Jan Born

Summary

Country: Germany

Publications

  1. pmc Sleep enforces the temporal order in memory
    Spyridon Drosopoulos
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 2:e376. 2007
  2. pmc System consolidation of memory during sleep
    Jan Born
    Department of Medical Psychology and Neurobiology, University of Tubingen, Gartenstr 29, 72074, Tubingen, Germany
    Psychol Res 76:192-203. 2012
  3. pmc Sleep and immune function
    Luciana Besedovsky
    Department of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Tubingen, Germany
    Pflugers Arch 463:121-37. 2012
  4. pmc Bifrontal transcranial direct current stimulation slows reaction time in a working memory task
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology H23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Neurosci 6:23. 2005
  5. ncbi Implicit learning -- explicit knowing: a role for sleep in memory system interaction
    Stefan Fischer
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee, D 23538 Lubeck, Germany
    J Cogn Neurosci 18:311-9. 2006
  6. ncbi Combined blockade of cholinergic receptors shifts the brain from stimulus encoding to memory consolidation
    Björn H Rasch
    University of Lubeck, Germany
    J Cogn Neurosci 18:793-802. 2006
  7. ncbi Memory consolidation during sleep: role of cortisol feedback
    Jan Born
    University of Lubeck, Department of Neuroendocrinology, Ratzeburger Allee 160, Hs 23a, D 23538 Lubeck, Germany
    Ann N Y Acad Sci 1032:198-201. 2004
  8. ncbi Sleep, hormones, and memory
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Haus 23a, Lubeck, Germany
    Obstet Gynecol Clin North Am 36:809-29, x. 2009
  9. ncbi Slow-wave sleep and the consolidation of long-term memory
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    World J Biol Psychiatry 11:16-21. 2010
  10. doi Impaired off-line consolidation of motor memories after combined blockade of cholinergic receptors during REM sleep-rich sleep
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 34:1843-53. 2009

Detail Information

Publications119 found, 100 shown here

  1. pmc Sleep enforces the temporal order in memory
    Spyridon Drosopoulos
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 2:e376. 2007
    ..To address this issue we tested the influence of sleep on the strength of forward and backward associations in word-triplets...
  2. pmc System consolidation of memory during sleep
    Jan Born
    Department of Medical Psychology and Neurobiology, University of Tubingen, Gartenstr 29, 72074, Tubingen, Germany
    Psychol Res 76:192-203. 2012
    ....
  3. pmc Sleep and immune function
    Luciana Besedovsky
    Department of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Tubingen, Germany
    Pflugers Arch 463:121-37. 2012
    ....
  4. pmc Bifrontal transcranial direct current stimulation slows reaction time in a working memory task
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology H23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Neurosci 6:23. 2005
    ....
  5. ncbi Implicit learning -- explicit knowing: a role for sleep in memory system interaction
    Stefan Fischer
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee, D 23538 Lubeck, Germany
    J Cogn Neurosci 18:311-9. 2006
    ..Because before sleep subjects only had implicit knowledge on the sequence of target transitions, these data point to an interaction between implicit and explicit memory systems during sleep-dependent off-line learning...
  6. ncbi Combined blockade of cholinergic receptors shifts the brain from stimulus encoding to memory consolidation
    Björn H Rasch
    University of Lubeck, Germany
    J Cogn Neurosci 18:793-802. 2006
    ....
  7. ncbi Memory consolidation during sleep: role of cortisol feedback
    Jan Born
    University of Lubeck, Department of Neuroendocrinology, Ratzeburger Allee 160, Hs 23a, D 23538 Lubeck, Germany
    Ann N Y Acad Sci 1032:198-201. 2004
    ..The findings are consistent with the view that cortisol via activation of limbic glucocorticoid receptors generally diminishes memory consolidation...
  8. ncbi Sleep, hormones, and memory
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Haus 23a, Lubeck, Germany
    Obstet Gynecol Clin North Am 36:809-29, x. 2009
    ....
  9. ncbi Slow-wave sleep and the consolidation of long-term memory
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    World J Biol Psychiatry 11:16-21. 2010
    ..This synchronization is thought to be critical to the long-term storage of respective memories within neocortical networks...
