Michael Bohm

Summary

Country: Germany

Publications

  1. ncbi request reprint Renal denervation: a novel non-pharmacological approach in heart failure
    Michael Bohm
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str 1, DE 66424, Homburg Saar, Germany
    J Cardiovasc Transl Res 7:330-7. 2014
  2. ncbi request reprint Rationale and design of a large registry on renal denervation: the Global SYMPLICITY registry
    Michael Bohm
    Universitatskliniken des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    EuroIntervention 9:484-92. 2013
  3. doi request reprint Renal sympathetic denervation: applications in hypertension and beyond
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße 1, DE 66421 Homburg Saar, Germany
    Nat Rev Cardiol 10:465-76. 2013
  4. pmc Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar 66421, Germany
    J Transl Med 10:187. 2012
  5. doi request reprint Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    Am Heart J 166:306-314.e7. 2013
  6. doi request reprint Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    EuroIntervention 9:R122-6. 2013
  7. ncbi request reprint Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke
    Michael Bohm
    Universitatskliniken des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str 1, D 66424 Homburg Saar, Germany
    Eur Heart J 33:2804-12. 2012
  8. doi request reprint Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66424, Homburg Saar, Germany
    Clin Res Cardiol 102:11-22. 2013
  9. doi request reprint From evidence to rationale: cardiovascular protection by angiotensin II receptor blockers compared with angiotensin-converting enzyme inhibitors
    Michael Bohm
    Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg Saar, Germany
    Cardiology 117:163-73. 2010
  10. ncbi request reprint Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Atherosclerosis 212:55-62. 2010

Collaborators

Detail Information

Publications159 found, 100 shown here

  1. ncbi request reprint Renal denervation: a novel non-pharmacological approach in heart failure
    Michael Bohm
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str 1, DE 66424, Homburg Saar, Germany
    J Cardiovasc Transl Res 7:330-7. 2014
    ..Altogether, renal denervation is a promising novel technique that may improve the outcome of patients with sympathetic hyperactivity and cardiovascular diseases. ..
  2. ncbi request reprint Rationale and design of a large registry on renal denervation: the Global SYMPLICITY registry
    Michael Bohm
    Universitatskliniken des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    EuroIntervention 9:484-92. 2013
    ..Smaller ancillary studies in hypertensive patients suggest a benefit from renal denervation in a variety of conditions such as chronic kidney disease, glucose intolerance, sleep apnoea and heart failure...
  3. doi request reprint Renal sympathetic denervation: applications in hypertension and beyond
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße 1, DE 66421 Homburg Saar, Germany
    Nat Rev Cardiol 10:465-76. 2013
    ....
  4. pmc Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar 66421, Germany
    J Transl Med 10:187. 2012
    ..The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized...
  5. doi request reprint Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    Am Heart J 166:306-314.e7. 2013
    ..The impact of nonpersistence on events and of events on persistence is unclear. We studied the effects of nonpersistence on outcomes and events on nonadherence in a randomized placebo controlled trial in 40 countries on 25,620 patients...
  6. doi request reprint Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    EuroIntervention 9:R122-6. 2013
    ....
  7. ncbi request reprint Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke
    Michael Bohm
    Universitatskliniken des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str 1, D 66424 Homburg Saar, Germany
    Eur Heart J 33:2804-12. 2012
    ..A high heart rate is associated with cardiovascular outcomes. We investigated the effects of the resting heart rate on cardiovascular and neurological outcomes after recurrent stroke in the high-risk population of the PRoFESS study...
  8. doi request reprint Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66424, Homburg Saar, Germany
    Clin Res Cardiol 102:11-22. 2013
    ..A cut-off value of ≥75 bpm was chosen by the EMEA for approval for the use of ivabradine in chronic heart failure...
  9. doi request reprint From evidence to rationale: cardiovascular protection by angiotensin II receptor blockers compared with angiotensin-converting enzyme inhibitors
    Michael Bohm
    Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg Saar, Germany
    Cardiology 117:163-73. 2010
    ....
