G Binder

Summary

Country: Germany

Publications

  1. ncbi request reprint Screening for insulin-like growth factor-I receptor mutations in patients with Silver-Russell syndrome
    Gerhard Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1167-71. 2002
  2. ncbi request reprint Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling
    R Schweizer
    Pediatric Endocrinology Section, University Children s Hospital, University of Tuebingen D 72076, Germany
    J Clin Endocrinol Metab 88:5266-72. 2003
  3. ncbi request reprint The early dehydroepiandrosterone sulfate rise of adrenarche and the delay of pubarche indicate primary ovarian failure in Turner syndrome
    David D Martin
    University Children s Hospital, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 89:1164-8. 2004
  4. ncbi request reprint Variability of isolated autosomal dominant GH deficiency (IGHD II): impact of the P89L GH mutation on clinical follow-up and GH secretion
    Souzan Salemi
    Paediatric Endocrinology, University Children s Hospital, Inselspital, CH 3010 Bern, Switzerland
    Eur J Endocrinol 153:791-802. 2005
  5. doi request reprint The endocrine phenotype in silver-russell syndrome is defined by the underlying epigenetic alteration
    Gerhard Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 93:1402-7. 2008
  6. ncbi request reprint Insulin tolerance test causes hypokalaemia and can provoke cardiac arrhythmias
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 62:84-7. 2004
  7. ncbi request reprint Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:484-92. 2005
  8. ncbi request reprint Isolated GH deficiency (IGHD) type II: imaging of the pituitary gland by magnetic resonance reveals characteristic differences in comparison with severe IGHD of unknown origin
    G Binder
    University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Eur J Endocrinol 147:755-60. 2002
  9. ncbi request reprint Isolated growth hormone deficiency and the GH-1 gene: update 2002
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 58:2-6. 2002
  10. ncbi request reprint Radiological signs of Leri-Weill dyschondrosteosis in Turner syndrome
    G Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    Horm Res 55:71-6. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Screening for insulin-like growth factor-I receptor mutations in patients with Silver-Russell syndrome
    Gerhard Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1167-71. 2002
    ..Our data do not support the suggestion that the IGF-I receptor is frequently involved in the pathogenesis of SRS...
  2. ncbi request reprint Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling
    R Schweizer
    Pediatric Endocrinology Section, University Children s Hospital, University of Tuebingen D 72076, Germany
    J Clin Endocrinol Metab 88:5266-72. 2003
    ..Thus, the manifestation of GH deficiency is evidently similar in children and adults, and pQCT provides important information in addition to DEXA measurements, as DEXA does not take bone structure into account...
  3. ncbi request reprint The early dehydroepiandrosterone sulfate rise of adrenarche and the delay of pubarche indicate primary ovarian failure in Turner syndrome
    David D Martin
    University Children s Hospital, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 89:1164-8. 2004
    ..These data demonstrate that normal timing of adrenarche is dependent on gonadal function and suggest that normal pubarche is the clinical manifestation of the ovarian conversion of DHEAS to active androgens...
  4. ncbi request reprint Variability of isolated autosomal dominant GH deficiency (IGHD II): impact of the P89L GH mutation on clinical follow-up and GH secretion
    Souzan Salemi
    Paediatric Endocrinology, University Children s Hospital, Inselspital, CH 3010 Bern, Switzerland
    Eur J Endocrinol 153:791-802. 2005
    ....
  5. doi request reprint The endocrine phenotype in silver-russell syndrome is defined by the underlying epigenetic alteration
    Gerhard Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 93:1402-7. 2008
    ..Around 50% of children with Silver-Russell syndrome (SRS) carry a hypomethylation of the imprinting control region 1 at the IGF2/H19 locus on 11p15, the functional significance of which is unknown...
  6. ncbi request reprint Insulin tolerance test causes hypokalaemia and can provoke cardiac arrhythmias
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 62:84-7. 2004
    ..In addition, in the case of a comatose child during ITT the determination of the glucose and potassium level as well as adequate treatment are necessary...
  7. ncbi request reprint Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:484-92. 2005
    ..In women, this mode of aromatase excess may remain clinically inapparent...
  8. ncbi request reprint Isolated GH deficiency (IGHD) type II: imaging of the pituitary gland by magnetic resonance reveals characteristic differences in comparison with severe IGHD of unknown origin
    G Binder
    University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Eur J Endocrinol 147:755-60. 2002
    ..To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II)...
  9. ncbi request reprint Isolated growth hormone deficiency and the GH-1 gene: update 2002
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 58:2-6. 2002
    ....
  10. ncbi request reprint Radiological signs of Leri-Weill dyschondrosteosis in Turner syndrome
    G Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    Horm Res 55:71-6. 2001
    ..The aim of this study was to systematically examine left-hand radiographs from Turner girls for the presence of signs of LWD...
