N G Morgenthaler

Summary

Affiliation: Biotechnology Centre
Country: Germany

Publications

  1. ncbi Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Chem 52:112-9. 2006
  2. pmc Copeptin and risk stratification in patients with acute dyspnea
    Mihael Potocki
    Department of Cardiology, University Hospital, Petersgraben 4, Basel, 4031, Switzerland
    Crit Care 14:R213. 2010
  3. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006
  4. pmc Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
    Renato Seligman
    Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, Brazil
    Crit Care 12:R11. 2008
  5. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
  6. pmc Midregional pro-adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study
    Mihael Potocki
    Department of Internal Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 13:R122. 2009
  7. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
  8. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
  9. pmc Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study
    Nils G Morgenthaler
    Research Department, BRAHMS AG, Biotechnology Center, Hennigsdorf Berlin, Germany
    Crit Care 9:R37-45. 2005
  10. doi Copeptin: clinical use of a new biomarker
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre, Henningsdorf Berlin, Germany
    Trends Endocrinol Metab 19:43-9. 2008

Collaborators

Detail Information

Publications64

  1. ncbi Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Chem 52:112-9. 2006
    ..We present a method for quantifying AVP release by use of copeptin, a glycopeptide comprising the C-terminal part of the AVP prohormone...
  2. pmc Copeptin and risk stratification in patients with acute dyspnea
    Mihael Potocki
    Department of Cardiology, University Hospital, Petersgraben 4, Basel, 4031, Switzerland
    Crit Care 14:R213. 2010
    ..This study investigates the prognostic value of Copeptin, the C-terminal part of the vasopressin prohormone alone and combined to N-terminal pro B-type natriuretic peptide (NT-proBNP) in patients with acute dyspnea...
  3. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006
    ..A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP...
  4. pmc Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
    Renato Seligman
    Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, Brazil
    Crit Care 12:R11. 2008
    ..The present study sought to investigate the correlation of copeptin with the severity of septic status in patients with ventilator-associated pneumonia (VAP), and to analyze the usefulness of copeptin as a predictor of mortality in VAP...
  5. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  6. pmc Midregional pro-adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study
    Mihael Potocki
    Department of Internal Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 13:R122. 2009
    ....
  7. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
    ..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
  8. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
    ..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
  9. pmc Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study
    Nils G Morgenthaler
    Research Department, BRAHMS AG, Biotechnology Center, Hennigsdorf Berlin, Germany
    Crit Care 9:R37-45. 2005
    ....
  10. doi Copeptin: clinical use of a new biomarker
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre, Henningsdorf Berlin, Germany
    Trends Endocrinol Metab 19:43-9. 2008
    ..Here we review recent findings regarding the relationship between AVP and copeptin, and affirm the value of AVP as a surrogate marker for AVP...
  11. ncbi Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection
    N G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Center Hennigsdorf Berlin, Neuensdorfstrasse 25, 16761 Hennigsdorf Berlin, Germany
    Horm Metab Res 35:290-5. 2003
    ..Our primate model offers a valuable tool for further investigation of PCT's pathophysiological role and its immunoneutralization as a therapy for sepsis...
  12. ncbi Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, 16761 Hennigsdorf, Germany
    Clin Chem 50:234-6. 2004
  13. ncbi Affinity purification and diagnostic use of TSH receptor autoantibodies from human serum
    Nils G Morgenthaler
    Research Department of BRAHMS AG, Biotechnology Center Hennigsdorf Berlin, Neuendorfstr 25, D 16761 Hennigsdorf, Germany
    Mol Cell Endocrinol 212:73-9. 2003
    ..Also, their use as tracer in a competitive assay is the first report on a completely homogenous assay with high sensitivity for TSH-R autoantibodies...
  14. doi Copeptin: a biomarker of cardiovascular and renal function
    Nils G Morgenthaler
    From the Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungszentrum, EnForCé, Charite, Berlin, Germany
    Congest Heart Fail 16:S37-44. 2010
    ....
  15. ncbi Sensitive immunoluminometric assay for the detection of procalcitonin
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre, D 16761 Hennigsdorf Berlin, Germany
    Clin Chem 48:788-90. 2002
  16. ncbi Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Lab 48:263-70. 2002
    ..The aim of our study was the characterization of a new sensitive PCT assay, the establishment of reference values and the assessment of diagnostic accuracy...
