F Binkofski

Summary

Country: Germany

Publications

  1. ncbi [Apraxias]
    F Binkofski
    Klinik und Poliklinik für Neurologie und Neuroimage Nord, Universitätskrankenhaus Schleswig Holstein, Campus Lubeck, Deutschland
    Nervenarzt 76:493-509; quiz 510-1. 2005
  2. ncbi The role of ventral premotor cortex in action execution and action understanding
    Ferdinand Binkofski
    Department of Neurology and Neuroimage Nord, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Physiol Paris 99:396-405. 2006
  3. ncbi Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia
    F Binkofski
    Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Neurology 69:842-50. 2007
  4. pmc Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
    B F L van Nuenen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neurology 72:1041-7. 2009
  5. ncbi A fronto-parietal circuit for object manipulation in man: evidence from an fMRI-study
    F Binkofski
    Department of Neurology, Heinrich Heine University of Dusseldorf, Germany
    Eur J Neurosci 11:3276-86. 1999
  6. doi Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
    C Eggers
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 74:1798-805. 2010
  7. ncbi The role of diaschisis in stroke recovery
    R J Seitz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Stroke 30:1844-50. 1999
  8. ncbi Role of the premotor cortex in recovery from middle cerebral artery infarction
    R J Seitz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Arch Neurol 55:1081-8. 1998
  9. ncbi Activation of frontoparietal cortices during memorized triple-step sequences of saccadic eye movements: an fMRI study
    W Heide
    Department of Neurology, Medical University at Lubeck, D 23538 Lubeck, Germany
    Eur J Neurosci 13:1177-89. 2001
  10. ncbi Neural activity related to self- versus externally generated painful stimuli reveals distinct differences in the lateral pain system in a parametric fMRI study
    Christoph Helmchen
    NeuroImage Nord, Department of Neurology, University of Lubeck, Lubeck, Germany
    Hum Brain Mapp 27:755-65. 2006

