Jan Born

Summary

Country: Germany

Publications

  1. ncbi Hypothalamus-pituitary-adrenal activity during human sleep: a coordinating role for the limbic hippocampal system
    J Born
    Clinical Neuroendocrinology and Department of Internal Medicine, Medical University of Lubeck, Germany
    Exp Clin Endocrinol Diabetes 106:153-63. 1998
  2. ncbi Awareness in memory: being explicit about the role of sleep
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Trends Cogn Sci 8:242-4. 2004
  3. ncbi Sleep to remember
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Neuroscientist 12:410-24. 2006
  4. ncbi Sniffing neuropeptides: a transnasal approach to the human brain
    Jan Born
    Department of Neuroendocrinology, , Ratzeburger Allee 160, , Germany
    Nat Neurosci 5:514-6. 2002
  5. ncbi Neuropsychological effects of vasopressin in healthy humans
    J Born
    University of Lubeck, Germany
    Prog Brain Res 119:619-43. 1998
  6. ncbi Impaired off-line consolidation of motor memories after combined blockade of cholinergic receptors during REM sleep-rich sleep
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 34:1843-53. 2009
  7. ncbi Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balance
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Psychoneuroendocrinology 34:455-62. 2009
  8. ncbi Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Regul Pept 149:79-83. 2008
  9. ncbi Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
  10. ncbi Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Diabetes 59:1101-7. 2010

Detail Information

Publications102 found, 100 shown here

  1. ncbi Hypothalamus-pituitary-adrenal activity during human sleep: a coordinating role for the limbic hippocampal system
    J Born
    Clinical Neuroendocrinology and Department of Internal Medicine, Medical University of Lubeck, Germany
    Exp Clin Endocrinol Diabetes 106:153-63. 1998
    ..First clinical trials suggest that this trias of symptoms may benefit from intranasal treatment with neuropeptides like vasopressin and growth hormone releasing hormone...
  2. ncbi Awareness in memory: being explicit about the role of sleep
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Trends Cogn Sci 8:242-4. 2004
    ..These new data add to emerging evidence that sleep-related memory consolidation involves an interaction between different memory systems...
  3. ncbi Sleep to remember
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Neuroscientist 12:410-24. 2006
    ....
  4. ncbi Sniffing neuropeptides: a transnasal approach to the human brain
    Jan Born
    Department of Neuroendocrinology, , Ratzeburger Allee 160, , Germany
    Nat Neurosci 5:514-6. 2002
  5. ncbi Neuropsychological effects of vasopressin in healthy humans
    J Born
    University of Lubeck, Germany
    Prog Brain Res 119:619-43. 1998
    ..A mediation of effects by peripheral changes can be excluded since the central nervous effects were observed in studies using intranasal VP administration providing a direct access to brain functions...
  6. ncbi Impaired off-line consolidation of motor memories after combined blockade of cholinergic receptors during REM sleep-rich sleep
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 34:1843-53. 2009
    ..Taken together, these results identify high cholinergic activity during late, REM sleep-rich sleep as an essential factor promoting sleep-dependent consolidation of motor skills...
  7. ncbi Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balance
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Psychoneuroendocrinology 34:455-62. 2009
    ..Sleep is not critically involved in this glucose-glucocorticoid feedback loop but may reduce the brain's sensitivity to the anorexigenic effect of enhanced glucose supply...
  8. ncbi Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Regul Pept 149:79-83. 2008
    ..Our results may contribute to the future development of therapeutic strategies in disorders like obesity and cognitive impairments that derive from dysfunctions of central nervous neuropeptidergic pathways...
  9. ncbi Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
    ..Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown...
  10. ncbi Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Diabetes 59:1101-7. 2010
    ....
  11. ncbi Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory
    Björn Rasch
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 12:396-7. 2009
    ..Our results indicate that REM sleep as a unitary phenomenon is not required for skill-memory consolidation...
  12. ncbi Intranasal insulin improves memory in humans: superiority of insulin aspart
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 32:239-43. 2007
    ..This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease...
  13. ncbi Altered neuroendocrine sleep architecture in patients with type 1 diabetes
    Kamila Jauch-Chara
    Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany
    Diabetes Care 31:1183-8. 2008
    ..Disturbances of sleep may arise from and contribute to the disease process in chronically ill patients with type 1 diabetes...