  10. ncbi request reprint Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Atherosclerosis 212:55-62. 2010
    ..To determine the effect of heart rate reduction with ivabradine on atherosclerotic lesions and erectile dysfunction...
  11. ncbi request reprint Effects of renal sympathetic denervation on exercise blood pressure, heart rate, and capacity in patients with resistant hypertension
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 63:839-45. 2014
    ..No changes were observed in the control group. In conclusion, renal denervation reduced blood pressure and heart rate during exercise, improved mean workload, and increased exercise time without impairing chronotropic competence. ..
  12. ncbi request reprint Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    Christoph Maack
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 108:1567-74. 2003
    ..Isoprenylation of rac1 can be inhibited by statin therapy. Thus, we examined ROS and rac1 in human failing myocardium and tested their regulation by statins in vivo...
  13. ncbi request reprint Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 93:e98-103. 2003
    ..Statin treatment improves endothelium-dependent coronary vasomotion within 24 hours in the absence of significant cholesterol reduction. The full text of this article is available online at http://www.circresaha.org...
  14. ncbi request reprint Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 105:2083-91. 2002
    ..It has not been completely clarified whether selective estrogen receptor modulators (SERMs) such as raloxifene exert vasoprotective effects similar to those of estrogens...
  15. ncbi request reprint Cellular antioxidant effects of atorvastatin in vitro and in vivo
    Sven Wassmann
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:300-5. 2002
    ..These effects of atorvastatin may contribute to the vasoprotective effects of statins...
  16. doi request reprint Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Pharmacol Exp Ther 327:692-8. 2008
    ..This result emphasizes the beneficial effect of inhibition of the renin-angiotensin system even in terms of erectile function...
  17. ncbi request reprint Role of Rac1 GTPase activation in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 50:359-67. 2007
    ..We aimed to study the role of Rac1 GTPase in atrial fibrillation (AF)...
  18. pmc Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße D 66421, Homburg Saar, Germany
    Eur Heart J 34:2839-49. 2013
    ..The aim of this study was to characterize myocardial function and ventricular-arterial coupling in a mouse model of diabetes and to analyse the effect of selective heart rate (HR) reduction by If-inhibition in this HFPEF-model...
  19. doi request reprint Ramipril and telmisartan exhibit differential effects in cardiac pressure overload-induced hypertrophy without an additional benefit of the combination of both drugs
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Cardiovasc Pharmacol Ther 18:87-93. 2013
    ..We aimed to characterize different cellular effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin 1 (AT1) receptor blockers (ARBs) as mono- or combination therapy in cardiac pressure overload. Methods and..
  20. doi request reprint Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  21. doi request reprint ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 83:106-14. 2009
    ..We hypothesized that ACE inhibitors may exert beneficial effects during pressure-induced myocardial hypertrophy by regulating progenitor cell function...
  22. doi request reprint Paclitaxel and sirolimus differentially affect growth and motility of endothelial progenitor cells and coronary artery smooth muscle cells
    Yvonne P Clever
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 7:K32-42. 2011
    ..This study investigates the time-dependent influence on growth and motility of paclitaxel and sirolimus alone and combined with the coating additive iopromide on EPC and hCASMC...
  23. doi request reprint Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 61:225-31. 2013
    ..Modulation of the autonomic nervous system by RDN might provide rate control and reduce susceptibility to AF. Whether RDN may provide rate control in a larger number of patients with AF deserves further clinical studies...
  24. doi request reprint Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Atherosclerosis 216:23-34. 2011
    ..PPAR-γ agonists may mediate vascular effects in addition to insulin sensitizing. We therefore examined whether pioglitazone regulates vascular telomere biology...
  25. doi request reprint Expanding the indication spectrum: renal denervation in diabetes
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R117-21. 2013
    ..This review highlights the background of approaching the renal sympathetic nerves as a potential new therapeutic option to improve glycaemic control in patients with resistant hypertension...
