H M Bolt

Summary

Country: Germany

Publications

  1. ncbi request reprint Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Curr Drug Metab 7:613-28. 2006
  2. ncbi request reprint N-acetyltransferase-2 and medical history in bladder cancer cases with a suspected occupational disease (BK 1301) in Germany
    Wobbeke Weistenhofer
    Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Dortmund, Germany
    J Toxicol Environ Health A 71:906-10. 2008
  3. ncbi request reprint Endocrine disruptors: update on xenoestrogens
    G H Degen
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Int Arch Occup Environ Health 73:433-41. 2000
  4. ncbi request reprint Proposed criteria for specific and non-specific chromosomal genotoxicity based on hydrophobic interactions
    Susanne B Dorn
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Mutat Res 628:67-75. 2007
  5. ncbi request reprint Induction and control of oxidative stress
    Jan G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 81:823-4. 2007
  6. pmc New results on formaldehyde: the 2nd International Formaldehyde Science Conference (Madrid, 19-20 April 2012)
    Hermann M Bolt
    Leibniz Research Centre on Working Environment and Human Factors, TU Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 87:217-22. 2013
  7. doi request reprint 1,3-Propane sultone as an extremely potent human carcinogen: description of an exposed cohort in Germany
    Hermann M Bolt
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    J Toxicol Environ Health A 75:544-50. 2012
  8. doi request reprint Human environmental and occupational exposures to boric acid: reconciliation with experimental reproductive toxicity data
    Hermann M Bolt
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    J Toxicol Environ Health A 75:508-14. 2012
  9. ncbi request reprint The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
    Hermann M Bolt
    Institut fur Arbeitsphysiologie, University of Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany
    Int Arch Occup Environ Health 76:174-85. 2003
  10. ncbi request reprint Genotoxicity and potential carcinogenicity of 2,4,6-TNT trinitrotoluene: structural and toxicological considerations
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Rev Environ Health 21:217-28. 2006

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Curr Drug Metab 7:613-28. 2006
    ..This appears relevant in industrial toxicology and in drug metabolism...
  2. ncbi request reprint N-acetyltransferase-2 and medical history in bladder cancer cases with a suspected occupational disease (BK 1301) in Germany
    Wobbeke Weistenhofer
    Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Dortmund, Germany
    J Toxicol Environ Health A 71:906-10. 2008
    ....
  3. ncbi request reprint Endocrine disruptors: update on xenoestrogens
    G H Degen
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Int Arch Occup Environ Health 73:433-41. 2000
    ..Together with a critical appraisal of methods to detect and quantitate the estrogenic activity of synthetic and naturally occurring chemicals, novel aspects in the risk assessment for endocrine active compounds are discussed...
  4. ncbi request reprint Proposed criteria for specific and non-specific chromosomal genotoxicity based on hydrophobic interactions
    Susanne B Dorn
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Mutat Res 628:67-75. 2007
    ..A general procedure is proposed, applicable in chemical product development, to screen specific and non-specific modes of action...
  5. ncbi request reprint Induction and control of oxidative stress
    Jan G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 81:823-4. 2007
  6. pmc New results on formaldehyde: the 2nd International Formaldehyde Science Conference (Madrid, 19-20 April 2012)
    Hermann M Bolt
    Leibniz Research Centre on Working Environment and Human Factors, TU Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 87:217-22. 2013
    ..Thus, new research results are now at hand to be incorporated into existing evaluations on formaldehyde by official bodies...
  7. doi request reprint 1,3-Propane sultone as an extremely potent human carcinogen: description of an exposed cohort in Germany
    Hermann M Bolt
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    J Toxicol Environ Health A 75:544-50. 2012
    ..Evidence indicates that 12 cases with various neoplasms were legally compensated within the period of 1985-2010 as an occupational disease, based on the "opening clause" of § 9 (2) SGB VII of legislation in Germany...
  8. doi request reprint Human environmental and occupational exposures to boric acid: reconciliation with experimental reproductive toxicity data
    Hermann M Bolt
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    J Toxicol Environ Health A 75:508-14. 2012
    ..It clearly appears that human B exposures, even in the highest exposed cohorts, are too low to reach the blood (and target tissue) concentrations that would be required to exert adverse effects on reproductive functions...