  14. ncbi Processing of food stimuli is selectively enhanced during insulin-induced hypoglycemia in healthy men
    Bernd Schultes
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Psychoneuroendocrinology 30:496-504. 2005
    ..If executive control of attention becomes affected by hypoglycemia, cognitive resources appear to be preferentially allocated to the processing of food stimuli...
  15. ncbi Shift of monocyte function toward cellular immunity during sleep
    Tanja Lange
    Department of Internal Medicine, , , Germany
    Arch Intern Med 166:1695-700. 2006
    ....
  16. ncbi Intranasal atrial natriuretic peptide acts as central nervous inhibitor of the hypothalamo-pituitary-adrenal stress system in humans
    Boris Perras
    Medizinische Klinik I, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23558 Lübeck, Germany
    J Clin Endocrinol Metab 89:4642-8. 2004
    ..The absence of an effect on CRH/VP-induced pituitary-adrenal responses suggests a direct action of the peptide on the central nervous system inhibiting stimulated hypothalamo-pituitary-adrenal activity at the hypothalamic level...
  17. ncbi Intranasal insulin improves memory in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 29:1326-34. 2004
    ..These findings could be of relevance for the treatment of patients with memory disorders like in Alzheimer's disease...
  18. ncbi Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory
    Rosemarie Krug
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 50 1, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 95:E468-72. 2010
    ....
  19. ncbi Improvement of sleep and pituitary-adrenal inhibition after subchronic intranasal vasopressin treatment in elderly humans
    Boris Perras
    Institute of Neuroendocrinology, University of Lubeck, Germany
    J Clin Psychopharmacol 23:35-44. 2003
    ..Overall, results indicate a promoting effect of AVP on SWS in aged accompanied by a beneficial rather than impairing influence on the neuroendocrine pattern of sleep...
  20. ncbi Effects of cortisol suppression on sleep-associated consolidation of neutral and emotional memory
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Germany
    Biol Psychiatry 58:885-93. 2005
    ..The role of the strong cortisol rise accompanying late sleep for emotional memory consolidation has not yet been investigated...
  21. ncbi The memory function of noradrenergic activity in non-REM sleep
    Steffen Gais
    University of Lubeck, Germany
    J Cogn Neurosci 23:2582-92. 2011
    ..We conclude that noradrenergic activity during non-REM sleep interacts with other sleep-related mechanisms to functionally contribute to off-line memory consolidation...
  22. ncbi Transcranial direct current stimulation during sleep improves declarative memory
    Lisa Marshall
    Institute of Neuroendocrinology H23a, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 24:9985-92. 2004
    ..Shifts in extracellular ionic concentration in frontocortical tissue (expressed as negative DC potentials during SWS) may facilitate sleep-dependent consolidation of declarative memories...
  23. ncbi Meal anticipation potentiates postprandial ghrelin suppression in humans
    Volker Ott
    Department of Neuroendocrinology, Hs 50 1, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 37:1096-100. 2012
    ....
  24. ncbi Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, , Ratzeburger Allee 160, Haus 23a, , Germany
    Brain Behav Immun 18:341-8. 2004
    ..001). Though unexpected, the most pronounced effect of sleep on T cell cytokine production was a robust decrease in TNF-alpha producing CD8+ cells probably reflecting increased extravasation of cytotoxic effector and memory T cells...
  25. ncbi Sleep selectively enhances memory expected to be of future relevance
    Ines Wilhelm
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 31:1563-9. 2011
    ..In conclusion, our work shows that sleep preferentially benefits consolidation of memories that are relevant for future behavior, presumably through a SWS-dependent reprocessing of these memories...
  26. ncbi Sleep, hormones, and memory
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Haus 23a, Lubeck, Germany
    Obstet Gynecol Clin North Am 36:809-29, x. 2009
    ....
  27. ncbi High-calorie glucose-rich food attenuates neuroglycopenic symptoms in patients with Addison's disease
    Johanna Klement
    University of Lubeck, Department of Internal Medicine I, Ratzeburger Allee 160, House 32, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 95:522-8. 2010
    ..It will be important to investigate whether additional oral glucose supply may be helpful in improving patients' well-being...