  10. doi Impaired off-line consolidation of motor memories after combined blockade of cholinergic receptors during REM sleep-rich sleep
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 34:1843-53. 2009
    ..Taken together, these results identify high cholinergic activity during late, REM sleep-rich sleep as an essential factor promoting sleep-dependent consolidation of motor skills...
  11. doi Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balance
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Psychoneuroendocrinology 34:455-62. 2009
    ..Sleep is not critically involved in this glucose-glucocorticoid feedback loop but may reduce the brain's sensitivity to the anorexigenic effect of enhanced glucose supply...
  12. ncbi Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Regul Pept 149:79-83. 2008
    ..Our results may contribute to the future development of therapeutic strategies in disorders like obesity and cognitive impairments that derive from dysfunctions of central nervous neuropeptidergic pathways...
  13. pmc Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Diabetes 59:1101-7. 2010
    ....
  14. doi Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
    ..Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown...
  15. doi Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory
    Björn Rasch
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 12:396-7. 2009
    ..Our results indicate that REM sleep as a unitary phenomenon is not required for skill-memory consolidation...
  16. pmc Oxytocin reduces reward-driven food intake in humans
    Volker Ott
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Diabetes 62:3418-25. 2013
    ..These effects can be assumed to converge with the psychosocial function of oxytocin and imply possible applications in the treatment of metabolic disorders. ..
  17. ncbi Shift of monocyte function toward cellular immunity during sleep
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Lubeck, Germany
    Arch Intern Med 166:1695-700. 2006
    ..We hypothesized that sleep achieves this effect by shifting the balance between types 1 and 2 cytokine activity toward increased type 1 activity, thereby supporting adaptive cellular immune responses...
  18. ncbi Intranasal insulin improves memory in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 29:1326-34. 2004
    ..These findings could be of relevance for the treatment of patients with memory disorders like in Alzheimer's disease...
  19. ncbi Intranasal atrial natriuretic peptide acts as central nervous inhibitor of the hypothalamo-pituitary-adrenal stress system in humans
    Boris Perras
    Medizinische Klinik I, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23558 Lübeck, Germany
    J Clin Endocrinol Metab 89:4642-8. 2004
    ..The absence of an effect on CRH/VP-induced pituitary-adrenal responses suggests a direct action of the peptide on the central nervous system inhibiting stimulated hypothalamo-pituitary-adrenal activity at the hypothalamic level...
  20. doi Altered neuroendocrine sleep architecture in patients with type 1 diabetes
    Kamila Jauch-Chara
    Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany
    Diabetes Care 31:1183-8. 2008
    ..Disturbances of sleep may arise from and contribute to the disease process in chronically ill patients with type 1 diabetes...
  21. ncbi Improvement of sleep and pituitary-adrenal inhibition after subchronic intranasal vasopressin treatment in elderly humans
    Boris Perras
    Institute of Neuroendocrinology, University of Lubeck, Germany
    J Clin Psychopharmacol 23:35-44. 2003
    ..Overall, results indicate a promoting effect of AVP on SWS in aged accompanied by a beneficial rather than impairing influence on the neuroendocrine pattern of sleep...
  22. ncbi Processing of food stimuli is selectively enhanced during insulin-induced hypoglycemia in healthy men
    Bernd Schultes
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Psychoneuroendocrinology 30:496-504. 2005
    ..If executive control of attention becomes affected by hypoglycemia, cognitive resources appear to be preferentially allocated to the processing of food stimuli...
  23. doi Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory
    Rosemarie Krug
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 50 1, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 95:E468-72. 2010
    ....
  24. ncbi Intranasal insulin improves memory in humans: superiority of insulin aspart
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 32:239-43. 2007
    ..This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease...
  25. ncbi Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Brain Behav Immun 18:341-8. 2004
    ..001). Though unexpected, the most pronounced effect of sleep on T cell cytokine production was a robust decrease in TNF-alpha producing CD8+ cells probably reflecting increased extravasation of cytotoxic effector and memory T cells...