  26. doi request reprint Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Hypertension 62:767-74. 2013
    ..However, the generation of atrial oxidative stress was not modulated. ..
  27. ncbi request reprint Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  28. ncbi request reprint Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1567-72. 2002
    ..Despite the anticipated stem cell plasticity, the role of bone marrow-derived endothelial progenitor cells has not been clarified in vascular lesion development...
  29. ncbi request reprint Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH
    Janine Pöss
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur J Prev Cardiol 19:1066-73. 2012
    ..Physical activity improves endothelial function. This analysis aims to explore the impact of regular physical exercise on the prevalence and the degree of MAU in hypertensive individuals at high cardiovascular risk...
  30. doi request reprint Two year follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Clin Res Cardiol 97:773-81. 2008
    ..We are presenting an extension of a previously published trial on the efficacy and safety of a paclitaxel-coated balloon in coronary ISR in a larger patient population and after a complete follow-up of 2 years...
  31. pmc Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, 66421 Homburg Saar, Germany
    Cardiovasc Res 90:484-92. 2011
    ..However, their effects on blood monocytes, endothelial function, atherogenesis, and sterol tissue concentrations are poorly understood...
  32. ncbi request reprint Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Chem Phys Lipids 164:451-6. 2011
    ..The aim of the present study was to evaluate markers of cholesterol metabolism and determine their relationship with CVD in patients without diabetes mellitus who were not receiving statin treatment...
  33. doi request reprint Long-term follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Klinik fur Innere Medizin, III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    JACC Cardiovasc Interv 5:323-30. 2012
    ..This study presents long-term clinical follow-up, including binary restenosis rate and major adverse cardiovascular events, of the PACCOCATH-ISR (Treatment of In-Stent Restenosis by Paclitaxel Coated PTCA Balloons) I and II trial...
  34. ncbi request reprint Response and non-response to renal denervation: who is the ideal candidate?
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R54-7. 2013
    ..In order to ensure treatment success further criteria have to be fulfilled, such as exclusion of secondary hypertension and optimised medical therapy...
  35. ncbi request reprint Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins
    Bodo Cremers
    Medizinische Klinik und Poliklinik, Innere Medizin III, Chirurgische Klinik und Poliklinik, Abteilung Thorax und Herz, Homburg, Germany
    J Cardiovasc Pharmacol 41:734-43. 2003
    ..4 +/- 10.1%, n = 4, P < 0.02) as well as in veins (73.5 +/- 6.3%, n = 6, P < 0.02). Sildenafil exerts potent vasodilatory actions but has no direct influence on human myocardial contractility or proarrhythmic effects in vitro...
  36. doi request reprint Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Kirrbergerstraße, Homburg Saar, Germany
    Eur J Heart Fail 14:404-13. 2012
    ..Cognitive function and psychological co-morbidities are associated with hospitalization, disability, and mortality...
  37. ncbi request reprint Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
    ..The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase...
  38. ncbi request reprint Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Circulation 117:2377-87. 2008
    ..We hypothesized that selective heart rate reduction may influence endothelial function and atherogenesis and tested the effects of the I(f) current inhibitor ivabradine in apolipoprotein E-deficient mice...
  39. doi request reprint The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
    Basic Res Cardiol 105:725-35. 2010
    ..Aliskiren increased number and function of PAC in mice and prevented atherosclerotic lesion formation. The effects were observed independent of blood pressure lowering...
  40. ncbi request reprint Drug-eluting balloon: very short-term exposure and overlapping
    Bodo Cremers
    University of Saarland, Homburg Saar, Department of Internal Medicine III, Germany
    Thromb Haemost 101:201-6. 2009
    ..DEB were found to effectively reduce neointimal proliferation regardless of inflation time and dose within the tested range. No adverse reactions were seen as dose was increased to more than three times the clinically tested dose...
  41. doi request reprint Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Mol Cell Cardiol 50:678-85. 2011
    ..In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. Inhibition of this signaling pathway may therefore represent a target for the prevention of fibrotic atrial remodeling...