  17. ncbi Technical evaluation of a new immunoradiometric and a new immunoluminometric assay for thyroglobulin
    Nils G Morgenthaler
    B R A H M S Biotechnology Centre Hennigsdorf Berlin, D 16761 Hennigsdorf bei Berlin, Germany
    Clin Chem 48:1077-83. 2002
    ..After removal of differentiated thyroid carcinoma (DTC), serum thyroglobulin (Tg) can indicate persistent or recurrent disease. We describe two novel two-step assays designed to measure low Tg concentrations...
  18. ncbi Stimulating and blocking thyroid-stimulating hormone (TSH) receptor autoantibodies from patients with Graves' disease and autoimmune hypothyroidism have very similar concentration, TSH receptor affinity, and binding sites
    Nils G Morgenthaler
    Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungs Centrum, EnForCé der Charité, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Clin Endocrinol Metab 92:1058-65. 2007
    ..Here we compare serum concentration, affinity to the TSH-R, and binding sites on the TSH-R of stimulating (TSAb) and blocking (TBAb) TRAbs...
  19. ncbi Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Chem 51:1823-9. 2005
    ..Here we report the technical evaluation of an assay for midregional pro-ADM (MR-proADM) that does not have these problems...
  20. ncbi Isolation and characterization of serum procalcitonin from patients with sepsis
    W Weglöhner
    InVivo Diagnostica Entwicklungsgesellschaft mbH, Neuendorfstr 25, D 16761, Hennigsdorf, Germany
    Peptides 22:2099-103. 2001
    ..This information on the primary structure of PCT might help in further studies on the physiological role of PCT during sepsis...
  21. ncbi Detection of low titre TBII in patients with Graves' disease using recombinant human TSH receptor
    Nils G Morgenthaler
    Research Laboratories, BRAHMS AG, Biotechnology Center, Berlin, Germany
    Clin Endocrinol (Oxf) 57:193-8. 2002
    ....
  22. ncbi Immunoluminometric assay for measurement of the C-terminal endothelin-1 precursor fragment in human plasma
    Jana Papassotiriou
    Research Department, B R A H M S AG, Biotechnology Centre, Hennigsdorf Berlin, Germany
    Clin Chem 52:1144-51. 2006
    ..We report a rapid, robust way to indirectly quantify ET-1 release by measuring the C-terminal ET-1 precursor fragment (CT-proET-1) without an extraction step...
  23. ncbi High concentrations of procalcitonin but not mature calcitonin in normal human milk
    J Struck
    Research Laboratories, B R A H M S AG, Biotechnology Center Hennigsdorf, Hennigsdorf, Germany
    Horm Metab Res 34:460-5. 2002
    ..Similar speculations were proposed for a variety of other pro-inflammatory cytokines, which had comparable kinetics in human milk...
  24. ncbi Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in Type-I diabetes
    N G Morgenthaler
    Department of Medicine III, University of Leipzig, Germany
    Horm Metab Res 30:559-64. 1998
    ..This new assay can facilitate the measurement of IA-2A in routine laboratories where the radioligand assay is inconvenient or not available...
  25. ncbi Direct binding of thyrotropin receptor autoantibody to in vitro translated thyrotropin receptor: a comparison to radioreceptor assay and thyroid stimulating bioassay
    N G Morgenthaler
    Department of Internal Medicine III, University of Leipzig, Germany
    Thyroid 9:466-75. 1999
    ....
  26. ncbi Proteolytic processing pattern of the endothelin-1 precursor in vivo
    Joachim Struck
    Department of Research, BRAHMS Aktiengesellschaft, Neuendorfstr 25, D 16761 Hennigsdorf, Germany
    Peptides 26:2482-6. 2005
    ..Stable proET-1 fragments maybe used in the future as reliable diagnostic targets to indirectly assess the release of ET-1, which might help to more selectively direct therapeutic measures...
  27. ncbi Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Neuendorfstrasse 25, D 16761 Hennigsdorf bei Berlin, Germany
    Shock 28:219-26. 2007
    ..The availability of a reliable assay for the measurement of AVP release can also prove useful for the assessment of fluid and osmosis status in various diseases...