  11. ncbi request reprint SHOX haploinsufficiency and Leri-Weill dyschondrosteosis: prevalence and growth failure in relation to mutation, sex, and degree of wrist deformity
    Gerhard Binder
    Section of Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 89:4403-8. 2004
    ..No statistically significant effects of type of mutation, age of menarche, or sex on height were observed. The effect of GH therapy varied between individuals and needs to be examined in controlled studies...
  12. ncbi request reprint Significance of basal IGF-I, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 54:60-8. 2000
    ..We conclude that the determination of basal IGF parameters is, together with anthropometry and imaging techniques, an indispensable tool for differentiating between GHD and ISS; and that IGFBP-2 plays an additional role in this process...
  13. ncbi request reprint Relevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Horm Res 55:115-24. 2001
    ..We determined the extent to which the IGF parameters exceed the normal ranges and identified those parameters which are predictive of 1st-year growth...
  14. doi request reprint Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention
    J Schum
    Pediatric Endocrinology and Diabetes, University Children s Hospital, Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 120:128-31. 2012
    ..To investigate the impact of variants of the FTO gene (rs1421085, rs17817449, rs9939609) in obese children before and after lifestyle intervention...
  15. doi request reprint The functional muscle-bone unit in obese children - altered bone structure leads to normal strength strain index
    S Ehehalt
    Pediatric Endocrinology and Diabetology, University Children s Hospital, Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 119:321-6. 2011
    ..Obese children have a twofold increased risk of fracture of the forearm compared to non-obese children...
  16. ncbi request reprint Catch-up growth in autosomal dominant isolated growth hormone deficiency (IGHD type II)
    G Binder
    University Children s Hospital, Pediatric Endocrinology Section, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    Growth Horm IGF Res 17:242-8. 2007
    ..Data on the GH-induced catch-up growth of severely GH-deficient children affected by monogenetic defects are missing...
  17. ncbi request reprint The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short small-for-gestational-age children
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:659-64. 2006
    ....
  18. doi request reprint Prevalence and incidence of endocrine disorders in children: results of a survey in Baden-Wuerttemberg and Bavaria (EndoPrIn BB) 2000-2001
    R Schweizer
    University Children s Hospital, Pediatric Endocrinology and Diabetology, Hoppe Seyler Strasse 1, Tubingen, Germany
    Klin Padiatr 222:67-72. 2010
    ..Sparse data is available on the incidence of endocrine disorders among children in Germany...
  19. doi request reprint Metacarpal thickness, width, length and medullary diameter in children--reference curves from the First Zürich Longitudinal Study
    D D Martin
    Pediatric Endocrinology and Diabetology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Osteoporos Int 22:1525-36. 2011
    ..Reference data for the four metacarpal measures are presented...
  20. doi request reprint Auxology-based cut-off values for biochemical testing of GH secretion in childhood
    G Binder
    University Children s Hospital, Pediatric Endocrinology, Tuebingen, Germany
    Growth Horm IGF Res 21:212-8. 2011
    ..The diagnosis of GH deficiency (GHD) in childhood requires GH tests with arbitrary cut-offs. We aimed to define GH cut-offs based on auxology...
  21. doi request reprint Analysis of the GH content within archived dried blood spots of newborn screening cards from children diagnosed with growth hormone deficiency after the neonatal period
    G Binder
    University Children s Hospital, Pediatric Endocrinology, Tuebingen, Germany
    Growth Horm IGF Res 21:314-7. 2011
    ..We aimed to determine the GH content within archived dried blood spots of newborn screening cards from children diagnosed with GHD at childhood...
  22. doi request reprint Rational approach to the diagnosis of severe growth hormone deficiency in the newborn
    G Binder
    Department of Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 95:2219-26. 2010
    ..Reviews and consensus papers on the diagnosis of GHD repeatedly state the lack of a practical evidence-based approach to the diagnosis of GHD in the newborn...
  23. ncbi request reprint Mutant and misfolded human growth hormone is rapidly degraded through the proteasomal degradation pathway in a cellular model for isolated growth hormone deficiency type II
    K Kannenberg
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Neuroendocrinol 19:882-90. 2007
    ..The results of the present study indicate that, in IGHD II, somatotrophs continuously have to remove misfolded del(32-71)-hGH via the proteasomal degradation pathway, suggesting a mechanism that may result in chronic cellular stress...
  24. ncbi request reprint IGF-II serum levels are normal in children with Silver-Russell syndrome who frequently carry epimutations at the IGF2 locus
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:4709-12. 2006
    ..It has been speculated that these mutations characterized by demethylation of ICR1 cause diminished IGF2 expression...
  25. ncbi request reprint The course of neonatal cholestasis in congenital combined pituitary hormone deficiency
    G Binder
    University Children s Hospital, Tuebingen, Germany
    J Pediatr Endocrinol Metab 20:695-702. 2007
    ..Neonatal cholestatic hepatitis is frequently associated with congenital combined pituitary hormone deficiency (CCPHD). Data on the course of this hepatopathy are scarce...
