Thomas Blankenstein

Summary

Country: Germany

Publications

  1. ncbi request reprint Tumor-induced antibodies resemble the response to tissue damage
    Susanne Preiss
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 115:456-62. 2005
  2. pmc Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness
    Gerald Willimsky
    Institute of Immunology, Charite Campus Benjamin Franklin, 12200 Berlin, Germany
    J Exp Med 205:1687-700. 2008
  3. pmc The determinants of tumour immunogenicity
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin 13125, Germany
    Nat Rev Cancer 12:307-13. 2012
  4. ncbi request reprint Do autochthonous tumors interfere with effector T cell responses?
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin, Germany
    Semin Cancer Biol 17:267-74. 2007
  5. ncbi request reprint The role of tumor stroma in the interaction between tumor and immune system
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Curr Opin Immunol 17:180-6. 2005
  6. ncbi request reprint The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Curr Opin Immunol 15:148-54. 2003
  7. ncbi request reprint Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells
    Thomas Schüler
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Immunol 170:4427-31. 2003
  8. doi request reprint In vivo imaging of an inducible oncogenic tumor antigen visualizes tumor progression and predicts CTL tolerance
    Christian Buschow
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    J Immunol 184:2930-8. 2010
  9. ncbi request reprint CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells
    Thomas Kammertoens
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    Cancer Res 65:2560-4. 2005
  10. ncbi request reprint A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells
    Zhihai Qin
    Institute of Immunology, University Clinic Benjamin Franklin, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 63:4095-100. 2003

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Tumor-induced antibodies resemble the response to tissue damage
    Susanne Preiss
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 115:456-62. 2005
    ..We conclude that the tumor-induced antibodies mirror tissue damage and that the antibody-inducing antigens can serve as rejection antigens if they are recognized as foreign...
  2. pmc Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness
    Gerald Willimsky
    Institute of Immunology, Charite Campus Benjamin Franklin, 12200 Berlin, Germany
    J Exp Med 205:1687-700. 2008
    ....
  3. pmc The determinants of tumour immunogenicity
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin 13125, Germany
    Nat Rev Cancer 12:307-13. 2012
    ..So, what do we know about tumour immunogenicity and how might we therapeutically improve tumour immunogenicity? We asked four leading cancer immunologists around the world for their opinions on this important issue...
  4. ncbi request reprint Do autochthonous tumors interfere with effector T cell responses?
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin, Germany
    Semin Cancer Biol 17:267-74. 2007
    ..This can be explained by the absence of evolutionary pressure...
  5. ncbi request reprint The role of tumor stroma in the interaction between tumor and immune system
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Curr Opin Immunol 17:180-6. 2005
    ..These cytokines inhibit tumor-induced angiogenesis, probably through different cellular targets...
  6. ncbi request reprint The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Curr Opin Immunol 15:148-54. 2003
    ..During MCA-induced tumorigenesis IFN-gamma is involved in the inhibition of MCA diffusion by encapsulation and reduction of DNA damage. This mechanism may primarily protect tissue from damage and simultaneously inhibit tumor development...
  7. ncbi request reprint Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells
    Thomas Schüler
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Immunol 170:4427-31. 2003
    ..Together, CD8(+) effector T cells recognize Ag directly on tumor cells, and this recognition is sufficient to reject tumors by IFN-gamma acting on host cells...
  8. doi request reprint In vivo imaging of an inducible oncogenic tumor antigen visualizes tumor progression and predicts CTL tolerance
    Christian Buschow
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    J Immunol 184:2930-8. 2010
    ....
  9. ncbi request reprint CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells
    Thomas Kammertoens
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    Cancer Res 65:2560-4. 2005
    ..1 and B7.2 and to secrete tumor necrosis factor alpha and IL-12. Based on these data, CY15 is a dendritic cell-like tumor cell line and may serve as a transplantable tumor model for histiocytosis in humans...
  10. ncbi request reprint A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells
    Zhihai Qin
    Institute of Immunology, University Clinic Benjamin Franklin, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 63:4095-100. 2003
    ..Taken together with our previous findings, we conclude that IFN-gamma-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4(+) and CD8(+) T-cell effectors...
  11. ncbi request reprint Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity
    Monika Weinhold
    Institute of Immunology, Charite, Hindenburgdamm 30, Berlin, Germany
    J Immunol 179:5534-42. 2007
    ..Our data demonstrate that the approach of adoptively transferring TCR redirected T cells can be effective without severe side effects, even when high numbers of T cells with self-reactivity were transferred...
