Martin Bornhauser

Summary

Country: Germany

Publications

  1. doi request reprint Prophylactic transfer of BCR-ABL-, PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Blood 117:7174-84. 2011
  2. doi request reprint Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 trial
    Martin Bornhauser
    Department of Haematology, University Hospital, Dresden, Germany
    Lancet Oncol 13:1035-44. 2012
  3. doi request reprint Gemtuzumab ozogamicin as part of reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in patients with relapsed acute myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Clin Cancer Res 14:5585-93. 2008
  4. pmc Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Haematologica 94:1613-7. 2009
  5. ncbi request reprint A second infusion of CD34+ selected cells to improve poor graft function
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I Universitätsklinikum Carl Gustav Carus, Dresden, Germany
    Haematologica 91:870. 2006
  6. ncbi request reprint Allogeneic haematopoietic cell transplantation for chronic myelogenous leukaemia in the era of imatinib: a retrospective multicentre study
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Eur J Haematol 76:9-17. 2006
  7. pmc Hematopoietic stem cells in co-culture with mesenchymal stromal cells--modeling the niche compartments in vitro
    Duohui Jing
    Medical Clinic and Policlinic I University Hospital, Dresden, Germany
    Haematologica 95:542-50. 2010
  8. ncbi request reprint Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells: effects on proliferation and clonogenicity
    Daniel Freund
    Medical Clinic and Polyclinic I, University Hospital Carl Gustav Carus, D 01307, Dresden, Germany
    Stem Cells Dev 15:815-29. 2006
  9. doi request reprint Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts
    Angela Jacobi
    Department of Pediatrics, University Clinic Carl Gustav Carus Dresden, Dresden, Germany
    Exp Hematol 38:180-90. 2010
  10. pmc Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells
    Sabine Stopp
    Medical Clinic and Policlinic I, Dresden, Germany
    Haematologica 98:505-13. 2013

Detail Information

Publications73

  1. doi request reprint Prophylactic transfer of BCR-ABL-, PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Blood 117:7174-84. 2011
    ..This trial was registered at www.clinicaltrials.gov as #NCT00460629...
  2. doi request reprint Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 trial
    Martin Bornhauser
    Department of Haematology, University Hospital, Dresden, Germany
    Lancet Oncol 13:1035-44. 2012
    ..In this prospective, open-label randomised phase 3 trial we compared a reduced-intensity fludarabine-based conditioning regimen with a standard regimen in patients with acute myeloid leukaemia in first complete remission...
  3. doi request reprint Gemtuzumab ozogamicin as part of reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in patients with relapsed acute myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Clin Cancer Res 14:5585-93. 2008
    ..We hypothesized that GO might be safe and effective as part of a reduced-intensity conditioning regimen as salvage therapy of CD33+ acute myeloid leukemia...
  4. pmc Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Haematologica 94:1613-7. 2009
    ..Monitoring of CD34(+) donor chimerism in the peripheral blood allows prediction of imminent relapse after allogeneic stem cell transplantation even when a disease-specific marker is lacking...
  5. ncbi request reprint A second infusion of CD34+ selected cells to improve poor graft function
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I Universitätsklinikum Carl Gustav Carus, Dresden, Germany
    Haematologica 91:870. 2006
  6. ncbi request reprint Allogeneic haematopoietic cell transplantation for chronic myelogenous leukaemia in the era of imatinib: a retrospective multicentre study
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Eur J Haematol 76:9-17. 2006
    ....
  7. pmc Hematopoietic stem cells in co-culture with mesenchymal stromal cells--modeling the niche compartments in vitro
    Duohui Jing
    Medical Clinic and Policlinic I University Hospital, Dresden, Germany
    Haematologica 95:542-50. 2010
    ..Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion...
  8. ncbi request reprint Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells: effects on proliferation and clonogenicity
    Daniel Freund
    Medical Clinic and Polyclinic I, University Hospital Carl Gustav Carus, D 01307, Dresden, Germany
    Stem Cells Dev 15:815-29. 2006
    ..Together, this co-culture offers a unique experimental system to further characterize the biology and role of markers of rare stem cell populations...
