gland
    Cibele C Cardoso
    Department of Internal Medicine III, University Medical Center, University of Dresden, Germany
    Cell Transplant 19:565-72. 2010
    ....
  47. doi request reprint Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress
    Katja Petrowski
    Department of Psychotherapy and Psychosomatic Medicine, University Hospital Carl Gustav Carus Dresden, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Int J Psychophysiol 88:35-9. 2013
    ..Whether the present findings can be replicated on a patient sample with pure PD using both salivary cortisol and total plasma cortisol as outcome variables remains to be elucidated...
  48. doi request reprint Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways
    Sarama Saha
    Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany
    Cell Tissue Res 348:71-80. 2012
    ....
  49. doi request reprint Acute effects of lipid apheresis on human serum lipidome
    Sergey Tselmin
    Department of Internal Medicine III, University Hosptial Carl Gustav Carus at the Technische Universität Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Atheroscler Suppl 10:27-33. 2009
    ..The importance of specific changes in particular lipid species remains to be established...
  50. pmc The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance
    Julia Phieler
    Division of Vascular Inflammation, Diabetes and Kidney, Department of Medicine III, Dresden University, 01307 Dresden, Germany
    J Immunol 191:4367-74. 2013
    ..These results suggest that C5aR contributes to macrophage accumulation and M1 polarization in the obese AT and thereby to AT dysfunction and development of AT insulin resistance. ..
  51. doi request reprint Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells
    Slobodanka Korten
    Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital Carl Gustav Carus, University of Technology Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Basic Res Cardiol 108:362. 2013
    ..Our data support an important role of Hey2 and COUP-TFII in arteriovenous differentiation of human endothelial cells...
  52. ncbi request reprint Role of interleukin-6 in stress response in normal and tumorous adrenal cells and during chronic inflammation
    Holger S Willenberg
    Department of Endocrinology at the University of Düsseldorf, Dusseldorf, Germany
    Ann N Y Acad Sci 966:304-14. 2002
    ..We infer that the loss of responsivity of tumorous adrenal cells to IL-6, and in part corticotropin, is an important step in the process of adrenal tumorigenesis by which regulation by differentiating proteins is bypassed...
  53. pmc Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 109:5022-7. 2012
    ..Consequently, this system opens up a fundamental strategy for therapy of diabetes and may provide a promising avenue for future approaches to xenotransplantation...
  54. doi request reprint The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells
    Claudia Goettsch
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, Fetscherstrasse 74, D 01307 Dresden, Germany
    Endocrinology 152:4915-26. 2011
    ..Our data suggest that OSCAR, originally described in bone as immunological mediator and regulator of osteoclast differentiation, may be involved in cell activation and inflammation during atherosclerosis...
  55. pmc A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language
    Ronny Herzog
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Genome Biol 12:R8. 2011
    ....
  56. doi request reprint Shotgun lipidomics on a LTQ Orbitrap mass spectrometer by successive switching between acquisition polarity modes
    Kai Schuhmann
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany
    J Mass Spectrom 47:96-104. 2012
    ..In this way, shotgun analysis of total lipid extracts of human blood plasma enabled to quantify 222 species from 15 major lipid classes within 7 min acquisition cycle...
  57. doi request reprint Role of toll-like receptors and inflammation in adrenal gland insufficiency
    Waldemar Kanczkowski
    Department of Medicine III, Carl Gustav Carus University Hospital, Dresden, Germany
    Neuroimmunomodulation 17:180-3. 2010
    ..TLRs are implicated in adrenal cell turnover and steroidogenesis during inflammation. Therefore, TLRs play a crucial role in the activation of adrenal inflammation mediating adrenal gland dysfunction during septicemia...
  58. doi request reprint Upregulation of TLR2 and TLR4 in the human adrenocortical cells differentially modulates adrenal steroidogenesis
    Waldemar Kanczkowski
    Department of Medicine III, Technical University Dresden, University of Technology, Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 336:41-6. 2011
    ..Together, these data suggest that TLR upregulation in the steroid producing cells may be involved in the adrenal gland dysfunction during sepsis...