  12. doi request reprint T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy
    Matthias Leisegang
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Clin Cancer Res 16:2333-43. 2010
    ..We analyzed tumor-infiltrating lymphocytes (TIL) from RCC to identify T-cell specificities with shared tumor-specific recognition to develop T-cell receptor (TCR)-engineered T lymphocytes for adoptive therapy of RCC...
  13. ncbi request reprint Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells
    Hye Jung Kim
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    J Immunol 172:4037-47. 2004
    ....
  14. doi request reprint Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer
    Karin Schmidt
    Institute of Immunology, Charite Campus Buch, Berlin, Germany
    Blood 121:1740-8. 2013
    ..Together, iMC expand independent of the type of antitumor response and are not immunosuppressive in a cell-autonomous fashion...
  15. doi request reprint The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed
    Jelena Popovic
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Blood 118:946-54. 2011
    ....
  16. doi request reprint Visualizing the dynamic of adoptively transferred T cells during the rejection of large established tumors
    Jehad Charo
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Eur J Immunol 41:3187-97. 2011
    ....
  17. pmc Fas expression by tumor stroma is required for cancer eradication
    Joanna J Listopad
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 110:2276-81. 2013
    ..Therefore, T(E) cells lacking IFNγ or FasL cannot prevent progression of antigenic cancer because the tumor stroma escapes destruction if its Fas expression is down-regulated...
  18. pmc Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance
    Gerald Willimsky
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    J Clin Invest 123:1032-43. 2013
    ..Thus, we have developed a model of virus-induced HCC that may allow for a better understanding of human HCC...
  19. pmc Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer
    Kathleen Anders
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cancer Cell 20:755-67. 2011
    ....
  20. doi request reprint CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis
    Susanne A Wolf
    Max Delbruck Center for Molecular Medicine, Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    J Immunol 182:3979-84. 2009
    ..We propose that systemic CD4-T cell activity is required for maintaining cellular plasticity in the adult hippocampus and represents an evolutionary relevant communication route for the brain to respond to environmental changes...
  21. doi request reprint Making and circumventing tolerance to cancer
    Thomas Kammertoens
    Institute of Immunology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Immunol 39:2345-53. 2009
    ..Effective adoptive T-cell therapy has become feasible by methods to identify TCR against tumor-associated (self-) antigens with high affinity and to graft a new antigen specificity to patients' T cells by TCR gene transfer...
  22. pmc A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
    Elisa Kieback
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Proc Natl Acad Sci U S A 105:623-8. 2008
    ..This safeguard allows termination of adoptive therapy in case of severe side effects...
  23. doi request reprint Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo
    Shabnam Shalapour
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    Eur J Immunol 40:2391-400. 2010
    ..In summary, our data suggest a feedback loop in which commensal bacteria drive IFN-gamma production by lymphocytes, which in turn promotes epithelial cell IL-7 production and the survival of IL-7-dependent lymphocytes...
  24. ncbi request reprint Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance
    Thomas Blankenstein
    Max Delbrück Centrum for Molecular Medicine, 13092 Berlin, Germany
    Adv Cancer Res 90:179-207. 2003
    ....
  25. doi request reprint Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates
    Dana Briesemeister
    Institute of Immunology, Charite Campus Benjamin Franklin, 12200 Berlin, Germany
    Cytokine 60:626-33. 2012
    ..This suggests an altered base-line inflammatory responsiveness in the TM-breeding colonies...
  26. doi request reprint Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis
    Dana Briesemeister
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 128:371-8. 2011
    ..This suggests that transplanted tumors became less susceptible to local IFN-γ treatment the better they are established...
  27. ncbi request reprint Immunotherapy: target the stroma to hit the tumor
    Thomas Kammertoens
    Institute of Immunology, Charite Campus Benjamin Franklin, 12200 Berlin, Germany
    Trends Mol Med 11:225-31. 2005
    ..These findings are important for the development of more effective and specific immunotherapies for cancer...
  28. ncbi request reprint Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    Gerald Willimsky
    Institute of Immunology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Nature 437:141-6. 2005
    ..Furthermore, in the primary host tumour-induced tolerance is associated with the expansion of non-functional T cells. Together, our data argue against immunosurveillance of spontaneous cancer...