  9. doi request reprint Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts
    Angela Jacobi
    Department of Pediatrics, University Clinic Carl Gustav Carus Dresden, Dresden, Germany
    Exp Hematol 38:180-90. 2010
    ..The aim of this study was to evaluate the impact of FLT3-ITD on cell proliferation and CXCR4-dependent migration in human hematopoietic progenitor cells and to investigate their response to CXCR4 inhibition...
  10. pmc Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells
    Sabine Stopp
    Medical Clinic and Policlinic I, Dresden, Germany
    Haematologica 98:505-13. 2013
    ....
  11. doi request reprint High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Clin Oncol 31:2094-102. 2013
    ..To assess the treatment outcome benefit of multiagent consolidation in young adults with acute myeloid leukemia (AML) in a prospective, randomized, multicenter trial...
  12. doi request reprint Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors
    Kristina Hölig
    Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Blood 114:3757-63. 2009
    ..Long-term monitoring of healthy PBSC donors remains important to guarantee the safety standards of PBSC mobilization and collection...
  13. doi request reprint Reconstitution of 6-sulfo LacNAc dendritic cells after allogeneic stem-cell transplantation
    Konrad Mager
    Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
    Transplantation 93:1270-5. 2012
    ..We investigated for the first time the reconstitution of slanDCs in the blood of patients after SCT and the modulation of their frequency by bacterial infection, cytomegalovirus (CMV) reactivation, and acute GvHD...
  14. ncbi request reprint Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma
    Frank Kroschinsky
    1st Medical Department, University Hospital Dresden, Dresden, Germany
    Transfusion 46:1417-23. 2006
    ....
  15. doi request reprint Extracellular matrix functionalized microcavities to control hematopoietic stem and progenitor cell fate
    Ina Kurth
    Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden, Germany
    Macromol Biosci 11:739-47. 2011
    ....
  16. doi request reprint 188Re anti-CD66 radioimmunotherapy combined with reduced-intensity conditioning and in-vivo T cell depletion in elderly patients undergoing allogeneic haematopoietic cell transplantation
    Anett Lauter
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Fetscherstrasse 74, Dresden, Germany
    Br J Haematol 148:910-7. 2010
    ..Further optimisation, probably involving less T cell depletion, is necessary before a randomized comparison with standard conditioning can be planned...
  17. doi request reprint Reciprocal activating interaction between 6-sulfo LacNAc+ dendritic cells and NK cells
    Rebekka Wehner
    Institute of Immunology, Department of Medicine I, Medical Faculty, Technical University of Dresden, Dresden, Germany
    Int J Cancer 124:358-66. 2009
    ..In conclusion, we demonstrate a reciprocal activating interaction between slanDCs and NK cells, which may play a pivotal role in the regulation of antitumor immunity...
  18. pmc Mesenchymal stem cells efficiently inhibit the proinflammatory properties of 6-sulfo LacNAc dendritic cells
    Rebekka Wehner
    Institute of Immunology, Medical Faculty, Technical University, Dresden, Germany
    Haematologica 94:1151-6. 2009
    ..These results indicate that mesenchymal stem cells significantly impair the high proinflammatory capacity of slanDCs and further substantiate their potential for the treatment of graft-versus-host disease...
  19. doi request reprint TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells
    Hanka Jähnisch
    Institute of Immunology, Medical Faculty, Technical University of Dresden, Dresden, Germany
    Cancer Lett 335:119-27. 2013
    ..These results indicate that imiquimod and resiquimod trigger various immunostimulatory properties of slanDCs, which may contribute to their antitumor effects...
  20. doi request reprint Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex vivo expansion
    Nael Alakel
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Dresden, Germany
    Exp Hematol 37:504-13. 2009
    ..To investigate the impact of direct contact between mesenchymal stromal cells (MSCs) and CD133(+) hematopoietic stem cells in terms of expansion potential, differentiation, migratory capacity, and gene expression profile...
