Saskia Biskup

Summary

Country: Germany

Publications

  1. pmc Dynamic and redundant regulation of LRRK2 and LRRK1 expression
    Saskia Biskup
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Neurosci 8:102. 2007
  2. ncbi request reprint Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
    Andrew B West
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 16:223-32. 2007
  3. pmc Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
    Eva Andres-Mateos
    Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:15846-50. 2009
  4. pmc Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2
    João Paulo L Daher
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 21:2420-31. 2012
  5. pmc Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    Andrew B West
    Institute for Cell Engineering, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:16842-7. 2005
  6. ncbi request reprint Localization of LRRK2 to membranous and vesicular structures in mammalian brain
    Saskia Biskup
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann Neurol 60:557-69. 2006
  7. ncbi request reprint Detrimental deletions: mitochondria, aging and Parkinson's disease
    Saskia Biskup
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bioessays 28:963-7. 2006

Collaborators

Detail Information

Publications7

  1. pmc Dynamic and redundant regulation of LRRK2 and LRRK1 expression
    Saskia Biskup
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Neurosci 8:102. 2007
    ..The expression profiles of the murine LRRK proteins have not been fully described and insufficiently characterized antibodies have produced conflicting results in the literature...
  2. ncbi request reprint Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
    Andrew B West
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 16:223-32. 2007
    ..These results suggest a link between LRRK2 kinase activity and pathogenic mechanisms relating to neurodegeneration, further supporting a gain-of-function role for LRRK2 mutations...
  3. pmc Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
    Eva Andres-Mateos
    Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:15846-50. 2009
    ..Thus, PD due to LRRK2 mutations are likely not due to a loss of function. Moreover, LRRK2 is not required for the susceptibility of DA neurons to MPTP...
  4. pmc Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2
    João Paulo L Daher
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 21:2420-31. 2012
    ..These observations fail to provide support for a pathophysiological interaction of LRRK2 and α-synuclein in vivo, at least within neurons of the mouse hindbrain...
  5. pmc Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    Andrew B West
    Institute for Cell Engineering, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:16842-7. 2005
    ..These results suggest a gain-of-function mechanism for LRRK2-linked disease with a central role for kinase activity in the development of PD...
  6. ncbi request reprint Localization of LRRK2 to membranous and vesicular structures in mammalian brain
    Saskia Biskup
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann Neurol 60:557-69. 2006
    ..The studies herein explore the localization of LRRK2 in the mammalian brain...
  7. ncbi request reprint Detrimental deletions: mitochondria, aging and Parkinson's disease
    Saskia Biskup
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bioessays 28:963-7. 2006
    ....