Collaborators

Detail Information

Publications45

  1. ncbi [Apraxias]
    F Binkofski
    Klinik und Poliklinik für Neurologie und Neuroimage Nord, Universitätskrankenhaus Schleswig Holstein, Campus Lubeck, Deutschland
    Nervenarzt 76:493-509; quiz 510-1. 2005
    ..Therefore, appropriate diagnosis and treatment of the different forms are of foremost clinical importance...
  2. ncbi The role of ventral premotor cortex in action execution and action understanding
    Ferdinand Binkofski
    Department of Neurology and Neuroimage Nord, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Physiol Paris 99:396-405. 2006
    ..Experimental evidence in favour of this hypothesis both in the monkey and humans is shortly reviewed...
  3. ncbi Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia
    F Binkofski
    Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Neurology 69:842-50. 2007
    ..We hypothesized that subclinical nigrostriatal neurodegeneration caused by these mutations would induce morphologic changes in the dysfunctional striatal gray matter...
  4. pmc Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
    B F L van Nuenen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neurology 72:1041-7. 2009
    ..Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease alters the cortical control of sequential finger movements...
  5. ncbi A fronto-parietal circuit for object manipulation in man: evidence from an fMRI-study
    F Binkofski
    Department of Neurology, Heinrich Heine University of Dusseldorf, Germany
    Eur J Neurosci 11:3276-86. 1999
    ..It is proposed that area SII analyses the intrinsic object characteristics whilst the superior parietal lobule is related to kinaesthesia...
  6. doi Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
    C Eggers
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 74:1798-805. 2010
    ..While homozygous mutations in the PINK1 gene cause recessively inherited early-onset Parkinson disease (PD), heterozygous mutations have been suggested as a susceptibility factor...
  7. ncbi The role of diaschisis in stroke recovery
    R J Seitz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Stroke 30:1844-50. 1999
    ..To address this question, we studied regional cerebral blood flow in 7 patients (mean+/-SD age, 54+/-8 years) after their first hemiparetic stroke...
  8. ncbi Role of the premotor cortex in recovery from middle cerebral artery infarction
    R J Seitz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Arch Neurol 55:1081-8. 1998
    ..To study the mechanisms underlying recovery from middle cerebral artery infarction in 7 patients with an average age of 53 years who showed marked recovery of hand function after acute severe hemiparesis caused by their first-ever stroke...
  9. ncbi Activation of frontoparietal cortices during memorized triple-step sequences of saccadic eye movements: an fMRI study
    W Heide
    Department of Neurology, Medical University at Lubeck, D 23538 Lubeck, Germany
    Eur J Neurosci 13:1177-89. 2001
    ....
  10. ncbi Neural activity related to self- versus externally generated painful stimuli reveals distinct differences in the lateral pain system in a parametric fMRI study
    Christoph Helmchen
    NeuroImage Nord, Department of Neurology, University of Lubeck, Lubeck, Germany
    Hum Brain Mapp 27:755-65. 2006
    ..The attenuated activation of SI during self-generated painful stimulation might be a result of the predictability of the sensory consequences of the pain-related action...
  11. ncbi Reduced neuronal activity in the V5 complex underlies smooth-pursuit deficit in schizophrenia: evidence from an fMRI study
    Rebekka Lencer
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Neuroimage 24:1256-9. 2005
    ....
  12. ncbi Cortical mechanisms of smooth pursuit eye movements with target blanking. An fMRI study
    Rebekka Lencer
    Department of Psychiatry and Psychotherapy, University of Leubeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Eur J Neurosci 19:1430-6. 2004
    ....
  13. ncbi Recovery of motor functions following hemiparetic stroke: a clinical and magnetic resonance-morphometric study
    F Binkofski
    Department of Neurology, Heinrich Heine University of Dusseldorf, Germany
    Cerebrovasc Dis 11:273-81. 2001
    ..Since lesion size was not correlated with outcome the amount of spared residual function appeared as major determinant for the capacity for motor recovery...
  14. ncbi Control of action as mediated by the human frontal lobe
    R J Seitz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Exp Brain Res 133:71-80. 2000
    ..It is suggested that the initiational aspects of conscious motor activity are implemented in a medial system of information flow and the integrative aspects in a lateral system of the human frontal lobe...
  15. ncbi Parametric modulation of cortical activation during smooth pursuit with and without target blanking. an fMRI study
    Matthias Nagel
    Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany
    Neuroimage 29:1319-25. 2006
    ..Furthermore, we suggest that parietal areas are related to the suppression of saccades during smooth pursuit...
  16. ncbi Motor impairment in patients with parietal lesions: disturbances of meaningless arm movement sequences
    P H Weiss
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neuropsychologia 39:397-405. 2001
    ..These results demonstrate that lesions in the left parietal lobe lead to a disturbed spatio-temporal organisation of movement that becomes increasingly prominent for more complex movements...
  17. doi The role of ipsilateral primary motor cortex in movement control and recovery from brain damage
    M C Stoeckel
    Department of Neurology, University of Lubeck, Germany
    Exp Neurol 221:13-7. 2010
    ..This comment briefly summarizes the relevant findings supporting both views and discusses potential causes for the prima facie contradictory findings...
  18. ncbi Tactile apraxia: unimodal apractic disorder of tactile object exploration associated with parietal lobe lesions
    F Binkofski
    Department of Neurology, Heinrich-Heine-University, , Germany
    Brain 124:132-44. 2001
    ....
  19. ncbi The anterior cingulate cortex contains distinct areas dissociating external from self-administered painful stimulation: a parametric fMRI study
    C Mohr
    NeuroImage Nord NIN, Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Pain 114:347-57. 2005
    ....
  20. ncbi Left and right superior parietal lobule in tactile object discrimination
    M C Stoeckel
    Department of Neurology, University Hospital Düsseldorf Moorenstr 5, 40225 Dusseldorf, Germany
    Eur J Neurosci 19:1067-72. 2004
    ....
  21. ncbi Cerebellar neural responses related to actively and passively applied noxious thermal stimulation in human subjects: a parametric fMRI study
    C Helmchen
    Department of Neurology, University of Luebeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Neurosci Lett 361:237-40. 2004
    ..The cerebellum seems to be capable of distinguishing active from passive painful stimuli...
  22. doi Cortical mechanisms of retinal and extraretinal smooth pursuit eye movements to different target velocities
    Matthias Nagel
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Neuroimage 41:483-92. 2008
    ..The activation of the inferior parietal cortex seems to be related to the interaction between velocity and blanking thereby underlining its relevance for task switching and sensorimotor transformation...