  21. ncbi request reprint Overexpression of Jagged-1 and its intracellular domain in human mesenchymal stromal cells differentially affect the interaction with hematopoietic stem and progenitor cells
    Regina Duryagina
    1 Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany
    Stem Cells Dev 22:2736-50. 2013
    ..JICD-overexpressing MSC induce proliferation of HSPCs in short-term culture at the expense of immature precursors (LTC-ICs), whereas Jagged-1 overexpressing MSC favor LTC-IC formation. ..
  22. pmc Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles--a role of the endocytic-exocytic pathway
    Nicola Bauer
    Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, Dresden, Germany
    EMBO Mol Med 3:398-409. 2011
    ..Collectively, these data support the concept that prominin-1-containing lipid rafts may host key determinants necessary to maintain stem cell properties and their quantitative reduction or loss may result in cellular differentiation...
  23. doi request reprint The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML
    Nona Shayegi
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 122:83-92. 2013
    ..Our results in a large data set define and optimize cutoff values for early diagnosis of molecular relapse. These results may be especially important for defining triggers for early therapeutic intervention...
  24. ncbi request reprint Reconstitution of interleukin-17-producing T helper cells after allogeneic hematopoietic cell transplantation
    Felix Bahr
    Department of Medicine I, University Hospital Carl Gustav Carus, Fetscherstrasse 74, Dresden, Germany
    Biol Blood Marrow Transplant 19:357-65. 2013
    ..Cytomegalovirus reactivation, but not acute GVHD or bacterial infection, triggered the absolute expansion of these T cell subsets...
  25. ncbi request reprint Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells
    Jana Babatz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Cancer Immunol Immunother 55:268-76. 2006
    ..After incubation with the CEAalt peptide and keyhole limpet hemocyanin, DCs were administered to patients intravenously at dose levels of 1 x 10(7) and 5 x 10(7) cells. Patients received four immunizations every second week...
  26. ncbi request reprint Single-dose pegfilgrastim for the mobilization of allogeneic CD34+ peripheral blood progenitor cells in healthy family and unrelated donors
    Frank Kroschinsky
    University Hospital Dresden, 1st Medical Department, Dresden, Germany
    Haematologica 90:1665-71. 2005
    ..The pegylated form of filgrastim (pegfilgrastim) has a longer elimination half-life because of decreased serum clearance and might be a convenient alternative for stem cell mobilization...
  27. doi request reprint Allogeneic hematopoietic cell transplantation in patients age 60-70 years with de novo high-risk myelodysplastic syndrome or secondary acute myelogenous leukemia: comparison with patients lacking donors who received azacitidine
    Uwe Platzbecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Biol Blood Marrow Transplant 18:1415-21. 2012
    ..This retrospective cohort analysis suggests a survival advantage for allogeneic HCT compared with AZA therapy in medically fit patients with high-risk MDS age 60-70 years. Prospective controlled studies are warranted...
  28. doi request reprint Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German Transplant Study Group
    Johannes Schetelig
    Medizinische KIinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    J Clin Oncol 26:5183-91. 2008
    ..We sought to determine whether donor type is a prognostic factor in elderly patients in the era of high-resolution DNA-based HLA typing...
  29. doi request reprint Clonal evolution including partial loss of human leukocyte antigen genes favoring extramedullary acute myeloid leukemia relapse after matched related allogeneic hematopoietic stem cell transplantation
    Friedrich Stölzel
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Transplantation 93:744-9. 2012
    ..We hypothesized that this mechanism applies to extramedullary AML relapse which occurs frequently after allogeneic HSCT and might also not be restricted to haploidentical HSCT...
