Research Topics
| Werner BoeckerSummaryCountry: Germany Publications
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Detail Information
Publications
Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarraysDaniel H Wai
Gerhard-Domagk-Institute of Pathology, University of Muenster, D-48149 Muenster, Germany
Int J Oncol 20:441-51. 2002..We demonstrate that gains of genetic material contribute essentially to differential gene expression...- Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patternsW Boecker
Gerhard Domagk Institute of Pathology, University of Munster, Germany
J Pathol 195:415-21. 2001.... - Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell conceptWerner Boecker
Gerhard Domagk Institute of Pathology, University of Munster, Domagkstr 17, D 48149 Munster, Germany
Cell Prolif 36:73-84. 2003..Furthermore, this model provides a new tool for unravelling further the regulatory mechanisms that govern normal and pathological cell growth... - Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological conceptWerner Bocker
Institute of Pathology, University of Munster, Munster, Germany
Lab Invest 82:737-46. 2002..The significance of this new cell biological model is that it might serve as a tool to unravel the regulatory mechanisms that govern regeneration and abnormal proliferation of breast epithelium at the cellular level... - Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situWerner Boecker
Gerhard Domagk Institute of Pathology, University of Munster, Domagkstr 17, D 48149 Munster, Germany
J Pathol 198:458-67. 2002..The committed stem (progenitor) cell model may contribute to a better understanding of both benign proliferative breast disease and breast cancer development... - Egfr amplification specific gene expression in phyllodes tumours of the breastKonstantin Agelopoulos
Institute of Pathology, University of Muenster, Muenster, Germany
Cell Oncol 29:443-51. 2007..Recently, we were able to show that amplifications of the epidermal growth factor receptor (egfr) gene and the overexpression of EGFR were associated with the initiation and progression of phyllodes tumours... - The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?Eberhard Korsching
Institute of Pathology, University of Munster, Germany
J Pathol 206:451-7. 2005..We therefore propose the alternative hypothesis that vimentin-expressing breast carcinomas may derive from breast progenitor cells with bilinear (glandular and myoepithelial) differentiation potential... - Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progressionChristian Kersting
Institute of Pathology, University of Muenster, Muenster, Germany
Lab Invest 86:54-61. 2006..The observed association between intron 1 amplification and overexpression of EGFR provides further insight into regulation mechanisms of EGFR overexpression... 
Adenomyoepithelial tumours and myoepithelial carcinomas of the breast--a spectrum of monophasic and biphasic tumours dominated by immature myoepithelial cellsDaniela Hungermann
Institute of Pathology, Muenster University Hospital, Domagkstrasse 17, 48149 Muenster, Germany
BMC Cancer 5:92. 2005..Current classification schemes are based on purely descriptive features and an assessment of individual prognosis is still problematic...- Nitric oxide synthase in muscular dystrophies: a re-evaluationIgor B Buchwalow
Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, 48149, Muenster, Germany
Acta Neuropathol 111:579-88. 2006.... - Improvements in the analysis strategy make single nucleotide polymorphism analysis a powerful tool in the detection and characterization of amplified chromosomal regions in human tumorsEberhard Korsching
Institute of Pathology, , Germany
Pathobiology 73:18-25. 2006..Our software tool improves the analysis of SNP data and the presentation of the results, bridging the gap to existing CGH knowledge (http://bioinformatics.uni-muenster.de, 'Publications and Supplements')... - Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer studyHorst Buerger
Institute of Pathology, University of Munster, Albert Schweitzer Strasse 33, 48139 Münster, Germany
J Pathol 203:545-50. 2004..This new knowledge about mechanisms of regulation of EGFR expression might serve as an additional basis for evaluating anti-EGFR-based therapies... - Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseasesAgnes Bankfalvi
Institute of Pathology, Munster University Hospital, Munster, Germany
Mod Pathol 17:1051-61. 2004..Our results provide cell kinetic support to the functional progenitor cell hypothesis, and we propose this concept as an operative model for understanding benign proliferative and malignant breast diseases... - L-Arginine-NO-cGMP signaling following acute liver injury in the ratEvgeny A Minin
Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr. 17, 48149 Muenster, Germany
Exp Toxicol Pathol 57:161-71. 2005..Up-regulation of NOS after CCl4 intoxication fell behind the oxidative stress and was found to be associated with the initiation of parenchymal regeneration implying a beneficial effect of NO... 
Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostateOlaf Bettendorf
Institute of Pathology, University of Munster, Munster, Germany
Genes Chromosomes Cancer 47:565-72. 2008..Our results indicate that IDC-P in general follows the genetic pathway from normal epithelium over PIN lesion. IDC-P represents a separate prostatic lesion and should be graded as a poorly differentiated carcinoma...- The role of arterial smooth muscle in vasorelaxationIgor B Buchwalow
Gerhard Domagk Institute of Pathology, University of Muenster, 48149 Muenster, Germany
Biochem Biophys Res Commun 377:504-7. 2008..These findings imply that VSMC can release NO in amounts sufficient to account for the vasorelaxatory response and challenge the concept of the obligatory role of endothelial cells in the relaxation of arterial smooth muscle... - Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesisEberhard Korsching
Institute of Pathology, University of Muenster, Muenster, Germany
Lab Invest 82:1525-33. 2002.... - Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinomaChristian Kersting
Institute of Pathology, University of Muenster, Muenster, Germany
Lab Invest 84:582-7. 2004..7% of cases. However, since about 75% of cases with EGFR protein overexpression lack either of these amplifications, other expression regulating mechanisms must be considered... - Comparison of automated and manual determination of HER2 status in breast cancer for diagnostic use: a comparative methodological study using the Ventana BenchMark automated staining system and manual testsAgnes Bankfalvi
Institute of Pathology, University of Munster, Domagkstrasse, D 48149 Munster, Germany
Int J Oncol 25:929-35. 2004..64%) and increased efficiency (92% vs. 89%). We conclude that automation improves the accuracy of HER2 detection in diagnostic breast carcinoma tissues and provides a new approach for the global standardization of clinical HER2 tests... - Early placenta insulin-like growth factor (pro-EPIL) is overexpressed and secreted by c-erbB-2-positive cells with high invasion potentialBurkhard Brandt
Institute for Clinical Chemistry and Laboratory Medicine, Westfalische Wilhelms Universitat Munster, Germany 48149
Cancer Res 62:1020-4. 2002..Our results give new suggestions for the presence of a signaling network of receptor tyrosine kinases underlying breast cancer invasion and metastasis... - An in situ evidence for autocrine function of NO in the vasculatureIgor B Buchwalow
Interdisciplinary Center of Clinical Research and Gerhard Domagk Institute of Pathology, University of Muenster, D 48149 Muenster, Germany
Nitric Oxide 10:203-12. 2004.... - Compartmentalization of NO signaling cascade in skeletal musclesIgor B Buchwalow
Gerhard Domagk Institute of Pathology, University of Muenster, Muenster, Germany
Biochem Biophys Res Commun 330:615-21. 2005..Our findings are indicative of an autocrine fashion of NO signaling in skeletal muscles at both cellular and subcellular levels, and challenge the notion that the NO generation is restricted to the sarcolemma... - A multicolor fluorescence immunostaining technique for simultaneous antigen targetingIgor B Buchwalow
Interdisciplinary Center of Clinical Research, Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, D 48149 Muenster, Germany
Acta Histochem 107:143-8. 2005..This approach is widely applicable and offers a simple procedure for simultaneously detecting two or more antigens... - Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTRChristopher Poremba
Gerhard Domagk Institute of Pathology, Westfalische Wilhelms University, Domagkstrasse 17, 48149 Munster, Germany
J Pathol 198:181-9. 2002..These findings suggest that TA should be included in future validation studies as a prognostic marker in breast cancer... - Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization--design and objectives of the Diagnosis Optimisation Study (DIOS)Alexander Kluttig
Clinical Epidemiology Unit, Institute of Medical Epidemiology, Biometry and Informatics, University Halle Wittenberg, Halle Saale, Germany
BMC Cancer 7:100. 2007..This paper describes the design and objectives of the DIOS Study... - Nitric oxide synthase is up-regulated in muscle fibers in muscular dystrophyKarla Punkt
Institute of Anatomy, University of Leipzig, Leipzig, Germany
Biochem Biophys Res Commun 348:259-64. 2006..These results support the hypothesis that NO deficiency with consequent muscle degeneration in DMD results from NO scavenging by superoxides rather than from reduced NOS expression... - Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis using DNA microarraysKarl-Ludwig Schaefer
Gerhard-Domagk-Institute of Pathology, , Domagkstrasse 17, , Germany
Virchows Arch 440:476-84. 2002..Altogether our findings demonstrate the MMSP derivation of GG-62 and may shed light on the mechanisms of tumorigenesis in this rare disease... - Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assayArno Kuijper
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
J Pathol 197:575-81. 2002..These findings indicate that fibroadenoma can progress in an epithelial direction to CIS and in a stromal direction to phyllodes tumour... - Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer developmentNicola Tidow
Institute of Clinical Chemistry and Laboratory Medicine, , , Germany
Cancer Res 63:1172-8. 2003..Furthermore, they point to the presence of prognosis-associated markers for breast cancer already in morphological normal breast tissue... - Improving the reproducibility of diagnosing micrometastases and isolated tumor cellsGabor Cserni
Department of Pathology, Bacs Kiskun County Teaching Hospital, Kecskemet, Hungary
Cancer 103:358-67. 2005..The reproducibility of these categories has not been assessed previously... - First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancerMike W Helms
Institute of Clinical Chemistry and Laboratory Medicine, , , Germany
J Pathol 206:366-76. 2005..The definition of this pathway characterizes a new potential target in the molecular treatment of invasive breast cancer... - Different mechanisms of chromosome 16 loss of heterozygosity in well- versus poorly differentiated ductal breast cancerAnne Marie Cleton-Jansen
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
Genes Chromosomes Cancer 41:109-16. 2004..These different somatic genetic mechanisms may reflect the presence of multiple tumor suppressor genes that are the target of LOH at chromosome arm 16q...