  9. ncbi request reprint The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
    Hermann M Bolt
    Institut fur Arbeitsphysiologie, University of Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany
    Int Arch Occup Environ Health 76:174-85. 2003
    ....
  10. ncbi request reprint Genotoxicity and potential carcinogenicity of 2,4,6-TNT trinitrotoluene: structural and toxicological considerations
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Rev Environ Health 21:217-28. 2006
    ..05) were observed at significant levels in high-dose (50 mg kg(-1)) females and in one or two females, respectively, at 10 mg kg(-1). Taking all the available evidence together, the appropriate precautions should be taken...
  11. ncbi request reprint Occupational versus environmental and lifestyle exposures of children and adolescents in the European Union
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, Germany
    Toxicol Lett 127:121-6. 2002
    ..iv) INCIDENTAL ACUTE EXPOSURE: Besides drugs, household chemicals are a source of incidental acute intoxications in children. In Germany, there has been a particular focus on ingestion of lamp petroleum oils since 1989. (v)..
  12. ncbi request reprint Vinyl chloride-a classical industrial toxicant of new interest
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Leibniz Research Center for Working Environment and Human Factors, Dortmund, Germany
    Crit Rev Toxicol 35:307-23. 2005
    ..In essence, fundamentals of the hepatocarcinogenicity of vinyl chloride appear now well established, providing a solid scientific basis for regulatory activities...
  13. ncbi request reprint Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Dortmund, Germany
    Drug Metab Rev 36:497-509. 2004
    ..Studies of the structure and substrate affinities of PXR have provided the rational explanation of the unique species difference of rifampicin induction between humans and rats that was first described by Herbert Remmer...
  14. ncbi request reprint Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:29-41. 2004
    ..This should be changed, as the philosophy of separation of a strictly sequential "hazard assessment" and "risk assessment" appears out-of-date...
  15. ncbi request reprint Human carcinogenic risk evaluation, part II: contributions of the EUROTOX specialty section for carcinogenesis
    Hermann M Bolt
    Institute for Occupational Physiology at the University of Dortmund, Leibniz Research Center for Working Environment and Human Factors, D 44139, Germany
    Toxicol Sci 81:3-6. 2004
    ....
  16. ncbi request reprint Genotoxicity--threshold or not? Introduction of cases of industrial chemicals
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139, Dortmund, Germany
    Toxicol Lett 140:43-51. 2003
    ..Current instruments of regulation should be adjusted to allow adequate consideration of carcinogenic effects of chemicals that are practically relevant at high doses only. Also, research into this field is encouraged...
  17. ncbi request reprint The debate on carcinogenicity of permanent hair dyes: new insights
    Hermann M Bolt
    Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund, Dortmund, Germany
    Crit Rev Toxicol 37:521-36. 2007
    ..Since earlier exposures could have an impact decades later, the possibility of bladder cancer in hairdressers having intensively worked with permanent hair dyes during earlier decades (prior to the 1980s) should be taken into account...
  18. ncbi request reprint Is multiple chemical sensitivity a clinically defined entity?
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 128:99-106. 2002
    ..The new situation will call for a re-evaluation of traditional positions...
  19. doi request reprint [Historical development of the European legislation on chemicals]
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Dortmund, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51:1381-6. 2008
    ..Other important fields of European legislation concerning chemicals, which were developed further, are environmental protection, consumer protection and occupational safety...
  20. ncbi request reprint Strategy of the scientific committee on occupational exposure limits (SCOEL) in the derivation of occupational exposure limits for carcinogens and mutagens
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Leibniz Research Centre for Working Environment and Human Factors, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 82:61-4. 2008
    ..Substantial progress is currently being made in the incorporation of new types of mechanistic data into these regulatory procedures...
  21. ncbi request reprint Re-investigation of the concordance of human NAT2 phenotypes and genotypes
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, 44139, Dortmund, Germany
    Arch Toxicol 79:196-200. 2005
    ..Based on discussions in the literature and the data presented here, there is accumulating evidence that current assignments of the NAT2*12 and NAT2*13 alleles as determinants of a rapid acetylator state should be reconsidered...
  22. ncbi request reprint Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1
    R Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Arch Toxicol 73:197-202. 1999
    ....
  23. ncbi request reprint Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts
    Ricarda Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystrasse 67, Germany
    Toxicol Lett 127:321-7. 2002
    ..Also, smoking and induction of head and neck squamous cell cancer are considered...