  42. doi request reprint Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Coron Artery Dis 20:376-82. 2009
    ..Therefore, the aim of this study was to investigate differences in cholesterol metabolism in relation to vascular diseases in this subset of patients...
  43. doi request reprint Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:172-8. 2012
    ..Renal denervation displays antiarrhythmic effects by reducing NTP-induced AERP shortening and inhibits postapneic BP rises associated with obstructive events...
  44. doi request reprint Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 60:419-24. 2012
    ....
  45. doi request reprint RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection
    Christian Werner
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:418-31. 2008
    ....
  46. doi request reprint Heart rate reduction in cardiovascular disease and therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Germany
    Clin Res Cardiol 100:11-9. 2011
    ..Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy...
  47. doi request reprint Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 123:1940-6. 2011
    ..We investigated the effect of catheter-based renal sympathetic denervation on glucose metabolism and blood pressure control in patients with resistant hypertension...
  48. ncbi request reprint Modulation of antioxidant enzyme expression and function by estrogen
    Kerstin Strehlow
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circ Res 93:170-7. 2003
    ..Estrogen acts antioxidative at least to some extent via stimulation of MnSOD and ecSOD expression and activity, which may contribute to its vasoprotective effects...
  49. ncbi request reprint AT1 receptor antagonism improves endothelial dysfunction in postmenopausal women
    Kerstin Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Maturitas 53:176-83. 2006
    ..AT1 receptor antagonism improves vascular function in postmenopausal women without HRT. Thus, AT1 receptor blockade may resemble an efficient approach for the prevention of vascular dysfunction in estrogen-deficient women...
  50. doi request reprint Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Pharmacol Exp Ther 325:818-23. 2008
    ..These effects may be related to a reduction of ROS production, which is independent of heart rate reduction, because metoprolol did not increase endothelial function...
  51. doi request reprint Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 120:2438-47. 2009
    ..This study examines the effects of exercising on vascular telomere biology and endothelial apoptosis in mice and the effects of long-term endurance training on telomere biology in humans...
  52. doi request reprint Aldosterone promotes atrial fibrillation
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, D 66421 Homburg Saar, Germany
    Eur Heart J 33:2098-108. 2012
    ..However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology...
  53. ncbi request reprint Short- and long-term effects of a novel paclitaxel coated stent in the porcine coronary model
    Bruno Scheller
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:118-23. 2008
    ..The aim of the present animal studies was to evaluate the novel paclitaxel coated Coroflex. Please stent in the porcine coronary model...
  54. doi request reprint Cardiorespiratory response to exercise after renal sympathetic denervation in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 58:1176-82. 2011
    ..This study sought to investigate the effects of interventional renal sympathetic denervation (RD) on cardiorespiratory response to exercise...
  55. ncbi request reprint Improvements in left ventricular hypertrophy and diastolic function following renal denervation: effects beyond blood pressure and heart rate reduction
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 63:1916-23. 2014
    ..This study sought to investigate the interaction between blood pressure (BP) and heart rate (HR) reduction and changes in left ventricular (LV) structure and function following renal sympathetic denervation (RDN)...
  56. ncbi request reprint Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    Heart Rhythm 10:1525-30. 2013
    ..Increased sympathetic activation during acute ventricular ischemia is involved in the occurrence of life-threatening arrhythmias...
  57. doi request reprint Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Int J Cardiol 167:2846-51. 2013
    ..Renal sympathetic denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. The present study aimed to investigate the effects of RDN on HR and other electrocardiographic parameters...
  58. ncbi request reprint Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
    Michael Bohm
    Klinik für Innere Medizin III Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg Saar, Germany
    J Hypertens 26:18-25. 2008
    ..In patients in sinus rhythm (n = 18 900) the relationship between increased heart rate and the prevalence of MAU was analysed...
  59. ncbi request reprint Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, D 66421 Homburg Saar, Germany
    Atherosclerosis 210:362-5. 2010
    ..Therefore, prospective clinical trials are needed to evaluate whether subjects with altered cholesterol homeostasis may benefit from treatment strategies that reduce cholesterol absorption in addition to statin treatment...
