Markus Bohm

Summary

Country: Germany

Publications

  1. ncbi [Alpha-melanocyte-stimulating hormone. Its current significance for dermatology]
    M Bohm
    Klinik und Poliklinik für Hautkrankheiten, Allgemeine Dermatologie und Venerologie, Universitatsklinikum Munster, Munster
    Hautarzt 55:436-45. 2004
  2. doi Modulation of basophil activity: a novel function of the neuropeptide α-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    J Allergy Clin Immunol 129:1085-93. 2012
  3. pmc Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research
    Markus Bohm
    Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Endocr Rev 33:623-51. 2012
  4. ncbi Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ
    M Bohm
    Dept of Dermatology, University of Munster, Germany
    Exp Dermatol 8:453-61. 1999
  5. ncbi [Highlights in dermato-endocrinology]
    M Bohm
    Klinik und Poliklinik für Dermatologie und Venerologie und Ludwig Boltzmann Institut für Zellbiologie und Immunobiologie der Haut, Munster
    Hautarzt 55:786-7. 2004
  6. ncbi Melanocortins in fibroblast biology--current update and future perspective for dermatology
    Markus Bohm
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 13:16-21. 2004
  7. ncbi Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Germany
    J Invest Dermatol 126:1966-75. 2006
  8. ncbi alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    J Biol Chem 280:5795-802. 2005
  9. ncbi Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells
    Markus Bohm
    Department of Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    Endocrinology 146:4635-46. 2005
  10. doi [Alpha-melanocyte-stimulating hormone. From bench to bedside]
    M Bohm
    Klinik und Poliklinik für Hautkrankheiten Allgemeine Dermatologie und Venerologie, Universitatsklinikum Munster, Von Esmarch Str 58, 48149, Munster, Germany
    Hautarzt 61:497-504. 2010