  30. doi request reprint Cytarabine dose of 36 g/m² compared with 12 g/m² within first consolidation in acute myeloid leukemia: results of patients enrolled onto the prospective randomized AML96 study
    Markus Schaich
    Medizinische Klinik I, Universitätsklinikum C G Carus, Dresden, Germany
    J Clin Oncol 29:2696-702. 2011
    ..To assess the optimal cumulative dose of cytarabine for treatment of young adults with acute myeloid leukemia (AML) within a prospective multicenter treatment trial...
  31. doi request reprint Peripheral blood stem cell collection in allogeneic donors: impact of venous access
    Kristina Hölig
    Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden Cellex GmbH, Dresden, Germany
    Transfusion 52:2600-5. 2012
    ..Results of the leukapheresis procedures and side effects in the donors were evaluated...
  32. doi request reprint Differential effect of platelet-rich plasma and fetal calf serum on bone marrow-derived human mesenchymal stromal cells expanded in vitro
    Anja Goedecke
    University Hospital Carl Gustav Carus, Department of Haematology, Dresden, Germany
    J Tissue Eng Regen Med 5:648-54. 2011
    ..However, the requirements of the specific clinical application must be carefully considered before the respective serum source is selected...
  33. doi request reprint Impact of lenalidomide on the functional properties of human mesenchymal stromal cells
    Manja Wobus
    Medical Clinic and Polyclinic I, University Hospital, Dresden, Germany
    Exp Hematol 40:867-76. 2012
    ..In addition to their growth and differentiation characteristics, we focused on the ability of MSC to modulate T-cell function and support hematopoietic stem cells (HSCs)...
  34. ncbi request reprint Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells
    F Philipp Seib
    Leibniz Institute for Polymer Research, Max Bergmann Centre for Biomaterials Dresden, Dresden, Germany
    Tissue Eng Part A 15:3161-71. 2009
    ..The ability to regulate the expression of stromal factors using engineered ECM is exciting and warrants further studies to identify the ECM components and combinations that maximize the expansion of clonogenic HSCs...
  35. doi request reprint A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
    Christoph Rollig
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstrasse 74, Dresden, Germany
    Blood 116:971-8. 2010
    ..5%, 30%, 10.6%, and 3.3%, respectively. The risk model allows further stratification of patients with intermediate-risk karyotype into 2 prognostic groups with implications for the therapeutic strategy...
  36. pmc Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors
    Stefani Parmentier
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstraße 74, 01307 Dresden, Germany
    Haematologica 97:723-30. 2012
    ..No 'normal' values have been established. Therefore, we investigated dyshematopoiesis in bone marrow aspirate squash preparations of 120 healthy bone marrow donors...
  37. ncbi request reprint After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B
    Johannes Schetelig
    Medical Department I, University Hospital Carl Gustay Carus, Dresden, Germany
    Transfusion 45:779-87. 2005
    ..Graft-versus-host reactions are capable of accelerating the clearance of isohemagglutinins. Whether immunogenicity of the A- and B-antigen is important in this process is unknown...
  38. ncbi request reprint Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
    Jan M Middeke
    Universitätsklinikum Carl Gustav Carus der Technische Universität Dresden, Medizinische Klinik und Poliklinik I, Dresden, Germany
    Blood 123:2960-7. 2014
    ..Our findings confirm the high-risk of treatment failure in abnl(17p) AML even after allogeneic HSCT in CR1. Although allogeneic HSCT remains a valid option in CR1, alternative treatment strategies are needed for the remaining patients. ..
  39. ncbi request reprint CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid
    Martin Bornhauser
    Med Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann Hematol 83:401-2. 2004
    ..The risk of CNS disease has to be kept in mind when patients with CML in chronic phase who are at an increased risk for blastic transformation are treated with imatinib mesylate...
  40. doi request reprint Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments
    Marina C Prewitz
    Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Dresden, Germany
    Nat Methods 10:788-94. 2013
    ..Our methodology enables the deciphering and modulation of native-like multicomponent ECMs of tissue-resident stem cells and will therefore prepare the ground for a more rational design of engineered stem cell niches. ..
