Research Topics
| M BornhauserSummaryCountry: Germany Publications
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Detail Information
Publications
Allogeneic transplantation of G-CSF mobilized peripheral blood stem cells from unrelated donors: a retrospective analysisM Bornhauser
Med Klinik I, Universit tsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
Haematologica 85:839-47. 2000..We report the outcome of 79 patients transplanted with PBSC from unrelated donors...- Dose-reduced conditioning and allogeneic hematopoietic stem cell transplantation from unrelated donors in 42 patientsM Bornhauser
Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
Clin Cancer Res 7:2254-62. 2001..A fludarabine-based "nonmyeloablative" preparative regimen was investigated in 42 patients with hematological malignancies receiving hematopoietic stem cell grafts from unrelated volunteer donors... - Treatment of relapsing leukemia after allogeneic blood stem cell transplantation by using dose-reduced conditioning followed by donor blood stem cells and GM-CSFU Platzbecker
Medizinische Klinik I und Poliklinik, Universitatsklinikum Carl Gustav Carus, Dresden, Fetscherstr 74, 01307 Dresden, Germany
Ann Hematol 80:144-9. 2001..The potential of GM-CSF to enhance the graft-versus-leukemia reactivity after cytoreductive therapy for allogeneic transplantation warrants further investigation... - Intravenous busulphan for conditioning before autologous or allogeneic human blood stem cell transplantationU S Schuler
Department of Internal Medicine I, Technical University, Fetscherstrasse 74, D 01307 Dresden, Germany
Br J Haematol 114:944-50. 2001..The total dose of busulphan can be given in four (rather than the typical 16) doses. With such a regimen, the intravenous administration becomes feasible on an outpatient basis... - Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemiaU Platzbecker
Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
Leukemia 20:707-14. 2006..Up-front allogeneic HSCT as part of primary induction therapy seems to be an effective strategy in high-risk AML patients and warrants further investigation... - Evidence for a graft-versus-tumor effect in refractory ovarian cancerM Hanel
Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
J Cancer Res Clin Oncol 129:12-6. 2003..A 31-year-old woman suffered a 4th relapse of epithelial ovarian cancer refractory to several cytotoxic drugs including platinum, paclitaxel, and topotecan... 
Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantationI Haentzschel
Medizinische Klinik und Poliklinik I, University Hospital, Fetscherstrasse 74, Dresden, Germany
Bone Marrow Transplant 42:113-20. 2008..A simplified MMF targeting strategy based on MPA C(max) or C(2h) levels seems to be warranted in future trials involving more patients at later time points in the outpatient setting...- [Place of hematopoietic stem cell transplantation in the treatment of myelodysplastic syndromes]F Kroschinsky
Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, TU Dresden
Med Klin (Munich) 96:135-43. 2001..FUTURE DIRECTIONS: Clinical trials are currently evaluating dose-modified preparative regimens with decreased toxicity, which offer transplantation options also to older patients or patients with comorbidities... - Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing mediumM von Bonin
Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Dresden, Germany
Bone Marrow Transplant 43:245-51. 2009..In our patient cohort, response to MSC transfusion was lower than in the series reported earlier. However, our experience supports the potential efficacy of MSC in the treatment of steroid-refractory aGVHD... - Imatinib mesylate selectively influences the cellular metabolism of cytarabine in BCR/ABL negative leukemia cell lines and normal CD34+ progenitor cellsM Bornhauser
Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
Ann Hematol 83:S61-4. 2004..Further investigations will have to show whether theses effects can lead to increased cytotoxicity in primary blasts of patients with acute leukemia... - Extramedullary blast crisis of chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation mimicking aggressive, translocation t(14;18)-positive B-cell lymphomaF Kroschinsky
Universitatsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik I, Fetscherstrasse 74, 01307 Dresden, Germany
Ann Hematol 82:47-52. 2003..We conclude that lymphoid neoplasia occurring in our patient should be interpreted as an extramedullary, very immature blast crisis of CML expressing lymphoid differentiation markers rather than a true de novo NHL... - Accidental busulfan overdose during conditioning for stem cell transplantationA Jenke
Universitatsklinik Carl Gustav Carus, Medizinische Klinik I, Fetscherstrasse 74, 01307 Dresden, Germany
Bone Marrow Transplant 35:125-8. 2005..One patient is alive in remission after an observation time of 18 months. These cases show that busulfan overdosing may occur and pharmacokinetic evaluation is warranted to estimate risk of early and late toxicity... - Respiratory failure in patients undergoing allogeneic hematopoietic SCT--a randomized trial on early non-invasive ventilation based on standard care hematology wardsM Wermke
Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
Bone Marrow Transplant 47:574-80. 2012..The limited influence of NIV may be related to the study design allowing for switching of treatment in case of unsatisfactory efficacy... - Inhibition of platelet-derived growth factor receptorbeta by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitroF Fierro
Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Dresden, Germany
Cell Prolif 40:355-66. 2007..Recent data show that Imatinib mesylate (IM) also affects haematopoietic stem cells (HSC), T lymphocytes and dendritic cells that do not harbour constitutively active tyrosine kinases... - Risk stratification using a new prognostic score for patients with secondary acute myeloid leukemia: results of the prospective AML96 trialF Stölzel
Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
Leukemia 25:420-8. 2011..In conclusion, for the first time, a prognostic scoring system is provided for sAML patients, allowing differential treatment strategies in the future... - Thawing of cryopreserved mobilized peripheral blood--comparison between waterbath and dry warming deviceC Rollig
Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Germany
Cytotherapy 4:551-5. 2002..We compared the effectiveness of thawing cryopreserved MPB in a waterbath with an electric dry-warming device containing warmed gel pads (Sahara, Transmed)... - Determination of mycophenolic acid and mycophenolate mofetil by high-performance liquid chromatography using postcolumn derivatizationU D Renner
Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
Anal Chem 73:41-6. 2001..Compared to published quantification limits for MPA and MMF by UV detection, this method is more than 100-fold more sensitive, with a lower limit of quantification of 45 fmol for both MPA and MMF... - Severe epidermal necrolysis after treatment with imatinib and consecutive allogeneic hematopoietic stem cell transplantationM Schaich
Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstr 74, 01307, Dresden, Germany
Ann Hematol 82:303-4. 2003..Prolonged inhibition of platelet-derived growth factor by imatinib may be an explanation for this observed skin toxicity... - Activity of sirolimus in patients with myelodysplastic syndrome--results of a pilot studyU Platzbecker
Medizinische Klinik und Poliklinik I des Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany
Br J Haematol 128:625-30. 2005..Major side-effects were hyperlipidaemia (n = 4), stomatitis (n = 3), thrombocytopenia (n = 2) and urinary tract infection (n = 1). These data suggest that sirolimus has activity in a subset of patients with more advanced MDS... - Efficacy and tolerability of prophylactic treatment with intravenous piperacillin/tazobactam in patients undergoing hematopoietic stem cell transplantationF Kroschinsky
Medical Department I Hematology Oncology, University Hospital, Fetscherstrasse 74, D 01307 Dresden, Germany
Transpl Infect Dis 4:132-6. 2002..About 80% of patients experience fever during aplasia and early engraftment despite oral antibacterial chemoprophylaxis...