  26. ncbi Transcranial direct current stimulation during sleep improves declarative memory
    Lisa Marshall
    Institute of Neuroendocrinology H23a, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 24:9985-92. 2004
    ..Shifts in extracellular ionic concentration in frontocortical tissue (expressed as negative DC potentials during SWS) may facilitate sleep-dependent consolidation of declarative memories...
  27. doi The memory function of noradrenergic activity in non-REM sleep
    Steffen Gais
    University of Lubeck, Germany
    J Cogn Neurosci 23:2582-92. 2011
    ..We conclude that noradrenergic activity during non-REM sleep interacts with other sleep-related mechanisms to functionally contribute to off-line memory consolidation...
  28. ncbi Effects of cortisol suppression on sleep-associated consolidation of neutral and emotional memory
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Germany
    Biol Psychiatry 58:885-93. 2005
    ..The role of the strong cortisol rise accompanying late sleep for emotional memory consolidation has not yet been investigated...
  29. ncbi Sleep enhances serum interleukin-7 concentrations in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    Brain Behav Immun 21:1058-62. 2007
    ..The findings concur with the notion of a supportive influence of sleep on T cell function related to formation of T cell memory...
  30. pmc Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
    ..Thus, activation of the major stress hormones during daytime favor immediate effector defense but diminish capabilities for initiating adaptive immune responses...
  31. ncbi Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Germany
    Int Immunopharmacol 6:216-25. 2006
    ..Yet, our finding of predominant type1 activity after cortisol administration, rules out any relevance of this suppression for the shift towards type1 activity during SWS...
  32. doi Meal anticipation potentiates postprandial ghrelin suppression in humans
    Volker Ott
    Department of Neuroendocrinology, Hs 50 1, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 37:1096-100. 2012
    ....
  33. doi Suppressing the morning rise in cortisol impairs free recall
    Ulrike Rimmele
    Department of Neuroendocrinology, University of Lubeck, Luebeck 23562, Germany
    Learn Mem 17:186-90. 2010
    ..Thus, not only high, but also very low glucocorticoid levels impair retrieval, with the latter effect possibly reflecting insufficient occupation of hippocampal/amygdalar mineralocorticoid receptors (MRs)...
  34. ncbi A 3-day estrogen treatment improves prefrontal cortex-dependent cognitive function in postmenopausal women
    Rosemarie Krug
    Department of Neuroendocrinologie, University of Lubeck, Ratzeburger Allee 160, Hs 23a, D 23538 Lubeck, Germany
    Psychoneuroendocrinology 31:965-75. 2006
    ..Our results encourage future studies to investigate whether repeated induction of short-lasting estrogen peaks could enhance cognitive efficacy of hormonal replacement therapy...
  35. doi Sleep selectively enhances memory expected to be of future relevance
    Ines Wilhelm
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 31:1563-9. 2011
    ..In conclusion, our work shows that sleep preferentially benefits consolidation of memories that are relevant for future behavior, presumably through a SWS-dependent reprocessing of these memories...
  36. ncbi High-calorie glucose-rich food attenuates neuroglycopenic symptoms in patients with Addison's disease
    Johanna Klement
    University of Lubeck, Department of Internal Medicine I, Ratzeburger Allee 160, House 32, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 95:522-8. 2010
    ..Neuroglycopenic and autonomic symptoms, cognitive function (short-term memory, attention), and hormones of the sympathoadrenal system (ACTH, cortisol, catecholamines) were assessed throughout the sessions...
  37. doi Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
    ....
  38. ncbi Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
    ....
  39. doi The sleeping child outplays the adult's capacity to convert implicit into explicit knowledge
    Ines Wilhelm
    Department of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Tuebingen, Germany
    Nat Neurosci 16:391-3. 2013
    ..Our data indicate the superiority of children in extracting invariant features from complex environments, possibly as a result of enhanced reprocessing of hippocampal memory representations during slow-wave sleep...
  40. pmc Influence of captopril on symptomatic and hormonal responses to hypoglycaemia in humans
    Kerstin M Oltmanns
    Department of Internal Medicine I, Institute of Pharmacology and Clinical Neuroendocrinology, Medical University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Br J Clin Pharmacol 55:347-53. 2003
    ..Although ACE inhibitors are approved for controlling diabetic complications, previous investigations regarding this putative side-effect are controversial...