  28. doi Method for the selective measurement of amino-terminal variants of procalcitonin
    Joachim Struck
    Research Department, BRAHMS Aktiengesellschaft, Hennigsdorf Berlin, Germany
    Clin Chem 55:1672-9. 2009
    ..Here we describe the development of monoclonal antibodies recognizing the amino-termini of PCT1-116 and PCT3-116 and their use in the selective measurement of these PCT species...
  29. ncbi Release of the mitochondrial enzyme carbamoyl phosphate synthase under septic conditions
    Joachim Struck
    Department of Research, B R A H M S Aktiengesellschaft, D 16761 Hennigsdorf, Germany
    Shock 23:533-8. 2005
    ..We suggest that circulating CPS-1 might serve as a novel serum marker indicating mitochondrial impairment of the liver and/or the small intestine in critically ill patients...
  30. ncbi Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients
    Joachim Struck
    Department of Research, B R A H M S Aktiengesellschaft, Neuendorfstr 25, D 16761 Hennigsdorf, Germany
    Peptides 25:1369-72. 2004
    ..Thus, proADM 45-92 represents a suitable diagnostic target which could be used to assess the concentrations of Adrenomedullin gene products released into the bloodstream...
  31. ncbi Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients
    Joachim Struck
    Department of Research, BRAHMS Aktiengesellschaft, Neuendorfstr 25, D 16761 Hennigsdorf, Germany
    Peptides 26:2500-4. 2005
    ....
  32. ncbi Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    J Am Coll Cardiol 50:1973-80. 2007
    ..Our aim was assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) using a new immunoassay in patients with chronic heart failure (HF)...
  33. doi New assay for the measurement of selenoprotein P as a sepsis biomarker from serum
    Birgit Hollenbach
    Institute of Experimental Endocrinology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Trace Elem Med Biol 22:24-32. 2008
    ..Since SePP contains the major fraction of serum Se, we conclude that downregulation of SePP biosynthesis or removal of circulating SePP from blood underlies the negative acute phase response of serum Se in critical illness...
  34. doi Comparison of copeptin, B-type natriuretic peptide, and amino-terminal pro-B-type natriuretic peptide in patients with chronic heart failure: prediction of death at different stages of the disease
    Stephanie Neuhold
    Department of Cardiology, Medical University of Vienna, Vienna, Austria
    J Am Coll Cardiol 52:266-72. 2008
    ....
  35. ncbi Midregional pro-A-type natriuretic peptide and carboxy-terminal provasopressin may predict prognosis in community-acquired pneumonia
    Mar Masia
    Infectious Diseases Unit, Internal Medicine Department, Hospital General Universitario de Elche, Alicante, Spain
    Clin Chem 53:2193-201. 2007
    ..We aimed to explore the diagnostic accuracy of MR-proANP and CT-proAVP to predict mortality in patients with CAP...
  36. ncbi C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study
    Sohail Q Khan
    Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Am Heart J 154:736-42. 2007
    ..We investigated the cardiovascular prognostic value post-AMI of CT-proET-1 and compared it to N-terminal pro-B-type natriuretic peptide (NTproBNP), a marker of death and HF...
  37. ncbi Pro-atrial natriuretic peptide and pro-vasopressin to predict severity and prognosis in community-acquired pneumonia: results from the German competence network CAPNETZ
    Stefan Kruger
    Medizinische Klinik I, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Intensive Care Med 33:2069-78. 2007
    ..The aim of this substudy was to evaluate the value of pro-atrial natriuretic peptide (MR-proANP) and pro-vasopressin (CT-proAVP) for severity assessment and outcome prediction in CAP...
  38. ncbi Decreased serum amyloid beta(1-42) autoantibody levels in Alzheimer's disease, determined by a newly developed immuno-precipitation assay with radiolabeled amyloid beta(1-42) peptide
    Sylvia Brettschneider
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Biol Psychiatry 57:813-6. 2005
    ..Autoantibodies against amyloid beta (A beta) peptide found in patients with Alzheimer's disease (AD) also occur naturally in the general population independently of the cognitive status...
  39. pmc The influence of corticosteroids on the release of novel biomarkers in human endotoxemia
    Martijn D de Kruif
    Center for Experimental and Molecular Medicine, Room G2 132, Academic Medical Center, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands
    Intensive Care Med 34:518-22. 2008
    ..However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone...