  59. pmc Neurovascular signals suggest a propagation mechanism for endogenous stem cell activation along blood vessels
    Jimmy Masjkur
    Department of Medicine, University of Dresden, Dresden, Germany
    CNS Neurol Disord Drug Targets 11:805-17. 2012
    ....
  60. ncbi request reprint Endothelial cell-mediated regulation of aldosterone release from human adrenocortical cells
    Ishrath Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
    Mol Cell Endocrinol 265:150-6. 2007
    ..In conclusion, human endothelial cells are important intra-adrenal regulators of human aldosterone synthesis and release...
  61. pmc Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients
    Juergen Graessler
    Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University Dresden, Dresden, Germany
    PLoS ONE 4:e6261. 2009
    ..The objective of this study was to determine whether hypertension specifically affects the plasma lipidome independently and differently from the effects induced by obesity and insulin resistance...
  62. doi request reprint Differential expression and action of Toll-like receptors in human adrenocortical cells
    Waldemar Kanczkowski
    Department of Medicine, Carl Gustav Carus University Hospital, Technical University of Dresden, 01307 Dresden, Germany
    Mol Cell Endocrinol 300:57-65. 2009
    ..Therefore, Toll-like receptors expression and function is a novel feature of the adrenal stress system contributing to adrenal tissue homeostasis, regeneration and tumorigenesis...
  63. pmc Differential expression of the regulated catecholamine secretory pathway in different hereditary forms of pheochromocytoma
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, University of Dresden, Dresden, Germany
    Am J Physiol Endocrinol Metab 295:E1223-33. 2008
    ....
  64. ncbi request reprint [Prevention of type 2 diabetes in Germany. Ideas, evidence, implementation]
    Peter E H Schwarz
    Medizinische Klinik III, Universitätsklinikum Carl Gustav Carus der technischen Universität Dresden, Fetscherstrasse 74, 01307 Dresden
    Med Klin (Munich) 101:730-6. 2006
    ..This guideline also includes the structure of a national prevention program with a prevention manager having a central role in the concept and suggestions for evaluation and quality control...
  65. doi request reprint Polymorphisms in perilipin gene (PLIN) are not associated with obesity and weight variation in people with high risk of type 2 diabetes
    A Bergmann
    Health Care Centre of Medical Faculty Carl Gustav Carus of the Technical University Dresden, Dresden, Germany
    Exp Clin Endocrinol Diabetes 116:S56-8. 2008
    ..But some other studies showed that, this association was not significant in Chinese and French . The aim of the current study was to examine whether the associations manifested in a German population with high risk of type 2 diabetes...
  66. doi request reprint Stimulation of phagocyte adhesion to endothelial cells by modified VLDL and HDL requires scavenger receptor BI
    Sarama Saha
    Pathological Biochemistry, Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Fetscherstraße 74, 01307, Dresden, Germany
    Mol Cell Biochem 383:21-8. 2013
    ....
  67. pmc Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma
    Christina Pamporaki
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at the TU Dresden, Fetscherstrasse 74, Dresden, Germany
    Clin Endocrinol (Oxf) 79:476-83. 2013
    ..Plasma-deconjugated normetanephrine and metanephrine have been proposed as alternative, equivalent, but easier to measure biomarkers...
  68. doi request reprint Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells
    Vladimir Vukicevic
    Molecular Endocrinology, MKIII, University Clinic Dresden, Fiedlerstr 42, 01307 Dresden, Germany
    Mech Ageing Dev 131:124-32. 2010
    ....
  69. doi request reprint Bottom-up shotgun lipidomics by higher energy collisional dissociation on LTQ Orbitrap mass spectrometers
    Kai Schuhmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Anal Chem 83:5480-7. 2011
    ..We argue that now both bottom-up and top-down shotgun lipidomics could be performed on the same instrumentation platform...