  24. ncbi request reprint Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation
    R Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Arch Toxicol 73:479-84. 1999
    ..The increased excretion of thymidine glycol after kidney transplantation may be explained by ischaemia-reperfusion induced oxidative DNA damage of the transplanted kidney...
  25. ncbi request reprint Pathological excretion patterns of urinary proteins in renal cell cancer patients exposed to trichloroethylene
    T Bruning
    Institut fur Arbeitsphysiologie, Universitat Dortmund, Germany
    Occup Med (Lond) 49:299-305. 1999
    ..3) The findings indicate that urine protein patterns, on the basis of the SDS-PAGE methodology, represent a 'biological effect parameter' for the medical surveillance of persons occupationally exposed to trichloroethylene...
  26. ncbi request reprint Glutathione transferase alpha as a marker for tubular damage after trichloroethylene exposure
    T Bruning
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Arch Toxicol 73:246-54. 1999
    ....
  27. ncbi request reprint Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile
    R Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Mutat Res 482:41-6. 2001
    ..The study also confirmed the impact of GSTT1 polymorphism on background N-(hydroxyethyl)-valine adduct levels in haemoglobin which are caused by endogenous ethylene oxide...
  28. ncbi request reprint Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers
    Bernd Wiesenhütter
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Int Arch Occup Environ Health 81:247-51. 2007
    ..Because of a potential involvement of N-acetylation in the detoxication of reactive trichloroethylene metabolite(s) to N-acetyl-cysteine derivatives, polymorphisms of the NAT2 gene may also be relevant...
  29. ncbi request reprint Glutathione S-transferase P1 ILE105Val polymorphism in occupationally exposed bladder cancer cases
    Silke Kopps
    Leibniz Research Centre for Working Environment and Human Factors, Institute for Occupational Physiology at the University of Dortmund IfADo, Dortmund, Germany
    J Toxicol Environ Health A 71:898-901. 2008
    ..Data indicated that in Caucasians exposed to aromatic amines the GSTP1 A1578G polymorphism did not appear to play a significant role as a predisposing factor for bladder cancer incidence...
  30. ncbi request reprint Comparative assessment of endocrine modulators with oestrogenic activity: I. Definition of a hygiene-based margin of safety (HBMOS) for xeno-oestrogens against the background of European developments
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Arch Toxicol 74:649-62. 2001
    ..The estimated HBMOS values for the industrial chemicals (nonylphenol, bisphenol A) appear sufficiently high to ensure the absence of a practical risk to human health under the present exposure conditions...
  31. ncbi request reprint UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism in bladder cancer cases
    Anna Zimmermann
    Leibniz Research Centre for Working Environment and Human Factors, Institute for Occupational Physiology at the University of Dortmund IfADo, Dortmund, Germany
    J Toxicol Environ Health A 71:911-4. 2008
    ..Furthermore, in contrast to an earlier investigation in benzidine-exposed Chinese bladder cancer patients, no relevant differences between bladder cancer patients and urological hospital controls were observed in Germany...
  32. ncbi request reprint Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene
    T Bruning
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    J Occup Environ Med 43:610-5. 2001
    ..Within the cluster of cancer patients observed among the DNT-exposed workers, only in exceptional cases were normal biomarker excretions found...
  33. ncbi request reprint Differential substrate behaviours of ethylene oxide and propylene oxide towards human glutathione transferase theta hGSTT1-1
    R Thier
    Institut fur Arbeitsphysiologie, an der Universität Dortmund, Germany
    Arch Toxicol 73:489-92. 1999
    ..This is corroborated by experimental data of acid-catalysed hydrolysis of a number of aliphatic epoxides, including ethylene oxide and propylene oxide and consistent with semi-empirical molecular orbital modelings...
  34. ncbi request reprint Species differences in acrylonitrile metabolism and toxicity between experimental animals and humans based on observations in human accidental poisonings
    R Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Arch Toxicol 74:184-9. 2000
    ....
  35. ncbi request reprint Determination of glutathione transferase (GSTT1-1) activities in different tissues based on formation of radioactive metabolites using 35S-glutathione
    R Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Germany
    Arch Toxicol 72:811-5. 1998
    ..These ought to be considered in species-specific modellings of organ toxicities of chlorinated hydrocarbons...
