Jan Bieschke

Summary

Country: Germany

Publications

  1. pmc EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
    Jan Bieschke
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 107:7710-5. 2010
  2. doi Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils
    Jan Bieschke
    Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nat Chem Biol 8:93-101. 2012
  3. doi EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
    Dagmar E Ehrnhoefer
    Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
    Nat Struct Mol Biol 15:558-66. 2008
  4. doi Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils
    Gerlinde Grelle
    Max Delbruck Centrum fur Molekulare Medizin, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Biochemistry 50:10624-36. 2011

Collaborators

Detail Information

Publications4

  1. pmc EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
    Jan Bieschke
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 107:7710-5. 2010
    ..These findings suggest that EGCG is a potent remodeling agent of mature amyloid fibrils...
  2. doi Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils
    Jan Bieschke
    Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nat Chem Biol 8:93-101. 2012
    ..These results support the hypothesis that small, diffusible prefibrillar amyloid species rather than mature fibrillar aggregates are toxic for mammalian cells...
  3. doi EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
    Dagmar E Ehrnhoefer
    Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
    Nat Struct Mol Biol 15:558-66. 2008
    ..Instead of beta-sheet-rich amyloid, the formation of unstructured, nontoxic alpha-synuclein and amyloid-beta oligomers of a new type is promoted, suggesting a generic effect on aggregation pathways in neurodegenerative diseases...
  4. doi Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils
    Gerlinde Grelle
    Max Delbruck Centrum fur Molekulare Medizin, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Biochemistry 50:10624-36. 2011
    ..When compared to EGCG, TF3 was less susceptible to air oxidation and had an increased efficacy under oxidizing conditions. These findings suggest that theaflavins might be used to remove toxic amyloid deposits...