  28. ncbi A 3-day estrogen treatment improves prefrontal cortex-dependent cognitive function in postmenopausal women
    Rosemarie Krug
    Department of Neuroendocrinologie, University of Lubeck, Ratzeburger Allee 160, Hs 23a, D 23538 Lubeck, Germany
    Psychoneuroendocrinology 31:965-75. 2006
    ..Our results encourage future studies to investigate whether repeated induction of short-lasting estrogen peaks could enhance cognitive efficacy of hormonal replacement therapy...
  29. ncbi Sleep enhances serum interleukin-7 concentrations in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    Brain Behav Immun 21:1058-62. 2007
    ..The findings concur with the notion of a supportive influence of sleep on T cell function related to formation of T cell memory...
  30. ncbi Suppressing the morning rise in cortisol impairs free recall
    Ulrike Rimmele
    Department of Neuroendocrinology, University of Lubeck, Luebeck 23562, Germany
    Learn Mem 17:186-90. 2010
    ..Thus, not only high, but also very low glucocorticoid levels impair retrieval, with the latter effect possibly reflecting insufficient occupation of hippocampal/amygdalar mineralocorticoid receptors (MRs)...
  31. ncbi Modulation of food intake by glucose in patients with type 2 diabetes
    Bernd Schultes
    Department of Internal Medicine I, Medical University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Diabetes Care 28:2884-9. 2005
    ..On this background, we hypothesized that a short-term reduction of blood glucose concentration to normal values acutely increases food intake in type 2 diabetic patients...
  32. ncbi Combined blockade of cholinergic receptors shifts the brain from stimulus encoding to memory consolidation
    Björn H Rasch
    University of Lubeck, Germany
    J Cogn Neurosci 18:793-802. 2006
    ....
  33. ncbi Contribution of norepinephrine to emotional memory consolidation during sleep
    Sabine Groch
    Department of Neuroendocrinology, University of Luebeck, Haus 50 1, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 36:1342-50. 2011
    ..Here, we examined whether NE supports the consolidation of amygdala-dependent emotional memory during SWS...
  34. ncbi Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 93:1339-44. 2008
    ..Long-term administration of intranasal insulin reduces body weight in men, but not in women, while improving hippocampus-dependent memory processing in both genders...
  35. ncbi Sleep-stage-specific regulation of plasma catecholamine concentration
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 32:884-91. 2007
    ....
  36. ncbi Shifting from implicit to explicit knowledge: different roles of early- and late-night sleep
    Juliana Yordanova
    Department of Neurology, University of Lubeck, 23538 Lubeck, Germany
    Learn Mem 15:508-15. 2008
    ....
  37. ncbi Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells
    Tanja Lange
    Department of Internal Medicine, , Germany
    Int Immunopharmacol 6:216-25. 2006
    ..Yet, our finding of predominant type1 activity after cortisol administration, rules out any relevance of this suppression for the shift towards type1 activity during SWS...
  38. ncbi Influence of captopril on symptomatic and hormonal responses to hypoglycaemia in humans
    Kerstin M Oltmanns
    Department of Internal Medicine I, Institute of Pharmacology and Clinical Neuroendocrinology, Medical University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Br J Clin Pharmacol 55:347-53. 2003
    ..Although ACE inhibitors are approved for controlling diabetic complications, previous investigations regarding this putative side-effect are controversial...
  39. ncbi Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
    ....
  40. ncbi Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
    ..Thus, activation of the major stress hormones during daytime favor immediate effector defense but diminish capabilities for initiating adaptive immune responses...
  41. ncbi Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    Metabolism 54:1356-61. 2005
    ..However, the effect is not observed with prolonged administration of the hormone, suggesting the emergence of counterregulatory processes...
  42. ncbi Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain
    Manfred Hallschmid
    University of Lubeck, Institute of Neuroendocrinology, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:2202-8. 2004
    ..The rapid emergence of the DC potential shift, reflecting gross ionic changes in brain tissues, indicates that systemic insulin can serve as an immediate feedback signal in the control of hypothalamic and higher brain functions...