  36. ncbi request reprint Quantification of endogenous carcinogens. The ethylene oxide paradox
    H M Bolt
    Institut fur Arbeitsphysiologie, Universitat Dortmund, Germany
    Biochem Pharmacol 52:1-5. 1996
    ..This paradox is unresolved. It points, however, to the biological importance of endogenous DNA alkylations and questions current regulatory procedures of assessing the risk of minute doses of exogenous carcinogens...
  37. ncbi request reprint Renal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, Germany
    Thomas Bruning
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Dortmund, Germany
    Am J Ind Med 43:274-85. 2003
    ..German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI)...
  38. ncbi request reprint Bacterial mutagenicity of 2-chloro-1,3-butadiene (chloroprene) caused by decomposition products
    G A Westphal
    Institut fur Arbeitsphysiologie, Universitat Dortmund, Germany
    Arch Toxicol 68:79-84. 1994
    ....
  39. ncbi request reprint Renal carcinogenicity of trichloroethylene: update, mode of action, and fundamentals for occupational standard setting
    Volker Harth
    Institut fur Arbeitsphysiologie, Universität Dortmund IfADo, Ardeystr 67, D 44139 Dortmund, Germany
    Rev Environ Health 20:103-18. 2005
    ....
  40. ncbi request reprint Reconstruction of N-acetyltransferase 2 haplotypes using PHASE
    Klaus Golka
    Institute for Occupational Physiology at the University of Dortmund IfADo, Dortmund, Germany
    Arch Toxicol 82:265-70. 2008
    ..A clear assignment is indispensable in surveys of human bladder cancer caused by aromatic amine exposures. In conclusion, PHASE v2.1.1 software allowed an unambiguous haplotype reconstruction in 2,920 of 2,921 cases (>99.9%)...
  41. ncbi request reprint The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: a review considering ethnic differences
    Klaus Golka
    Institute of Occupational Physiology at the University of Dortmund IfADo, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 128:229-41. 2002
    ..This points to different mechanisms of susceptibility for bladder cancer upon exposure to aromatic amines between European (Caucasian) and Chinese populations...
  42. ncbi request reprint Integration of mechanistic data in the toxicological evaluation of endocrine modulators
    Gisela H Degen
    Institute of Occupational Physiology IfADo, University of Dortmund, Ardeystr 67, Germany
    Toxicol Lett 127:225-37. 2002
    ..For slowly accumulating compounds (e.g. DDT) with much longer half-lifes than isoflavones, such comparison should be based on comparative blood levels rather than on scenarios of daily exposures...
  43. ncbi request reprint Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1
    Peter H Roos
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Leibniz Research Centre for Working Environment and Human Factors, Ardeystr 67, D 44139 Dortmund, Germany
    Expert Opin Drug Metab Toxicol 1:187-202. 2005
    ..It appears that CYP1B1 plays a key role for the activation of carcinogens at several organ targets, with a likelihood of complex gene-environment interactions implying Phase II enzymes...
  44. doi request reprint Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure
    Klaus Golka
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse, Dortmund, Germany
    Pharmacogenet Genomics 19:903-6. 2009
    ..Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens...
  45. ncbi request reprint Urinary alpha1-microglobulin excretion as biomarker of renal toxicity in trichloroethylene-exposed persons
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany
    Int Arch Occup Environ Health 77:186-90. 2004
    ..This process is visualised by the excretion of tubular marker proteins in the urine of exposed persons. For this purpose, surveillance of alpha1-microglobulin excretion is being suggested by the Deutsche Forschungsgemeinschaft...
  46. ncbi request reprint Occupational exposure and urological cancer
    Klaus Golka
    Institute for Occupational Physiology at the University of Dortmund IfADo, Ardeystr 67, 44139 Dortmund, Germany
    World J Urol 21:382-91. 2004
    ..Occupationally related cancers of the prostate or the testes appear currently not relevant...
  47. ncbi request reprint Elevated bladder cancer risk due to colorants--a statewide case-control study in North Rhine-Westphalia, Germany
    Klaus Golka
    Institute for Occupational Physiology at the University of Dortmund IfADo, Leibniz Research Centre for Working Environment and Human Factors, Germany
    J Toxicol Environ Health A 71:851-5. 2008
    ..41). Ten of these 16 cases reported chronic exposure to colorants (OR 1.84, 95% CI 0.68-4.95). The results of this epidemiological study confirm the hypothesis that individuals exposed to colorants show an elevated bladder cancer risk...