  29. doi request reprint Depot formation of doxycycline impairs Tet-regulated gene expression in vivo
    Kathleen Anders
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125, Berlin, Germany
    Transgenic Res 21:1099-107. 2012
    ..rtTA-CM2 mice may be a useful tool to analyze the function of genes in various organs but also reveal that down-regulation of gene expression is not complete...
  30. ncbi request reprint Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors
    Zhihai Qin
    Institute of Immunology, Universitaetsklinikum Benjamin Franklin, Haus IA, Hindenburgdamm 30, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 62:2856-60. 2002
    ..Thus, the lack of TAP1 expression did not change the immunogenicity of tumor cells. It may enable tumor cells to escape T-cell recognition during the effector phase of an antitumor immune response...
  31. ncbi request reprint Naive CD8(+) but not CD4(+) T cells induce maturation of dendritic cells
    Thomas Schüler
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    J Mol Med (Berl) 80:533-41. 2002
    ..This suggests that CD8(+) T cells contribute to DC activation prior to CD4(+) T cells and implies that CD8(+) T cells can provide help to CD4(+) T cells...
  32. ncbi request reprint The adaptive immune response to sporadic cancer
    Gerald Willimsky
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    Immunol Rev 220:102-12. 2007
    ..Based on this model, we conclude that immunosurveillance plays little or no role against sporadic cancer and that tumors must not escape immune recognition or destruction...
  33. ncbi request reprint CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
    Lars Ohl
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    Immunity 21:279-88. 2004
    ..Thus, our data identify CCR7 as a key regulator that governs trafficking of skin DC under both inflammatory and steady-state conditions...
  34. pmc Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas
    Anna Kruschinski
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    Proc Natl Acad Sci U S A 105:17481-6. 2008
    ..Taken together, these results indicate that the expression of this activating receptor overrides inhibitory signals in primary human NK cells and directs them specifically toward HER-2 expressing tumor cells both in vitro and in vivo...
  35. pmc Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction
    Zhihai Qin
    Institute of Immunology, Free University Berlin, 12200 Berlin, Germany
    J Exp Med 195:1479-90. 2002
    ..This mechanism is more efficient in the presence of IFN-gammaR. Our results indicates that inflammation and scarring, both suspected to contribute to malignancy, prevent cancer in certain situations...
  36. doi request reprint Generation of transgenic mice with megabase-sized human yeast artificial chromosomes by yeast spheroplast-embryonic stem cell fusion
    Liangping Li
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Protoc 8:1567-82. 2013
    ..The protocol takes ∼1 year to complete, from reconstruction of the entire TRA gene locus from YACs containing partial but overlapping TRA regions to germline transmission of the YAC. ..
  37. ncbi request reprint Retroviral vectors for high-level transgene expression in T lymphocytes
    Boris Engels
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Hum Gene Ther 14:1155-68. 2003
    ..In summary, MP71 vectors are useful tools for stable, high-level gene expression in T lymphocytes, for example, in the expression of T cell receptor genes...
  38. doi request reprint Transgenic mice with a diverse human T cell antigen receptor repertoire
    Liang Ping Li
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Med 16:1029-34. 2010
    ..These mice will allow researchers to identify pathogenic and therapeutic human TCRs...
  39. doi request reprint Molecular pathways: comparing the effects of drugs and T cells to effectively target oncogenes
    Kathleen Anders
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Clin Cancer Res 19:320-6. 2013
    ..We argue that the ideal conditions of ATT in the experimental cancer model can be translated to individuals with cancer...
  40. doi request reprint IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis
    Michael Rothe
    Institute of Immunology, Charite Campus Buch, 13125, Berlin, Germany
    Cancer Med 2:815-25. 2013
    ..Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades...
  41. ncbi request reprint Designer T cells by T cell receptor replacement
    Daniel Sommermeyer
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Eur J Immunol 36:3052-9. 2006
    ....
  42. ncbi request reprint Cross-priming versus cross-tolerance: are two signals enough?
    Thomas Blankenstein
    Institute of Immunology, Free University Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Trends Immunol 23:171-3. 2002
    ..However, new data show that it is not the expression of costimulatory molecules alone that determines whether DCs induce immunity or tolerance, because mature DCs can induce tolerance also...
  43. doi request reprint It's the peptide-MHC affinity, stupid
    Thomas Kammertoens
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Cancer Cell 23:429-31. 2013
    ..In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy...
  44. ncbi request reprint The role of inflammation in tumour growth and tumour suppression
    Thomas Blankenstein
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Novartis Found Symp 256:205-10; discussion 210-4, 259-69. 2004
    ..This response is related to a tissue repair response induced by the tissue damaging effects of the carcinogen in the course of which MCA is encapsulated and no longer able to induce tumours...