  41. pmc Sleep to implement an intention
    Susanne Diekelmann
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Sleep 36:149-53. 2013
    ..Sleep supports the consolidation of new memories. However, this effect has mainly been shown for memories of past events. Here we investigated the role of sleep for the implementation of intentions for the future...
  42. pmc Shifting from implicit to explicit knowledge: different roles of early- and late-night sleep
    Juliana Yordanova
    Department of Neurology, University of Lubeck, 23538 Lubeck, Germany
    Learn Mem 15:508-15. 2008
    ....
  43. pmc Sleep enhances explicit recollection in recognition memory
    Spyridon Drosopoulos
    University of Lubeck, Department of Neuroendocrinology, D 23538 Lubeck, Germany
    Learn Mem 12:44-51. 2005
    ..05). The data indicate that in a task that allows separating the contribution of explicit and implicit memory, sleep particularly supports explicit memory formation. The mechanism of this effect appears to be linked to SWS...
  44. doi Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 93:1339-44. 2008
    ..Long-term administration of intranasal insulin reduces body weight in men, but not in women, while improving hippocampus-dependent memory processing in both genders...
  45. doi Sleep enhances false memories depending on general memory performance
    Susanne Diekelmann
    Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany
    Behav Brain Res 208:425-9. 2010
    ..The other is related to the recovery function of sleep and affects cognitive control processes of retrieval. Both effects are unmasked when the material is relatively weakly encoded...
  46. ncbi Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain
    Manfred Hallschmid
    University of Lubeck, Institute of Neuroendocrinology, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:2202-8. 2004
    ..The rapid emergence of the DC potential shift, reflecting gross ionic changes in brain tissues, indicates that systemic insulin can serve as an immediate feedback signal in the control of hypothalamic and higher brain functions...
  47. doi Contribution of norepinephrine to emotional memory consolidation during sleep
    Sabine Groch
    Department of Neuroendocrinology, University of Luebeck, Haus 50 1, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 36:1342-50. 2011
    ..Here, we examined whether NE supports the consolidation of amygdala-dependent emotional memory during SWS...
  48. doi Sleep and awareness about presence of regularity speed the transition from implicit to explicit knowledge
    Spyridon Drosopoulos
    University of Lubeck, Department of Neuroendocrinology, Lubeck, Germany
    Biol Psychol 86:168-73. 2011
    ..We conclude that whilst sleep facilitates the conversion of implicit into explicit knowledge, the effect of awareness is not specific to sleep-dependent consolidation...
  49. ncbi Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    Metabolism 54:1356-61. 2005
    ..However, the effect is not observed with prolonged administration of the hormone, suggesting the emergence of counterregulatory processes...
  50. ncbi Modulation of food intake by glucose in patients with type 2 diabetes
    Bernd Schultes
    Department of Internal Medicine I, Medical University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Diabetes Care 28:2884-9. 2005
    ..On this background, we hypothesized that a short-term reduction of blood glucose concentration to normal values acutely increases food intake in type 2 diabetic patients...
  51. pmc Declarative memory consolidation: mechanisms acting during human sleep
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, Lubeck 23538, Germany
    Learn Mem 11:679-85. 2004
    ..In addition, sleep seems to provide an optimal milieu for declarative memory reprocessing and consolidation by reducing cholinergic activation and the cortisol feedback to the hippocampus during SWS...
  52. doi Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    FASEB J 23:3629-36. 2009
    ..01). Other types of memory were not affected. The ability of IL-6 to enhance sleep-associated emotional memory consolidation highlights an example of a functional interaction between the central nervous and immune system...
  53. doi Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations
    Daria Antonenko
    Department of Neuroendocrinology, University of Lubeck, 23538, Lubeck, Germany
    Eur J Neurosci 37:1142-51. 2013
    ..Our results indicate that sleep SWA enhances the capacity for encoding of declarative materials, possibly by down-scaling hippocampal synaptic networks that were potentiated towards saturation during the preceding period of wakefulness...