  48. ncbi request reprint Comparative assessment of endocrine modulators with oestrogenic activity. II. Persistent organochlorine pollutants
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 76:187-93. 2002
    ..An HBMOS of 137 is derived for o,p'-DDT indicative of a sufficient margin of safety to ensure the absence of risk to human health due to its hormonal action, under exposure conditions now prevailing in Western countries...
  49. ncbi request reprint Risk potentials for humans of original and remediated PAH-contaminated soils: application of biomarkers of effect
    Peter H Roos
    Institute of Occupational Physiology, University of Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicology 205:181-94. 2004
    ..This concerns, for example, the identification of the suitable animal model, the identification of biomarkers for other contaminants and concepts to transpose the in vivo data to in vitro technologies or to mathematical modelling...
  50. ncbi request reprint Mutagenic effects of cutting fluids and components in the Salmonella typhimurium mutagenicity assay
    Marcus Kleber
    Institut fur Arbeitsphysiologie, Universität Dortmund IfADo, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Ind Health 18:425-33. 2002
    ..Under aspects of workers' safety, a further discussion about the use of specific components in cutting fluids is recommended...
  51. ncbi request reprint Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1 and CYP4B1 in cultured transitional cells from specimens of the human urinary tract and from urinary sediments
    P H Roos
    Institute for Occupational Physiology at the University of Dortmund IfADo, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 80:45-52. 2006
    ..In particular, transcripts of CYP1B1 and CYP4B1 are present, coding for enzymes which are active in the metabolism of polycyclic aromatic hydrocarbons and arylamines, respectively...
  52. ncbi request reprint 1,3-Propane sultone, an extremely potent experimental carcinogen: what should be expected in humans?
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:251-4. 2004
    ..The present case studies point to long latency times (up to 30-40 years or more) after limited periods of past exposure...
  53. ncbi request reprint Evaluation of time dependence and interindividual differences in benzo[a]pyrene-mediated CYP1A1 induction and genotoxicity in porcine urinary bladder cell cultures
    Sabine Plottner
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Dortmund, Germany
    J Toxicol Environ Health A 71:969-75. 2008
    ..Hence, individual differences in metabolic capacities and responsiveness to xenobiotics of urothelial cells from individual donors may be factors in susceptibility to genotoxic effects induced by PAHs...
  54. ncbi request reprint A pilot study on the application of statistical classification procedures to molecular epidemiological data
    Holger Schwender
    Department of Statistics, Collaborative Research Centre 475, University of Dortmund, Dortmund, Germany
    Toxicol Lett 151:291-9. 2004
    ..The findings, nevertheless, suggest that SNP data might be useful for the classification of individuals into categories of high or low risk of diseases...
  55. ncbi request reprint Genotoxicity of inorganic mercury salts based on disturbed microtubule function
    Daniela Bonacker
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, 44139, Germany
    Arch Toxicol 78:575-83. 2004
    ....
  56. ncbi request reprint Biological monitoring and Biological Limit Values (BLV): the strategy of the European Union
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 162:119-24. 2006
    ..Recent progress has been made with respect to formulation of a strategy related to health-based BLVs...
  57. ncbi request reprint Micronucleus induction in V79 cells by the anabolic doping steroids desoxymethyltestosterone (madol) and 19-norandrostenedione
    Susanne B Dorn
    IfADo Leibniz Research Centre for Working Environment and Human Factors, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 183:58-64. 2008
    ..Therefore it cannot be ruled out that MAD and NA present genotoxic hazards under current misuse conditions by athletes in sports or in body building...
  58. ncbi request reprint Estrogenic isoflavones in rodent diets
    Gisela H Degen
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 128:145-57. 2002
    ....
  59. doi request reprint Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P450 1A1
    Sabine Plottner
    Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 83:131-8. 2009
    ..In conclusion, we have identified two functionally distinct subpopulations of urinary bladder epithelial cells. It will be interesting to study whether the CYP1A inducible subtype is more susceptible to bladder carcinogens...