  60. doi request reprint Heart failure with normal left ventricular ejection fraction: what is the evidence?
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Trends Cardiovasc Med 18:280-92. 2008
    ..In contrast to heart failure with reduced ejection fraction, large-scale randomized controlled drug trials for HFNEF are scarce and could not demonstrate mortality reduction so far...
  61. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance
    Christian Werner
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Diabetes 56:2609-15. 2007
    ..The effect represents a potential regenerative mechanism in atherosclerosis and is observed in normoglycemic individuals with stable coronary artery disease...
  62. doi request reprint Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease
    Christian Werner
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 377:331-6. 2008
    ..Functionally, ILK is necessary and sufficient for SDF-1-triggered migration and adhesion in EPCs. These data extend current knowledge about the role of ILK in EPC biology and implicate ILK as a therapeutic target in CAD...
  63. ncbi request reprint Microalbuminuria independently correlates to cardiovascular comorbidity burden in patients with hypertension
    Felix Mahfoud
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 101:761-6. 2012
    ..Microalbuminuria (MAU) is a marker for endothelial dysfunction and a predictor of cardiovascular events. Cardiovascular risk and mortality are mainly influenced by associated morbidities and risk factors...
  64. doi request reprint Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis
    Andrey Kazakov
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Cardiovasc Res 93:397-405. 2012
    ..We hypothesized that eNOS of the bone marrow (BM) affects cardiac remodelling during myocardial hypertrophy via the regulation of BM-derived vascular progenitor cells...
  65. doi request reprint Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 55:469-80. 2010
    ..We studied the signal transduction of atrial structural remodeling that contributes to the pathogenesis of atrial fibrillation (AF)...
  66. doi request reprint Update on myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strasse 1, Homburg Saar, Germany
    J Am Coll Cardiol 59:779-92. 2012
    ..Further investigations by controlled, randomized studies are needed to definitively determine their role in the treatment of myocarditis...
  67. doi request reprint Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients
    Michael Bohm
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitat des Saarlandes, Kirrberger Strasse, 66424 Homburg Saar, Germany
    Eur Heart J 30:1364-71. 2009
    ..To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF...
  68. doi request reprint Beneficial association of β-blocker therapy on recovery from severe acute heart failure treatment: data from the Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support trial
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Crit Care Med 39:940-4. 2011
    ..The aim is to determine whether β-blocker use at study entry and/or at discharge has an impact on 31- and 180-day survival...
  69. ncbi request reprint Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial
    Michael Bohm
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Lancet 376:886-94. 2010
    ..We aimed to test our hypothesis by investigating the association between heart rate and events in this patient population...
  70. doi request reprint Hot topics in cardiology: data from IABP-SHOCK II, TRILOGY-ACS, WOEST, ALTIDUDE, FAME II and more
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:861-74. 2012
    ..in Clin Res Cardiol 100:955-971, 2011; Schirmer et al. in Clin Res Cardiol 98:691-699, 2009)...
  71. ncbi request reprint Rapid immunomodulation by rosuvastatin in patients with acute coronary syndrome
    Andreas Link
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421Homburg Saar, Germany
    Eur Heart J 27:2945-55. 2006
    ..It is unclear how rapidly the beneficial effects of statins occur in patients with ACS and whether these drug properties are related to lipid lowering...
  72. ncbi request reprint Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts
    Patrick Muller
    Departments of Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 106:31-5. 2002
    ....
  73. doi request reprint Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy
    Stephanie I Bettink
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 397:208-13. 2010
    ..We conclude that in both SDF-1- and angiotensin II-triggered signaling, ILK is a central mediator of rac1-induced oxidative stress and myocardial hypertrophy...
  74. doi request reprint Prognostic electrocardiographic parameters in patients with suspected myocarditis
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstraße, 66421 Homburg Saar, Germany
    Eur J Heart Fail 13:398-405. 2011
    ..The objective of this study was to investigate the prognostic value of electrocardiographic (ECG) parameters for outcome in patients acutely admitted with myocarditis without previous heart failure who underwent endomyocardial biopsy...