  43. ncbi Declarative memory consolidation: mechanisms acting during human sleep
    Steffen Gais
    Department of Neuroendocrinology, , , Germany
    Learn Mem 11:679-85. 2004
    ..In addition, sleep seems to provide an optimal milieu for declarative memory reprocessing and consolidation by reducing cholinergic activation and the cortisol feedback to the hippocampus during SWS...
  44. ncbi Sleep and awareness about presence of regularity speed the transition from implicit to explicit knowledge
    Spyridon Drosopoulos
    University of Lubeck, Department of Neuroendocrinology, Lubeck, Germany
    Biol Psychol 86:168-73. 2011
    ..We conclude that whilst sleep facilitates the conversion of implicit into explicit knowledge, the effect of awareness is not specific to sleep-dependent consolidation...
  45. ncbi Sleep enhances false memories depending on general memory performance
    Susanne Diekelmann
    Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany
    Behav Brain Res 208:425-9. 2010
    ..The other is related to the recovery function of sleep and affects cognitive control processes of retrieval. Both effects are unmasked when the material is relatively weakly encoded...
  46. ncbi Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans
    Kerstin M Oltmanns
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Am J Physiol Regul Integr Comp Physiol 294:R12-6. 2008
    ..A disturbance of these mechanisms may have far-reaching implications for metabolic dysregulation associated with obesity or diabetes mellitus...
  47. ncbi Odor cues during slow-wave sleep prompt declarative memory consolidation
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
    Science 315:1426-9. 2007
    ..Concurring with these findings, functional magnetic resonance imaging revealed significant hippocampal activation in response to odor re-exposure during SWS...
  48. ncbi No elevated plasma catecholamine levels during sleep in newly diagnosed, untreated hypertensives
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e21292. 2011
    ....
  49. ncbi Intranasal insulin reduces body fat in men but not in women
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:3024-9. 2004
    ..Our results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex...
  50. ncbi Food anticipation and subsequent food withdrawal increase serum cortisol in healthy men
    Volker Ott
    Department of Neuroendocrinology, University of Luebeck, Germany
    Physiol Behav 103:594-9. 2011
    ....
  51. ncbi The influence of learning on sleep slow oscillations and associated spindles and ripples in humans and rats
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Eur J Neurosci 29:1071-81. 2009
    ..Slow oscillations might provide an effective temporal frame for hippocampus-to-neocortical information transfer only when thalamo-neocortical systems are already critically involved during learning...
  52. ncbi Blocking NMDA receptor signaling does not decrease hormonal counterregulation to hypoglycemia in humans
    Isabel Pais
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 33:1069-76. 2008
    ..Our data do not support the view that in humans, enhanced glutamate signaling during hypoglycemia supports the satisfaction of increased central nervous energy demands by enforcing hormonal counterregulation...
  53. ncbi Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    FASEB J 23:3629-36. 2009
    ..01). Other types of memory were not affected. The ability of IL-6 to enhance sleep-associated emotional memory consolidation highlights an example of a functional interaction between the central nervous and immune system...
  54. ncbi Transcranial electrical currents to probe EEG brain rhythms and memory consolidation during sleep in humans
    Lisa Marshall
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e16905. 2011
    ....
  55. ncbi Sleep enhances explicit recollection in recognition memory
    Spyridon Drosopoulos
    University of Lubeck, Department of Neuroendocrinology, D 23538 Lubeck, Germany
    Learn Mem 12:44-51. 2005
    ..05). The data indicate that in a task that allows separating the contribution of explicit and implicit memory, sleep particularly supports explicit memory formation. The mechanism of this effect appears to be linked to SWS...
  56. ncbi Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
    ....
  57. ncbi Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, Ratzeburger Allee 160, Hs 50 1, 23538 Lubeck, Germany
    Neurobiol Learn Mem 98:103-11. 2012
    ..External reactivation cues can accelerate the consolidation process even during shorter sleep episodes...
  58. ncbi Boosting slow oscillations during sleep potentiates memory
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 444:610-3. 2006
    ..Our findings indicate that endogenous slow potential oscillations have a causal role in the sleep-associated consolidation of memory, and that this role is enhanced by field effects in cortical extracellular space...
  59. ncbi Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 31:786-91. 2006
    ....