  60. ncbi request reprint Some molecular descriptors for non-specific chromosomal genotoxicity based on hydrophobic interactions
    Susanne B Dorn
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystrasse 67, Dortmund, Germany
    Arch Toxicol 82:333-8. 2008
    ..In essence, the relation of polar surface to the total molecular surface appears pivotal to determine the non-specific chromosomal genotoxicity of lipophilic compounds...
  61. ncbi request reprint Simultaneous determination of daidzein, equol, genistein and bisphenol A in human urine by a fast and simple method using SPE and GC-MS
    Stefan Moors
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Dortmund, Germany
    Mol Nutr Food Res 51:787-98. 2007
    ..In conclusion, a reliable method to determine BPA and isoflavones in urine was established and applied in a pilot study: Biomonitoring results show much higher dietary exposure to phytoestrogens than to BPA in German adults...
  62. ncbi request reprint Chromosomal genotoxicity of nitrobenzene and benzonitrile
    Daniela Bonacker
    Institut fur Arbeitsphysiologie, Universitat Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 78:49-57. 2004
    ..Aneugenic effects of both compounds occur at remarkably low concentrations, with lowest-effect-concentrations being 0.1 micro M. This points to the relevance of interactions with the cellular spindle apparatus...
  63. ncbi request reprint Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair
    Volker Harth
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, University of Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:887-97. 2008
    ..53) as well as CYP1B1 (Leu432Val) G/G genotype and GSTM1 null/null genotype (OR, 11.79; 95% CI, 2.18-63.77) with HNSCC. The findings underline the relevance of genotypes of polymorphic CYP1B1 combined with exposures to tobacco smoke...
  64. ncbi request reprint Comments on "Endocrine disrupting nonylphenols are ubiquitous in food"
    Gisela H Degen
    Environ Sci Technol 37:2622-3; author reply 2624. 2003
  65. ncbi request reprint Nephrotoxicity and nephrocarcinogenicity of dinitrotoluene: new aspects to be considered
    Thomas Bruning
    Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin der Ruhr Universität, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Rev Environ Health 17:163-72. 2002
    ..The differential pathways of metabolic activation of DNT appear to apply to the proximal tubule of the kidney and to the urothelium of the renal pelvis and lower urinary tract as target tissues of carcinogenicity...
  66. ncbi request reprint Statistical methods for detecting genetic interactions: a head and neck squamous-cell cancer study
    Katja Ickstadt
    Fakultat Statistik, Collaborative Research Centre 475, Technische Universitat Dortmund, Dortmund
    J Toxicol Environ Health A 71:803-15. 2008
    ....
  67. ncbi request reprint Cancer of the urinary bladder in highly exposed workers in the production of dinitrotoluenes: a case report
    Volker Harth
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Int Arch Occup Environ Health 78:677-80. 2005
    ..The observation of the cluster of urothelial cancer in persons highly exposed to nitrotoluenes underlines the putative human carcinogenicity of dinitrotoluenes with the human urothelium as a relevant target tissue...
  68. ncbi request reprint VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference?
    Hiltrud Brauch
    Dr Margarete Fischer Bosch Institut für Klinische Pharmakologie, Auerbachstr 112, D 70396 Stuttgart, Germany
    Toxicol Lett 151:301-10. 2004
    ..These data support the notion of a putative genotoxic effect of TCE leading to VHL gene damage and subsequent occurrence of RCC in highly exposed subjects...
  69. ncbi request reprint Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer
    Thomas Neuhaus
    Medizinische Universitäts Poliklinik Bonn, Universitat Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Toxicol Lett 151:273-82. 2004
    ..Further studies have to focus on the -71G>T polymorphism and its possible linkage to cancers, in which smoking is a known risk-factor, as well as its functional relevance concerning the bioactivation of tobacco-related substances...
  70. ncbi request reprint Association between head and neck cancer and microsomal epoxide hydrolase genotypes
    Matthias Wenghoefer
    Department of Oncology Medizinische Universitäts Poliklinik, University of Bonn, Wilhelmstrasse 35 37, 53111 Bonn, Germany
    Arch Toxicol 77:37-41. 2003
    ..54, 95% CI 0.13-2.17). This supports uncertainties in categorizing genotypes with respect to limited enzyme activity data, especially when taken from in vitro experiments...
