Christoph Bock

Summary

Country: Germany

Publications

  1. ncbi EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data
    Christoph Bock
    Max Planck Institut für Informatik, Campus E1 4, 66123 Saarbrucken, Germany
    Genome Biol 10:R14. 2009
  2. ncbi BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing
    Christoph Bock
    Max Planck Institut für Informatik Saarbrücken, Germany
    Bioinformatics 21:4067-8. 2005
  3. ncbi CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Genet 2:e26. 2006
  4. ncbi Epigenetic biomarker development
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Epigenomics 1:99-110. 2009
  5. ncbi CpG island mapping by epigenome prediction
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Comput Biol 3:e110. 2007
  6. ncbi Computational epigenetics
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Bioinformatics 24:1-10. 2008
  7. ncbi Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
    Christoph Bock
    Max Planck Institut für Informatik and Universität des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Saarbrucken, Germany
    Nucleic Acids Res 36:e55. 2008
  8. ncbi Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Methods Mol Biol 628:275-96. 2010
  9. ncbi Analyzing epigenome data in context of genome evolution and human diseases
    Lars Feuerbach
    Max Planck Institute, Saarbrucken, Germany
    Methods Mol Biol 856:431-67. 2012
  10. ncbi MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays
    Peter Schüffler
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Genome Biol 10:R105. 2009

Detail Information

Publications16

  1. ncbi EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data
    Christoph Bock
    Max Planck Institut für Informatik, Campus E1 4, 66123 Saarbrucken, Germany
    Genome Biol 10:R14. 2009
    ..This paper demonstrates EpiGRAPH's practical utility in a case study on monoallelic gene expression and describes its novel approach to reproducible bioinformatic analysis...
  2. ncbi BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing
    Christoph Bock
    Max Planck Institut für Informatik Saarbrücken, Germany
    Bioinformatics 21:4067-8. 2005
    ..AVAILABILITY: The program is available without charge for non-commercial users and can be downloaded from http://biq-analyzer.bioinf.mpi-inf.mpg.de/..
  3. ncbi CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Genet 2:e26. 2006
    ..This finding may have a strong impact on our understanding of changes in CpG island methylation in development and disease...
  4. ncbi Epigenetic biomarker development
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Epigenomics 1:99-110. 2009
    ..Here, I outline a systematic approach to epigenetic biomarker development and highlight key bioinformatic tools that facilitate discovery, optimization and validation of novel biomarkers...
  5. ncbi CpG island mapping by epigenome prediction
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Comput Biol 3:e110. 2007
    ....
  6. ncbi Computational epigenetics
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Bioinformatics 24:1-10. 2008
    ..In addition, we give a brief introduction into epigenetics-targeted at bioinformaticians who are new to the field-and we outline future challenges in computational epigenetics...
  7. ncbi Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
    Christoph Bock
    Max Planck Institut für Informatik and Universität des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Saarbrucken, Germany
    Nucleic Acids Res 36:e55. 2008
    ..We substantiate these conclusions by an in silico benchmarking study of six widely used methods for DNA methylation mapping. Based on our findings, we propose a cost-optimized two-track strategy for mammalian methylome projects...
  8. ncbi Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Methods Mol Biol 628:275-96. 2010
    ..This paper is supplemented with video tutorials (http://tinyurl.com/yc5xkqq), which provide a step-by-step guide through each example analysis...
  9. ncbi Analyzing epigenome data in context of genome evolution and human diseases
    Lars Feuerbach
    Max Planck Institute, Saarbrucken, Germany
    Methods Mol Biol 856:431-67. 2012
    ....
  10. ncbi MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays
    Peter Schüffler
    Max Planck Institut für Informatik, Saarbrucken, Germany
    Genome Biol 10:R105. 2009
    ..Furthermore, MethMarker implements a bioinformatic workflow for transforming disease-specific differentially methylated genomic regions into robust clinical biomarkers...
  11. ncbi BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
    Pavlo Lutsik
    Department of Genetics Epigenetics, Saarland University, 66123 Saarbrucken, Germany
    Nucleic Acids Res 39:W551-6. 2011
    ..In addition, it is useful for locus-specific visualization of genome-wide bisulfite sequencing data...
  12. ncbi Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region
    Martin Kircher
    Max Planck Institut für Informatik, Saarbrucken, Germany
    BMC Genomics 9:346. 2008
    ..This cluster contains more than 40 microRNA genes that are expressed only from the maternal chromosome in mouse...
  13. ncbi Managing drug resistance in cancer: lessons from HIV therapy
    Christoph Bock
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Nat Rev Cancer 12:494-501. 2012
    ..In this Opinion article, we argue that HIV therapy provides a 'blueprint' for designing and validating patient-specific combination therapies in cancer...
  14. ncbi Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis
    Thomas Mikeska
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Mol Diagn 9:368-81. 2007
    ..The optimized pyrosequencing assay performed best and provides a sensitive, robust, and easy-to-use method for quantitative assessment of MGMT methylation, for both snap-frozen and paraffin-embedded specimens...
  15. ncbi The human genomic melting map
    Fang Liu
    Department of Tumor Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    PLoS Comput Biol 3:e93. 2007
    ..The human DNA melting map may be further explored at http://meltmap.uio.no...
  16. ncbi Analysis and prediction of helix shift errors in homology modeling
    Christoph Bock
    Institute for Computational Medicine, Universities of Mannheim and Heidelberg, Germany
    In Silico Biol 6:131-45. 2006
    ..Therefore, a further increase of prediction accuracy is expected from the combination of these methods...