  60. ncbi Hypoglycemia counterregulation during sleep
    Steffen Gais
    Departments of Neuroendocrinology, Medical University of Lubeck, 23538 Lubeck, Germany
    Sleep 26:55-9. 2003
    ..This study examined the influence of sleep on the counterregulatory response to hypoglycemia in healthy subjects...
  61. ncbi Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Germany
    Diabetes 60:114-8. 2011
    ..We determined the effect of intranasal insulin, which directly targets the brain, on glucose metabolism and energy expenditure in humans...
  62. ncbi Overweight humans are resistant to the weight-reducing effects of melanocortin4-10
    Manfred Hallschmid
    Department of Neuroendocrinology, , Ratzeburger Allee 160, Haus 23, , Germany
    J Clin Endocrinol Metab 91:522-5. 2006
    ..In overweight subjects, a decreased sensitivity to ACTH/MSH peptides may derive from alterations at the level of the melanocortin receptor or at subsequent steps in the processing of the body fat signal...
  63. ncbi Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Physiol Behav 83:55-64. 2004
    ..The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders...
  64. ncbi Gut protein uptake and mechanisms of meal-induced cortisol release
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 90:1692-6. 2005
    ..We conclude that the meal-related hypothalamo-pituitary-adrenal axis response to amino acids results from a signal that rather acts at the gastrointestinal mucosa than directly via the circulating blood...
  65. ncbi Memory consolidation during sleep: interactive effects of sleep stages and HPA regulation
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Stress 11:28-41. 2008
    ..The increase in cortisol release during late REM sleep-rich sleep may counteract an overshooting consolidation of emotional memories...
  66. ncbi Slow-wave sleep and the consolidation of long-term memory
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    World J Biol Psychiatry 11:16-21. 2010
    ..This synchronization is thought to be critical to the long-term storage of respective memories within neocortical networks...
  67. ncbi Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men
    Tanja Lange
    Department of Internal Medicine, , Germany
    Brain Behav Immun 16:663-74. 2002
    ..Also, IL-2 increased the TSH concentration. There were no hints at a sleep promoting effect of IL-2. Immune changes suggest that nocturnal IL-2 administration induces a shift towards Th2 mediated defense...
  68. ncbi Learning-dependent increases in sleep spindle density
    Steffen Gais
    Department of Neuroendocrinology, , , Germany
    J Neurosci 22:6830-4. 2002
    ..56; p < 0.05). Power spectra and time spent in sleep stages did not differ between learning and nonlearning conditions. Results indicate that spindle activity during non-REM sleep is sensitive to previous learning experience...
  69. ncbi Sleep loss produces false memories
    Susanne Diekelmann
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 3:e3512. 2008
    ..This effect was abolished by caffeine administration prior to retrieval, indicating that adenosinergic mechanisms can contribute to the generation of false memories associated with sleep loss...
  70. ncbi The whats and whens of sleep-dependent memory consolidation
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Sleep Med Rev 13:309-21. 2009
    ....
  71. ncbi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
    ....
  72. ncbi The impact of post-learning sleep vs. wakefulness on recognition memory for faces with different facial expressions
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neurobiol Learn Mem 87:679-87. 2007
    ..Results suggest that face recognition, despite its dependence on specialized brain systems, nevertheless relies on the general neural mechanisms of sleep-associated memory consolidation...
  73. ncbi Sleep in children improves memory performance on declarative but not procedural tasks
    Ines Wilhelm
    Department of Neuroendocrinology, University of Lubeck, Lubeck 23538, Germany
    Learn Mem 15:373-7. 2008
    ..However, opposite to adults, children showed smaller improvement in finger-tapping skill across retention sleep than wakefulness, indicating that sleep-dependent procedural memory consolidation depends on developmental stage...
  74. ncbi Growth hormone-releasing hormone facilitates hypoglycemia-induced release of cortisol
    Boris Perras
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Regul Pept 110:85-91. 2002
    ..e. hypothalamic) level as suggested by restriction of the effect to the hypoglycemia-induced cortisol release with no effects after pituitary stimulation with CRH/vasopressin...