  41. doi request reprint Extracorporeal photopheresis efficiently impairs the proinflammatory capacity of human 6-sulfo LacNAc dendritic cells
    Michael Gerner
    Institute of Immunology, Medical Faculty, Technical University of Dresden, Dresden, Germany
    Transplantation 87:1134-9. 2009
    ..This study evaluated the direct impact of ECP on the proinflammatory capacity of 6-sulfo LacNAc (slan) DCs, representing a major subpopulation of human blood DCs...
  42. doi request reprint Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: evaluation of the proposed reporting system
    Christoph Rollig
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Dresden, Germany
    J Clin Oncol 29:2758-65. 2011
    ..We assessed the prognostic value of the new risk classification in a large cohort of patients...
  43. doi request reprint Altered phenotype of natural killer cell subsets after haploidentical stem cell transplantation
    Astrid Schulze
    Medizinische Klinik und Poliklinik I, Dresden, Germany
    Exp Hematol 36:378-89. 2008
    ..The success of this regimen is based mainly on natural killer (NK) cell-mediated antileukemia effects...
  44. doi request reprint Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial
    Uwe Platzbecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Biol Blood Marrow Transplant 15:101-8. 2009
    ..Although this new combination appears to be effective as a prophylactic regimen for acute GVHD, the incidence of TMA and SOS is considerably higher than seen with other regimens...
  45. doi request reprint Differential effects of mixed lymphocyte reaction supernatant on human mesenchymal stromal cells
    Frederick Fasslrinner
    Medical Clinic and Polyclinic I, University Hospital Carl Gustav Carus, Dresden, Germany
    Exp Hematol 40:934-44. 2012
    ..In summary, our data shed light on the dysfunction of the stromal environment during graft-vs-host disease, possibly aggravating cytopenia and leading to an enhanced immunogenicity of MSCs...
  46. pmc In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice
    Malte von Bonin
    Regeneration in Hematopoiesis, Center for Regenerative Therapies Dresden CRTD, DFG Research Center and Cluster of Excellence, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e60680. 2013
    ..Engraftment of mainly myeloid cell types can be enforced by the prevention of T cell expansion through the depletion of lymphocytes from the graft prior transplantation...
  47. doi request reprint Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantation
    Martin Wermke
    Department of Medicine I, University Hospital Carl Gustav Carus, Fetscherstraße 74, Dresden, Germany
    Biol Blood Marrow Transplant 16:1718-27. 2010
    ..The importance of these markers in prediction models for GVHD and relapse remain to be defined in large prospective clinical trials...
  48. ncbi request reprint T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantation
    Johannes Schetelig
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstr 74, 01307 Dresden, Germany
    Cancer Immunol Immunother 54:1043-58. 2005
    ..Finally, the prospects for immunological research that have evolved with the increasing use of reduced-intensity conditioning and allogeneic stem cell transplantation are highlighted...
  49. ncbi request reprint Comparison of flow cytometry and laser scanning cytometry for the analysis of CD34+ hematopoietic stem cells
    Joachim Oswald
    Institute of Polymer Research Dresden, Department of Biocompatible Materials, and Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
    Cytometry A 57:100-7. 2004
    ..For this purpose, adherent HSCs were grown in culture on thin polymer films coated with reconstituted collagen I fibrils and subsequently analyzed by LSC...
  50. pmc Red blood cell transfusion dependence and outcome after allogeneic peripheral blood stem cell transplantation in patients with de novo myelodysplastic syndrome (MDS)
    Uwe Platzbecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Biol Blood Marrow Transplant 14:1217-25. 2008
    ..Whether clinical intervention in the form of iron chelation can improve the outcome of allogeneic PBSCT in TD patients with MDS remains to be determined...
  51. doi request reprint Treatment of chronic steroid-refractory graft-versus-host disease with low-dose rituximab
    Malte von Bonin
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Fetscherstrasse, Dresden, Germany
    Transplantation 86:875-9. 2008
    ..We conclude that low-dose rituximab seems to be active and safe in intensively pretreated patients with steroid-refractory cGvHD...