  71. ncbi request reprint Toxicological comments to the discussion about REACH
    Helmut Greim
    Institute of Toxicology and Environmental Hygiene, Technical University of Munich, Hohenbachernstrasse 15 17, 85350 Freising Weihenstephan, Germany
    Arch Toxicol 80:121-4. 2006
    ....
  72. ncbi request reprint Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes
    Ricarda Thier
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, St Lucia, Australia
    Int J Hyg Environ Health 206:149-71. 2003
    ..Studies of individual susceptibility to toxicants and gene-environment interaction are now emerging as an important component of molecular epidemiology...
  73. ncbi request reprint Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile
    Ricarda Thier
    Department Physiology and Pharmacology, University of Queensland, St Lucia, QLD 4072, Australia
    Toxicol Lett 128:249-55. 2002
    ..Higher adduct levels would be compatible with a slower CYP2E1-mediated metabolism of acrylonitrile and with lower extents of toxification to cyanide...
  74. ncbi request reprint Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
    Ricarda Thier
    Department Physiology and Pharmacology, University of Queensland, St Lucia, QLD 4072, Australia
    Arch Toxicol 76:249-56. 2002
    ....
  75. ncbi request reprint Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, P O Box 1140, D 49440 Lemförde, Germany
    Toxicology 206:461-70. 2005
    ..With respect to STELIAs and extrapolated concentrations at 65 degrees C (14.7, 1.47 and 1.68 mg/m(3), for xylene, formaldehyde and acetaldehyde, respectively), however, a reduction of the concentration of formaldehyde may be necessary...
  76. ncbi request reprint New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Arch Toxicol 79:367-76. 2005
    ..All secondary metabolites are unsusceptible to contamination. Furthermore, there are strong hints that the secondary oxidised DEHP metabolites-not DEHP or MEHP-are the ultimate developmental toxicants...
  77. ncbi request reprint Occupational exposure of hairdressers to [14C]-para-phenylenediamine-containing oxidative hair dyes: a mass balance study
    Frédérique Hueber-Becker
    L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 45:160-9. 2007
    ....
  78. ncbi request reprint New aspects in the classification of carcinogens
    Heidi Foth
    Institut für Umwelttoxikologie der Universität Halle Wittenberg, Halle, Germany
    Arh Hig Rada Toksikol 56:167-75. 2005
    ..Taking into account the presence of endogenous carcinogens, it is now becoming evident that carcinogenic risk extrapolation to low doses must be considered according to the mode of action...
  79. ncbi request reprint Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, Lemförde, Germany
    Toxicol Lett 160:93-104. 2006
    ..A systematic toxicological evaluation of the risk associated with benzene exposure in cars seems to be necessary...
  80. ncbi request reprint Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide
    Melanie I Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, Erlangen 91054, Germany
    Arch Toxicol 80:55-61. 2006
    ..Consequently a genotoxic potency of AA mediated by GA could be supposed to be comparable in rats and humans...
  81. ncbi request reprint Editorial: Evaluation of chemosensory effects due to occupational exposures
    Christoph van Thriel
    Int Arch Occup Environ Health 79:265-7. 2006
  82. ncbi request reprint Dephenylation of the rubber chemical N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine: a classical problem revisited
    Tobias Weiss
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Research Institute for Occupational Medicine of the Institutions for Statutory Accident Insurance and Prevention, Institute of the Ruhr University, Bochum, Bochum, Germany
    Crit Rev Toxicol 37:553-66. 2007
    ..The assumption, which may well be an overestimation, is compatible with findings in animal experiments, and explains the lack of direct evidence of carcinogenicity of PBNA in both experimental and epidemiological studies...
  83. ncbi request reprint Acrylamide exposure via the diet: influence of fasting on urinary mercapturic acid metabolite excretion in humans
    Melanie I Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 80:817-9. 2006
    ..This confirms that the diet is the main source of environmental AA exposure in humans, apart from smoking. Other possible AA sources could be of minor quantitative importance only...
  84. ncbi request reprint Breast cancer: a candidate gene approach across the estrogen metabolic pathway
    Christina Justenhoven
    Molecular Mechanisms of Origin and Treatment of Breast Cancer, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, Stuttgart, Germany
    Breast Cancer Res Treat 108:137-49. 2008
    ..The tested polymorphisms of the estrogen metabolic pathway may not play a direct role in breast cancer risk. Therefore, future association studies should be extended to other polymorphisms and other regulatory pathways...