  54. ncbi Learning-dependent increases in sleep spindle density
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23564 Lübeck, Germany
    J Neurosci 22:6830-4. 2002
    ..56; p < 0.05). Power spectra and time spent in sleep stages did not differ between learning and nonlearning conditions. Results indicate that spindle activity during non-REM sleep is sensitive to previous learning experience...
  55. doi Auditory closed-loop stimulation of the sleep slow oscillation enhances memory
    Hong Viet V Ngo
    Institute of Medical Psychology and Behavioral Neurobiology, and Center for Integrative Neuroscience, University of Tubingen, 72076 Tubingen, Germany
    Neuron 78:545-53. 2013
    ..Stimulation out of phase with the ongoing slow oscillation rhythm remained ineffective. Closed-loop in-phase stimulation provides a straight-forward tool to enhance sleep rhythms and their functional efficacy...
  56. ncbi Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans
    Kerstin M Oltmanns
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Am J Physiol Regul Integr Comp Physiol 294:R12-6. 2008
    ..A disturbance of these mechanisms may have far-reaching implications for metabolic dysregulation associated with obesity or diabetes mellitus...
  57. pmc No elevated plasma catecholamine levels during sleep in newly diagnosed, untreated hypertensives
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e21292. 2011
    ....
  58. doi Food anticipation and subsequent food withdrawal increase serum cortisol in healthy men
    Volker Ott
    Department of Neuroendocrinology, University of Luebeck, Germany
    Physiol Behav 103:594-9. 2011
    ....
  59. ncbi Blocking NMDA receptor signaling does not decrease hormonal counterregulation to hypoglycemia in humans
    Isabel Pais
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 33:1069-76. 2008
    ..Our data do not support the view that in humans, enhanced glutamate signaling during hypoglycemia supports the satisfaction of increased central nervous energy demands by enforcing hormonal counterregulation...
  60. ncbi Sleep-stage-specific regulation of plasma catecholamine concentration
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 32:884-91. 2007
    ....
  61. ncbi Odor cues during slow-wave sleep prompt declarative memory consolidation
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
    Science 315:1426-9. 2007
    ..Concurring with these findings, functional magnetic resonance imaging revealed significant hippocampal activation in response to odor re-exposure during SWS...
  62. pmc Transcranial electrical currents to probe EEG brain rhythms and memory consolidation during sleep in humans
    Lisa Marshall
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e16905. 2011
    ....
  63. doi The influence of learning on sleep slow oscillations and associated spindles and ripples in humans and rats
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Eur J Neurosci 29:1071-81. 2009
    ..Slow oscillations might provide an effective temporal frame for hippocampus-to-neocortical information transfer only when thalamo-neocortical systems are already critically involved during learning...
  64. ncbi Intranasal insulin reduces body fat in men but not in women
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:3024-9. 2004
    ..Our results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex...
  65. ncbi Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans
    Luciana Besedovsky
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Brain Behav Immun 26:1116-21. 2012
    ....
  66. ncbi Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, Ratzeburger Allee 160, Hs 50 1, 23538 Lubeck, Germany
    Neurobiol Learn Mem 98:103-11. 2012
    ..External reactivation cues can accelerate the consolidation process even during shorter sleep episodes...
  67. ncbi Sleep in children improves memory performance on declarative but not procedural tasks
    Ines Wilhelm
    Department of Neuroendocrinology, University of Lubeck, Lubeck 23538, Germany
    Learn Mem 15:373-7. 2008
    ..However, opposite to adults, children showed smaller improvement in finger-tapping skill across retention sleep than wakefulness, indicating that sleep-dependent procedural memory consolidation depends on developmental stage...
  68. ncbi Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 31:786-91. 2006
    ....
  69. ncbi Memory consolidation during sleep: interactive effects of sleep stages and HPA regulation
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Stress 11:28-41. 2008
    ..The increase in cortisol release during late REM sleep-rich sleep may counteract an overshooting consolidation of emotional memories...
  70. ncbi Hippocampal sharp wave-ripples linked to slow oscillations in rat slow-wave sleep
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    J Neurophysiol 96:62-70. 2006
    ..The preceding disfacilitation of hippocampal events temporally coupled to the negative slow oscillation half-wave appears to serve a synchronizing role in this neocorticohippocampal interplay...