  52. pmc The cell surface proteome of human mesenchymal stromal cells
    Christian Niehage
    Biotechnology Center, Dresden University of Technology, Dresden, Germany
    PLoS ONE 6:e20399. 2011
    ..Multipotent human mesenchymal stromal cells (hMSCs) are considered as promising biological tools for regenerative medicine. Their antibody-based isolation relies on the identification of reliable cell surface markers...
  53. doi request reprint Differential expression of biofunctional GM1 and GM3 gangliosides within the plastic-adherent multipotent mesenchymal stromal cell population
    Daniel Freund
    Tissue Engineering Laboratories, BIOTEC and DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Dresden, Germany
    Cytotherapy 12:131-42. 2010
    ....
  54. ncbi request reprint Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
    Barbara Wassmann
    Departments of Hematology Oncology of University Hospitals Frankfurt, Hannover, Dresden, Munster, Ulm, Heidelberg, Munich, Germany
    Blood 106:458-63. 2005
    ..Continued detection of bcr-abl transcripts after 2 to 3 months on imatinib identifies patients who will ultimately experience relapse and in whom additional or alternative antileukemic treatment should be initiated...
  55. doi request reprint mRNA transfection of CXCR4-GFP fusion--simply generated by PCR-results in efficient migration of primary human mesenchymal stem cells
    Martin F Ryser
    Department of Pediatrics, University Clinic Dresden, Dresden, Germany
    Tissue Eng Part C Methods 14:179-84. 2008
    ..The presented strategy to construct a PCR-based fluorescent fusion protein can be generally applied to other genes of interest to study their function by simple overexpression and easy detection in primary cells...
  56. doi request reprint Cancellous bone allograft seeded with human mesenchymal stromal cells: a potential good manufacturing practice-grade tool for the regeneration of bone defects
    Maik Stiehler
    Department of Orthopaedics, University Hospital Carl Gustav Carus, Dresden, Germany
    Cytotherapy 12:658-68. 2010
    ....
  57. ncbi request reprint Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 102:820-6. 2003
    ..Based on these encouraging results, further studies of fludarabine and targeted busulfan are warranted in standard-risk patients...
  58. ncbi request reprint G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity
    Susanne H C Baumeister
    Institute of Immunology, Technische Universitat Dresden, Dresden, Germany
    Blood 110:3078-81. 2007
    ..Thus, slanDCs transfused into recipients of allogeneic peripheral blood stem cell (PBSC) transplants are functionally fully capable and may be critical in supporting graft-versus-host disease as well as graft-versus-leukemia effects...
  59. doi request reprint Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia
    Brigitte Mohr
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany
    Br J Haematol 161:237-44. 2013
    ..In conclusion, allogeneic HSCT does not improve survival in patients with abnl(17p) AML as compared to other adverse cytogenetic risk abnormalities...
  60. doi request reprint Induction of cellular immune responses in patients with stage-I multiple myeloma after vaccination with autologous idiotype-pulsed dendritic cells
    Christoph Rollig
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Germany
    J Immunother 34:100-6. 2011
    ..Further trials are needed to increase the rate of responses and to define the role of DC-based vaccination in the era of new pharmacologic therapies...
  61. ncbi request reprint Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Acta Haematol 112:16-23. 2004
    ..In addition, the potential impact of novel procedures, e.g. subset chimerism or real-time PCR-based procedures, is discussed...
  62. pmc Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network
    Ana Violeta Fonseca
    Tissue Engineering Laboratories, Technische Universitat, Dresden, Germany
    J Biol Chem 285:31661-71. 2010
    ..Collectively, our data provide new insights regarding the role of RhoA/ROCK I and the microtubules in the migration of stem cells...