  75. ncbi Preserved inhibitory effect of recurrent hypoglycaemia on the male gonadotrophic axis
    Kerstin M Oltmanns
    Department of Psychiatry and Psychotherapy, University of Leubeck, Luebeck, Germany
    Clin Endocrinol (Oxf) 62:217-22. 2005
    ..As counterregulatory stress hormone release is attenuated during recurrent hypoglycaemia, we questioned whether the gonadotrophic axis and PRL adapt similarly...
  76. ncbi Signs of REM sleep dependent enhancement of implicit face memory: a repetition priming study
    Ullrich Wagner
    Department of Physiological Psychology, University of Bamberg, Markusplatz 3, D 96045 Bamberg, Germany
    Biol Psychol 62:197-210. 2003
    ..Together, these findings indicate that implicit face memories particularly benefit from REM sleep associated brain mechanisms...
  77. ncbi Hypoxia causes glucose intolerance in humans
    Kerstin M Oltmanns
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Am J Respir Crit Care Med 169:1231-7. 2004
    ..9) despite clear differences in stress hormonal responses. Hypoxia acutely causes glucose intolerance. One of the factors mediating this effect could be an elevated release of epinephrine...
  78. ncbi Modulation of hunger by plasma glucose and metformin
    Bernd Schultes
    Department of Internal Medicine I, University of Luebeck, D 23538 Luebeck, Germany
    J Clin Endocrinol Metab 88:1133-41. 2003
    ..Metformin attenuates hypoglycemia-induced hunger, but does not appear to influence posthypoglycemic food intake...
  79. ncbi Sleep's function in the spontaneous recovery and consolidation of memories
    Spyridon Drosopoulos
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    J Exp Psychol Gen 136:169-83. 2007
    ..In combination, the results indicate that the benefit of sleep for declarative memory consolidation is greater for weaker associations, regardless of whether weak associations result from retroactive interference or poor encoding...
  80. ncbi Sleep enforces the temporal order in memory
    Spyridon Drosopoulos
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 2:e376. 2007
    ..To address this issue we tested the influence of sleep on the strength of forward and backward associations in word-triplets...
  81. ncbi Bifrontal transcranial direct current stimulation slows reaction time in a working memory task
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology H23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Neurosci 6:23. 2005
    ....
  82. ncbi Acute hypoxia decreases plasma VEGF concentration in healthy humans
    Kerstin M Oltmanns
    Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany
    Am J Physiol Endocrinol Metab 290:E434-9. 2006
    ..Contrary to in vitro studies, in healthy humans hypoxia decreases plasma VEGF concentration, suggesting that systemic VEGF concentration may be differently regulated than the expression on cellular basis...
  83. ncbi Visual-procedural memory consolidation during sleep blocked by glutamatergic receptor antagonists
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 28:5513-8. 2008
    ..An off-line activation of glutamatergic synapses therefore seems to play a critical part in the consolidation of plastic changes in the visual cortex...
  84. ncbi Persistent suppression of resting energy expenditure after acute hypoxia
    Kerstin M Oltmanns
    Department of Psychiatry, University of Luebeck, 23538 Luebeck, Germany
    Metabolism 55:669-75. 2006
    ..2). Our data demonstrate that the REE decrease persists 150 minutes after acute hypoxia, indicating an adaptation of energy metabolism. This should be valued as an additive pathogenic factor in diseases with disturbed energy metabolism...
  85. ncbi Hippocampus whispering in deep sleep to prefrontal cortex--for good memories?
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Neuron 61:496-8. 2009
    ..e., a time window that allows for synaptic plastic changes in the neocortical cells. These observations corroborate evidence for a hippocampo-to-neocortical transfer of memories taking place during SWS...
  86. ncbi Brief sleep after learning keeps emotional memories alive for years
    Ullrich Wagner
    Department of Neuroendocrinology, Medical University of Lubeck, Lubeck, Germany
    Biol Psychiatry 60:788-90. 2006
    ....
  87. ncbi Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients
    Kerstin M Oltmanns
    Department of Internal Medicine I, University of Luebeck, Germany
    Eur J Endocrinol 154:325-31. 2006
    ..We sought to assess the relationship between diabetes-associated metabolic disturbances and cortisol concentrations in patients with type 2 diabetes...