  71. ncbi Overweight humans are resistant to the weight-reducing effects of melanocortin4-10
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 91:522-5. 2006
    ....
  72. pmc Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Germany
    Diabetes 60:114-8. 2011
    ..We determined the effect of intranasal insulin, which directly targets the brain, on glucose metabolism and energy expenditure in humans...
  73. ncbi Boosting slow oscillations during sleep potentiates memory
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 444:610-3. 2006
    ..Our findings indicate that endogenous slow potential oscillations have a causal role in the sleep-associated consolidation of memory, and that this role is enhanced by field effects in cortical extracellular space...
  74. doi The whats and whens of sleep-dependent memory consolidation
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Sleep Med Rev 13:309-21. 2009
    ....
  75. doi Sleep after vaccination boosts immunological memory
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 187:283-90. 2011
    ..Like the nervous system, the immune system takes advantage of the offline conditions during sleep to foster adaptive immune responses resulting in improved immunological memory...
  76. doi Visual-procedural memory consolidation during sleep blocked by glutamatergic receptor antagonists
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 28:5513-8. 2008
    ..An off-line activation of glutamatergic synapses therefore seems to play a critical part in the consolidation of plastic changes in the visual cortex...
  77. ncbi Intranasal insulin to improve memory function in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuroendocrinology 86:136-42. 2007
    ..e., declarative) memory. Intranasal administration of insulin provides an effective way of delivering the compound to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects...
  78. ncbi Hippocampus whispering in deep sleep to prefrontal cortex--for good memories?
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Neuron 61:496-8. 2009
    ..e., a time window that allows for synaptic plastic changes in the neocortical cells. These observations corroborate evidence for a hippocampo-to-neocortical transfer of memories taking place during SWS...
  79. ncbi Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Physiol Behav 83:55-64. 2004
    ..The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders...
  80. ncbi EEG theta synchronization conjoined with alpha desynchronization indicate intentional encoding
    Matthias Mölle
    Department of Clinical Neuroendocrinology, Medical University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Eur J Neurosci 15:923-8. 2002
    ....
  81. ncbi Growth hormone-releasing hormone facilitates hypoglycemia-induced release of cortisol
    Boris Perras
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Regul Pept 110:85-91. 2002
    ..e. hypothalamic) level as suggested by restriction of the effect to the hypoglycemia-induced cortisol release with no effects after pituitary stimulation with CRH/vasopressin...
  82. pmc Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Proc Natl Acad Sci U S A 101:2140-4. 2004
    ..These findings are in line with predictions that a low cholinergic tone during SWS is essential for declarative memory consolidation...
  83. ncbi Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Germany
    Brain Behav Immun 16:663-74. 2002
    ..Also, IL-2 increased the TSH concentration. There were no hints at a sleep promoting effect of IL-2. Immune changes suggest that nocturnal IL-2 administration induces a shift towards Th2 mediated defense...
  84. ncbi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
    ....
  85. ncbi Acute influences of estrogen and testosterone on divergent and convergent thinking in postmenopausal women
    Rosemarie Krug
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, D 23538 Lubeck, Germany
    Neuropsychopharmacology 28:1538-45. 2003
    ..05), and tended to increase EEG dimensional complexity during divergent thinking. Data indicate a differential sensitivity of modes of thinking to short-term treatment with estrogen and testosterone in postmenopausal women...
  86. pmc Fast and slow spindles during the sleep slow oscillation: disparate coalescence and engagement in memory processing
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Sleep 34:1411-21. 2011
    ..We examined interactions between SOs and spindles in human slow wave sleep, focusing on the presumed existence of 2 kinds of spindles, i.e., slow frontocortical and fast centro-parietal spindles...
  87. ncbi Sleep inspires insight
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 427:352-5. 2004
    ..We conclude that sleep, by restructuring new memory representations, facilitates extraction of explicit knowledge and insightful behaviour...
  88. doi Slow oscillations orchestrating fast oscillations and memory consolidation
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Prog Brain Res 193:93-110. 2011
    ....