  70. doi request reprint Cross-talk between adrenal medulla and adrenal cortex in stress
    Monika Ehrhart-Bornstein
    Department of Medicine, University of Dresden, Dresden, Germany
    Ann N Y Acad Sci 1148:112-7. 2008
    ..The data summarized here indicate an involvement of intra-adrenal interactions in this coordination of the body's response to stress...
  71. ncbi request reprint Human adipocytes attenuate cardiomyocyte contraction: characterization of an adipocyte-derived negative inotropic activity
    Valeria Lamounier-Zepter
    Medical Clinic III, University of Dresden, Fetscherstr 74, Dresden 01307, Germany
    FASEB J 20:1653-9. 2006
    ..In summary, adipose tissue exerts highly potent activity with an acute depressant effect directly on cardiomyocytes, which may well contribute to increased heart failure risk in overweight patients...
  72. ncbi request reprint DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells
    Christian G Ziegler
    Department of Medicine, Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann N Y Acad Sci 1073:306-11. 2006
    ..Hence, we speculate that DHEA might influence NGF-mediated chromaffin differentiation processes using the ERK1/2 MAP kinase pathway during adrenal tissue development...
  73. ncbi request reprint Insulin resistance in hypertension and cardiovascular disease
    Valeria Lamounier-Zepter
    Department of Endocrinology, Diabetes and Metabolism, University Medical Center, University of Dresden, 01307 Dresden, Germany
    Best Pract Res Clin Endocrinol Metab 20:355-67. 2006
    ..Concerning the antihypertensive therapy of insulin-resistant hypertensive patients, most hypertensive guidelines fail to provide specific advice...
  74. pmc Gout--current diagnosis and treatment
    Anne Kathrin Tausche
    Bereich Rheumatologie, Medizinische Klinik und Poliklinik III, Universitatsklinikum, Carl Gustav Carus an der TU Dresden, Dresden, Germany
    Dtsch Arztebl Int 106:549-55. 2009
    ..In Germany, the prevalence of gouty arthritis is estimated at 1.4%, higher than that of rheumatoid arthritis. There are no German guidelines to date for the treatment of gout. Its current treatment is based largely on expert opinion...
  75. doi request reprint BMS309403 directly suppresses cardiac contractile function
    Christiane Look
    Medical Clinic III, University of Technology Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 384:255-63. 2011
    ..BMS309403 has an acute cardiac depressant effect in vitro. The potential therapeutic applicability of this compound requires additional consideration...
  76. doi request reprint The Janus faces of allopurinol-allopurinol hypersensitivity syndrome
    Anne Kathrin Tausche
    Department of Internal Medicine, Section of Endocrinology and Rheumatology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Am J Med 121:e3-4. 2008
  77. doi request reprint Beyond lowering circulating LDL: apheresis-induced changes of systemic oxidative stress markers by four different techniques
    Steffi Kopprasch
    Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany
    Atheroscler Suppl 10:34-8. 2009
    ....
  78. ncbi request reprint The European perspective on diabetes prevention: development and Implementation of A European Guideline and training standards for diabetes prevention (IMAGE)
    Peter E H Schwarz
    Department of Internal Medicine III, Clinic for Endocrinology, Diabetes and Metabolism, Technical University Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Diab Vasc Dis Res 4:353-7. 2007
    ....
  79. doi request reprint LDL apheresis improves deranged cardiovagal modulation in hypercholesterolemic patients
    Manja Reimann
    Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
    Atherosclerosis 213:212-7. 2010
    ..To evaluate the impact of LDL apheresis on autonomic cardiovascular control we investigated hypercholesterolemic patients before and after a single LDL apheresis in comparison to an age-matched control group...