  63. doi request reprint Prolonged transendothelial migration of human haematopoietic stem and progenitor cells (HSPCs) towards hydrogel-released SDF1
    Lidia Sobkow
    Leibniz Institute for Polymer Research Dresden, Max Bergmann Centre for Biomaterials Dresden, Dresden, Germany
    Ann Hematol 90:865-71. 2011
    ..In conclusion, regulating SDF1 gradients with heparin-containing hydrogels may offer valuable options to direct site-specific migration of HSPC...
  64. doi request reprint Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells
    F Philipp Seib
    Leibniz Institute for Polymer Research, Max Bergmann Centre for Biomaterials Dresden, Dresden, Germany
    Eur J Cell Biol 88:257-71. 2009
    ..Spontaneous mineralisation was also abrogated following PI-3K inhibition. Thus, endogenous BMPs could contribute to spontaneous osteogenesis through Smad-independent PI-3K-dependent signalling...
  65. doi request reprint Hematopoietic stem and progenitor cells in adhesive microcavities
    Ina Kurth
    Leibniz Institute of Polymer Research, Max Bergmann Center of Biomaterials, Dresden, Germany
    Integr Biol (Camb) 1:427-34. 2009
    ..Our results suggest that confining human HSCs in ECM-coated microcavities is a possible method to maintain these cells in a quiescent and immature state, an important advantage for several HSC applications...
  66. doi request reprint The hematopoietic cell transplantation-specific comorbidity index fails to predict outcomes in high-risk AML patients undergoing allogeneic transplantation--investigation of potential limitations of the index
    Nicole Birninger
    Medical Department I, University Hospital Carl Gustav Carus, Dresden, Germany
    Biol Blood Marrow Transplant 17:1822-32. 2011
    ..The use of HSCT-CI as a decision-making tool for transplantation eligibility should not be considered until its validity has been unequivocally shown in crossvalidation studies...
  67. ncbi request reprint Alemtuzumab depletes dendritic cells more effectively in blood than in skin: a pilot study in patients with chronic lymphocytic leukemia
    Susanne Auffermann-Gretzinger
    Medizinische Klinik und Poliklinik I Universitätsklinikum Dresden, Dresden, Germany
    Transplantation 83:1268-72. 2007
    ....
  68. ncbi request reprint The graft content of donor T cells expressing gamma delta TCR+ and CD4+foxp3+ predicts the risk of acute graft versus host disease after transplantation of allogeneic peripheral blood stem cells from unrelated donors
    Caroline Pabst
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus Dresden, Dresden, Germany
    Clin Cancer Res 13:2916-22. 2007
    ..Therefore, the aim of this study was to define the yet-unknown role of regulatory and gamma delta TCR(+) T cells in human PBSCT from unrelated donors...
  69. ncbi request reprint Chimerism analysis after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Haematologica 90:1301A. 2005
  70. doi request reprint BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells
    Fernando A Fierro
    Medical Clinic and Policlinic I, Technical University, Dresden, Germany
    J Mol Biol 377:1082-93. 2008
    ....
  71. ncbi request reprint Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
    Matthias Stelljes
    Department of Medicine Hematology and Oncology, University of Muenster, Albert Schweitzer Str 33, D 48129 Muenster, Germany
    Blood 106:3314-21. 2005
    ....
  72. ncbi request reprint Haploidentical allogeneic hematopoietic cell transplantation in adults with reduced-intensity conditioning and CD3/CD19 depletion: fast engraftment and low toxicity
    Wolfgang A Bethge
    Medical Center, University of Tuebingen, Tuebingen, Germany
    Exp Hematol 34:1746-52. 2006
    ....
  73. ncbi request reprint Kinetics of CXCR-4 and adhesion molecule expression during autologous stem cell mobilisation with G-CSF plus AMD3100 in patients with multiple myeloma
    Uta Oelschlaegel
    Medical Clinic and Polyclinic I, University Hospital of the Technical University of Dresden, House 66, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann Hematol 86:569-73. 2007
    ..Further studies will define the possible prognostic role of AMD3100 mediated changes in CXCR-4 expression for the prediction of stem cell yield attainable with this new mobilisation regimen...