Werner Boecker

Summary

Country: Germany

Publications

  1. ncbi request reprint Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays
    Daniel H Wai
    Gerhard Domagk Institute of Pathology, University of Muenster, D 48149 Muenster, Germany
    Int J Oncol 20:441-51. 2002
  2. ncbi request reprint Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns
    W Boecker
    Gerhard Domagk Institute of Pathology, University of Munster, Germany
    J Pathol 195:415-21. 2001
  3. ncbi request reprint Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept
    Werner Boecker
    Gerhard Domagk Institute of Pathology, University of Munster, Domagkstr 17, D 48149 Munster, Germany
    Cell Prolif 36:73-84. 2003
  4. ncbi request reprint Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ
    Werner Boecker
    Gerhard Domagk Institute of Pathology, University of Munster, Domagkstr 17, D 48149 Munster, Germany
    J Pathol 198:458-67. 2002
  5. ncbi request reprint Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept
    Werner Bocker
    Institute of Pathology, University of Munster, Munster, Germany
    Lab Invest 82:737-46. 2002
  6. ncbi request reprint Egfr amplification specific gene expression in phyllodes tumours of the breast
    Konstantin Agelopoulos
    Institute of Pathology, University of Muenster, Muenster, Germany
    Cell Oncol 29:443-51. 2007
  7. ncbi request reprint The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?
    Eberhard Korsching
    Institute of Pathology, University of Munster, Germany
    J Pathol 206:451-7. 2005
  8. ncbi request reprint Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression
    Christian Kersting
    Institute of Pathology, University of Muenster, Muenster, Germany
    Lab Invest 86:54-61. 2006
  9. pmc Adenomyoepithelial tumours and myoepithelial carcinomas of the breast--a spectrum of monophasic and biphasic tumours dominated by immature myoepithelial cells
    Daniela Hungermann
    Institute of Pathology, Muenster University Hospital, Domagkstrasse 17, 48149 Muenster, Germany
    BMC Cancer 5:92. 2005
  10. ncbi request reprint Nitric oxide synthase in muscular dystrophies: a re-evaluation
    Igor B Buchwalow
    Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, 48149, Muenster, Germany
    Acta Neuropathol 111:579-88. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays
    Daniel H Wai
    Gerhard Domagk Institute of Pathology, University of Muenster, D 48149 Muenster, Germany
    Int J Oncol 20:441-51. 2002
    ..We demonstrate that gains of genetic material contribute essentially to differential gene expression...
  2. ncbi request reprint Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns
    W Boecker
    Gerhard Domagk Institute of Pathology, University of Munster, Germany
    J Pathol 195:415-21. 2001
    ....
  3. ncbi request reprint Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept
    Werner Boecker
    Gerhard Domagk Institute of Pathology, University of Munster, Domagkstr 17, D 48149 Munster, Germany
    Cell Prolif 36:73-84. 2003
    ..Furthermore, this model provides a new tool for unravelling further the regulatory mechanisms that govern normal and pathological cell growth...
  4. ncbi request reprint Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ
    Werner Boecker
    Gerhard Domagk Institute of Pathology, University of Munster, Domagkstr 17, D 48149 Munster, Germany
    J Pathol 198:458-67. 2002
    ..The committed stem (progenitor) cell model may contribute to a better understanding of both benign proliferative breast disease and breast cancer development...
  5. ncbi request reprint Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept
    Werner Bocker
    Institute of Pathology, University of Munster, Munster, Germany
    Lab Invest 82:737-46. 2002
    ..The significance of this new cell biological model is that it might serve as a tool to unravel the regulatory mechanisms that govern regeneration and abnormal proliferation of breast epithelium at the cellular level...
  6. ncbi request reprint Egfr amplification specific gene expression in phyllodes tumours of the breast
    Konstantin Agelopoulos
    Institute of Pathology, University of Muenster, Muenster, Germany
    Cell Oncol 29:443-51. 2007
    ..Recently, we were able to show that amplifications of the epidermal growth factor receptor (egfr) gene and the overexpression of EGFR were associated with the initiation and progression of phyllodes tumours...
  7. ncbi request reprint The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?
    Eberhard Korsching
    Institute of Pathology, University of Munster, Germany
    J Pathol 206:451-7. 2005
    ..We therefore propose the alternative hypothesis that vimentin-expressing breast carcinomas may derive from breast progenitor cells with bilinear (glandular and myoepithelial) differentiation potential...
  8. ncbi request reprint Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression
    Christian Kersting
    Institute of Pathology, University of Muenster, Muenster, Germany
    Lab Invest 86:54-61. 2006
    ..The observed association between intron 1 amplification and overexpression of EGFR provides further insight into regulation mechanisms of EGFR overexpression...