  80. doi request reprint Retinal vessel analysis in hypercholesterolemic patients before and after LDL apheresis
    Manja Reimann
    Autonomic and Neuroendocrinological Laboratory, Dept of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
    Atheroscler Suppl 10:39-43. 2009
    ..Using retinal vascular imaging techniques, we attempted to investigate the microvascular benefit of a single LDL apheresis in hypercholesterolemia...
  81. ncbi request reprint [Severe progression of coronary heart disease in a patient with elevated lipoprotein (a) level in spite of optimal LDL-C decrease]
    Sabine Fischer
    Medizinische Klinik und Poliklinik III, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Dresden
    Herz 32:578-82. 2007
    ..All other risk factors, e.g., diabetes or hypertension, should be strictly managed as well. Cardiologic and angiologic examinations have to be an integral part of the treatment of these patients...
  82. ncbi request reprint Metabolic syndrome and the endocrine stress system
    V Lamounier-Zepter
    Medical Clinic III, University of Dresden, Dresden, Germany
    Horm Metab Res 38:437-41. 2006
    ..This brief review discusses the role of stress and hypothalamic-pituitary-adrenal axis dysfunction in the development of metabolic syndrome as well as new insights into the crosstalk between adipose tissue and endocrine stress system...
  83. doi request reprint Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives
    P E H Schwarz
    Division of Endocrinology, Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Pharmacogenomics J 9:42-8. 2009
    ..Thus, to examine diabetes risk, a more global approach including the design of population-specific experimental strategies should be used, which will be crucial in developing health education and policies in a global health programme...
  84. doi request reprint Current progress and future challenges in the biochemical diagnosis and treatment of pheochromocytomas and paragangliomas
    G Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden, Germany
    Horm Metab Res 40:329-37. 2008
    ..Improvements in treatment may in the future come from several fronts, but proof of efficacy ideally will require well-coordinated multicenter prospective trials in larger numbers of patients than in previous studies...
  85. ncbi request reprint Increased aldosterone/renin quotient in obese hypertensive women: a novel role for low-density lipoproteins?
    V Lamounier-Zepter
    Medical Clinic III, University of Dresden, Dresden, Germany
    Horm Metab Res 38:471-5. 2006
    ....
  86. doi request reprint Cardiovascular events in patients with increased lipoprotein (a) - retrospective data analysis in an outpatient department of lipid disorders
    S Tselmin
    Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany
    Atheroscler Suppl 10:79-84. 2009
    ..Our retrospective study analyzed the incidence of cardiovascular events in patients with Lp(a) plasma level of more than 250 mg/l, which has been defined as a threshold in previous publications...
  87. doi request reprint Nitric oxide and endothelin after lipid apheresis - a pilot study
    J Beyer-Westendorf
    Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden
    Atheroscler Suppl 10:70-3. 2009
    ..Whether the improvements of endothelial function after lipid apheresis are mediated by increased NO-production or by an altered turnover of vasoconstrictors such as ET-1 is still unknown. This was the onset of the present study...
  88. ncbi request reprint Glycoxidised LDL isolated from subjects with impaired glucose tolerance increases CD36 and peroxisome proliferator-activator receptor gamma gene expression in macrophages
    J Graessler
    Department of Internal Medicine, Division of Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Diabetologia 50:1080-8. 2007
    ....
  89. doi request reprint A novel device for islet transplantation providing immune protection and oxygen supply
    B Ludwig
    University Hospital Carl Gustav Carus, Department of Medicine III, Dresden, Germany
    Horm Metab Res 42:918-22. 2010
    ....
  90. ncbi request reprint Vascular-adrenal niche--endothelial cell-mediated sensitization of human adrenocortical cells to angiotensin II
    I Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany
    Horm Metab Res 38:476-80. 2006
    ..This interaction may contribute to altered basal aldosterone release and have a role in patients with hypertension...
  91. ncbi request reprint Apoptosis in patients with dilated cardiomyopathy and diabetes: a feature of diabetic cardiomyopathy?