Detail Information

Publications49

  1. ncbi [Alpha-melanocyte-stimulating hormone. Its current significance for dermatology]
    M Bohm
    Klinik und Poliklinik für Hautkrankheiten, Allgemeine Dermatologie und Venerologie, Universitatsklinikum Munster, Munster
    Hautarzt 55:436-45. 2004
    ..These actions may be exploited in future by using super potent and truncated MSH peptides for the treatment of various skin disorders including inflammatory dermatoses...
  2. doi Modulation of basophil activity: a novel function of the neuropeptide α-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    J Allergy Clin Immunol 129:1085-93. 2012
    ..Little is known about the effect of neuropeptides on basophils, which are important effector cells in immune and allergic responses...
  3. pmc Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research
    Markus Bohm
    Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Endocr Rev 33:623-51. 2012
    ..The effects of these melanocortin peptides may be exploited in future for the treatment of patients with inflammatory and degenerative joint diseases...
  4. ncbi Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ
    M Bohm
    Dept of Dermatology, University of Munster, Germany
    Exp Dermatol 8:453-61. 1999
    ..Interfollicular epidermis was largely unreactive in adult skin as opposed to undifferentiated keratinocytes of fetal skin. Our findings form a framework within which MC-1 receptor expression can be studied in various skin diseases...
  5. ncbi [Highlights in dermato-endocrinology]
    M Bohm
    Klinik und Poliklinik für Dermatologie und Venerologie und Ludwig Boltzmann Institut für Zellbiologie und Immunobiologie der Haut, Munster
    Hautarzt 55:786-7. 2004
  6. ncbi Melanocortins in fibroblast biology--current update and future perspective for dermatology
    Markus Bohm
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 13:16-21. 2004
    ....
  7. ncbi Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Germany
    J Invest Dermatol 126:1966-75. 2006
    ..These findings should improve our understanding of skin physiology and pathophysiology and may offer novel strategies with MCs as future therapeutics for skin diseases...
  8. ncbi alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    J Biol Chem 280:5795-802. 2005
    ....
  9. ncbi Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells
    Markus Bohm
    Department of Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    Endocrinology 146:4635-46. 2005
    ....
  10. doi [Alpha-melanocyte-stimulating hormone. From bench to bedside]
    M Bohm
    Klinik und Poliklinik für Hautkrankheiten Allgemeine Dermatologie und Venerologie, Universitatsklinikum Munster, Von Esmarch Str 58, 48149, Munster, Germany
    Hautarzt 61:497-504. 2010
    ..In addition to alpha-MSH analogues, truncated tripeptides such as KDPT which do not bind to MC-1R but have sustained anti-inflammatory properties are currently emerging as another novel therapeutic strategy in dermatology...
  11. ncbi Non-pigmentary actions of alpha-melanocyte-stimulating hormone--lessons from the cutaneous melanocortin system
    M Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Str 58 D 48149 Münster, Germany
    Cell Mol Biol (Noisy-le-grand) 52:61-8. 2006
    ....
  12. ncbi Lichen planus responding to efalizumab
    Markus Bohm
    Department of Dermatology, University of Munster, Germany
    J Am Acad Dermatol 56:S92-3. 2007
    ..Both pruritus and the skin lesions responded promptly to this biologic. In accordance with the previously reported efficacy in oral erosive LP, efalizumab may be a promising novel future treatment option for patients with cutaneous LP...
  13. doi Disseminated giant molluscum contagiosum in a patient with idiopathic CD4+ lymphocytopenia. Successful eradication with systemic interferon
    Markus Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    Dermatology 217:196-8. 2008
    ..In this report we will further describe the nature of idiopathic CD4+ lymphocytopenia and emphasize its relevance to clinical dermatology...
  14. ncbi Successful treatment of anogenital lichen sclerosus with topical tacrolimus
    Markus Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 139:922-4. 2003
    ..Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice...
  15. ncbi The role of melanocortins in skin homeostasis
    M Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Germany
    Horm Res 54:287-93. 2000
    ..Expression of melanocortin receptors on various skin cell types further indicates novel pharmacological targets for the treatment of skin diseases...
  16. ncbi Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity
    M Bohm
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 117:132-40. 2001
    ....
  17. ncbi Cutaneous hyperpigmentation induced by doxycycline: histochemical and ultrastructural examination, laser microprobe mass analysis, and cathodoluminescence
    Markus Bohm
    Department of Dermatology, University of Munster, Germany
    Am J Dermatopathol 24:345-50. 2002
    ..Based on the presented unique case and the reviewed literature, only suprapharmacologic doses of doxycycline may be sufficient to cause such pigment changes...
  18. ncbi Bilateral upper limb lymphoedema associated with psoriatic arthritis: a case report and review of the literature
    M Bohm
    Departments of Dermatology and Nuclear Medicine, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    Br J Dermatol 143:1297-301. 2000
    ..Conservative management and therapy with cyclosporin (for worsening arthritis) resulted in partial resolution of the lymphoedema and improvement of flow parameters on the right side upon repeat lymphoscintigraphy...
  19. ncbi Alpha-melanocyte-stimulating hormone modulates activation of NF-kappa B and AP-1 and secretion of interleukin-8 in human dermal fibroblasts
    M Bohm
    Department of Dermatology, University of Munster, Germany
    Ann N Y Acad Sci 885:277-86. 1999
    ..These effects of alpha-MSH may have important regulatory functions in extracellular matrix composition, wound healing, or angiogenesis...
  20. ncbi Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    J Biol Chem 279:6959-66. 2004
    ..Melanocortins such as alpha-MSH may therefore represent a novel class of modulators with potential usefulness for the treatment of fibrotic disorders...
  21. ncbi Topical tacrolimus as a therapeutic adjunct in patients with cutaneous lupus erythematosus. A report of three cases
    Markus Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    Dermatology 207:381-5. 2003
    ..Treatment with topical tacrolimus was tolerated well without major side effects in all patients. The presented cases are in line with recent reports that topical tacrolimus may be effective in facial LE...
  22. ncbi Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 118:533-9. 2002
    ..By modulating interleukin-8 secretion, alpha-melanocyte-stimulating hormone may act as a modulator of inflammatory responses in the pilosebaceous unit...
  23. ncbi A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus
    Stefan Beissert
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 142:1447-54. 2006
    ..To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine sodium or mycophenolate mofetil for the treatment of pemphigus...
  24. doi alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma?
    Agatha Kokot
    University of Munster, Munster, Germany
    Arthritis Rheum 60:592-603. 2009
    ..In search of novel therapies for scleroderma (systemic sclerosis [SSc]), we used the bleomycin (BLM) model to investigate the effects of alpha-MSH on collagen synthesis and fibrosis...
  25. doi KdPT, a tripeptide derivative of alpha-melanocyte-stimulating hormone, suppresses IL-1 beta-mediated cytokine expression and signaling in human sebocytes