  9. pmc Adenomyoepithelial tumours and myoepithelial carcinomas of the breast--a spectrum of monophasic and biphasic tumours dominated by immature myoepithelial cells
    Daniela Hungermann
    Institute of Pathology, Muenster University Hospital, Domagkstrasse 17, 48149 Muenster, Germany
    BMC Cancer 5:92. 2005
    ..Current classification schemes are based on purely descriptive features and an assessment of individual prognosis is still problematic...
  10. ncbi request reprint Nitric oxide synthase in muscular dystrophies: a re-evaluation
    Igor B Buchwalow
    Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, 48149, Muenster, Germany
    Acta Neuropathol 111:579-88. 2006
    ....
  11. ncbi request reprint Improvements in the analysis strategy make single nucleotide polymorphism analysis a powerful tool in the detection and characterization of amplified chromosomal regions in human tumors
    Eberhard Korsching
    Institute of Pathology, University of Munster, Germany
    Pathobiology 73:18-25. 2006
    ..This was complemented by dilution experiments based on normal lymphocyte DNA to decipher the lower detection limit for genetic alterations...
  12. ncbi request reprint Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases
    Agnes Bankfalvi
    Institute of Pathology, Munster University Hospital, Munster, Germany
    Mod Pathol 17:1051-61. 2004
    ..Our results provide cell kinetic support to the functional progenitor cell hypothesis, and we propose this concept as an operative model for understanding benign proliferative and malignant breast diseases...
  13. ncbi request reprint Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer study
    Horst Buerger
    Institute of Pathology, University of Munster, Albert Schweitzer Strasse 33, 48139 Münster, Germany
    J Pathol 203:545-50. 2004
    ..This new knowledge about mechanisms of regulation of EGFR expression might serve as an additional basis for evaluating anti-EGFR-based therapies...
  14. ncbi request reprint L-Arginine-NO-cGMP signaling following acute liver injury in the rat
    Evgeny A Minin
    Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, 48149 Muenster, Germany
    Exp Toxicol Pathol 57:161-71. 2005
    ..Up-regulation of NOS after CCl4 intoxication fell behind the oxidative stress and was found to be associated with the initiation of parenchymal regeneration implying a beneficial effect of NO...
  15. doi request reprint The role of arterial smooth muscle in vasorelaxation
    Igor B Buchwalow
    Gerhard Domagk Institute of Pathology, University of Muenster, 48149 Muenster, Germany
    Biochem Biophys Res Commun 377:504-7. 2008
    ..These findings imply that VSMC can release NO in amounts sufficient to account for the vasorelaxatory response and challenge the concept of the obligatory role of endothelial cells in the relaxation of arterial smooth muscle...
  16. doi request reprint Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate
    Olaf Bettendorf
    Institute of Pathology, University of Munster, Munster, Germany
    Genes Chromosomes Cancer 47:565-72. 2008
    ..Our results indicate that IDC-P in general follows the genetic pathway from normal epithelium over PIN lesion. IDC-P represents a separate prostatic lesion and should be graded as a poorly differentiated carcinoma...
  17. ncbi request reprint Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis
    Eberhard Korsching
    Institute of Pathology, University of Muenster, Muenster, Germany
    Lab Invest 82:1525-33. 2002
    ....
  18. ncbi request reprint Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma
    Christian Kersting
    Institute of Pathology, University of Muenster, Muenster, Germany
    Lab Invest 84:582-7. 2004
    ..7% of cases. However, since about 75% of cases with EGFR protein overexpression lack either of these amplifications, other expression regulating mechanisms must be considered...
  19. ncbi request reprint Comparison of automated and manual determination of HER2 status in breast cancer for diagnostic use: a comparative methodological study using the Ventana BenchMark automated staining system and manual tests
    Agnes Bankfalvi
    Institute of Pathology, University of Munster, Domagkstrasse, D 48149 Munster, Germany
    Int J Oncol 25:929-35. 2004
    ..64%) and increased efficiency (92% vs. 89%). We conclude that automation improves the accuracy of HER2 detection in diagnostic breast carcinoma tissues and provides a new approach for the global standardization of clinical HER2 tests...
  20. ncbi request reprint Early placenta insulin-like growth factor (pro-EPIL) is overexpressed and secreted by c-erbB-2-positive cells with high invasion potential
    Burkhard Brandt
    Institute for Clinical Chemistry and Laboratory Medicine, Westfalische Wilhelms Universitat Munster, Germany 48149
    Cancer Res 62:1020-4. 2002
    ..Our results give new suggestions for the presence of a signaling network of receptor tyrosine kinases underlying breast cancer invasion and metastasis...
