M Bornhauser

Summary

Country: Germany

Publications

  1. ncbi request reprint Allogeneic transplantation of G-CSF mobilized peripheral blood stem cells from unrelated donors: a retrospective analysis
    M Bornhauser
    Med Klinik I, Universit tsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Haematologica 85:839-47. 2000
  2. ncbi request reprint Dose-reduced conditioning and allogeneic hematopoietic stem cell transplantation from unrelated donors in 42 patients
    M Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Clin Cancer Res 7:2254-62. 2001
  3. ncbi request reprint Graft clonogenicity and intensity of pre-treatment: factors affecting outcome of autologous peripheral hematopoietic cell transplantation in patients with acute myeloid leukemia in first remission
    D Strodtbeck
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Bone Marrow Transplant 36:1083-8. 2005
  4. ncbi request reprint Treatment of relapsing leukemia after allogeneic blood stem cell transplantation by using dose-reduced conditioning followed by donor blood stem cells and GM-CSF
    U Platzbecker
    Medizinische Klinik I und Poliklinik, Universitatsklinikum Carl Gustav Carus, Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Ann Hematol 80:144-9. 2001
  5. ncbi request reprint Intravenous busulphan for conditioning before autologous or allogeneic human blood stem cell transplantation
    U S Schuler
    Department of Internal Medicine I, Technical University, Fetscherstrasse 74, D 01307 Dresden, Germany
    Br J Haematol 114:944-50. 2001
  6. ncbi request reprint Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study
    J Babatz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Dresden, Germany
    J Hematother Stem Cell Res 12:515-23. 2003
  7. ncbi request reprint CD34+ cell dose, conditioning regimen and prior chemotherapy: factors with significant impact on the early kinetics of donor chimerism after allogeneic hematopoietic cell transplantation
    B Mohr
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Bone Marrow Transplant 34:949-54. 2004
  8. ncbi request reprint Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia
    U Platzbecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Leukemia 20:707-14. 2006
  9. doi request reprint Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation
    I Haentzschel
    Medizinische Klinik und Poliklinik I, University Hospital, Fetscherstrasse 74, Dresden, Germany
    Bone Marrow Transplant 42:113-20. 2008
  10. ncbi request reprint [Place of hematopoietic stem cell transplantation in the treatment of myelodysplastic syndromes]
    F Kroschinsky
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, TU Dresden
    Med Klin (Munich) 96:135-43. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Allogeneic transplantation of G-CSF mobilized peripheral blood stem cells from unrelated donors: a retrospective analysis
    M Bornhauser
    Med Klinik I, Universit tsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Haematologica 85:839-47. 2000
    ..We report the outcome of 79 patients transplanted with PBSC from unrelated donors...
  2. ncbi request reprint Dose-reduced conditioning and allogeneic hematopoietic stem cell transplantation from unrelated donors in 42 patients
    M Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Clin Cancer Res 7:2254-62. 2001
    ..A fludarabine-based "nonmyeloablative" preparative regimen was investigated in 42 patients with hematological malignancies receiving hematopoietic stem cell grafts from unrelated volunteer donors...
  3. ncbi request reprint Graft clonogenicity and intensity of pre-treatment: factors affecting outcome of autologous peripheral hematopoietic cell transplantation in patients with acute myeloid leukemia in first remission
    D Strodtbeck
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Bone Marrow Transplant 36:1083-8. 2005
    ..Additionally, a minimum of three chemotherapy cycles before ABSCT seems to be associated with an improved outcome...
  4. ncbi request reprint Treatment of relapsing leukemia after allogeneic blood stem cell transplantation by using dose-reduced conditioning followed by donor blood stem cells and GM-CSF
    U Platzbecker
    Medizinische Klinik I und Poliklinik, Universitatsklinikum Carl Gustav Carus, Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Ann Hematol 80:144-9. 2001
    ..The potential of GM-CSF to enhance the graft-versus-leukemia reactivity after cytoreductive therapy for allogeneic transplantation warrants further investigation...
  5. ncbi request reprint Intravenous busulphan for conditioning before autologous or allogeneic human blood stem cell transplantation
    U S Schuler
    Department of Internal Medicine I, Technical University, Fetscherstrasse 74, D 01307 Dresden, Germany
    Br J Haematol 114:944-50. 2001
    ..The total dose of busulphan can be given in four (rather than the typical 16) doses. With such a regimen, the intravenous administration becomes feasible on an outpatient basis...
