Christoph Bock

Summary

Country: Germany

Publications

  1. pmc EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data
    Christoph Bock
    Max Planck Institut für Informatik, Campus E1 4, 66123 Saarbrucken, Germany
    Genome Biol 10:R14. 2009
  2. pmc BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
    Pavlo Lutsik
    Department of Genetics Epigenetics, Saarland University, 66123 Saarbrucken, Germany
    Nucleic Acids Res 39:W551-6. 2011
  3. pmc Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
    Christoph Bock
    Max Planck Institut für Informatik and Universität des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Saarbrucken, Germany
    Nucleic Acids Res 36:e55. 2008
  4. ncbi request reprint Computational epigenetics
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Bioinformatics 24:1-10. 2008
  5. ncbi request reprint BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing
    Christoph Bock
    Max Planck Institut für Informatik Saarbrücken, Germany
    Bioinformatics 21:4067-8. 2005
  6. pmc CpG island mapping by epigenome prediction
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Comput Biol 3:e110. 2007
  7. doi request reprint Epigenetic biomarker development
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Epigenomics 1:99-110. 2009
  8. pmc CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Genet 2:e26. 2006
  9. doi request reprint Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Methods Mol Biol 628:275-96. 2010
  10. doi request reprint Analyzing epigenome data in context of genome evolution and human diseases
    Lars Feuerbach
    Max Planck Institute, Saarbrucken, Germany
    Methods Mol Biol 856:431-67. 2012

Detail Information

Publications17

  1. pmc EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data
    Christoph Bock
    Max Planck Institut für Informatik, Campus E1 4, 66123 Saarbrucken, Germany
    Genome Biol 10:R14. 2009
    ..This paper demonstrates EpiGRAPH's practical utility in a case study on monoallelic gene expression and describes its novel approach to reproducible bioinformatic analysis...
  2. pmc BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
    Pavlo Lutsik
    Department of Genetics Epigenetics, Saarland University, 66123 Saarbrucken, Germany
    Nucleic Acids Res 39:W551-6. 2011
    ..In addition, it is useful for locus-specific visualization of genome-wide bisulfite sequencing data...
  3. pmc Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
    Christoph Bock
    Max Planck Institut für Informatik and Universität des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Saarbrucken, Germany
    Nucleic Acids Res 36:e55. 2008
    ..We substantiate these conclusions by an in silico benchmarking study of six widely used methods for DNA methylation mapping. Based on our findings, we propose a cost-optimized two-track strategy for mammalian methylome projects...
  4. ncbi request reprint Computational epigenetics
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Bioinformatics 24:1-10. 2008
    ..In addition, we give a brief introduction into epigenetics-targeted at bioinformaticians who are new to the field-and we outline future challenges in computational epigenetics...
  5. ncbi request reprint BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing
    Christoph Bock
    Max Planck Institut für Informatik Saarbrücken, Germany
    Bioinformatics 21:4067-8. 2005
    ..The BiQ Analyzer program is implemented in the Java programming language and runs on any platform for which a recent Java virtual machine is available...
  6. pmc CpG island mapping by epigenome prediction
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Comput Biol 3:e110. 2007
    ....
  7. doi request reprint Epigenetic biomarker development
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Epigenomics 1:99-110. 2009
    ..Here, I outline a systematic approach to epigenetic biomarker development and highlight key bioinformatic tools that facilitate discovery, optimization and validation of novel biomarkers...
  8. pmc CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Genet 2:e26. 2006
    ..This finding may have a strong impact on our understanding of changes in CpG island methylation in development and disease...
  9. doi request reprint Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Methods Mol Biol 628:275-96. 2010
    ..This paper is supplemented with video tutorials (http://tinyurl.com/yc5xkqq), which provide a step-by-step guide through each example analysis...
  10. doi request reprint Analyzing epigenome data in context of genome evolution and human diseases
    Lars Feuerbach
    Max Planck Institute, Saarbrucken, Germany
    Methods Mol Biol 856:431-67. 2012
    ....
  11. pmc MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays
    Peter Schüffler
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Genome Biol 10:R105. 2009
    ..Furthermore, MethMarker implements a bioinformatic workflow for transforming disease-specific differentially methylated genomic regions into robust clinical biomarkers...
  12. pmc Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region
    Martin Kircher
    Max Planck Institut für Informatik, Saarbrucken, Germany
    BMC Genomics 9:346. 2008
    ..This cluster contains more than 40 microRNA genes that are expressed only from the maternal chromosome in mouse...
  13. ncbi request reprint BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives
    Daniel Becker
    Department of Genetics, Saarland University, Saarbrucken 66123, Germany Department of Computational Biology and Applied Algorithms, Max Planck Institute for Informatics, Saarbrucken 66123, Germany
    Nucleic Acids Res 42:W501-7. 2014
    ..The tool is freely available as a stand-alone installation package from http://biq-analyzer-himod.bioinf.mpi-inf.mpg.de/. ..
  14. doi request reprint Managing drug resistance in cancer: lessons from HIV therapy
    Christoph Bock
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Nat Rev Cancer 12:494-501. 2012
    ..In this Opinion article, we argue that HIV therapy provides a 'blueprint' for designing and validating patient-specific combination therapies in cancer...
  15. pmc Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis
    Thomas Mikeska
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Mol Diagn 9:368-81. 2007
    ..The optimized pyrosequencing assay performed best and provides a sensitive, robust, and easy-to-use method for quantitative assessment of MGMT methylation, for both snap-frozen and paraffin-embedded specimens...
  16. pmc The human genomic melting map
    Fang Liu
    Department of Tumor Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    PLoS Comput Biol 3:e93. 2007
    ..The human DNA melting map may be further explored at http://meltmap.uio.no...
  17. ncbi request reprint Analysis and prediction of helix shift errors in homology modeling
    Christoph Bock
    Institute for Computational Medicine, Universities of Mannheim and Heidelberg, Germany
    In Silico Biol 6:131-45. 2006
    ..Therefore, a further increase of prediction accuracy is expected from the combination of these methods...