  45. ncbi request reprint T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging
    Ralf Agger
    Institute of Medical Microbiology and Immunology, University of Aarhus, The Bartholin Building, Denmark
    J Immunother 30:29-39. 2007
    ..Accumulation of 124I was significantly higher in B16-OVA than in B16 tumors not expressing the OVA antigen...
  46. ncbi request reprint CD4+ T cell-mediated HER-2/neu-specific tumor rejection in the absence of B cells
    Jan Alvar Lindencrona
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 109:259-64. 2004
    ..We conclude that T cells are the main effector cells in DNA vaccine induced immunity against HER-2 and that anti HER-2 antibodies are not necessary to elicit a protective anti tumor immune response in this model...
  47. ncbi request reprint Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors
    Monika Gladow
    Institute of Biology, Humboldt University Berlin, Berlin, Germany
    Eur J Immunol 34:1882-91. 2004
    ..Taken together, despite a certain dominance of expression between two TCR on the same T cell, this need not necessarily have functional consequences...
  48. ncbi request reprint Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLs
    Bernhard Frankenberger
    Institute of Molecular Immunology, Forschungszentrum für Umwelt und Gesundheit National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
    Clin Cancer Res 11:1733-42. 2005
    ..The effect of these modifications on proliferation, function, and survival of autologous and allogeneic tumor-specific CTLs was assessed...
  49. ncbi request reprint Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18
    Terry H Wu
    Department of Pathology, Committee on Cancer Biology, Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    J Immunol 172:3243-51. 2004
    ..These results strongly suggest a novel function for the endogenous IFN-gamma pathway that without measurable IFN-gamma production or activity affects the ability of TNF to suppress tumor development...
  50. ncbi request reprint Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes
    Boris Engels
    Institute of Biology, Humboldt University Berlin, 10115 Berlin, Germany
    Hum Gene Ther 16:799-810. 2005
    ..The results demonstrate that use of an optimized retroviral vector yielded a high TCR transduction efficiency and stable and high TCR expression in primary human T lymphocytes and redirected their specificity toward RCC cells...
  51. pmc Tumor rejection by modulation of tumor stromal fibroblasts
    Thomas Schüler
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Exp Med 198:1487-93. 2003
    ..Our data demonstrate a novel mechanism by which IL-4 contributes to tumor rejection and show that the targeted modulation of tumor-associated fibroblasts can be sufficient for tumor rejection...
  52. ncbi request reprint A cancer immunosurveillance controversy
    Zhihai Qin
    Nat Immunol 5:3-4; author reply 4-5. 2004
  53. doi request reprint SV40 large T antigen-transformed human primary normal and cancerous mammary epithelial cells are phenotypically similar but can be distinguished in 3D culture with selection medium
    Liangping Li
    Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, Berlin, Federal Republic of Germany
    Int J Cancer 123:1516-25. 2008
    ..This data demonstrate that most primary breast cancer cells are still unable to overcome the in vitro growth restrictions and suggest that the relationship of in vitro immortalization and in vivo carcinogenesis should be re-evaluated...
  54. ncbi request reprint Necrotic death but not irradiation abolishes costimulation of T-cell effector functions and survival by CD80-expressing tumor cells
    Lilian Stärck
    Department of Hematology and Oncology, University Medical Center Charite, Berlin, Germany
    Int J Cancer 116:78-86. 2005
    ..Thus, irradiation does not seem to hamper tumor cell-mediated costimulation of T-cell effector functions. In contrast, necrosis of gene-modified tumor cells abrogates costimulation of T cells by CD80-expressing cells...
  55. ncbi request reprint Cell-based vaccines for renal cell carcinoma: genetically-engineered tumor cells and monocyte-derived dendritic cells
    Bernhard Frankenberger
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
    World J Urol 23:166-74. 2005
    ....
  56. doi request reprint Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice
    Dmitry V Kuprash
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
    Cancer Lett 268:70-5. 2008
    ....
  57. ncbi request reprint Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes
    Michael D Mühlebach
    Department of Medical Biotechnology, Paul Ehrlich Institut, 63225 Langen, Germany
    J Mol Med (Berl) 81:801-10. 2003
    ..Independently of the envelope used for pseudotyping neither the MLV nor the HIV-1 vectors yielded any significant transduction in nonactivated T lymphocytes (below 0.55% of GFP+ cells)..