  6. ncbi request reprint Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study
    J Babatz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Dresden, Germany
    J Hematother Stem Cell Res 12:515-23. 2003
    ..The selection can be performed in a closed system. Therefore, immunomagnetic CD14(+) selection can be seen as an alternative way to generate DC for clinical tumor vaccination protocols...
  7. ncbi request reprint CD34+ cell dose, conditioning regimen and prior chemotherapy: factors with significant impact on the early kinetics of donor chimerism after allogeneic hematopoietic cell transplantation
    B Mohr
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Bone Marrow Transplant 34:949-54. 2004
    ..0003) and the use of antithymocyte globulin (P=0.003) were associated with a faster increase of donor chimerism. The factors identified in this study can be used to predict the kinetics of early donor chimerism for an individual patient...
  8. ncbi request reprint Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia
    U Platzbecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Leukemia 20:707-14. 2006
    ..Up-front allogeneic HSCT as part of primary induction therapy seems to be an effective strategy in high-risk AML patients and warrants further investigation...
  9. doi request reprint Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation
    I Haentzschel
    Medizinische Klinik und Poliklinik I, University Hospital, Fetscherstrasse 74, Dresden, Germany
    Bone Marrow Transplant 42:113-20. 2008
    ..A simplified MMF targeting strategy based on MPA C(max) or C(2h) levels seems to be warranted in future trials involving more patients at later time points in the outpatient setting...
  10. ncbi request reprint [Place of hematopoietic stem cell transplantation in the treatment of myelodysplastic syndromes]
    F Kroschinsky
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, TU Dresden
    Med Klin (Munich) 96:135-43. 2001
    ..Supportive treatment with transfusions, antimicrobial agents, hematopoietic growth factors and conventional chemotherapy has only palliative character...
  11. ncbi request reprint Detection of relapse by sequential monitoring of chimerism in circulating CD34+ cells
    Ch Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Technischen Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann Hematol 81:S27-8. 2002
    ..This method appears especially useful in patients with high risk leukemia lacking other markers for detection of MRD...
  12. ncbi request reprint Evidence for a graft-versus-tumor effect in refractory ovarian cancer
    M Hanel
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    J Cancer Res Clin Oncol 129:12-6. 2003
    ..A 31-year-old woman suffered a 4th relapse of epithelial ovarian cancer refractory to several cytotoxic drugs including platinum, paclitaxel, and topotecan...
  13. ncbi request reprint Imatinib mesylate selectively influences the cellular metabolism of cytarabine in BCR/ABL negative leukemia cell lines and normal CD34+ progenitor cells
    M Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Ann Hematol 83:S61-4. 2004
    ..Further investigations will have to show whether theses effects can lead to increased cytotoxicity in primary blasts of patients with acute leukemia...
  14. doi request reprint Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium
    M von Bonin
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Dresden, Germany
    Bone Marrow Transplant 43:245-51. 2009
    ..In our patient cohort, response to MSC transfusion was lower than in the series reported earlier. However, our experience supports the potential efficacy of MSC in the treatment of steroid-refractory aGVHD...
  15. pmc Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia
    A Ehninger
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Blood Cancer J 4:e218. 2014
    ..These results stimulate the development of novel concepts to redirect immune effector cells toward CD33- and CD123-expressing blasts using bi-specific antibodies or engineered T cells expressing chimeric antigen receptors. ..
  16. ncbi request reprint Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation in myeloid diseases
    U Platzbecker
    Medical Clinic I, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany
    Ann Hematol 82:463-8. 2003
    ....
  17. ncbi request reprint Evaluation of STR informativity for chimerism testing--comparative analysis of 27 STR systems in 203 matched related donor recipient pairs
    C Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, Dresden, Germany
    Leukemia 18:248-54. 2004
    ..86; P=0.0001), but not with the total number of alleles present. These data indicate that selection of suitable STR markers is important to improve diagnostics based on STR analysis...