    Arianna Mastrofrancesco
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 185:1903-11. 2010
    ..Our data demonstrate a promising anti-inflammatory potential of KdPT and point toward novel future directions in the treatment of acne-as well as of various other IL-1-mediated inflammatory diseases-with this small molecule...
  26. pmc Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin
    Agatha Kokot
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Endocrinology 150:3197-206. 2009
    ..Our data also highlight a novel facet in the cytoprotective and antioxidative effector mechanisms of alpha-MSH and perhaps of related melanocortin peptides...
  27. ncbi Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Nat Cell Biol 4:26-31. 2002
    ..Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines...
  28. ncbi Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo
    Meinhard Schiller
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Muenster, Germany
    J Invest Dermatol 122:468-76. 2004
    ..Proopiomelanocortin-derived neuropeptides, such as alpha-melanocyte-stimulating hormone may therefore play an important part in modulating ultraviolet-induced inflammation...
  29. pmc Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions
    Meinhard Schiller
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, 48149 Munster, Germany
    J Biol Chem 285:409-21. 2010
    ..Our findings identify the cAMP pathway as a potent but differential and promoter-specific regulator of TGF-beta-mediated effects involved in extracellular matrix homeostasis...
  30. ncbi Terminating the stress: peripheral peptidolysis of proopiomelanocortin-derived regulatory hormones by the dermal microvascular endothelial cell extracellular peptidases neprilysin and angiotensin-converting enzyme
    Thomas E Scholzen
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Endocrinology 148:2793-805. 2007
    ..Because NEP and ACE are regulated by inflammatory mediators and UV light, this may be important for ACTH/MSH-modulated skin inflammation...
  31. ncbi New insights into the functions of alpha-MSH and related peptides in the immune system
    Thomas A Luger
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    Ann N Y Acad Sci 994:133-40. 2003
    ..Therefore, therapeutic application of alpha-MSH or related peptides (KPVs) as well as alpha-MSH/KPV-pulsed DCs may be a useful approach for the treatment of inflammatory, autoimmune, and allergic diseases in the future...
  32. doi Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model
    Agatha Stegemann
    University of Munster, Munster, Germany
    Arthritis Rheum 65:792-804. 2013
    ....
  33. ncbi Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles
    Sonja Ständer
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:42-51. 2002
    ..In conclusion, preserved MC-1R expression in adnexal epithelia suggests a functional role of proopiomelanocortin (POMC) in various malformations and neoplasms of the skin...
  34. doi Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases
    Thomas Brzoska
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Endocr Rev 29:581-602. 2008
    ....
  35. doi Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts
    Bettina Ramser
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 129:2419-26. 2009
    ..Our findings indicate that HDFs are target cells of HCQ and form a rationale on the basis of which the in vivo effects of antimalarials can be studied in patients with aberrant fibroblast function...
  36. doi Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon
    Gabriele Stengel
    Department of Dermatology, University of Munster, Munster, Germany
    J Am Acad Dermatol 59:S7-9. 2008
    ..Long-term immunointervention with pegylated interferon alfa-2b, however, led to marked clinical improvement of the patient's condition and a radiologically proven stabilization of the disease...
  37. ncbi The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells
    Markus Seifert
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    J Invest Dermatol 128:203-13. 2008
    ..In conclusion, we demonstrate that MSH2 modulates in human melanocytes both UV-B-induced cell cycle regulation and apoptosis, most likely via independent, uncoupled mechanisms...
  38. ncbi Human mast cells in the neurohormonal network: expression of POMC, detection of precursor proteases, and evidence for IgE-dependent secretion of alpha-MSH
    Metin Artuc
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 126:1976-81. 2006
    ..Moreover, IgE-dependent release of alpha-MSH suggests an immunomodulatory role of this neurohormone during inflammatory and allergic reactions of the skin...
  39. ncbi Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma
    Zhuo Li
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 123:737-45. 2004
    ..SOCS-1 is a progression marker of human melanoma and may downregulate biological responses by endogenous and/or therapeutically administered cytokines...
  40. doi Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells
    Nina Weis
    Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 134:168-75. 2014
    ..Our findings encourage further studies on SKI-1 as a potential target for melanoma therapy. ..
  41. doi Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  42. doi Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore
    Thomas Brzoska
    Department of Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    Adv Exp Med Biol 681:107-16. 2010
    ....
  43. pmc The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function
    Dominik Bettenworth
    Department of Medicine B, University of Munster, Munster, Germany
    Am J Pathol 179:1230-42. 2011
    ..Furthermore, KdPT does not induce pigmentation, emphasizing the potential of this small molecule for the future treatment of IBD...
  44. ncbi Dermatomyositis associated with malignant melanoma--a marker of poor prognosis?
    Meinhard Schiller
    Department of Dermatology, University of Munster, Munster, Germany
    J Am Acad Dermatol 54:221-6. 2006
    ..Dermatomyositis (DM) is an inflammatory connective tissue disorder well recognized as a paraneoplastic syndrome in adults...
  45. ncbi [Linear symptomless skin atrophy in a 14-year old girl]
    Barbara Gansz
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 1:319-21. 2003
  46. ncbi A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid
    Stefan Beissert
    Department of Dermatology, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Arch Dermatol 143:1536-42. 2007
    ..To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine sodium or mycophenolate mofetil for the treatment of bullous pemphigoid...
  47. doi Is MC1 dispensable for regulation of cutaneous inflammatory and immune responses?
    Markus Bohm
    Department of Dermatology, Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, University of Munster, Munster, Germany
    Exp Dermatol 22:792-4. 2013
    ..Future studies are thus needed to clarify whether these findings are due to limitations in the chosen mouse model and/or point to additional MC subtypes that may regulate inflammatory and immune responses in the skin...
  48. ncbi KU812 basophils express urocortin, CRH-R, MC1R and steroidogenic enzymes and secrete progesterone
    Markus Bohm
    Exp Dermatol 21:541-3. 2012
    ..These cells are not only target cells for multiple hormones of the HPA axis but may also generate neuroendocrine mediators autonomously...
  49. ncbi Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Dermatol 13:31-5. 2004
    ..By means of their autocrine, paracrine and endocrine actions, these neuroendocrine factors appear to mediate centrally and topically induced stress towards the sebaceous gland, ultimately affecting the clinical course of acne...