  75. doi request reprint Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Eur Heart J 33:1223-31. 2012
    ..Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth...
  76. doi request reprint Virus serology in patients with suspected myocarditis: utility or futility?
    Felix Mahfoud
    Klinik fur Innere Medizin III, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Homburg Saar, Germany
    Eur Heart J 32:897-903. 2011
    ..We determined prospectively the diagnostic value of virus serology in comparison with endomyocardial biopsy (EMB) including viral genome detection and immunohistochemistry in patients with clinically suspected myocarditis...
  77. ncbi request reprint Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy
    Roland Fries
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 112:2980-5. 2005
    ..Vasodilatory therapy of Raynaud's phenomenon represents a difficult clinical problem because treatment often remains inefficient and may be not tolerated because of side effects...
  78. ncbi request reprint Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telm
    Michael Bohm
    Klinik für Innere Medizin III des Universitätsklinikum des Saarlandes, Saarland, Homburg, Germany
    Am Heart J 154:94-101. 2007
    ..The effects of treatment with telmisartan and ramipril, alone or in combination, including a telmisartan versus placebo arm will be determined prospectively during a follow-up of 4 years...
  79. ncbi request reprint Images in cardiovascular medicine. Cardiac imaging in isolated noncompaction of ventricular myocardium
    Magnus Baumhakel
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 106:e16-7. 2002
  80. ncbi request reprint Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
    ..Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are well known, the underlying mechanisms are poorly understood...
  81. ncbi request reprint Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice
    Florian Custodis
    Kliniken für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Vasc Res 49:432-40. 2012
    ..Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE(-)/(-)) mice...
  82. ncbi request reprint Drug coated balloons in acute coronary syndromes--opportunities and limitations
    Bruno Scheller
    Clinical and Experimental Interventional Cardiology, Internal Medicine III, University Hospital of Saarland, Homburg Saar, Germany
    Curr Vasc Pharmacol 10:472-5. 2012
    ..Patients in hemodynamic critical situations under catecholamine therapy may present with too small vessel diameters. Another clinically relevant scenario represents in-stent restenosis (ISR) which is frequently associated with ACS...
  83. ncbi request reprint Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy
    Florian Custodis
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 71:342-51. 2006
    ..NADPH oxidase is a major source of ROS production. The small GTPase Rac1 mediates the activation of NADPH oxidase; however, the mechanism of Rac1 activation is incompletely understood...
  84. ncbi request reprint Carvedilol but not metoprolol reduces beta-adrenergic responsiveness after complete elimination from plasma in vivo
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 109:3182-90. 2004
    ..Here, we determined the significance of this phenomenon on human beta-ARs in vitro and in vivo...
  85. ncbi request reprint Inhibition of neointimal hyperplasia with a novel zotarolimus coated balloon catheter
    Bodo Cremers
    Department of Internal Medicine III, University of Saarland, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:469-76. 2012
    ..The aim of the present study was to evaluate the safety and efficacy of a prototype zotarolimus coated balloon (ZCB) catheter in comparison to a zotarolimus eluting stent (ZES) in the porcine coronary overstretch model...
  86. doi request reprint The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein E-deficient mice
    Illkyu O Lee
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Pharmacol Exp Ther 343:253-7. 2012
    ..Interference with the coagulation system might provide a therapeutic target to modify atherosclerotic disease progression...
  87. doi request reprint Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, 66424 Homburg Saar, Germany
    Stroke 42:1742-9. 2011
    ..Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia...
  88. doi request reprint Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS
    Christian Ukena
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Card Fail 18:439-45. 2012
    ..The present analysis investigated the prognostic value of postadmission blood glucose (BG) concentration on clinical outcomes in high-risk patients with heart failure after acute myocardial infarction...
  89. doi request reprint Procollagen propeptides: serum markers for atrial fibrosis?
