- Structure of simian virus 40 DNA replicated by herpes simplex virus type 1J Blumel
Institut fur Medizinische Mikrobiologie und Immunologie, Universitat Bonn, Sigmund Freud Strasse 25, Bonn, D 53127, Germany
Virology 276:445-54. 2000..This indicates that initiation of DNA synthesis on HSV-ori determines some, yet undefined, property of replicating HSV DNA, which is crucial for regular processing of the replication intermediates to daughter genomes...
- Inactivation of parvovirus B19 during pasteurization of human serum albuminJohannes Blümel
Virus Safety Section, Paul Ehrlich Institute, Langen, Germany
Transfusion 42:1011-8. 2002..Studies with animal parvoviruses indicate considerable heat resistance at 60 degrees C. However, due to the lack of a suitable cell culture system, the pasteurization process has not been investigated in the past...
- Parvovirus B19 transmission by heat-treated clotting factor concentratesJohannes Blümel
Paul Ehrlich Institute, Langen, Germany
Transfusion 42:1473-81. 2002..Therefore, the correlation between B19 DNA in blood components and infectivity remains unclear...
- Cell culture-based assay of parvovirus B19 and the relevance of animal model virusesJ Blumel
Paul Ehrlich lnstitut, Langen, Germany
Dev Biol (Basel) 118:107-12. 2004..The understanding of the mechanism underlying virus inactivation/removal might be helpful for the selection of model viruses and for the assessment of validation data on its relevance for a specific virus in question...
- Characterization of Parvovirus B19 genotype 2 in KU812Ep6 cellsJohannes Blümel
Paul Ehrlich Institut, Langen, Germany
J Virol 79:14197-206. 2005....
- [Important aspects of virus safety of advanced therapy medicinal products]J Blumel
Paul Ehrlich Institut, Paul Ehrlich Str 51 59, 63225, Langen
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:38-44. 2010..Only in the production of small and stable non-enveloped viral gene vectors is it conceivable to implement steps to selectively inactivate or remove potential contaminating enveloped viruses...
- Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assaysS A Baylis
National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
Vox Sang 98:441-6. 2010..Two lyophilized preparations (coded 99/800 and 99/802) had been evaluated in the original collaborative study. The present study re-evaluates these two preparations in terms of potency, stability and encapsidation of virus DNA...