  26. ncbi request reprint Screening for growth hormone (GH) gene splice-site mutations in sporadic cases with severe isolated GH deficiency using ectopic transcript analysis
    G Binder
    University Children s Hospital, Tubingen, Germany
    J Clin Endocrinol Metab 80:1247-52. 1995
    ..abstract truncated at 400 words)..
  27. ncbi request reprint PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 90:5377-81. 2005
    ....
  28. doi request reprint Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial
    G Binder
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    J Clin Endocrinol Metab 94:1182-90. 2009
    ..The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown. Our study aimed to evaluate this therapy...
  29. doi request reprint Increased incidence of aberrant DNA methylation within diverse imprinted gene loci outside of IGF2/H19 in Silver-Russell syndrome
    K Kannenberg
    Pediatric Endocrinology, University Children s Hospital Tubingen, Hoppe Seyler Street 1, Tubingen, Germany
    Clin Genet 81:366-77. 2012
    ....
  30. ncbi request reprint IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia
    Michael Zeschnigk
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Eur J Hum Genet 16:328-34. 2008
    ..Furthermore, we show that methylation analysis by QAMA and MLPA is more sensitive in detecting ICR1 hypomethylation than Southern blot analysis of CTS3...
  31. ncbi request reprint IGF-I and IGF binding protein-3 levels during initial GH dosage step-up are indicators of GH sensitivity in GH-deficient children and short children born small for gestational age
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 64:68-76. 2005
    ..A stepwise increment of the GH dose is an approach aimed at avoiding adverse events. We investigated GH sensitivity by studying IGF-I and IGFBP-3 concentrations during the initial phase of GH treatment...
  32. ncbi request reprint Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature
    Gerhard Binder
    University Children s Hospital, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 88:4891-6. 2003
    ..Our observations suggest that it is rational to limit SHOX mutation screening to children with an extremities-trunk ratio less than 1.95 + 1/2 height (m) and to add a critical judgment of the hand radiography...
  33. ncbi request reprint No evidence for additional imprinting defects in Silver-Russell syndrome patients with maternal uniparental disomy 7 or 11p15 epimutation
    Nadine Schönherr
    Institute of Human Genetics, Technical University of Aachen, Germany
    J Pediatr Endocrinol Metab 20:1329-31. 2007
    ..We showed that further epigenetic defects did not occur in the groups of SRS with LOM of ICR1 or mUPD7, and that these subentities do not belong to the diseases with a general hypomethylation defect, such as TNDM and BWS...
  34. doi request reprint Search for subtelomeric imbalances by multiplex ligation-dependent probe amplification in Silver-Russell syndrome
    Katja Eggermann
    Institute of Human Genetics, RWTH Aachen, Aachen, Germany
    Genet Test 12:111-3. 2008
    ..It can therefore be concluded that this type of chromosomal aberration does not belong to the genetic causes of SRS and it is not necessary to include this test in the diagnostic algorithm of the disease...
  35. ncbi request reprint Structural analysis of human growth hormone with respect to the dominant expression of growth hormone (GH) mutations in isolated GH deficiency type II
    Daniel I Iliev
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen Germany
    Endocrinology 146:1411-7. 2005
    ..The inhibitory effect of GH mutants on heterologously expressed, non-GH proteins suggests that the dominant negative effect is not limited to GH or to proteins of the regulated secretory pathway, but may depend on expression levels...
  36. ncbi request reprint The A645D mutation in the hinge region of the human androgen receptor (AR) gene modulates AR activity, depending on the context of the polymorphic glutamine and glycine repeats
    Ralf Werner
    Department of Pediatric and Adolescent Medicine, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 91:3515-20. 2006
    ..In addition, they also harbor a rare A645D substitution...
  37. ncbi request reprint Isolated autosomal dominant growth hormone deficiency: an evolving pituitary deficit? A multicenter follow-up study
    Primus E Mullis
    Pediatric Endocrinology, Diabetology, and Metabolism, University Children s Hospital, Inselspital, CH 3010 Bern, Switzerland
    J Clin Endocrinol Metab 90:2089-96. 2005
    ..The message of clinical importance from these studies is that the pituitary endocrine status of all such patients should continue to be monitored closely over the years because further hormonal deficiencies may evolve with time...
  38. ncbi request reprint In vitro analysis of hGH secretion in the presence of mutations of amino acids involved in zinc binding
    Daniel I Iliev
    Pediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
    J Mol Endocrinol 39:163-7. 2007
    ..Our in vitro data do not support the hypothesis of disturbed Zn(2+) binding as a major pathogenetic mechanism in dominantly transmitted GH deficiency...
  39. ncbi request reprint Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children
    Roland Schweizer
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076, Tubingen, Germany
    Bone 41:875-81. 2007
    ..Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength...
  40. doi request reprint No evidence for isolated imprinting mutations in the PEG1/MEST locus in Silver-Russell patients
    Nadine Schöherr
    Institute of Human Genetics, RWTH Aachen, University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Eur J Med Genet 51:322-4. 2008
    ..However, the role of imprinting disturbances in other genes cannot be excluded...