  40. ncbi Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity
    Sabine Costagliola
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, ULB, 808 Lennik Street, B 1070 Brussels, Belgium
    Mol Endocrinol 18:3020-34. 2004
    ..Delineation of the conformational epitopes of these stimulating antibodies opens the way to the identification of the molecular mechanisms implicated in the activation of the TSHr...
  41. ncbi Clinical results of anti-inflammatory therapy in Graves' ophthalmopathy and association with thyroidal autoantibodies
    Anja K Eckstein
    Department of Ophthalmology, University of Essen, Germany
    Clin Endocrinol (Oxf) 61:612-8. 2004
    ..Fifty-two patients had inactive GO, 41 had moderately active and 15 still had very active (non-responsive) GO. Concerning severity, 27 patients had mild GO, 64 moderately severe and 17 severe GO...
  42. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
    ..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
  43. ncbi Diagnostic performance of mid-regional pro-adrenomedullin as an analyte for the exclusion of left ventricular dysfunction
    Elif Elmas
    Int J Cardiol 128:107-11. 2008
    ..In ambulatory patients with coronary artery disease (CAD) we aimed to evaluate the diagnostic performance of mid-regional pro-adrenomedullin (MR-proADM) for the detection or exclusion of impaired left ventricular ejection fraction (LVEF)...
  44. ncbi The effect of thyrotropin-receptor blocking antibodies on stimulating autoantibodies from patients with Graves' disease
    Cornelia Lenzner
    Bioassays GmbH, Biotechnology Center Hennigsdorf bei Berlin, Germany
    Thyroid 13:1153-61. 2003
    ..Also of interest, when a TBAb serum was added to a TSAb serum, the TBAb effect was predominant even at high dilutions...
  45. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  46. ncbi Midregional pro-A-type natriuretic peptide measurements for diagnosis of acute destabilized heart failure in short-of-breath patients: comparison with B-type natriuretic peptide (BNP) and amino-terminal proBNP
    Alfons Gegenhuber
    Department of Internal Medicine, Konventhospital Barmherzige Brueder, Linz, Austria
    Clin Chem 52:827-31. 2006
    ....
  47. ncbi Thyrotropin receptor autoantibodies in Graves' disease
    Matthias Schott
    Department of Endocrinology, Diabetes and Rheumatology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    Trends Endocrinol Metab 16:243-8. 2005
    ....
  48. ncbi Thyrotropin receptor autoantibodies are independent risk factors for Graves' ophthalmopathy and help to predict severity and outcome of the disease
    Anja K Eckstein
    Department of Ophthalmology, Essen University Clinic, Hufelandstrasse 55, D 45122 Essen, Germany
    J Clin Endocrinol Metab 91:3464-70. 2006
    ..The objective of this study was to examine whether TSH-receptor antibody [TSH binding inhibitory antibodies (TBII)] levels are associated with the severity of Graves' ophthalmopathy (GO) over the entire course of the disease...
  49. ncbi Copeptin and arginine vasopressin concentrations in critically ill patients
    Stefan Jochberger
    Department of Anesthesiology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Clin Endocrinol Metab 91:4381-6. 2006
    ..Determination of arginine vasopressin (AVP) concentrations may be helpful to guide therapy in critically ill patients. A new assay analyzing copeptin, a stable peptide derived from the AVP precursor, has been introduced...
  50. ncbi Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and Copeptin to predict 1-year mortality in patients with acute destabilized heart failure
    Alfons Gegenhuber
    Department of Internal Medicine, Konventhospital Barmherzige Brueder Linz, Linz, Austria
    J Card Fail 13:42-9. 2007
    ....
  51. ncbi The relationship between adrenomedullin, metabolic factors, and vascular function in individuals with type 2 diabetes
    Su Chi Lim
    Department of Medicine, Alexandra Hospital, Singapore, Republic of Singapore
    Diabetes Care 30:1513-9. 2007
    ..Several vasoactive factors (e.g., angiotensin) have been implicated. We hypothesize that adrenomedullin, a novel vascoactive factor, is deranged in subjects with type 2 diabetes...