    F Kuethe
    Klinik fur Innere Medizin I, Friedrich Schiller Universitat Jena, Jena, Germany
    Horm Metab Res 39:672-6. 2007
    ....
  92. doi request reprint [New oral antidiabetic agents--clinical perspectives]
    S Fischer
    Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus der technischen Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Internist (Berl) 49:495-501. 2008
    ..In the near future one should await the discovery of more oral antidiabetic agents acting through modulation of important enzymes in glucose metabolism and transport pathways...
  93. doi request reprint Alcohol consumption and other psycho-social conditions as important factors in the development of diabetic foot ulcers
    N Altenburg
    Department of Internal Medicine III, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden, Germany
    Diabet Med 28:168-74. 2011
    ..To characterize bio-psycho-social factors, particularly mental disorders and self-harm behaviour, associated with the development of diabetic foot ulcers...
  94. ncbi request reprint Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population
    P E H Schwarz
    III Medical Clinic Department of Endocrinopathies and Metabolic Diseases, Dresden, Germany
    Horm Metab Res 38:447-51. 2006
    ..006) after correction for BMI and age. Our observations suggest that diploid combinations of haplotype in the adiponectin gene promoter region contribute to the genetic risk of T2D in individuals from a German Caucasian population...
  95. ncbi request reprint Human adipocytes induce an ERK1/2 MAP kinases-mediated upregulation of steroidogenic acute regulatory protein (StAR) and an angiotensin II-sensitization in human adrenocortical cells
    A W Krug
    Medical Clinic III, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, D 01309 Dresden, Germany
    Int J Obes (Lond) 31:1605-16. 2007
    ..In addition to a direct stimulation, a sensitization toward angiotensin II (AngII) might be involved. The second objective was to determine a possible adipokines-induced sensitization of human adrenocortical cells to AngII...
  96. ncbi request reprint Low-density lipoproteins induce the renin-angiotensin system and their receptors in human endothelial cells
    R A Catar
    Department of Vascular Endothelium and Microcirculation, Medical Clinic and Policlinic III, University of Technology Dresden, Dresden, Germany
    Horm Metab Res 39:801-5. 2007
    ..These data suggest a novel link between hypercholesterolemia and hypertension in patients with the metabolic syndrome...
  97. ncbi request reprint Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes
    J Li
    Department of Endocrinopathies and Metabolic Diseases, Medical Faculty Carl Gustav Carus of the Technical University Dresden, Dresden, Germany
    Exp Clin Endocrinol Diabetes 116:178-83. 2008
    ..The aim of the current study was to investigate the relevance of NGN3 variants for the clinical spectrum of diabetes development and disease progressions...
  98. pmc Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus
    Elena Tsourdi
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany
    Biomed Res Int 2013:385641. 2013
    ..In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care...
  99. ncbi request reprint Mineralocorticoid-stimulating activity of adipose tissue
    Valeria Lamounier-Zepter
    Department of Endocrinology, Diabetes and Metabolism, University Medical Centre, University of Dresden, Germany
    Best Pract Res Clin Endocrinol Metab 19:567-75. 2005
    ..Indeed, adipose mineralocorticoid-stimulating activity was recently observed in isolated human adipocytes, suggesting a hitherto unknown direct involvement of adipose tissue in the regulation of blood pressure in obesity...
  100. ncbi request reprint Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2)
    Stefan R Bornstein
    Endocrinology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 17:1928-30. 2003
    ..The data, however, establish a crucial role for ascorbic acid in adrenal chromaffin cell function...
  101. ncbi request reprint The Metabolic Syndrome - a global challenge for prevention
    P E H Schwarz
    Department of Internal Medicine III, Clinic for Endocrinology, Diabetes and Metabolism, Technical University Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
    Horm Metab Res 39:777-80. 2007
    ..A global health strategy has to take into account political, epidemiological, environmental, infrastructural and genetic aspects. The Metabolic Syndrome is not a mystery - it is a clinical paradigm and global challenge...