  89. ncbi Motor memory consolidation in sleep shapes more effective neuronal representations
    Stefan Fischer
    Department of Neuroendocrinology, University of Lubeck, D 23538 Lubeck, Germany
    J Neurosci 25:11248-55. 2005
    ..Our findings indicate that storing a motor skill during sleep reorganizes its brain representation toward enhanced efficacy...
  90. pmc A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e23435. 2011
    ..They provide first evidence for a critical contribution of central nervous somatotropic activity to hippocampus-dependent memory consolidation...
  91. ncbi The impact of post-learning sleep vs. wakefulness on recognition memory for faces with different facial expressions
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neurobiol Learn Mem 87:679-87. 2007
    ..Results suggest that face recognition, despite its dependence on specialized brain systems, nevertheless relies on the general neural mechanisms of sleep-associated memory consolidation...
  92. ncbi Sleep's function in the spontaneous recovery and consolidation of memories
    Spyridon Drosopoulos
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    J Exp Psychol Gen 136:169-83. 2007
    ..In combination, the results indicate that the benefit of sleep for declarative memory consolidation is greater for weaker associations, regardless of whether weak associations result from retroactive interference or poor encoding...
  93. ncbi Gut protein uptake and mechanisms of meal-induced cortisol release
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 90:1692-6. 2005
    ..We conclude that the meal-related hypothalamo-pituitary-adrenal axis response to amino acids results from a signal that rather acts at the gastrointestinal mucosa than directly via the circulating blood...
  94. ncbi Immediate as well as delayed post learning sleep but not wakefulness enhances declarative memory consolidation in children
    Jutta Backhaus
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Neurobiol Learn Mem 89:76-80. 2008
    ..The results support the hypothesis that sleep plays an active role in declarative memory consolidation even if delayed and further show for the first time the importance of sleep for declarative memory consolidation during childhood...
  95. ncbi Sleep after learning aids memory recall
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    Learn Mem 13:259-62. 2006
    ..Sleep deprivation has a detrimental effect on memory, which was significant after a night of recovery sleep. Thus, fatigue accumulating during wake intervals could be ruled out as a confound...
  96. pmc Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding
    Roumen Kirov
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    Proc Natl Acad Sci U S A 106:15460-5. 2009
    ..In response to tSOS during wakefulness the brain transposes stimulation by responding preferentially with theta oscillations and facilitated encoding...
  97. ncbi Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans
    Peter Wellhoener
    Department of Internal Medicine I, University Hospital Schleswig Holstein, D 23538 Luebeck, Germany
    J Clin Endocrinol Metab 89:5048-52. 2004
    ..The undiminished concentration of ACTH in the presence of elevated cortisol levels suggests that blockade of MR shifts the set point for cortisol feedback inhibition of the HPA axis toward higher cortisol levels...
  98. ncbi Targeting metabolic and cognitive pathways of the CNS by intranasal insulin administration
    Manfred Hallschmid
    Expert Opin Drug Deliv 4:319-22. 2007
    ..These results may fuel the future development of therapeutic strategies in disorders such as obesity and Alzheimer's disease that are promoted by dysfunctions of central nervous neuropeptidergic pathways...
  99. ncbi Signs of impaired selective attention in patients with amyotrophic lateral sclerosis
    Elmar H Pinkhardt
    Dept of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Neurol 255:532-8. 2008
    ..We conclude impaired selective attention reflects a subtle variant of frontotemporal dementia frequently observed in ALS patients at a relatively early stage of the disease...
  100. ncbi Signs of REM sleep dependent enhancement of implicit face memory: a repetition priming study
    Ullrich Wagner
    Department of Physiological Psychology, University of Bamberg, Markusplatz 3, D 96045 Bamberg, Germany
    Biol Psychol 62:197-210. 2003
    ..Together, these findings indicate that implicit face memories particularly benefit from REM sleep associated brain mechanisms...
  101. ncbi Changes in emotional responses to aversive pictures across periods rich in slow-wave sleep versus rapid eye movement sleep
    Ullrich Wagner
    Department of Physiological Psychology, University of Bamberg, Bamberg, Germany
    Psychosom Med 64:627-34. 2002
    ..The present study compared processing pictures with negative emotional impact over intervals covering either early sleep dominated by slow-wave sleep (SWS) or late REM sleep-dominated sleep...