  23. doi Dissociating networks of imitation
    Mareike M Menz
    Department of Neurology and Neuroimage Nord, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Hum Brain Mapp 30:3339-50. 2009
    ..This indicates a late integration of object affordances into the movement as the time course of activity in this network pertains to action rather than perception of the object...
  24. ncbi Functional properties and interaction of the anterior and posterior intraparietal areas in humans
    Elisa Shikata
    Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University School of Medicine, Martinstrasse 52, D 20246 Hamburg, Germany
    Eur J Neurosci 17:1105-10. 2003
    ..These data clearly indicate that the function of human CIP is more involved in coding 3D features of the objects, whereas human AIP is more involved in visually guided hand movements, similar to its role in the monkey...
  25. ncbi Action observation has a positive impact on rehabilitation of motor deficits after stroke
    Denis Ertelt
    Department of Neurology and Neuroimage Nord, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neuroimage 36:T164-73. 2007
    ....
  26. ncbi Modular organization of parietal lobe functions as revealed by functional activation studies
    Rudiger J Seitz
    Department of Neurology, University Hospital Dusseldorf, Dusseldorf, Germany
    Adv Neurol 93:281-92. 2003
  27. ncbi Increased functional connectivity is crucial for learning novel muscle synergies
    Adam McNamara
    NeuroImage Nord, Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, UKSH Luebeck, 23539, Germany
    Neuroimage 35:1211-8. 2007
    ..Greater levels of daily activity may increase the integration of muscle representations across the motor cortex, enabling faster learning of novel movements...
  28. doi Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers
    Kathrin Reetz
    Department of Neurology, University of Luebeck, Luebeck, Germany
    Biol Psychiatry 64:241-7. 2008
    ..Mutations in the PINK1 gene can cause Parkinson's disease and are frequently associated with psychiatric symptoms that might even precede motor signs...
  29. ncbi Modulation of the BOLD-response in early recovery from sensorimotor stroke
    Ferdinand Binkofski
    Department of Neurology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23539 Lübeck, Germany
    Neurology 63:1223-9. 2004
    ..The BOLD signal in functional MRI (fMRI) is closely related to neural activity...
  30. ncbi Different extraretinal neuronal mechanisms of smooth pursuit eye movements in schizophrenia: An fMRI study
    Matthias Nagel
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Neuroimage 34:300-9. 2007
    ..The results implicate that schizophrenic patients employ different strategies during SPEM both with and without target blanking than healthy subjects. These strategies predominantly involve extraretinal mechanisms...
  31. ncbi A fronto-parietal circuit for tactile object discrimination: an event-related fMRI study
    M Cornelia Stoeckel
    Department of Neurology, University Hospital Dusseldorf, Dusseldorf, Germany
    Neuroimage 19:1103-14. 2003
    ..The results reveal a prominent role of the human prefrontal cortex for somatosensory object discrimination in correspondence with recent models on stimulus discrimination and working memory...
  32. pmc Neural dynamics of learning sound-action associations
    Adam McNamara
    NeuroImage Nord, Department of Neurology, UKSH, Luebeck, Germany
    PLoS ONE 3:e3845. 2008
    ....
  33. ncbi Activation of cerebellar hemispheres in spatial memorization of saccadic eye movements: an fMRI study
    Matthias F Nitschke
    Department of Neurology, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Hum Brain Mapp 22:155-64. 2004
    ....
  34. ncbi Supramodal representation of objects and actions in the human inferior temporal and ventral premotor cortex
    Ferdinand Binkofski
    Dept of Neurology, University Hospital Schleswig Holstein, Campus Lubeck, Germany
    Cortex 40:159-61. 2004
  35. ncbi Mirror apraxia affects the peripersonal mirror space. A combined lesion and cerebral activation study
    Ferdinand Binkofski
    Department of Neurology, University Hospital Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Exp Brain Res 153:210-9. 2003
    ..The results demonstrate that acting through a mirror is processed in a number of cortical areas of the dorsal stream...
  36. ncbi Introduction: higher motor cognition - from basic neuroscience to apraxia
    Ferdinand Binkofski
    Neuroimage 36:T1. 2007
  37. ncbi The mirror neuron system and action recognition
    Giovanni Buccino
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Brain Lang 89:370-6. 2004
    ..It has been proposed that this system is involved in action recognition. Experimental evidence in favor of this hypothesis both in the monkey and humans are shortly reviewed...
  38. ncbi Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit?
    Katja Hedrich
    Department of Neurology, University of Lubeck, Germany
    Arch Neurol 63:833-8. 2006
    ..Although homozygous mutations in the PTEN-induced putative kinase 1 (PINK1) gene have been unequivocally associated with early-onset Parkinson disease (PD), the role of single heterozygous PINK1 mutations is less clear...
  39. ncbi Polymodal conceptual processing of human biological actions in the left inferior frontal lobe
    Annette Baumgaertner
    NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Eur J Neurosci 25:881-9. 2007
    ..We conclude that the pars opercularis of Broca's area is endowed with polymodal capabilities, allowing the processing of higher-level conceptual aspects of action understanding...
  40. ncbi Localization of human intraparietal areas AIP, CIP, and LIP using surface orientation and saccadic eye movement tasks
    Elisa Shikata
    NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Germany
    Hum Brain Mapp 29:411-21. 2008
    ....
  41. ncbi Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis
    Anne Grünewald
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurogenetics 8:103-9. 2007
    ..1366C>T mutation...
  42. ncbi Motor functions of the Broca's region
    Ferdinand Binkofski
    Department of Neuroscience, Section of Physiology, University of Parma, Italy
    Brain Lang 89:362-9. 2004
    ..Brodmann's area 44 is also a part of a specialized parieto-premotor network and interacts significantly with the neighboring premotor areas...
  43. ncbi A fronto-parietal network is mediating improvement of motor function related to repetitive peripheral magnetic stimulation: A PET-H2O15 study
    Albrecht Struppler
    Sensorimotor Integration Research Group, Klinikum rechts der Isar der TUM, Psychiatrische Klinik 7 0, Ismaningerstr 22, 81675 Munchen, Germany
    Neuroimage 36:T174-86. 2007
    ..These results emphasize the positive therapeutic effect of RPMS and describe the physiological bases of its function on the central level...
  44. ncbi [Which patients benefit?]
    Ferdinand Binkofski
    MMW Fortschr Med 146:6. 2004
  45. ncbi The neural basis for understanding non-intended actions
    Giovanni Buccino
    Department of Neuroscience, Section of Physiology, University of Parma, Via Volturno 31, 43100 Parma, Italy
    Neuroimage 36:T119-27. 2007
    ..The concomitant activation of mesial prefrontal areas, known to be involved in self-referential processing, might reflect how deeply participants are involved in the observed scenes...