J Blumel

Summary

Country: Germany

Publications

  1. ncbi request reprint Structure of simian virus 40 DNA replicated by herpes simplex virus type 1
    J Blumel
    Institut fur Medizinische Mikrobiologie und Immunologie, Universitat Bonn, Sigmund Freud Strasse 25, Bonn, D 53127, Germany
    Virology 276:445-54. 2000
  2. ncbi request reprint Inactivation of parvovirus B19 during pasteurization of human serum albumin
    Johannes Blümel
    Virus Safety Section, Paul Ehrlich Institute, Langen, Germany
    Transfusion 42:1011-8. 2002
  3. ncbi request reprint Parvovirus B19 transmission by heat-treated clotting factor concentrates
    Johannes Blümel
    Paul Ehrlich Institute, Langen, Germany
    Transfusion 42:1473-81. 2002
  4. ncbi request reprint Cell culture-based assay of parvovirus B19 and the relevance of animal model viruses
    J Blumel
    Paul Ehrlich lnstitut, Langen, Germany
    Dev Biol (Basel) 118:107-12. 2004
  5. pmc Characterization of Parvovirus B19 genotype 2 in KU812Ep6 cells
    Johannes Blümel
    Paul Ehrlich Institut, Langen, Germany
    J Virol 79:14197-206. 2005
  6. doi request reprint [Important aspects of virus safety of advanced therapy medicinal products]
    J Blumel
    Paul Ehrlich Institut, Paul Ehrlich Str 51 59, 63225, Langen
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:38-44. 2010
  7. doi request reprint Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays
    S A Baylis
    National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Vox Sang 98:441-6. 2010

Collaborators

  • D Candotti
  • S A Baylis
  • M Chudy
  • A B Heath
  • M Jose
  • G Pisani

Detail Information

Publications7

  1. ncbi request reprint Structure of simian virus 40 DNA replicated by herpes simplex virus type 1
    J Blumel
    Institut fur Medizinische Mikrobiologie und Immunologie, Universitat Bonn, Sigmund Freud Strasse 25, Bonn, D 53127, Germany
    Virology 276:445-54. 2000
    ..This indicates that initiation of DNA synthesis on HSV-ori determines some, yet undefined, property of replicating HSV DNA, which is crucial for regular processing of the replication intermediates to daughter genomes...
  2. ncbi request reprint Inactivation of parvovirus B19 during pasteurization of human serum albumin
    Johannes Blümel
    Virus Safety Section, Paul Ehrlich Institute, Langen, Germany
    Transfusion 42:1011-8. 2002
    ..Studies with animal parvoviruses indicate considerable heat resistance at 60 degrees C. However, due to the lack of a suitable cell culture system, the pasteurization process has not been investigated in the past...
  3. ncbi request reprint Parvovirus B19 transmission by heat-treated clotting factor concentrates
    Johannes Blümel
    Paul Ehrlich Institute, Langen, Germany
    Transfusion 42:1473-81. 2002
    ..Therefore, the correlation between B19 DNA in blood components and infectivity remains unclear...
  4. ncbi request reprint Cell culture-based assay of parvovirus B19 and the relevance of animal model viruses
    J Blumel
    Paul Ehrlich lnstitut, Langen, Germany
    Dev Biol (Basel) 118:107-12. 2004
    ..The understanding of the mechanism underlying virus inactivation/removal might be helpful for the selection of model viruses and for the assessment of validation data on its relevance for a specific virus in question...
  5. pmc Characterization of Parvovirus B19 genotype 2 in KU812Ep6 cells
    Johannes Blümel
    Paul Ehrlich Institut, Langen, Germany
    J Virol 79:14197-206. 2005
    ....
  6. doi request reprint [Important aspects of virus safety of advanced therapy medicinal products]
    J Blumel
    Paul Ehrlich Institut, Paul Ehrlich Str 51 59, 63225, Langen
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:38-44. 2010
    ..Only in the production of small and stable non-enveloped viral gene vectors is it conceivable to implement steps to selectively inactivate or remove potential contaminating enveloped viruses...
  7. doi request reprint Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays
    S A Baylis
    National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Vox Sang 98:441-6. 2010
    ..Two lyophilized preparations (coded 99/800 and 99/802) had been evaluated in the original collaborative study. The present study re-evaluates these two preparations in terms of potency, stability and encapsidation of virus DNA...