  18. ncbi request reprint Accidental busulfan overdose during conditioning for stem cell transplantation
    A Jenke
    Universitatsklinik Carl Gustav Carus, Medizinische Klinik I, Fetscherstrasse 74, 01307 Dresden, Germany
    Bone Marrow Transplant 35:125-8. 2005
    ..One patient is alive in remission after an observation time of 18 months. These cases show that busulfan overdosing may occur and pharmacokinetic evaluation is warranted to estimate risk of early and late toxicity...
  19. ncbi request reprint Extramedullary blast crisis of chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation mimicking aggressive, translocation t(14;18)-positive B-cell lymphoma
    F Kroschinsky
    Universitatsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik I, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann Hematol 82:47-52. 2003
    ..We conclude that lymphoid neoplasia occurring in our patient should be interpreted as an extramedullary, very immature blast crisis of CML expressing lymphoid differentiation markers rather than a true de novo NHL...
  20. ncbi request reprint Allogeneic transplantation of CD34+ selected hematopoietic cells--clinical problems and current challenges
    U Platzbecker
    Med Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany
    Leuk Lymphoma 45:447-53. 2004
    ..Although these question have not been resolved yet, allogeneic transplantation of highly purified CD34+ PBSC has become an therapeutic option for patients who are at high-risk for severe GvHD...
  21. doi request reprint Respiratory failure in patients undergoing allogeneic hematopoietic SCT--a randomized trial on early non-invasive ventilation based on standard care hematology wards
    M Wermke
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
    Bone Marrow Transplant 47:574-80. 2012
    ..The limited influence of NIV may be related to the study design allowing for switching of treatment in case of unsatisfactory efficacy...
  22. ncbi request reprint Inhibition of platelet-derived growth factor receptorbeta by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro
    F Fierro
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Dresden, Germany
    Cell Prolif 40:355-66. 2007
    ..Recent data show that Imatinib mesylate (IM) also affects haematopoietic stem cells (HSC), T lymphocytes and dendritic cells that do not harbour constitutively active tyrosine kinases...
  23. doi request reprint Risk stratification using a new prognostic score for patients with secondary acute myeloid leukemia: results of the prospective AML96 trial
    F Stölzel
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
    Leukemia 25:420-8. 2011
    ..In conclusion, for the first time, a prognostic scoring system is provided for sAML patients, allowing differential treatment strategies in the future...
  24. ncbi request reprint Determination of mycophenolic acid and mycophenolate mofetil by high-performance liquid chromatography using postcolumn derivatization
    U D Renner
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Anal Chem 73:41-6. 2001
    ..Compared to published quantification limits for MPA and MMF by UV detection, this method is more than 100-fold more sensitive, with a lower limit of quantification of 45 fmol for both MPA and MMF...
  25. ncbi request reprint Severe epidermal necrolysis after treatment with imatinib and consecutive allogeneic hematopoietic stem cell transplantation
    M Schaich
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstr 74, 01307, Dresden, Germany
    Ann Hematol 82:303-4. 2003
    ..Prolonged inhibition of platelet-derived growth factor by imatinib may be an explanation for this observed skin toxicity...
  26. ncbi request reprint Thawing of cryopreserved mobilized peripheral blood--comparison between waterbath and dry warming device
    C Rollig
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Germany
    Cytotherapy 4:551-5. 2002
    ..We compared the effectiveness of thawing cryopreserved MPB in a waterbath with an electric dry-warming device containing warmed gel pads (Sahara, Transmed)...
  27. ncbi request reprint Activity of sirolimus in patients with myelodysplastic syndrome--results of a pilot study
    U Platzbecker
    Medizinische Klinik und Poliklinik I des Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany
    Br J Haematol 128:625-30. 2005
    ..Major side-effects were hyperlipidaemia (n = 4), stomatitis (n = 3), thrombocytopenia (n = 2) and urinary tract infection (n = 1). These data suggest that sirolimus has activity in a subset of patients with more advanced MDS...
  28. ncbi request reprint Efficacy and tolerability of prophylactic treatment with intravenous piperacillin/tazobactam in patients undergoing hematopoietic stem cell transplantation
    F Kroschinsky
    Medical Department I Hematology Oncology, University Hospital, Fetscherstrasse 74, D 01307 Dresden, Germany
    Transpl Infect Dis 4:132-6. 2002
    ..About 80% of patients experience fever during aplasia and early engraftment despite oral antibacterial chemoprophylaxis...