  52. ncbi Stimulation of thyroid-stimulating hormone (TSH) receptor antibody production following painless thyroiditis
    Makoto Iitaka
    Department of Internal Medicine 4, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, Japan
    Clin Endocrinol (Oxf) 60:49-53. 2004
    ..Therefore, we measured titres of TSH receptor antibodies (TSHR Ab) using a novel sensitive TSHR Ab assay in patients with PT to determine whether PT enhances TSHR Ab production, possibly triggering the development or recurrence of GD...
  53. ncbi C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study
    Sohail Q Khan
    University of Leicester, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Circulation 115:2103-10. 2007
    ..We compared the prognostic value of copeptin and an established marker, N-terminal pro-B-type natriuretic peptide (NTproBNP), after acute myocardial infarction...
  54. ncbi A coated tube assay for the detection of blocking thyrotropin receptor autoantibodies
    Waldemar B Minich
    MiLo GmbH, B R A H M S AG, Biotechnology Center Hennigsdorf Berlin, D 16761 Hennigsdorf, Germany
    J Clin Endocrinol Metab 89:352-6. 2004
    ..This is the first report of a coated tube assay for the determination of TBAb employing an adaptation of the TSH binding-inhibitory format, which could be a useful alternative to the bioassay...
  55. ncbi Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
    ....
  56. ncbi Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects
    Gabor Szinnai
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:3973-8. 2007
    ..Copeptin is the C-terminal part of provasopressin and has been shown to be a useful tool to indicate AVP concentration in critically ill patients...
  57. doi Plasma pro-adrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPD
    Daiana Stolz
    Clinic of Pneumology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 134:263-72. 2008
    ..We investigated whether plasma pro-endothelin-1 (proET-1) and/or pro-adrenomedullin (proADM) on admission to the hospital for acute exacerbation predict survival in patients with COPD...
  58. ncbi Patients with severe Graves' ophthalmopathy have a higher risk of relapsing hyperthyroidism and are unlikely to remain in remission
    Anja K Eckstein
    Department of Ophthalmology, University of Essen, Essen, Germany
    Clin Endocrinol (Oxf) 67:607-12. 2007
    ..To evaluate the relationship between severity of Graves' ophthalmopathy (GO) and relapse/remission rate of associated thyroid disease...
  59. ncbi Midregional pro-atrial natriuretic peptide as a prognostic marker in pneumonia
    Cristina Prat
    Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    J Infect 55:400-7. 2007
    ..To evaluate the usefulness of midregional pro-atrial natriuretic peptide (MR-proANP) measurement in the stratification of severity in community-acquired pneumonia...
  60. ncbi Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation
    Andrea Ernst
    SphingoTec GmbH, Tulpenweg 6, D 16556 Borgsdorf, Germany
    J Neuroimmunol 189:169-74. 2007
    ..Our results indicate a central production of PCT and suggest PCT as a valuable marker candidate for the monitoring of dementia and acute neuroinflammation...
  61. ncbi Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay
    Mira Katan
    Department of Endocrinology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:2640-3. 2007
    ..However, AVP measurement is cumbersome. Copeptin, the stable C-terminal glycopeptide of the AVP prohormone, is stoichiometrically secreted from the posterior pituitary...
  62. ncbi Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease
    Fumiki Yoshihara
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Nephrol Dial Transplant 22:2263-8. 2007
    ..Objectives. We evaluated whether midregional proadrenomedullin reflects cardiac dysfunction, systemic inflammation or blood volume in haemodialysis patients...
  63. ncbi Effect of gastric bypass and gastric banding on proneurotensin levels in morbidly obese patients
    Mirjam Christ-Crain
    Department of Endocrinology, Charterhouse Square, St Bartholomews Hospital, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 91:3544-7. 2006
    ..Neurotensin is produced mainly in the N cells of the ileum and has a role in appetite regulation; levels are decreased in obese subjects and increase after bariatric surgery. Mature neurotensin is very unstable, with a short half-life...
  64. doi Plasma N-terminal B-Type natriuretic peptide as an indicator of long-term survival after acute myocardial infarction: comparison with plasma midregional pro-atrial natriuretic peptide: the LAMP (Leicester Acute Myocardial Infarction Peptide) study
    Sohail Q Khan
    University of Leicester, Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
    J Am Coll Cardiol 51:1857-64. 2008
    ..Our aim was to assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients after acute myocardial infarction (AMI)...