  21. ncbi request reprint An in situ evidence for autocrine function of NO in the vasculature
    Igor B Buchwalow
    Interdisciplinary Center of Clinical Research and Gerhard Domagk Institute of Pathology, University of Muenster, D 48149 Muenster, Germany
    Nitric Oxide 10:203-12. 2004
    ....
  22. ncbi request reprint Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR
    Christopher Poremba
    Gerhard Domagk Institute of Pathology, Westfalische Wilhelms University, Domagkstrasse 17, 48149 Munster, Germany
    J Pathol 198:181-9. 2002
    ..These findings suggest that TA should be included in future validation studies as a prognostic marker in breast cancer...
  23. ncbi request reprint Compartmentalization of NO signaling cascade in skeletal muscles
    Igor B Buchwalow
    Gerhard Domagk Institute of Pathology, University of Muenster, Muenster, Germany
    Biochem Biophys Res Commun 330:615-21. 2005
    ..Our findings are indicative of an autocrine fashion of NO signaling in skeletal muscles at both cellular and subcellular levels, and challenge the notion that the NO generation is restricted to the sarcolemma...
  24. ncbi request reprint A multicolor fluorescence immunostaining technique for simultaneous antigen targeting
    Igor B Buchwalow
    Interdisciplinary Center of Clinical Research, Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, D 48149 Muenster, Germany
    Acta Histochem 107:143-8. 2005
    ..This approach is widely applicable and offers a simple procedure for simultaneously detecting two or more antigens...
  25. doi request reprint K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation
    Werner Boecker
    1 Institute for Hematopathology, Reference Center for Gynaeco and Breast pathology, Hamburg, Germany 2 Gerhard Domagk Institute of Pathology, University of Muenster, Munster, Germany
    Mod Pathol 26:1086-100. 2013
    ..Taken together, our isTILT and RNA-expression data indicate that look-alike tumors of the breast represent a special subgroup of basal-type tumors with benign or usually low malignant potential. ..
  26. ncbi request reprint Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer development
    Nicola Tidow
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, 48149 Munster, Germany
    Cancer Res 63:1172-8. 2003
    ..Furthermore, they point to the presence of prognosis-associated markers for breast cancer already in morphological normal breast tissue...
  27. ncbi request reprint Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assay
    Arno Kuijper
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 197:575-81. 2002
    ..These findings indicate that fibroadenoma can progress in an epithelial direction to CIS and in a stromal direction to phyllodes tumour...
  28. ncbi request reprint Nitric oxide synthase is up-regulated in muscle fibers in muscular dystrophy
    Karla Punkt
    Institute of Anatomy, University of Leipzig, Leipzig, Germany
    Biochem Biophys Res Commun 348:259-64. 2006
    ..These results support the hypothesis that NO deficiency with consequent muscle degeneration in DMD results from NO scavenging by superoxides rather than from reduced NOS expression...
  29. pmc Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization--design and objectives of the Diagnosis Optimisation Study (DIOS)
    Alexander Kluttig
    Clinical Epidemiology Unit, Institute of Medical Epidemiology, Biometry and Informatics, University Halle Wittenberg, Halle Saale, Germany
    BMC Cancer 7:100. 2007
    ..This paper describes the design and objectives of the DIOS Study...
  30. ncbi request reprint Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis using DNA microarrays
    Karl Ludwig Schaefer
    Gerhard Domagk Institute of Pathology, University of Munster, Domagkstrasse 17, 48149 Munster, Germany
    Virchows Arch 440:476-84. 2002
    ..Altogether our findings demonstrate the MMSP derivation of GG-62 and may shed light on the mechanisms of tumorigenesis in this rare disease...
  31. ncbi request reprint First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer
    Mike W Helms
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Munster, Germany
    J Pathol 206:366-76. 2005
    ..The definition of this pathway characterizes a new potential target in the molecular treatment of invasive breast cancer...
  32. ncbi request reprint Improving the reproducibility of diagnosing micrometastases and isolated tumor cells
    Gabor Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Kecskemet, Hungary
    Cancer 103:358-67. 2005
    ..The reproducibility of these categories has not been assessed previously...
  33. ncbi request reprint Different mechanisms of chromosome 16 loss of heterozygosity in well- versus poorly differentiated ductal breast cancer
    Anne Marie Cleton-Jansen
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 41:109-16. 2004
    ..These different somatic genetic mechanisms may reflect the presence of multiple tumor suppressor genes that are the target of LOH at chromosome arm 16q...