Affiliation: Bezirkskrankenhaus Haar
- Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair familiesSibylle G Schwab
Western Australian Institute of Medical Research, University of Western Australia, Perth, Australia
Biol Psychiatry 58:446-50. 2005..In addition to impairment of protein-levels and phosphorylation levels in the pathway, association of DNA sequence variants in the AKT1 gene with schizophrenia has been detected in a family sample...
- [Integrated care of mentally ill patients--catchword or a real improvement in care?]Margot Albus
MMW Fortschr Med . 2006..Up until now, the project has shown that the patients' care can be improved through better coordination of the available resources and tighter intersector cooperation...
- A prospective 2-year follow-up study of neurocognitive functioning in patients with first-episode schizophreniaMargot Albus
Division of Teaching and Research, District Hospital Haar, Vockestr 72, 85540 Haar, Germany
Eur Arch Psychiatry Clin Neurosci 252:262-7. 2002..Our data suggest that there is no proof for the assumption of progressive deterioration in NP functioning during the first few years of illness...
- Neurocognitive functioning in patients with first-episode schizophrenia : results of a prospective 5-year follow-up studyMargot Albus
District Hospital Haar, Vockestr 72, 85540, Haar, Germany
Eur Arch Psychiatry Clin Neurosci 256:442-51. 2006..Our data suggest that NP impairment is already present at the onset of the illness and remains stable over the early course of schizophrenia...
- Neurological soft signs and neuropsychological performance in patients with first episode schizophreniaFriedrich Mohr
State Mental Hospital Haar Munich, Vockestrasse 72, Haar D 85529, Germany
Psychiatry Res 121:21-30. 2003..Neurologic soft signs influence NP performance and are correlated to a generalized NP deficit rather than to any specific NP functions...
- No support for an association with TAAR6 and schizophrenia in a linked population of European ancestryHerbert P Ludewick
Western Australian Institute of Medical Research and Centre for Medical Research, University of Western Australia, School of Psychiatry and Clinical Neuroscience, Nedlands, WA 6009, Australia
Psychiatr Genet 18:208-10. 2008..2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples...
- DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association studySibylle G Schwab
Western Australian Institute of Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
Psychiatr Genet 18:25-30. 2008..In this study, we focused on DNA sequence variants, for which association was reported and attempted to replicate association with schizophrenia or with cognitive deficits known to be present in patients with schizophrenia...
- Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophreniaAlexandra Schosser
Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Vienna, Austria
Am J Med Genet B Neuropsychiatr Genet 144:347-50. 2007..032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals...
- Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patientsBernd Frank
Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
Am J Med Genet B Neuropsychiatr Genet 131:1-5. 2004..49, 95% CI: 0.3-0.82; genotype-wise: 15,5% vs. 29,0%, P = 0.005, OR = 0.45, 95% CI: 0.26-0.77). We suggest that this deletion may influence translational efficiency, thereby possibly affecting the development of bipolar affective disease...
- Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expressionDubravka Hranilovic
Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Genetics, Rudjer Boskovic Institute, Zagreb, Croatia
Biol Psychiatry 55:1090-4. 2004..02). CONCLUSIONS: Our results indicate weak individual influence, but possible combined effect, of 5-HTTLPR and VNTR-2 polymorphisms on 5-HTT gene expression...
- Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophreniaSibylle G Schwab
Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
Schizophr Res 65:19-25. 2003..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]...
- [No association of 141C-ins/del polymorphism in the D2 dopamine receptor gene in schizophrenia]Thomas Rohrmeier
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum, Franz Josef Strauss Allee 11, 93042 Regensburg
Psychiatr Prax 30:S212-5. 2003..124). Thus, our data do not support the hypothesis that the -141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed...
- Reliability and validity of Quality of Life assessed by the Short-Form 36 and the Modular System for Quality of Life in patients with schizophrenia and patients with depressionRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
Psychiatry Res 119:63-79. 2003....
- Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad familiesSibylle G Schwab
Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
Am J Hum Genet 72:185-90. 2003....
- No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
- Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophreniaSibylle G Schwab
Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Bonn, Germany
Am J Med Genet 114:315-20. 2002..Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31...