    Hans Ruprecht Neuberger
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:655-61. 2012
    ..During collagen synthesis and degradation, collagen propeptides and telopeptides are released into the blood. This study tested the hypothesis that serum markers of collagen turnover correlate with atrial fibrosis...
  90. doi request reprint Effect of hypoxia on integrin-mediated adhesion of endothelial progenitor cells
    Ralf Kaiser
    Klinik für Innere Medizin V Pneumologie, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Cell Mol Med 16:2387-93. 2012
    ..We found novel evidence for a connection between hypoxia, AMPK-activity and integrin activity. This might affect the fate of EPCs in ischaemic tissue...
  91. ncbi request reprint Myocardial regeneration by endogenous adult progenitor cells
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie and Internistische Intensivmedizin, Universitat des Saarlandes, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    J Mol Cell Cardiol 39:377-87. 2005
    ..This review critically discusses the recent findings in the field of endogenous adult progenitor cells and proposes new areas for future research...
  92. doi request reprint CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography
    Kyrill S Rogacev
    Department of Internal Medicine IV, Saarland University Medical Center, Homburg Saar, Germany
    J Am Coll Cardiol 60:1512-20. 2012
    ..The aim of this study was to analyze the yet ill-defined relationship of distinct human monocyte subsets with cardiovascular outcomes in a broad patient population at cardiovascular risk...
  93. doi request reprint BEAUTIFUL results--the slower, the better?
    Jan Christian Reil
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, 66421 Homburg Saar, Germany
    Lancet 372:779-80. 2008
  94. doi request reprint Blood pressure and heart rate predict outcome in patients acutely admitted with suspected myocarditis without previous heart failure
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Hypertens 30:1217-24. 2012
    ..The study investigated the prognostic impact of blood pressure and heart rate in patients acutely admitted with suspected myocarditis without previous heart failure who underwent endomyocardial biopsy...
  95. ncbi request reprint Telmisartan prevents cardiovascular events in a broad group of at-risk patients
    Magnus Baumhakel
    University Hospital of the Saarland, Department of Cardiology, Homburg Saar, Germany
    Expert Opin Pharmacother 10:3113-7. 2009
    ..In these patients who are intolerant to ACE-Is or who do not achieve blood pressure control, the ARB with the best evidence for secondary prevention is telmisartan according to the results of the ONTARGET trial...
  96. doi request reprint Ischaemia-induced up-regulation of Toll-like receptor 2 in circulating monocytes in cardiogenic shock
    Simina Selejan
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Eur Heart J 33:1085-94. 2012
    ..To investigate the role of Toll-like receptor 2 (TLR2) in uncomplicated acute myocardial infarction (AMI) and in cardiogenic shock (CS)...
  97. doi request reprint [Erectile dysfunction: indicator of end-organ damage in cardiovascular patients]
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg Saar
    Med Klin (Munich) 104:309-13. 2009
    ..Furthermore, different trials suggest erectile function as a strong predictor of cardiovascular events like myocardial infarction or stroke...
  98. ncbi request reprint Long-term follow-up of early versus delayed invasive approach after fibrinolysis in acute myocardial infarction
    Yvonne P Clever
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circ Cardiovasc Interv 4:342-8. 2011
    ..The Southwest German Interventional Study in Acute Myocardial Infarction (SIAM III) evaluated the effects of transfer for early PCI in acute ST-elevation-myocardial infarction compared with a delayed PCI strategy...
  99. doi request reprint Antihypertensive and laxative effects by pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:1560-7. 2012
    ..Intestinal NHE3 blockade could be a new treatment strategy for elderly patients suffering from high blood pressure and constipation...
  100. doi request reprint Role of miR-21 in the pathogenesis of atrial fibrosis
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Basic Res Cardiol 107:278. 2012
    ..Activation of Rac1 by angiotensin II leads to a CTGF- and lysyl oxidase-mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium...
  101. doi request reprint Vascular pathophysiology in response to increased heart rate
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 56:1973-83. 2010
    ....