  88. ncbi Acute and prolonged effects of insulin-induced hypoglycemia on the pituitary-thyroid axis in humans
    Bernd Schultes
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Metabolism 51:1370-4. 2002
    ..The pattern of changes suggests that hypoglycemia exerts its influence primarily at a central, ie, pituitary and/or hypothalamic, site of the axis...
  89. ncbi Awakening and counterregulatory response to hypoglycemia during early and late sleep
    Kamila Jauch Chara
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Diabetes 56:1938-42. 2007
    ..Here, we investigated whether awakening and counterregulatory responses differ between early and late sleep...
  90. ncbi Hypoglycemia during sleep impairs consolidation of declarative memory in type 1 diabetic and healthy humans
    Kamila Jauch Chara
    Internal Medicine I, University of Luebeck, Luebeck, Germany
    Diabetes Care 30:2040-5. 2007
    ..Patients with type 1 diabetes frequently experience hypoglycemic episodes during sleep. We investigated whether short-lasting hypoglycemia during early nocturnal sleep affects the sleep-associated consolidation of declarative memories...
  91. ncbi Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men
    Bernd Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Metabolism 51:531-6. 2002
    ..1). Data indicate that metformin decreases the serum leptin concentration even without affecting body weight and body composition in normal-weight men...
  92. ncbi Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia
    Dorle Dantz
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany D-23538
    J Clin Endocrinol Metab 87:835-40. 2002
    ..569; P = 0.021). Findings show that acute hypoglycemia is accompanied by a brisk increase in circulating VEGF concentration and that VEGF could mediate rapid adaptation of the brain to neuroglycopenia...
  93. ncbi Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia
    Sebastian M Schmid
    Department of Internal Medicine, University of Luebeck, Germany
    J Clin Endocrinol Metab 92:3044-51. 2007
    ..Sleep loss has immediate effects on metabolic function that in the long run may contribute to the development of obesity and type 2 diabetes...
  94. ncbi Changes in blood pressure and plasma catecholamine levels during prolonged hyperinsulinemia
    Werner Kern
    Department of Internal Medicine I, University of Luebeck, D-23538 Luebeck, Germany
    Metabolism 54:391-6. 2005
    ....
  95. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
    ..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
  96. ncbi Defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus
    Bernd Schultes
    Department of Internal Medicine, University of Luebeck, Luebeck, Germany
    PLoS Med 4:e69. 2007
    ..Whether hypoglycemia normally provokes awakening from sleep in individuals who do not have diabetes, and whether this awakening response is impaired in T1DM patients, is unknown...
  97. ncbi Hormonal, subjective, and neurocognitive responses to brief hypoglycemia in postmenopausal women and age-matched men with type 2 diabetes mellitus
    Jan Phillip Bremer
    Department of Internal Medicine I, University of Luebeck, D-23538 Luebeck, Germany
    Metabolism 55:331-8. 2006
    ..Therefore, our results cannot be generalized to female patients with type 2 diabetes who are premenopausal or on hormone replacement therapy, that is, conditions characterized by increased blood estrogen levels...
  98. ncbi Elevated sleep spindle density after learning or after retrieval in rats
    Oxana Eschenko
    Department of Neuromodulation, Neuroplasticity, and Cognition, Centre National de la Recherche Scientifique, , , 75005 Paris, France
    J Neurosci 26:12914-20. 2006
    ....
  99. ncbi Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans
    Peter Wellhoener
    Department of Internal Medicine I, University Hospital Schleswig Holstein, D 23538 Luebeck, Germany
    J Clin Endocrinol Metab 89:5048-52. 2004
    ..The undiminished concentration of ACTH in the presence of elevated cortisol levels suggests that blockade of MR shifts the set point for cortisol feedback inhibition of the HPA axis toward higher cortisol levels...
  100. ncbi Developmental differences in sleep's role for implicit off-line learning: comparing children with adults
    Stefan Fischer
    Innsbruck Medical University, Innsbruck, Austria
    J Cogn Neurosci 19:214-27. 2007
    ..We speculate that the overnight decrease of implicit knowledge in children reflects a preferential effect of sleep toward the enhancement of explicit aspects of task performance that interferes with implicit performance gains...
  101. ncbi Differences between nighttime and daytime hypoglycemia counterregulation in healthy humans
    Volker Merl
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Metabolism 53:894-8. 2004
    ....